|
US4235871A
(en)
|
1978-02-24 |
1980-11-25 |
Papahadjopoulos Demetrios P |
Method of encapsulating biologically active materials in lipid vesicles
|
|
US4182449A
(en)
|
1978-04-18 |
1980-01-08 |
Kozlow William J |
Adhesive bandage and package
|
|
US4501728A
(en)
|
1983-01-06 |
1985-02-26 |
Technology Unlimited, Inc. |
Masking of liposomes from RES recognition
|
|
US4880635B1
(en)
|
1984-08-08 |
1996-07-02 |
Liposome Company |
Dehydrated liposomes
|
|
US4921757A
(en)
|
1985-04-26 |
1990-05-01 |
Massachusetts Institute Of Technology |
System for delayed and pulsed release of biologically active substances
|
|
US5139941A
(en)
|
1985-10-31 |
1992-08-18 |
University Of Florida Research Foundation, Inc. |
AAV transduction vectors
|
|
US4737323A
(en)
|
1986-02-13 |
1988-04-12 |
Liposome Technology, Inc. |
Liposome extrusion method
|
|
US5017492A
(en)
|
1986-02-27 |
1991-05-21 |
Life Technologies, Inc. |
Reverse transcriptase and method for its production
|
|
JP2874751B2
(ja)
|
1986-04-09 |
1999-03-24 |
ジェンザイム・コーポレーション |
希望する蛋白質をミルク中へ分泌する遺伝子移植動物
|
|
US4920016A
(en)
|
1986-12-24 |
1990-04-24 |
Linear Technology, Inc. |
Liposomes with enhanced circulation time
|
|
US4837028A
(en)
|
1986-12-24 |
1989-06-06 |
Liposome Technology, Inc. |
Liposomes with enhanced circulation time
|
|
JPH0825869B2
(ja)
|
1987-02-09 |
1996-03-13 |
株式会社ビタミン研究所 |
抗腫瘍剤包埋リポソ−ム製剤
|
|
US4917951A
(en)
|
1987-07-28 |
1990-04-17 |
Micro-Pak, Inc. |
Lipid vesicles formed of surfactants and steroids
|
|
US4911928A
(en)
|
1987-03-13 |
1990-03-27 |
Micro-Pak, Inc. |
Paucilamellar lipid vesicles
|
|
BR8807472A
(pt)
|
1987-04-23 |
1990-03-27 |
Fmc Corp |
Composto,composicao inseticida,processo de controle de insetos e acarideos e processo para preparacao de um composto
|
|
MC2115A1
(fr)
|
1987-12-15 |
1991-07-05 |
Gene Shears Pty Ltd |
Ribozynes
|
|
US5244797B1
(en)
|
1988-01-13 |
1998-08-25 |
Life Technologies Inc |
Cloned genes encoding reverse transcriptase lacking rnase h activity
|
|
EP1997891A1
(en)
|
1988-09-02 |
2008-12-03 |
Dyax Corporation |
Generation and selection of recombinant varied binding proteins
|
|
WO1991003162A1
(en)
|
1989-08-31 |
1991-03-21 |
City Of Hope |
Chimeric dna-rna catalytic sequences
|
|
US5264618A
(en)
|
1990-04-19 |
1993-11-23 |
Vical, Inc. |
Cationic lipids for intracellular delivery of biologically active molecules
|
|
US5427908A
(en)
|
1990-05-01 |
1995-06-27 |
Affymax Technologies N.V. |
Recombinant library screening methods
|
|
WO1991017424A1
(en)
|
1990-05-03 |
1991-11-14 |
Vical, Inc. |
Intracellular delivery of biologically active substances by means of self-assembling lipid complexes
|
|
US5637459A
(en)
|
1990-06-11 |
1997-06-10 |
Nexstar Pharmaceuticals, Inc. |
Systematic evolution of ligands by exponential enrichment: chimeric selex
|
|
US5580737A
(en)
|
1990-06-11 |
1996-12-03 |
Nexstar Pharmaceuticals, Inc. |
High-affinity nucleic acid ligands that discriminate between theophylline and caffeine
|
|
ES2134198T3
(es)
|
1990-09-28 |
1999-10-01 |
Hoffmann La Roche |
Mutaciones en la 5' a 3' exonucleasa de las adn polimerasas.
|
|
DE553264T1
(de)
|
1990-10-05 |
1994-04-28 |
Wayne M Barnes |
Thermostabile dna polymerase.
|
|
DE69123979T2
(de)
|
1990-10-12 |
1997-04-30 |
Max Planck Gesellschaft |
Abgeänderte ribozyme
|
|
NZ314630A
(en)
|
1991-01-17 |
2000-11-24 |
Harvard College |
Use of trans-splicing ribozymes for genetic modification and cell ablation in a host cell
|
|
NZ241310A
(en)
|
1991-01-17 |
1995-03-28 |
Gen Hospital Corp |
Trans-splicing ribozymes
|
|
DE4216134A1
(de)
|
1991-06-20 |
1992-12-24 |
Europ Lab Molekularbiolog |
Synthetische katalytische oligonukleotidstrukturen
|
|
US6872816B1
(en)
|
1996-01-24 |
2005-03-29 |
Third Wave Technologies, Inc. |
Nucleic acid detection kits
|
|
US5652094A
(en)
|
1992-01-31 |
1997-07-29 |
University Of Montreal |
Nucleozymes
|
|
JPH05274181A
(ja)
|
1992-03-25 |
1993-10-22 |
Nec Corp |
ブレークポイント設定・解除方式
|
|
US5587308A
(en)
|
1992-06-02 |
1996-12-24 |
The United States Of America As Represented By The Department Of Health & Human Services |
Modified adeno-associated virus vector capable of expression from a novel promoter
|
|
US5434058A
(en)
|
1993-02-09 |
1995-07-18 |
Arch Development Corporation |
Apolipoprotein B MRNA editing protein compositions and methods
|
|
AU680921B2
(en)
|
1993-05-17 |
1997-08-14 |
Regents Of The University Of California, The |
Ribozyme gene therapy for HIV infection and AIDS
|
|
US5651981A
(en)
|
1994-03-29 |
1997-07-29 |
Northwestern University |
Cationic phospholipids for transfection
|
|
US5912155A
(en)
|
1994-09-30 |
1999-06-15 |
Life Technologies, Inc. |
Cloned DNA polymerases from Thermotoga neapolitana
|
|
US5449639A
(en)
|
1994-10-24 |
1995-09-12 |
Taiwan Semiconductor Manufacturing Company Ltd. |
Disposable metal anti-reflection coating process used together with metal dry/wet etch
|
|
US5767099A
(en)
|
1994-12-09 |
1998-06-16 |
Genzyme Corporation |
Cationic amphiphiles containing amino acid or dervatized amino acid groups for intracellular delivery of therapeutic molecules
|
|
US6057153A
(en)
|
1995-01-13 |
2000-05-02 |
Yale University |
Stabilized external guide sequences
|
|
US5795587A
(en)
|
1995-01-23 |
1998-08-18 |
University Of Pittsburgh |
Stable lipid-comprising drug delivery complexes and methods for their production
|
|
US5830430A
(en)
|
1995-02-21 |
1998-11-03 |
Imarx Pharmaceutical Corp. |
Cationic lipids and the use thereof
|
|
US5851548A
(en)
|
1995-06-07 |
1998-12-22 |
Gen-Probe Incorporated |
Liposomes containing cationic lipids and vitamin D
|
|
NO953680D0
(no)
|
1995-09-18 |
1995-09-18 |
Hans Prydz |
Cellesyklusenzymer
|
|
US5962313A
(en)
|
1996-01-18 |
1999-10-05 |
Avigen, Inc. |
Adeno-associated virus vectors comprising a gene encoding a lyosomal enzyme
|
|
WO1997044348A1
(en)
|
1996-05-17 |
1997-11-27 |
Thomas Jefferson University |
Ribozyme-mediated gene replacement
|
|
GB9701425D0
(en)
|
1997-01-24 |
1997-03-12 |
Bioinvent Int Ab |
A method for in vitro molecular evolution of protein function
|
|
US5981182A
(en)
|
1997-03-13 |
1999-11-09 |
Albert Einstein College Of Medicine Of Yeshiva University |
Vector constructs for the selection and identification of open reading frames
|
|
US20040203109A1
(en)
|
1997-06-06 |
2004-10-14 |
Incyte Corporation |
Human regulatory proteins
|
|
US5849528A
