DE69533988D1 - Verfahren zum blokieren von sec-rezeptoren - Google Patents

Verfahren zum blokieren von sec-rezeptoren

Info

Publication number
DE69533988D1
DE69533988D1 DE69533988T DE69533988T DE69533988D1 DE 69533988 D1 DE69533988 D1 DE 69533988D1 DE 69533988 T DE69533988 T DE 69533988T DE 69533988 T DE69533988 T DE 69533988T DE 69533988 D1 DE69533988 D1 DE 69533988D1
Authority
DE
Germany
Prior art keywords
bloating
sec
receptors
sec receptors
peptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69533988T
Other languages
English (en)
Inventor
H Perlmutter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
St Louis University
Washington University in St Louis WUSTL
Original Assignee
St Louis University
Washington University in St Louis WUSTL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by St Louis University, Washington University in St Louis WUSTL filed Critical St Louis University
Application granted granted Critical
Publication of DE69533988D1 publication Critical patent/DE69533988D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8125—Alpha-1-antitrypsin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Indole Compounds (AREA)
  • Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
DE69533988T 1994-09-09 1995-09-07 Verfahren zum blokieren von sec-rezeptoren Expired - Lifetime DE69533988D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/306,872 US5514653A (en) 1994-09-09 1994-09-09 Method of blocking the SEC receptor
PCT/US1995/010989 WO1996007425A1 (en) 1994-09-09 1995-09-07 Method of blocking the sec receptor

Publications (1)

Publication Number Publication Date
DE69533988D1 true DE69533988D1 (de) 2005-03-10

Family

ID=23187244

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69533988T Expired - Lifetime DE69533988D1 (de) 1994-09-09 1995-09-07 Verfahren zum blokieren von sec-rezeptoren

Country Status (8)

Country Link
US (1) US5514653A (de)
EP (1) EP0781143B1 (de)
JP (1) JPH10505086A (de)
AT (1) ATE288280T1 (de)
AU (1) AU3498795A (de)
CA (1) CA2199180A1 (de)
DE (1) DE69533988D1 (de)
WO (1) WO1996007425A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5792749A (en) * 1997-01-09 1998-08-11 Virginia Commonwealth University Method and composition for lowering low density lipoprotein cholesterol
DE19725619A1 (de) * 1997-06-17 1998-12-24 Fraunhofer Ges Forschung Peptide als Agonisten und/oder Inhibitoren der Amyloidbildung und Zytotoxizität sowie der Verwendung bei Alzheimer'schen Krankheit, beim Typ II Diabetes mellitus und bei spongiformen Encephalopathien
US7704958B1 (en) 1999-03-05 2010-04-27 Bio Holding, Inc. Methods and compositions for inhibiting apoptosis using serine protease inhibitors
US6849605B1 (en) 1999-03-05 2005-02-01 The Trustees Of University Technology Corporation Inhibitors of serine protease activity, methods and compositions for treatment of viral infections
AU3864000A (en) * 1999-03-05 2000-09-21 Trustees Of University Technology Corporation, The Inhibitors of serine protease activity, methods and compositions for treatment of herpes viruses
AU3511500A (en) 1999-03-05 2000-09-21 Trustees Of University Technology Corporation, The Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide-induced clinical conditions
WO2001085093A2 (en) 1999-12-23 2001-11-15 Neurochem, Inc. Compounds and methods for modulating cerebral amyloid angiopathy
DE10148553A1 (de) * 2001-10-01 2003-04-17 Protagen Ag Proteinaseinhibitoren zur Therapie und Diagnose von neurodegenerativen Krankheiten
US20040220242A1 (en) * 2003-05-02 2004-11-04 Leland Shapiro Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide induced clinical conditions
EP3192872A1 (de) * 2003-08-26 2017-07-19 The Regents of the University of Colorado, a body corporate Inhibitoren der serinproteaseaktivität und deren verwendung in verfahren und zusammensetzungen zur behandlung bakterieller infektionen
US9938353B2 (en) 2011-06-24 2018-04-10 The Regents Of The University Of Colorado, A Body Corporate Compositions, methods and uses for alpha-1 antitrypsin fusion molecules
AU2013208293B2 (en) * 2012-01-09 2017-08-10 Serpin Pharma, Llc Peptides and methods of using same
CA2896951A1 (en) 2012-01-10 2013-07-18 The Regents Of The University Of Colorado, A Body Corporate Compositions, methods and uses for alpha-1 antitrypsin fusion molecules
WO2014207421A1 (en) 2013-06-26 2014-12-31 Tws (Macau Commercial Offshore) Limited Energy storage system
CA2996975C (en) 2015-08-28 2022-02-15 Serpin Pharma, Llc Methods for treatment of diseases

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU577259B2 (en) * 1982-08-13 1988-09-22 Zymogenetics Inc. Glycolytic promters for regulated protein expression protease inhibitor
JPS60186290A (ja) * 1983-08-10 1985-09-21 チモ−ジエネテイツクス　インコ−ポレ−テツド アルフア−１−アンチトリプシンを細菌に表現させる方法
US5157019A (en) * 1986-03-18 1992-10-20 Monsanto Company Serine protease inhibitors
US5187153A (en) * 1986-11-17 1993-02-16 Scios Nova Inc. Methods of treatment using Alzheimer's amyloid polypeptide derivatives
US5137873A (en) * 1990-07-27 1992-08-11 The Children's Medical Center Corporation Substance p and tachykinin agonists for treatment of alzheimer's disease
US5164295A (en) * 1991-03-06 1992-11-17 The Upjohn Company Method for identifying amyloid protein-extracellular matrix protein affinity altering compounds
US5175253A (en) * 1991-04-24 1992-12-29 Washington University Binding peptides
US5604201A (en) * 1993-01-08 1997-02-18 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University, A Non-Profit Organization Methods and reagents for inhibiting furin endoprotease

Also Published As

Publication number Publication date
AU3498795A (en) 1996-03-27
EP0781143A1 (de) 1997-07-02
ATE288280T1 (de) 2005-02-15
CA2199180A1 (en) 1996-03-14
US5514653A (en) 1996-05-07
JPH10505086A (ja) 1998-05-19
WO1996007425A1 (en) 1996-03-14
EP0781143B1 (de) 2005-02-02

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Legal Events

Date Code Title Description
8332 No legal effect for de