ATE280229T1 - Enterotoxine von shigella flexneri 2a - Google Patents

Enterotoxine von shigella flexneri 2a

Info

Publication number
ATE280229T1
ATE280229T1 AT95903130T AT95903130T ATE280229T1 AT E280229 T1 ATE280229 T1 AT E280229T1 AT 95903130 T AT95903130 T AT 95903130T AT 95903130 T AT95903130 T AT 95903130T AT E280229 T1 ATE280229 T1 AT E280229T1
Authority
AT
Austria
Prior art keywords
enterotoxins
shigella flexneri
reactogenic
antibodies
develop
Prior art date
Application number
AT95903130T
Other languages
English (en)
Inventor
Alessio Fasano
Fernando Noriega
Myron M Levine
James P Nataro
Original Assignee
Univ Maryland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/160,317 external-priority patent/US5468639A/en
Application filed by Univ Maryland filed Critical Univ Maryland
Application granted granted Critical
Publication of ATE280229T1 publication Critical patent/ATE280229T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/25—Shigella (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/825—Bacteria

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Cell Electrode Carriers And Collectors (AREA)
AT95903130T 1993-12-02 1994-12-01 Enterotoxine von shigella flexneri 2a ATE280229T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/160,317 US5468639A (en) 1992-06-05 1993-12-02 Isolated DNA molecule encoding ShET2 of Shigella flexneri 2a
US08/351,147 US5589380A (en) 1992-06-05 1994-11-30 Isolated DNA molecule encoding SHET1 of Shigella flexneri 2a and mutant Shigella flexneri 2a
PCT/US1994/013289 WO1995015396A1 (en) 1993-12-02 1994-12-01 ENTEROTOXINS OF SHIGELLA FLEXNERI 2a

Publications (1)

Publication Number Publication Date
ATE280229T1 true ATE280229T1 (de) 2004-11-15

Family

ID=26856785

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95903130T ATE280229T1 (de) 1993-12-02 1994-12-01 Enterotoxine von shigella flexneri 2a

Country Status (7)

Country Link
US (2) US5589380A (de)
EP (1) EP0734451B1 (de)
JP (4) JP3903347B2 (de)
AT (1) ATE280229T1 (de)
AU (1) AU675028B2 (de)
DE (1) DE69434087T2 (de)
WO (1) WO1995015396A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE312934T1 (de) * 1995-06-07 2005-12-15 Univ Washington Rekombinant bakterielle system mit umweltbeschränkte lebensfähigkeit
US6344201B1 (en) 1998-03-31 2002-02-05 Anthony T. Maurelli Methods of identifying bacterial genes that are incompatible with bacterial pathogenicity, and the use of such genes, such as cadA, to reduce pathogenicity in a bacteria or to combat pathogenic bacterial infections
WO2000018355A2 (en) * 1998-09-30 2000-04-06 Walter Reed Army Institute Of Research Use of purified invaplex from gram negative bacteria as a vaccine
AU2008246150B2 (en) 2007-04-25 2013-07-25 The United States Of America As Represented By The Secretary Of The Army, Walter Reed Army Institute Of Research Combinations of gene deletions for live attenuated shigella vaccine strains
JP2011514881A (ja) 2007-11-09 2011-05-12 ザ ソルク インスティテュート フォー バイオロジカル スタディーズ 免疫増強剤としてのｔａｍ受容体阻害剤の使用および免疫抑制剤としてのｔａｍ活性化剤の使用
EP2085466A1 (de) * 2008-01-29 2009-08-05 AEterna Zentaris GmbH Nicht pathogene und/oder gedämpfte Bakterien zur Herbeiführung von Apoptose in Makrophagen sowie Herstellungsverfahren dafür und Verwendungen davon
CN104245920A (zh) * 2011-06-10 2014-12-24 株式会社爱茉莉太平洋 分离自茶树叶的新型植物乳杆菌

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5204097A (en) * 1986-07-06 1993-04-20 Yeda Research And Development Company Limited Shiga toxin B chain polypeptides and vaccine thereto
SE8901188D0 (sv) * 1989-04-05 1989-04-05 Astra Ab A novel diagnostic method

Also Published As

Publication number Publication date
JP2004337171A (ja) 2004-12-02
AU1210595A (en) 1995-06-19
JPH09506254A (ja) 1997-06-24
AU675028B2 (en) 1997-01-16
DE69434087T2 (de) 2006-03-09
DE69434087D1 (de) 2004-11-25
US5589380A (en) 1996-12-31
EP0734451A1 (de) 1996-10-02
WO1995015396A1 (en) 1995-06-08
US5686580A (en) 1997-11-11
EP0734451A4 (de) 1997-11-26
JP2007020572A (ja) 2007-02-01
EP0734451B1 (de) 2004-10-20
JP2009022299A (ja) 2009-02-05
JP3903347B2 (ja) 2007-04-11

Similar Documents

Publication Publication Date Title
DK0733069T3 (da) Oprensede Primat CTLA-8-antigener og beslægtede reagenser
DE3854502D1 (de) Gegen hiv-antigene spezifischer monoklonaler antikörper.
DK0807178T3 (da) Mycobaktielle proteiner, mikroorganismer producerende samme og anvendelser af nævnte proteiner i vacciner og til påvisning af tuberkulose
DK261386A (da) Monoklonale antistoffer
ATE160575T1 (de) Für toxin b von clostridium difficile spezifische monoklonale antikörper
DE69622776T2 (de) Von Multitasking gebrauch machendes Sortieren
DK137793A (da) Ekstrakter af Cucurbita Sp., fremgangsmåde til fremstilling og anvendelse af disse i lægemidler og kosmetiske præparater
ITGE940043A0 (it) Metodo pe la produzione di feltri agugliati vellutati.
DE3885355D1 (de) Monoklonale Antikörper.
ATE162311T1 (de) Immunoassay zum nachweis von kollagen oder kollagenfragmenten
DK0594576T3 (da) Immunoafprøvninger for og monoklonale antistoffer over for prothrombin-aktivering-peptider og deres nedbrydningsprodukter
ATE280229T1 (de) Enterotoxine von shigella flexneri 2a
DE69634077D1 (de) Haemophilus adhäsionsproteinen
DE69014591T2 (de) Thermomagnetischer Sauerstoffsensor.
NO923781D0 (no) Ekspresjon av heterologt protein i gjaer
YU46858B (sh) Postupak za dobijanje imunoglobulinskih konjugata
ATE294237T1 (de) S?ugetier thymokingene
DE3850993T2 (de) Monoklonaler Antikörper spezifisch gegen humane Pankreas-Phospholipase-A2.
NO874107D0 (no) Nye monoklonale antistoffer mot ifn-omega, fremgangsmaate til fremstilling derav og anvendelse for rensing samt paavisning av ifn-omega.
DK49291D0 (da) Gramnegativ-bakterieendotoxinblokerende, monoklonale antistoffer
DK0556320T3 (da) Monoklonale antistoffer mod Hepatitis C-virus og fremgangsmåde til anvendelse heraf
DK0551501T3 (da) Anvendelse af endotheliel-leukocyt-adhæsions-
DE3484512D1 (de) Gleitkomma-zustandskode-erzeugung.
NO890116L (no) Monoklonale antistoffer.
DE69118702D1 (de) Neue verwendung eines monoklonalen antikörpers

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0734451

Country of ref document: EP

REN Ceased due to non-payment of the annual fee