(en)
|
1997-08-21 |
1998-12-15 |
Incyte Pharmaceuticals, Inc.. |
Polynucleotides encoding a human S100 protein
|
|
US6355415B1
(en)
|
1997-09-29 |
2002-03-12 |
Ohio University |
Compositions and methods for the use of ribozymes to determine gene function
|
|
US6429301B1
(en)
|
1998-04-17 |
2002-08-06 |
Whitehead Institute For Biomedical Research |
Use of a ribozyme to join nucleic acids and peptides
|
|
US8097648B2
(en)
|
1998-06-17 |
2012-01-17 |
Eisai R&D Management Co., Ltd. |
Methods and compositions for use in treating cancer
|
|
EP1129064B1
(en)
|
1998-11-12 |
2008-01-09 |
Invitrogen Corporation |
Transfection reagents
|
|
US7013219B2
(en)
|
1999-01-12 |
2006-03-14 |
Sangamo Biosciences, Inc. |
Regulation of endogenous gene expression in cells using zinc finger proteins
|
|
US6599692B1
(en)
|
1999-09-14 |
2003-07-29 |
Sangamo Bioscience, Inc. |
Functional genomics using zinc finger proteins
|
|
US6453242B1
(en)
|
1999-01-12 |
2002-09-17 |
Sangamo Biosciences, Inc. |
Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites
|
|
US6534261B1
(en)
|
1999-01-12 |
2003-03-18 |
Sangamo Biosciences, Inc. |
Regulation of endogenous gene expression in cells using zinc finger proteins
|
|
US20090130718A1
(en)
|
1999-02-04 |
2009-05-21 |
Diversa Corporation |
Gene site saturation mutagenesis
|
|
WO2000058480A1
(en)
|
1999-03-29 |
2000-10-05 |
Kansai Technology Licensing Organization Co., Ltd. |
Novel cytidine deaminase
|
|
CA2386341A1
(en)
|
1999-11-18 |
2001-05-25 |
Epimmune Inc. |
Heteroclitic analogs and related methods
|
|
JP2003514564A
(ja)
|
1999-11-24 |
2003-04-22 |
エムシーエス マイクロ キャリア システムズ ゲーエムベーハー |
核局在化シグナルまたはタンパク質導入領域の多量体を含むポリペプチド、および分子を細胞内へ移入するためのその使用法
|
|
AU776576B2
(en)
|
1999-12-06 |
2004-09-16 |
Sangamo Biosciences, Inc. |
Methods of using randomized libraries of zinc finger proteins for the identification of gene function
|
|
JP5047437B2
(ja)
|
2000-02-08 |
2012-10-10 |
サンガモ バイオサイエンシーズ, インコーポレイテッド |
薬物の発見のための細胞
|
|
US7078208B2
(en)
|
2000-05-26 |
2006-07-18 |
Invitrogen Corporation |
Thermostable reverse transcriptases and uses thereof
|
|
WO2002034771A2
(en)
|
2000-10-27 |
2002-05-02 |
Chiron Srl |
Nucleic acids and proteins from streptococcus groups a & b
|
|
CN101317825A
(zh)
|
2000-10-30 |
2008-12-10 |
欧罗赛铁克股份有限公司 |
控释氢可酮制剂
|
|
US20040003420A1
(en)
|
2000-11-10 |
2004-01-01 |
Ralf Kuhn |
Modified recombinase
|
|
US7067650B1
(en)
|
2000-11-22 |
2006-06-27 |
National Institute Of Advanced Industrial Science And Technology |
Ribozymes targeting bradeion transcripts and use thereof
|
|
WO2002059296A2
(en)
|
2001-01-25 |
2002-08-01 |
Evolva Biotech A/S |
Concatemers of differentially expressed multiple genes
|
|
US20050222030A1
(en)
|
2001-02-21 |
2005-10-06 |
Anthony Allison |
Modified annexin proteins and methods for preventing thrombosis
|
|
US20040115184A1
(en)
|
2001-02-27 |
2004-06-17 |
Smith Harold C |
Methods and compositions for modifying apolipoprotein b mrna editing
|
|
EP1490483B1
(en)
|
2001-04-19 |
2015-06-03 |
The Scripps Research Institute |
In vivo incorporation of unnatural amino acids
|
|
CA2449042A1
(en)
*
|
2001-05-30 |
2002-12-27 |
Biomedical Center |
In silico screening for phenotype-associated expressed sequences
|
|
JP4473573B2
(ja)
|
2001-07-26 |
2010-06-02 |
ストラタジーン カリフォルニア |
多部位突然変異誘発
|
|
WO2003104413A2
(en)
|
2002-06-05 |
2003-12-18 |
University Of Florida |
Production of pseudotyped recombinant aav virions
|
|
US9388459B2
(en)
|
2002-06-17 |
2016-07-12 |
Affymetrix, Inc. |
Methods for genotyping
|
|
AU2003251905A1
(en)
|
2002-07-12 |
2004-02-02 |
Affymetrix, Inc. |
Synthetic tag genes
|
|
AU2003288906C1
(en)
|
2002-09-20 |
2010-12-09 |
Yale University |
Riboswitches, methods for their use, and compositions for use with riboswitches.
|
|
ES2317016T3
(es)
|
2003-04-14 |
2009-04-16 |
Caliper Life Sciences, Inc. |
Reduccion de la interferencia en uin ensayo de desplazamiento por migracion.
|
|
US20050136429A1
(en)
|
2003-07-03 |
2005-06-23 |
Massachusetts Institute Of Technology |
SIRT1 modulation of adipogenesis and adipose function
|
|
DE602004011789T2
(de)
|
2003-07-07 |
2009-02-12 |
The Scripps Research Institute, La Jolla |
Zusammensetzungen der orthogonalen Lysyl-tRNA und Aminoacyl-tRNA Synthetase Paaren und ihre Verwendungen
|
|
EP3222715A1
(en)
|
2003-08-08 |
2017-09-27 |
Sangamo BioSciences, Inc. |
Methods and compositions for targeted cleavage and recombination
|
|
US7670807B2
(en)
|
2004-03-10 |
2010-03-02 |
East Tennessee State Univ. Research Foundation |
RNA-dependent DNA polymerase from Geobacillus stearothermophilus
|
|
WO2005098043A2
(en)
|
2004-03-30 |
2005-10-20 |
The President And Fellows Of Harvard College |
Ligand-dependent protein splicing
|
|
US7595179B2
(en)
|
2004-04-19 |
2009-09-29 |
Applied Biosystems, Llc |
Recombinant reverse transcriptases
|
|
US7919277B2
(en)
|
2004-04-28 |
2011-04-05 |
Danisco A/S |
Detection and typing of bacterial strains
|
|
EP1814896A4
(en)
|
2004-07-06 |
2008-07-30 |
Commercialisation Des Produits |
TARGET-RELATED NUCLEIC ACID ADAPTER
|
|
WO2006023207A2
(en)
|
2004-08-19 |
2006-03-02 |
The United States Of America As Represented By The Secretary Of Health And Human Services, Nih |
Coacervate of anionic and cationic polymer forming microparticles for the sustained release of therapeutic agents
|
|
JP5101288B2
(ja)
|
2004-10-05 |
2012-12-19 |
カリフォルニア インスティテュート オブ テクノロジー |
アプタマー調節される核酸及びその利用
|
|
JP2006248978A
(ja)
|
2005-03-10 |
2006-09-21 |
Mebiopharm Co Ltd |
新規なリポソーム製剤
|
|
US9783791B2
(en)
|
2005-08-10 |
2017-10-10 |
Agilent Technologies, Inc. |
Mutant reverse transcriptase and methods of use
|
|
AU2012244264B2
(en)
|
2005-08-26 |
2015-08-06 |
Dupont Nutrition Biosciences Aps |
Use
|
|
AU2015252023B2
(en)
|
2005-08-26 |
2017-06-29 |
Dupont Nutrition Biosciences Aps |
Use
|
|
EP2325332B1
(en)
|
2005-08-26 |
2012-10-31 |
DuPont Nutrition Biosciences ApS |
Use of CRISPR associated genes (CAS)
|
|
DE602006021587D1
(de)
|
2005-09-30 |
2011-06-09 |
Univ Hokkaido Nat Univ Corp |
Vektor zur zuführung einer zielsubstanz in den zellkern oder die zelle
|
|
KR100784478B1
(ko)
|
2005-12-05 |
2007-12-11 |
한국과학기술원 |
기능요소의 동시 삽입에 의한 신기능을 갖는 단백질을제조하는 방법
|
|
US20080051317A1
(en)
|
2005-12-15 |
2008-02-28 |
George Church |
Polypeptides comprising unnatural amino acids, methods for their production and uses therefor
|
|
JP5364574B2
(ja)
|
2006-05-05 |
2013-12-11 |
モレキュラー、トランスファー、インコーポレイテッド |
真核細胞のトランスフェクションのための新規試薬
|
|
US9816140B2
(en)
|
2006-05-19 |
2017-11-14 |
Dupont Nutrition Biosciences Aps |
Tagged microorganisms and methods of tagging
|
|
EP3045532A1
(en)
|
2006-06-02 |
2016-07-20 |
President and Fellows of Harvard College |
Protein surface remodeling
|
|
WO2007142202A1
(ja)
|
2006-06-06 |
2007-12-13 |
Panasonic Corporation |
ヌクレオチド鎖修飾方法
|
|
US7572618B2
(en)
|
2006-06-30 |
2009-08-11 |
Bristol-Myers Squibb Company |
Polynucleotides encoding novel PCSK9 variants
|
|
WO2008005529A2
(en)
|
2006-07-07 |
2008-01-10 |
The Trustees Columbia University In The City Of New York |
Cell-mediated directed evolution
|
|
US20120322861A1
(en)
|
2007-02-23 |
2012-12-20 |
Barry John Byrne |
Compositions and Methods for Treating Diseases
|
|
NZ579002A
(en)
|
2007-03-02 |
2012-03-30 |
Danisco |
Cultures with improved phage resistance
|
|
WO2009002418A2
(en)
|
2007-06-21 |
2008-12-31 |
Merck & Co., Inc. |
T-cell peptide epitopes from carcinoembryonic antigen, immunogenic analogs, and uses thereof
|
|
FR2919804B1
(fr)
|
2007-08-08 |
2010-08-27 |
Erytech Pharma |
Composition et vaccin therapeutique anti-tumoral
|
|
WO2009033027A2
(en)
|
2007-09-05 |
2009-03-12 |
Medtronic, Inc. |
Suppression of scn9a gene expression and/or function for the treatment of pain
|
|
EP2188384B1
(en)
|
2007-09-27 |
2015-07-15 |
Sangamo BioSciences, Inc. |
Rapid in vivo identification of biologically active nucleases
|
|
US20110014616A1
(en)
|
2009-06-30 |
2011-01-20 |
Sangamo Biosciences, Inc. |
Rapid screening of biologically active nucleases and isolation of nuclease-modified cells
|
|
WO2010102257A2
(en)
|
2009-03-06 |
2010-09-10 |
Synthetic Genomics, Inc. |
Methods for cloning and manipulating genomes
|
|
US9029524B2
(en)
|
2007-12-10 |
2015-05-12 |
California Institute Of Technology |
Signal activated RNA interference
|
|
EP2087789A1
(en)
|
2008-02-06 |
2009-08-12 |
Heinrich-Heine-Universität Düsseldorf |
Fto-modified non-human mammal
|
|
CA2714378A1
(en)
|
2008-02-08 |
2009-08-13 |
Sangamo Biosciences, Inc. |
Treatment of chronic pain with zinc finger proteins
|
|
GB0806562D0
(en)
|
2008-04-10 |
2008-05-14 |
Fermentas Uab |
Production of nucleic acid
|
|
WO2009146179A1
(en)
|
2008-04-15 |
2009-12-03 |
University Of Iowa Research Foundation |
Zinc finger nuclease for the cftr gene and methods of use thereof
|
|
CA2725601A1
(en)
|
2008-04-28 |
2009-11-05 |
President And Fellows Of Harvard College |
Supercharged proteins for cell penetration
|
|
US8394604B2
(en)
|
2008-04-30 |
2013-03-12 |
Paul Xiang-Qin Liu |
Protein splicing using short terminal split inteins
|
|
US9400597B2
(en)
|
2008-07-23 |
2016-07-26 |
Microsoft Technology Licensing, Llc |
Presenting dynamic grids
|
|
WO2010011961A2
(en)
|
2008-07-25 |
2010-01-28 |
University Of Georgia Research Foundation, Inc. |
Prokaryotic rnai-like system and methods of use
|
|
FR2934346B1
(fr)
|
2008-07-28 |
2010-09-03 |
Claude Benit |
Valve pour installation sanitaire et dispositif multifonction pour appareil sanitaire comprenant une telle valve
|
|
JP2010033344A
(ja)
|
2008-07-29 |
2010-02-12 |
Azabu Jui Gakuen |
核酸構成塩基の偏在性を表す方法
|
|
EP2159286A1
(en)
|
2008-09-01 |
2010-03-03 |
Consiglio Nazionale Delle Ricerche |
Method for obtaining oligonucleotide aptamers and uses thereof
|
|
CA3059768A1
(en)
|
2008-09-05 |
2010-03-11 |
President And Fellows Of Harvard College |
Continuous directed evolution of proteins and nucleic acids
|
|
US8790664B2
(en)
|
2008-09-05 |
2014-07-29 |
Institut National De La Sante Et De La Recherche Medicale (Inserm) |
Multimodular assembly useful for intracellular delivery
|
|
US8636884B2
(en)
|
2008-09-15 |
2014-01-28 |
Abbott Diabetes Care Inc. |
Cationic polymer based wired enzyme formulations for use in analyte sensors
|
|
US20100076057A1
(en)
|
2008-09-23 |
2010-03-25 |
Northwestern University |
TARGET DNA INTERFERENCE WITH crRNA
|
|
WO2010054108A2
(en)
|
2008-11-06 |
2010-05-14 |
University Of Georgia Research Foundation, Inc. |
Cas6 polypeptides and methods of use
|
|
MX337838B
(es)
|
2008-11-07 |
2016-03-22 |
Dupont Nutrition Biosci Aps |
Secuencias de repetidos palindromicos cortos regularmente intercalados agrupados de bifidobacterias.
|
|
EP2370598B1
(en)
|
2008-12-11 |
2017-02-15 |
Pacific Biosciences Of California, Inc. |
Classification of nucleic acid templates
|
|
US9175338B2
(en)
|
2008-12-11 |
2015-11-03 |
Pacific Biosciences Of California, Inc. |
Methods for identifying nucleic acid modifications
|
|
WO2010075424A2
(en)
|
2008-12-22 |
2010-07-01 |
The Regents Of University Of California |
Compositions and methods for downregulating prokaryotic genes
|
|
US20130022980A1
(en)
|
2009-02-04 |
2013-01-24 |
Lucigen Corporation |
Rna- and dna-copying enzymes
|
|
US8389679B2
(en)
|
2009-02-05 |
2013-03-05 |
The Regents Of The University Of California |
Targeted antimicrobial moieties
|
|
US20100305197A1
(en)
|
2009-02-05 |
2010-12-02 |
Massachusetts Institute Of Technology |
Conditionally Active Ribozymes And Uses Thereof
|
|
JP2012520073A
(ja)
|
2009-03-10 |
2012-09-06 |
ベイラー リサーチ インスティテュート |
抗原提示細胞ターゲティングワクチン
|
|
AU2010245304B2
(en)
|
2009-04-27 |
2015-06-04 |
Pacific Biosciences Of California, Inc. |
Real-time sequencing methods and systems
|
|
JP2012525146A
(ja)
|
2009-04-28 |
2012-10-22 |
プレジデント アンド フェロウズ オブ ハーバード カレッジ |
細胞透過のための過剰に荷電されたタンパク質
|
|
WO2010132092A2
(en)
|
2009-05-12 |
2010-11-18 |
The Scripps Research Institute |
Cytidine deaminase fusions and related methods
|
|
US9063156B2
(en)
|
2009-06-12 |
2015-06-23 |
Pacific Biosciences Of California, Inc. |
Real-time analytical methods and systems
|
|
US8569256B2
(en)
|
2009-07-01 |
2013-10-29 |
Protiva Biotherapeutics, Inc. |
Cationic lipids and methods for the delivery of therapeutic agents
|
|
US20120178647A1
(en)
|
2009-08-03 |
2012-07-12 |
The General Hospital Corporation |
Engineering of zinc finger arrays by context-dependent assembly
|
|
NZ598457A
(en)
|
2009-08-03 |
2014-06-27 |
Recombinetics Inc |
Methods and compositions for targeted gene modification
|
|
GB0913681D0
(en)
|
2009-08-05 |
2009-09-16 |
Glaxosmithkline Biolog Sa |
Immunogenic composition
|
|
MX2012005069A
(es)
|
2009-10-30 |
2012-07-17 |
Synthetic Genomics Inc |
Codificar texto hacia secuencias de acido nucleico.
|
|
WO2011053982A2
(en)
|
2009-11-02 |
2011-05-05 |
University Of Washington |
Therapeutic nuclease compositions and methods
|
|
US20110104787A1
(en)
|
2009-11-05 |
2011-05-05 |
President And Fellows Of Harvard College |
Fusion Peptides That Bind to and Modify Target Nucleic Acid Sequences
|
|
EP3403647A1
(en)
|
2009-12-01 |
2018-11-21 |
Translate Bio, Inc. |
Delivery of mrna for the augmentation of proteins and enzymes in human genetic diseases
|
|
WO2011068916A1
(en)
|
2009-12-01 |
2011-06-09 |
Intezyne Technologies, Incorporated |
Pegylated polyplexes for polynucleotide delivery
|
|
US20130011380A1
(en)
|
2009-12-18 |
2013-01-10 |
Blau Helen M |
Use of Cytidine Deaminase-Related Agents to Promote Demethylation and Cell Reprogramming
|
|
JP2013517774A
(ja)
|
2010-01-22 |
2013-05-20 |
ダウ アグロサイエンシィズ エルエルシー |
遺伝子改変生物における導入遺伝子の切除
|
|
WO2011091396A1
(en)
|
2010-01-25 |
2011-07-28 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of mylip/idol gene
|
|
CN102939380A
(zh)
|
2010-03-05 |
2013-02-20 |
合成基因组股份有限公司 |
用于克隆和操作基因组的方法
|
|
GB201004575D0
(en)
|
2010-03-19 |
2010-05-05 |
Immatics Biotechnologies Gmbh |
Composition of tumor associated peptides and related anti cancer vaccine for the treatment of gastric cancer and other cancers
|
|
WO2011123830A2
(en)
|
2010-04-02 |
2011-10-06 |
Amunix Operating Inc. |
Alpha 1-antitrypsin compositions and methods of making and using same
|
|
EA024121B9
(ru)
|
2010-05-10 |
2017-01-30 |
Дзе Реджентс Ов Дзе Юниверсити Ов Калифорния |
Композиции эндорибонуклеаз и способы их использования
|
|
CA2798988C
(en)
|
2010-05-17 |
2020-03-10 |
Sangamo Biosciences, Inc. |
Tal-effector (tale) dna-binding polypeptides and uses thereof
|
|
GB201008267D0
(en)
|
2010-05-18 |
2010-06-30 |
Univ Edinburgh |
Cationic lipids
|
|
BR112012030522A2
(pt)
|
2010-05-27 |
2020-10-13 |
Heinrich-Pette-Institut Leibniz-Institut Fur Experimentelle Virologie - Stiftung Burgerlichen Rechts |
Método para preparo de um vetor de expressão que codifica uma recombinase configurada, método para preparo de uma célula transformada, ácido nucleico, recombinase configurada codificada pelo ácido nucleico, célula transformada ecomposição farmacêutica"
|
|
EP2575767B1
(en)
|
2010-06-04 |
2017-01-04 |
Sirna Therapeutics, Inc. |
Novel low molecular weight cationic lipids for oligonucleotide delivery
|
|
EP2392208B1
(en)
|
2010-06-07 |
2016-05-04 |
Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) |
Fusion proteins comprising a DNA-binding domain of a Tal effector protein and a non-specific cleavage domain of a restriction nuclease and their use
|
|
AU2011265733B2
(en)
|
2010-06-14 |
2014-04-17 |
Iowa State University Research Foundation, Inc. |
Nuclease activity of TAL effector and Foki fusion protein
|
|
US8900814B2
(en)
|
2010-08-13 |
2014-12-02 |
Kyoto University |
Variant reverse transcriptase
|
|
JP6173912B2
(ja)
|
2010-09-20 |
2017-08-02 |
エスピーアイ ファーマ,インコーポレイテッド |
マイクロカプセル化プロセスおよび製品
|
|
EP2630156B1
(en)
|
2010-10-20 |
2018-08-22 |
DuPont Nutrition Biosciences ApS |
Lactococcus crispr-cas sequences
|
|
US20140005269A1
(en)
|
2010-11-26 |
2014-01-02 |
University Of The Witwatersrand, Johannesburg |
Polymeric matrix of polymer-lipid nanoparticles as a pharmaceutical dosage form
|
|
KR101255338B1
(ko)
|
2010-12-15 |
2013-04-16 |
포항공과대학교 산학협력단 |
표적 세포에 대한 폴리뉴클레오티드 전달체
|
|
JP6143675B2
(ja)
|
2010-12-16 |
2017-06-07 |
セルジーン コーポレイション |
難溶性薬物の制御放出経口剤形及びその使用
|
|
JP6088438B2
(ja)
|
2010-12-22 |
2017-03-01 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
連続的定向進化
|
|
US9499592B2
(en)
|
2011-01-26 |
2016-11-22 |
President And Fellows Of Harvard College |
Transcription activator-like effectors
|
|
KR101818126B1
(ko)
|
2011-02-09 |
2018-01-15 |
(주)바이오니아 |
열안정성이 증가된 역전사효소
|
|
US9528124B2
(en)
|
2013-08-27 |
2016-12-27 |
Recombinetics, Inc. |
Efficient non-meiotic allele introgression
|
|
US9200045B2
(en)
|
2011-03-11 |
2015-12-01 |
President And Fellows Of Harvard College |
Small molecule-dependent inteins and uses thereof
|
|
US9164079B2
(en)
|
2011-03-17 |
2015-10-20 |
Greyledge Technologies Llc |
Systems for autologous biological therapeutics
|
|
US20120244601A1
(en)
|
2011-03-22 |
2012-09-27 |
Bertozzi Carolyn R |
Riboswitch based inducible gene expression platform
|
|
JP2012210172A
(ja)
|
2011-03-30 |
2012-11-01 |
Japan Science & Technology Agency |
外部環境に応答して内部の物質組成を変えるリポソーム
|
|
US8709466B2
(en)
|
2011-03-31 |
2014-04-29 |
International Business Machines Corporation |
Cationic polymers for antimicrobial applications and delivery of bioactive materials
|
|
EP2694091B1
(en)
|
2011-04-05 |
2019-03-13 |
Cellectis |
Method for the generation of compact tale-nucleases and uses thereof
|
|
WO2012148953A1
(en)
|
2011-04-25 |
2012-11-01 |
Stc.Unm |
Solid compositions for pharmaceutical use
|
|
PT2702160T
(pt)
|
2011-04-27 |
2020-07-30 |
Amyris Inc |
Métodos para modificação genómica
|
|
WO2012158985A2
(en)
|
2011-05-17 |
2012-11-22 |
Transposagen Biopharmaceuticals, Inc. |
Methods for site-specific genetic modification in spermatogonial stem cells using zinc finger nuclease (zfn) for the creation of model organisms
|
|
US8691750B2
(en)
|
2011-05-17 |
2014-04-08 |
Axolabs Gmbh |
Lipids and compositions for intracellular delivery of biologically active compounds
|
|
WO2012158986A2
(en)
|
2011-05-17 |
2012-11-22 |
Transposagen Biopharmaceuticals, Inc. |
Methods for site-specific genetic modification in stem cells using xanthomonas tal nucleases (xtn) for the creation of model organisms
|
|
WO2012164565A1
(en)
|
2011-06-01 |
2012-12-06 |
Yeda Research And Development Co. Ltd. |
Compositions and methods for downregulating prokaryotic genes
|
|
US20140206753A1
(en)
|
2011-06-08 |
2014-07-24 |
Shire Human Genetic Therapies, Inc. |
Lipid nanoparticle compositions and methods for mrna delivery
|
|
EP3461896B1
(en)
|
2011-07-15 |
2023-11-29 |
The General Hospital Corporation |
Methods of transcription activator like effector assembly
|
|
CN103857797A
(zh)
|
2011-07-19 |
2014-06-11 |
帷幄生物技术公司 |
用于修复软骨损伤的非遗传修饰性重编程细胞的组合物和方法
|
|
WO2013066438A2
(en)
|
2011-07-22 |
2013-05-10 |
President And Fellows Of Harvard College |
Evaluation and improvement of nuclease cleavage specificity
|
|
WO2013039861A2
(en)
|
2011-09-12 |
2013-03-21 |
modeRNA Therapeutics |
Engineered nucleic acids and methods of use thereof
|
|
WO2013039857A1
(en)
|
2011-09-12 |
2013-03-21 |
modeRNA Therapeutics |
Engineered nucleic acids and methods of use thereof
|
|
CA2850411C
(en)
|
2011-09-28 |
2023-08-15 |
Era Biotech, S.A. |
Split inteins and uses thereof
|
|
RU2633510C2
(ru)
|
2011-09-28 |
2017-10-12 |
Рибомик Инк. |
Аптамер против ngf и его применение
|
|
CN103088008B
(zh)
|
2011-10-31 |
2014-08-20 |
中国科学院微生物研究所 |
胞苷脱氨酶及其编码基因和它们的应用
|
|
GB2496687A
(en)
|
2011-11-21 |
2013-05-22 |
Gw Pharma Ltd |
Tetrahydrocannabivarin (THCV) in the protection of pancreatic islet cells
|
|
WO2013086441A2
(en)
|
2011-12-08 |
2013-06-13 |
Sarepta Therapeutics, Inc. |
Oligonucleotide analogues targeting human lmna
|
|
KR20140102759A
(ko)
|
2011-12-16 |
2014-08-22 |
모더나 세라퓨틱스, 인코포레이티드 |
변형된 뉴클레오사이드, 뉴클레오타이드 및 핵산 조성물
|
|
JP2015500648A
(ja)
|
2011-12-16 |
2015-01-08 |
ターゲットジーン バイオテクノロジーズ リミテッド |
所定の標的核酸配列を修飾するための組成物及び方法
|
|
GB201122458D0
(en)
|
2011-12-30 |
2012-02-08 |
Univ Wageningen |
Modified cascade ribonucleoproteins and uses thereof
|
|
WO2013119602A1
(en)
|
2012-02-06 |
2013-08-15 |
President And Fellows Of Harvard College |
Arrdc1-mediated microvesicles (armms) and uses thereof
|
|
CN104284669A
(zh)
|
2012-02-24 |
2015-01-14 |
弗雷德哈钦森癌症研究中心 |
治疗血红蛋白病的组合物和方法
|
|
BR112014021104B1
(pt)
|
2012-02-29 |
2023-03-28 |
Sangamo Biosciences, Inc |
Proteína de fusão de ocorrência não natural compreendendo um domínio de ligação de dna de dedo de zinco manipulado que se liga a um gene htt, seu uso, método in vitro de modificação da expressão de um gene htt em uma célula, e método de geração de um sistema modelo para o estudo da doença de huntington
|
|
EP3692999A1
(en)
|
2012-03-17 |
2020-08-12 |
The Regents of the University of California |
Fast diagnosis and personalized treatments for acne
|
|
WO2013141680A1
(en)
|
2012-03-20 |
2013-09-26 |
Vilnius University |
RNA-DIRECTED DNA CLEAVAGE BY THE Cas9-crRNA COMPLEX
|
|
US9637739B2
(en)
|
2012-03-20 |
2017-05-02 |
Vilnius University |
RNA-directed DNA cleavage by the Cas9-crRNA complex
|
|
WO2013152359A1
(en)
|
2012-04-06 |
2013-10-10 |
The Regents Of The University Of California |
Novel tetrazines and method of synthesizing the same
|
|
WO2013160230A1
(en)
|
2012-04-23 |
2013-10-31 |
Bayer Cropscience Nv |
Targeted genome engineering in plants
|
|
UA115875C2
(uk)
|
2012-05-02 |
2018-01-10 |
ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі |
Рослина помідора зі зменшеною активністю малатдегідрогенази та спосіб її отримання
|
|
BR112014027813A2
(pt)
|
2012-05-07 |
2017-08-08 |
Dow Agrosciences Llc |
métodos e composições para integração de transgenes direcionada mediada por nuclease
|
|
US11120889B2
(en)
|
2012-05-09 |
2021-09-14 |
Georgia Tech Research Corporation |
Method for synthesizing a nuclease with reduced off-site cleavage
|
|
CA3133545C
(en)
|
2012-05-25 |
2023-08-08 |
Cellectis |
Use of pre t alpha or functional variant thereof for expanding tcr alpha deficient t cells
|
|
US20150017136A1
(en)
|
2013-07-15 |
2015-01-15 |
Cellectis |
Methods for engineering allogeneic and highly active t cell for immunotherapy
|
|
FI3597749T3
(fi)
|
2012-05-25 |
2023-10-09 |
Univ California |
Menetelmiä ja koostumuksia rna-ohjattua kohde-dna-modifikaatiota varten ja rna-ohjattua transkription modulaatiota varten
|
|
KR20150027756A
(ko)
|
2012-05-30 |
2015-03-12 |
베일러 칼리지 오브 메디신 |
Dna 수복, 변경 및 대체를 위한 도구로서의 초나선 미니벡터
|
|
WO2013188037A2
(en)
|
2012-06-11 |
2013-12-19 |
Agilent Technologies, Inc |
Method of adaptor-dimer subtraction using a crispr cas6 protein
|
|
CN104540382A
(zh)
|
2012-06-12 |
2015-04-22 |
弗·哈夫曼-拉罗切有限公司 |
用于产生条件性敲除等位基因的方法和组合物
|
|
EP2674501A1
(en)
|
2012-06-14 |
2013-12-18 |
Agence nationale de sécurité sanitaire de l'alimentation,de l'environnement et du travail |
Method for detecting and identifying enterohemorrhagic Escherichia coli
|
|
WO2013188638A2
(en)
|
2012-06-15 |
2013-12-19 |
The Regents Of The University Of California |
Endoribonucleases and methods of use thereof
|
|
US20150225734A1
(en)
|
2012-06-19 |
2015-08-13 |
Regents Of The University Of Minnesota |
Gene targeting in plants using dna viruses
|
|
PT2877490T
(pt)
|
2012-06-27 |
2019-02-12 |
Univ Princeton |
Inteínas clivadas, conjugados e suas utilizações
|
|
PL2867361T3
(pl)
|
2012-06-29 |
2018-07-31 |
Massachusetts Institute Of Technology |
Masowo równoległa genetyka kombinatoryczna
|
|
US9125508B2
(en)
|
2012-06-30 |
2015-09-08 |
Seasons 4, Inc. |
Collapsible tree system
|
|
WO2014011901A2
(en)
|
2012-07-11 |
2014-01-16 |
Sangamo Biosciences, Inc. |
Methods and compositions for delivery of biologics
|
|
ES2697912T3
(es)
|
2012-07-11 |
2019-01-29 |
Sangamo Therapeutics Inc |
Métodos y composiciones para el tratamiento de enfermedades monogénicas
|
|
EP2877213B1
(en)
|
2012-07-25 |
2020-12-02 |
The Broad Institute, Inc. |
Inducible dna binding proteins and genome perturbation tools and applications thereof
|
|
US10058078B2
(en)
|
2012-07-31 |
2018-08-28 |
Recombinetics, Inc. |
Production of FMDV-resistant livestock by allele substitution
|
|
EP2879678B1
(en)
|
2012-07-31 |
2023-03-01 |
Yeda Research and Development Co. Ltd. |
Enoxacin for treating amyotrophic lateral sclerosis
|
|
EP2880171B1
(en)
|
2012-08-03 |
2018-10-03 |
The Regents of The University of California |
Methods and compositions for controlling gene expression by rna processing
|
|
AU2013308770B2
(en)
|
2012-08-29 |
2019-01-17 |
Sangamo Therapeutics, Inc. |
Methods and compositions for treatment of a genetic condition
|
|
US9902962B2
(en)
|
2012-09-04 |
2018-02-27 |
The Scripps Research Institute |
Chimeric polypeptides having targeted binding specificity
|
|
AU2013312838B2
(en)
|
2012-09-04 |
2018-11-29 |
Cellectis |
Multi-chain chimeric antigen receptor and uses thereof
|
|
US9937205B2
(en)
|
2012-09-04 |
2018-04-10 |
The Trustees Of The University Of Pennsylvania |
Inhibition of diacylglycerol kinase to augment adoptive T cell transfer
|
|
UA118090C2
(uk)
|
2012-09-07 |
2018-11-26 |
ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі |
Спосіб інтегрування послідовності нуклеїнової кислоти, що представляє інтерес, у ген fad2 у клітині сої та специфічний для локусу fad2 білок, що зв'язується, здатний індукувати спрямований розрив
|
|
CA2884162C
(en)
|
2012-09-07 |
2020-12-29 |
Dow Agrosciences Llc |
Fad3 performance loci and corresponding target site specific binding proteins capable of inducing targeted breaks
|
|
UA119135C2
(uk)
|
2012-09-07 |
2019-05-10 |
ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі |
Спосіб отримання трансгенної рослини
|
|
US20140075593A1
(en)
|
2012-09-07 |
2014-03-13 |
Dow Agrosciences Llc |
Fluorescence activated cell sorting (facs) enrichment to generate plants
|
|
WO2014043143A1
(en)
|
2012-09-11 |
2014-03-20 |
Life Technologies Corporation |
Nucleic acid amplification
|
|
GB201216564D0
(en)
|
2012-09-17 |
2012-10-31 |
Univ Edinburgh |
Genetically edited animal
|
|
WO2014047103A2
(en)
|
2012-09-18 |
2014-03-27 |
The Translational Genomics Research Institute |
Isolated genes and transgenic organisms for producing biofuels
|
|
WO2014055782A1
(en)
|
2012-10-03 |
2014-04-10 |
Agrivida, Inc. |
Intein-modified proteases, their production and industrial applications
|
|
ES2824024T3
(es)
|
2012-10-10 |
2021-05-11 |
Sangamo Therapeutics Inc |
Compuestos modificadores de células T y usos de los mismos
|
|
EP2906602B1
(en)
|
2012-10-12 |
2019-01-16 |
The General Hospital Corporation |
Transcription activator-like effector (tale) - lysine-specific demethylase 1 (lsd1) fusion proteins
|
|
KR101656236B1
(ko)
|
2012-10-23 |
2016-09-12 |
주식회사 툴젠 |
표적 DNA에 특이적인 가이드 RNA 및 Cas 단백질을 암호화하는 핵산 또는 Cas 단백질을 포함하는, 표적 DNA를 절단하기 위한 조성물 및 이의 용도
|
|
US20140115728A1
(en)
|
2012-10-24 |
2014-04-24 |
A. Joseph Tector |
Double knockout (gt/cmah-ko) pigs, organs and tissues
|
|
CA2889502A1
(en)
|
2012-10-30 |
2014-05-08 |
Recombinetics, Inc. |
Control of sexual maturation in animals
|
|
US20150291967A1
(en)
|
2012-10-31 |
2015-10-15 |
Luc Mathis |
Coupling herbicide resistance with targeted insertion of transgenes in plants
|
|
AR093296A1
(es)
|
2012-10-31 |
2015-05-27 |
Kiss György Botond |
Identificacion de un gen de resistencia a xanthomonas euvesicatoria de pimienta (capsicum annuum) y metodo para generar plantas a esa resistencia
|
|
BR122019025681B1
(pt)
|
2012-11-01 |
2023-04-18 |
Factor Bioscience Inc |
Método para inserir uma sequência de ácido nucleico em uma localização segura de um genoma de uma célula
|
|
WO2014071235A1
(en)
|
2012-11-01 |
2014-05-08 |
Massachusetts Institute Of Technology |
Genetic device for the controlled destruction of dna
|
|
US20140127752A1
(en)
|
2012-11-07 |
2014-05-08 |
Zhaohui Zhou |
Method, composition, and reagent kit for targeted genomic enrichment
|
|
WO2014072941A1
(en)
|
2012-11-09 |
2014-05-15 |
Marco Archetti |
Diffusible factors and cancer cells
|
|
KR20150085846A
(ko)
|
2012-11-20 |
2015-07-24 |
제이.알.심프롯캄패니 |
Tal-매개 전이 DNA 삽입방법
|
|
CA2892012A1
(en)
|
2012-11-20 |
2014-05-30 |
Cold Spring Harbor Laboratory |
Mutations in solanaceae plants that modulate shoot architecture and enhance yield-related phenotypes
|
|
WO2014081855A1
(en)
|
2012-11-20 |
2014-05-30 |
Universite De Montreal |
Methods and compositions for muscular dystrophies
|
|
AU2013352156B2
(en)
|
2012-11-27 |
2018-12-06 |
Children's Medical Center Corporation |
Targeting BCL11A distal regulatory elements for fetal hemoglobin reinduction
|
|
WO2014085261A1
(en)
|
2012-11-29 |
2014-06-05 |
North Carolina State University |
Synthetic pathway for biological carbon dioxide sequestration
|
|
US20160010154A1
(en)
|
2012-11-30 |
2016-01-14 |
The Parkinson's Institute |
Screening assays for therapeutics for parkinson's disease
|
|
EP2925866B1
(en)
|
2012-11-30 |
2018-07-25 |
Aarhus Universitet |
Circular rna for inhibition of microrna
|
|
AU2013355327A1
(en)
|
2012-12-05 |
2015-06-11 |
Sangamo Therapeutics, Inc. |
Methods and compositions for regulation of metabolic disorders
|
|
PT3363902T
(pt)
|
2012-12-06 |
2019-12-19 |
Sigma Aldrich Co Llc |
Modificação e regulação de genoma baseadas em crispr
|
|
US9447422B2
(en)
|
2012-12-06 |
2016-09-20 |
Synthetic Genomics, Inc. |
Autonomous replication sequences and episomal DNA molecules
|
|
EP3401388B1
(en)
|
2012-12-06 |
2019-07-10 |
Synthetic Genomics, Inc. |
Algal mutants having a locked-in high light acclimated phenotype
|
|
US10272163B2
(en)
|
2012-12-07 |
2019-04-30 |
The Regents Of The University Of California |
Factor VIII mutation repair and tolerance induction
|
|
US9914931B2
(en)
|
2012-12-07 |
2018-03-13 |
Synthetic Genomics, Inc. |
Nannochloropsis spliced leader sequences and uses therefor
|
|
WO2014093479A1
(en)
|
2012-12-11 |
2014-06-19 |
Montana State University |
Crispr (clustered regularly interspaced short palindromic repeats) rna-guided control of gene regulation
|
|
PT2784162E
(pt)
|
2012-12-12 |
2015-08-27 |
Broad Inst Inc |
Engenharia de sistemas, métodos e composições guia otimizadas para a manipulação de sequências
|
|
EP2931899A1
(en)
|
2012-12-12 |
2015-10-21 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof
|
|
ES2576126T3
(es)
|
2012-12-12 |
2016-07-05 |
The Broad Institute, Inc. |
Modificación por tecnología genética y optimización de sistemas, métodos y composiciones enzimáticas mejorados para la manipulación de secuencias
|
|
KR20150105956A
(ko)
|
2012-12-12 |
2015-09-18 |
더 브로드 인스티튜트, 인코퍼레이티드 |
서열 조작 및 치료적 적용을 위한 시스템, 방법 및 조성물의 전달, 유전자 조작 및 최적화
|
|
US8697359B1
(en)
|
2012-12-12 |
2014-04-15 |
The Broad Institute, Inc. |
CRISPR-Cas systems and methods for altering expression of gene products
|
|
EP2931898B1
(en)
|
2012-12-12 |
2016-03-09 |
The Broad Institute, Inc. |
Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains
|
|
EP3434776A1
(en)
|
2012-12-12 |
2019-01-30 |
The Broad Institute, Inc. |
Methods, models, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof
|
|
US20140310830A1
(en)
|
2012-12-12 |
2014-10-16 |
Feng Zhang |
CRISPR-Cas Nickase Systems, Methods And Compositions For Sequence Manipulation in Eukaryotes
|
|
EP2932421A1
(en)
|
2012-12-12 |
2015-10-21 |
The Broad Institute, Inc. |
Methods, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof
|
|
EP4234696A3
(en)
|
2012-12-12 |
2023-09-06 |
The Broad Institute Inc. |
Crispr-cas component systems, methods and compositions for sequence manipulation
|
|
US20140173783A1
(en)
|
2012-12-13 |
2014-06-19 |
Dow Agrosciences Llc |
Precision gene targeting to a particular locus in maize
|
|
BR102013032129B1
(pt)
|
2012-12-13 |
2022-06-07 |
Dow Agrosciences Llc |
Método para identificar a presença de um polinucleotídeo de dna doador exógeno inserido dentro de um único locus genômico eucariótico alvo
|
|
CA2894710A1
(en)
|
2012-12-13 |
2014-06-19 |
Massachusetts Institute Of Technology |
Recombinase-based logic and memory systems
|
|
EP4282970A3
(en)
|
2012-12-17 |
2024-01-17 |
President and Fellows of Harvard College |
Rna-guided human genome engineering
|
|
US20140178561A1
(en)
|
2012-12-21 |
2014-06-26 |
Cellectis |
Potatoes with reduced cold-induced sweetening
|
|
JP6583918B2
(ja)
|
2012-12-27 |
2019-10-02 |
キージーン ナムローゼ フェンノートシャップ |
植物における遺伝連鎖を解消するための方法
|
|
US9988625B2
(en)
|
2013-01-10 |
2018-06-05 |
Dharmacon, Inc. |
Templates, libraries, kits and methods for generating molecules
|
|
WO2014110552A1
(en)
|
2013-01-14 |
2014-07-17 |
Recombinetics, Inc. |
Hornless livestock
|
|
EP3919505B1
(en)
|
2013-01-16 |
2023-08-30 |
Emory University |
Uses of cas9-nucleic acid complexes
|
|
CN103233028B
(zh)
|
2013-01-25 |
2015-05-13 |
南京徇齐生物技术有限公司 |
一种无物种限制无生物安全性问题的真核生物基因打靶方法及螺旋结构dna序列
|
|
KR20150133695A
(ko)
|
2013-02-05 |
2015-11-30 |
유니버시티 오브 조지아 리서치 파운데이션, 인코포레이티드 |
바이러스 제조를 위한 세포주 및 이의 사용 방법
|
|
WO2014124226A1
(en)
|
2013-02-07 |
2014-08-14 |
The Rockefeller University |
Sequence specific antimicrobials
|
|
PL2963113T3
(pl)
|
2013-02-14 |
2020-07-13 |
Osaka University |
Sposób izolowania określonych regionów genomowych z wykorzystaniem cząsteczki zdolnej do specyficznego wiązania się z endogenną sekwencją DNA
|
|
WO2014127287A1
(en)
|
2013-02-14 |
2014-08-21 |
Massachusetts Institute Of Technology |
Method for in vivo tergated mutagenesis
|
|
JP6475172B2
(ja)
|
2013-02-20 |
2019-02-27 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. |
ラットの遺伝子組換え
|
|
WO2014128659A1
(en)
|
2013-02-21 |
2014-08-28 |
Cellectis |
Method to counter-select cells or organisms by linking loci to nuclease components
|
|
ES2522765B2
(es)
|
2013-02-22 |
2015-03-18 |
Universidad De Alicante |
Método para dectectar inserciones de espaciadores en estructuras CRISPR
|
|
CA2901676C
(en)
|
2013-02-25 |
2023-08-22 |
Sangamo Biosciences, Inc. |
Methods and compositions for enhancing nuclease-mediated gene disruption
|
|
JP2016507244A
(ja)
|
2013-02-27 |
2016-03-10 |
ヘルムホルツ・ツェントルム・ミュンヒェン・ドイチェス・フォルシュンクスツェントルム・フューア・ゲズントハイト・ウント・ウムベルト(ゲーエムベーハー)Helmholtz Zentrum MuenchenDeutsches Forschungszentrum fuer Gesundheit und Umwelt (GmbH) |
Cas9ヌクレアーゼによる卵母細胞における遺伝子編集
|
|
US10047366B2
(en)
|
2013-03-06 |
2018-08-14 |
The Johns Hopkins University |
Telomerator-a tool for chromosome engineering
|
|
US10612043B2
(en)
|
2013-03-09 |
2020-04-07 |
Agilent Technologies, Inc. |
Methods of in vivo engineering of large sequences using multiple CRISPR/cas selections of recombineering events
|
|
EP2970886B1
(en)
|
2013-03-12 |
2018-05-23 |
Sangamo Therapeutics, Inc. |
Methods and compositions for modification of hla
|
|
US10329574B2
(en)
|
2013-03-12 |
2019-06-25 |
E I Du Pont De Nemours And Company |
Methods for the identification of variant recognition sites for rare-cutting engineered double-strand-break-inducing agents and compositions and uses thereof
|
|
US9777262B2
(en)
|
2013-03-13 |
2017-10-03 |
President And Fellows Of Harvard College |
Mutants of Cre recombinase
|
|
US20160138027A1
(en)
|
2013-03-14 |
2016-05-19 |
The Board Of Trustees Of The Leland Stanford Junior University |
Treatment of diseases and conditions associated with dysregulation of mammalian target of rapamycin complex 1 (mtorc1)
|
|
US20140283156A1
(en)
|
2013-03-14 |
2014-09-18 |
Cold Spring Harbor Laboratory |
Trans-splicing ribozymes and silent recombinases
|
|
AU2014235794A1
(en)
|
2013-03-14 |
2015-10-22 |
Caribou Biosciences, Inc. |
Compositions and methods of nucleic acid-targeting nucleic acids
|
|
EP3431592A1
(en)
|
2013-03-14 |
2019-01-23 |
Translate Bio, Inc. |
Mrna therapeutic compositions and use to treat diseases and disorders
|
|
US20140273235A1
(en)
|
2013-03-15 |
2014-09-18 |
Regents Of The University Of Minnesota |
ENGINEERING PLANT GENOMES USING CRISPR/Cas SYSTEMS
|
|
US9234213B2
(en)
|
2013-03-15 |
2016-01-12 |
System Biosciences, Llc |
Compositions and methods directed to CRISPR/Cas genomic engineering systems
|
|
EP2971006A4
(en)
|
2013-03-15 |
2017-02-08 |
Transposagen Biopharmaceuticals, Inc. |
Reproducible method for testis-mediated genetic modification (tgm) and sperm-mediated genetic modification (sgm)
|
|
KR102874079B1
(ko)
|
2013-03-15 |
2025-10-22 |
더 제너럴 하스피탈 코포레이션 |
Rna-안내 게놈 편집을 위해 특이성을 증가시키기 위한 절단된 안내 rna(tru-grnas)의 이용
|
|
US11332719B2
(en)
|
2013-03-15 |
2022-05-17 |
The Broad Institute, Inc. |
Recombinant virus and preparations thereof
|
|
ES2921207T3
(es)
|
2013-03-15 |
2022-08-19 |
Cibus Us Llc |
Procedimientos y composiciones para aumentar la eficiencia de la modificación genética direccionada utilizando la reparación genética mediada por oligonucleótidos
|
|
US20140273230A1
(en)
|
2013-03-15 |
2014-09-18 |
Sigma-Aldrich Co., Llc |
Crispr-based genome modification and regulation
|
|
US20140349400A1
(en)
|
2013-03-15 |
2014-11-27 |
Massachusetts Institute Of Technology |
Programmable Modification of DNA
|
|
US10760064B2
(en)
|
2013-03-15 |
2020-09-01 |
The General Hospital Corporation |
RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci
|
|
US20140363561A1
(en)
|
2013-03-15 |
2014-12-11 |
J.R. Simplot Company |
Tal-mediated transfer dna insertion
|
|
EP2975942B1
(en)
|
2013-03-21 |
2018-08-08 |
Sangamo Therapeutics, Inc. |
Targeted disruption of t cell receptor genes using engineered zinc finger protein nucleases
|
|
WO2014161821A1
(en)
|
2013-04-02 |
2014-10-09 |
Bayer Cropscience Nv |
Targeted genome engineering in eukaryotes
|
|
DK2981607T3
(da)
|
2013-04-03 |
2020-11-16 |
Memorial Sloan Kettering Cancer Center |
Effektiv generering af tumormålrettede t-celler afledt af pluripotente stamceller
|
|
EP2981617B1
(en)
|
2013-04-04 |
2023-07-05 |
President and Fellows of Harvard College |
Therapeutic uses of genome editing with crispr/cas systems
|
|
US11274305B2
(en)
|
2013-04-04 |
2022-03-15 |
Trustees Of Dartmouth College |
Compositions and methods for in vivo excision of HIV-1 proviral DNA
|
|
WO2014165612A2
(en)
|
2013-04-05 |
2014-10-09 |
Dow Agrosciences Llc |
Methods and compositions for integration of an exogenous sequence within the genome of plants
|
|
US20150056629A1
(en)
|
2013-04-14 |
2015-02-26 |
Katriona Guthrie-Honea |
Compositions, systems, and methods for detecting a DNA sequence
|
|
EP3456831B1
(en)
|
2013-04-16 |
2021-07-14 |
Regeneron Pharmaceuticals, Inc. |
Targeted modification of rat genome
|
|
WO2014172470A2
(en)
|
2013-04-16 |
2014-10-23 |
Whitehead Institute For Biomedical Research |
Methods of mutating, modifying or modulating nucleic acid in a cell or nonhuman mammal
|
|
WO2014172458A1
(en)
|
2013-04-16 |
2014-10-23 |
University Of Washington Through Its Center For Commercialization |
Activating an alternative pathway for homology-directed repair to stimulate targeted gene correction and genome engineering
|
|
EP2796558A1
(en)
|
2013-04-23 |
2014-10-29 |
Rheinische Friedrich-Wilhelms-Universität Bonn |
Improved gene targeting and nucleic acid carrier molecule, in particular for use in plants
|
|
CN103224947B
(zh)
|
2013-04-28 |
2015-06-10 |
陕西师范大学 |
一种基因打靶系统
|
|
EP2994531B1
(en)
|
2013-05-10 |
2018-03-28 |
Sangamo Therapeutics, Inc. |
Delivery methods and compositions for nuclease-mediated genome engineering
|
|
EP3693398A1
(en)
|
2013-05-10 |
2020-08-12 |
Whitehead Institute for Biomedical Research |
In vitro production of red blood cells with sortaggable proteins
|
|
RS65484B1
(sr)
|
2013-05-13 |
2024-05-31 |
Cellectis |
Cd19 specifični himerni antigenski receptor i njegove primene
|
|
AU2014266833B2
(en)
|
2013-05-13 |
2020-07-02 |
Cellectis |
Methods for engineering highly active T cell for immunotherapy
|
|
AU2014265331B2
(en)
|
2013-05-15 |
2019-12-05 |
Sangamo Therapeutics, Inc. |
Methods and compositions for treatment of a genetic condition
|
|
WO2014186686A2
(en)
|
2013-05-17 |
2014-11-20 |
Two Blades Foundation |
Targeted mutagenesis and genome engineering in plants using rna-guided cas nucleases
|
|
US20140349405A1
(en)
|
2013-05-22 |
2014-11-27 |
Wisconsin Alumni Research Foundation |
Rna-directed dna cleavage and gene editing by cas9 enzyme from neisseria meningitidis
|
|
EP3004349B1
(en)
|
2013-05-29 |
2018-03-28 |
Cellectis S.A. |
A method for producing precise dna cleavage using cas9 nickase activity
|
|
DK3004337T3
(da)
|
2013-05-29 |
2017-11-13 |
Cellectis |
Fremgangsmåde til konstruktion af T-celler til immunoterapi ved brug af RNA-guidet Cas nuklease-system
|
|
US9873907B2
(en)
|
2013-05-29 |
2018-01-23 |
Agilent Technologies, Inc. |
Method for fragmenting genomic DNA using CAS9
|
|
US11685935B2
(en)
|
2013-05-29 |
2023-06-27 |
Cellectis |
Compact scaffold of Cas9 in the type II CRISPR system
|
|
US20150067922A1
(en)
|
2013-05-30 |
2015-03-05 |
The Penn State Research Foundation |
Gene targeting and genetic modification of plants via rna-guided genome editing
|
|
US20140359796A1
(en)
|
2013-05-31 |
2014-12-04 |
Recombinetics, Inc. |
Genetically sterile animals
|
|
AU2014273091B2
(en)
|
2013-05-31 |
2019-12-12 |
Cellectis |
A LAGLIDADG homing endonuclease cleaving the T cell receptor alpha gene and uses thereof
|
|
EP3004149B1
(en)
|
2013-05-31 |
2018-12-19 |
Cellectis S.A. |
A laglidadg homing endonuclease cleaving the c-c chemokine receptor type-5 (ccr5) gene and uses thereof
|
|
US20140356956A1
(en)
|
2013-06-04 |
2014-12-04 |
President And Fellows Of Harvard College |
RNA-Guided Transcriptional Regulation
|
|
RU2690935C2
(ru)
|
2013-06-04 |
2019-06-06 |
Президент Энд Фэллоуз Оф Харвард Коллидж |
Направляемая рнк регуляция транскрипции
|
|
JP7085716B2
(ja)
|
2013-06-05 |
2022-06-17 |
デューク ユニバーシティ |
Rnaガイド遺伝子編集及び遺伝子調節
|
|
EP4491726A3
(en)
|
2013-06-11 |
2025-03-05 |
Takara Bio USA, Inc. |
Protein enriched microvesicles and methods of making and using the same
|
|
US20150315252A1
(en)
|
2013-06-11 |
2015-11-05 |
Clontech Laboratories, Inc. |
Protein enriched microvesicles and methods of making and using the same
|
|
US9982277B2
(en)
|
2013-06-11 |
2018-05-29 |
The Regents Of The University Of California |
Methods and compositions for target DNA modification
|
|
WO2014199358A1
(en)
|
2013-06-14 |
2014-12-18 |
Cellectis |
Methods for non-transgenic genome editing in plants
|
|
EP3011035B1
(en)
|
2013-06-17 |
2020-05-13 |
The Broad Institute, Inc. |
Assay for quantitative evaluation of target site cleavage by one or more crispr-cas guide sequences
|
|
CN107995927B
(zh)
|
2013-06-17 |
2021-07-30 |
布罗德研究所有限公司 |
用于肝靶向和治疗的crispr-cas系统、载体和组合物的递送与用途
|
|
CN105492611A
(zh)
|
2013-06-17 |
2016-04-13 |
布罗德研究所有限公司 |
用于序列操纵的优化的crispr-cas双切口酶系统、方法以及组合物
|
|
EP3674411A1
(en)
|
2013-06-17 |
2020-07-01 |
The Broad Institute, Inc. |
Delivery, engineering and optimization of tandem guide systems, methods and compositions for sequence manipulation
|
|
EP3725885A1
(en)
|
2013-06-17 |
2020-10-21 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions methods, screens and applications thereof
|
|
CA2915795C
(en)
|
2013-06-17 |
2021-07-13 |
The Broad Institute, Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for targeting disorders and diseases using viral components
|
|
JP6738729B2
(ja)
|
2013-06-17 |
2020-08-12 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
分裂終了細胞の疾患および障害をターゲティングおよびモデリングするための系、方法および組成物の送達、エンジニアリングおよび最適化
|
|
US20160145645A1
(en)
|
2013-06-19 |
2016-05-26 |
Sigma-Aldrich Co. Llc |
Targeted integration
|
|
US10011850B2
(en)
|
2013-06-21 |
2018-07-03 |
The General Hospital Corporation |
Using RNA-guided FokI Nucleases (RFNs) to increase specificity for RNA-Guided Genome Editing
|
|
AU2014301147B2
(en)
|
2013-06-25 |
2020-07-30 |
Cellectis |
Modified diatoms for biofuel production
|
|
US20160369268A1
(en)
|
2013-07-01 |
2016-12-22 |
The Board Of Regents Of The University Of Texas System |
Transcription activator-like effector (tale) libraries and methods of synthesis and use
|
|
CA2917638C
(en)
|
2013-07-09 |
2024-09-10 |
Harvard College |
RNA MULTIPLEX GUIDED GENOMIC ENGINEERING
|
|
EP3019595A4
(en)
|
2013-07-09 |
2016-11-30 |
|
THERAPEUTIC USES OF A GENERIC CHANGE WITH CRISPR / CAS SYSTEMS
|
|
SG10201800213VA
(en)
|
2013-07-10 |
2018-02-27 |
Harvard College |
Orthogonal cas9 proteins for rna-guided gene regulation and editing
|
|
DK3019602T3
(en)
|
2013-07-10 |
2018-11-12 |
Glykos Finland Oy |
MULTIPLE PROTEASE-DEFECTED FILAMENTARY FUNGAL CELLS AND PROCEDURES FOR USE THEREOF
|
|
EP3019005B1
(en)
|
2013-07-10 |
2019-02-20 |
EffStock, LLC |
Mrap2 knockouts
|
|
DK3019619T3
(da)
|
2013-07-11 |
2021-10-11 |
Modernatx Inc |
Sammensætninger, der omfatter syntetiske polynukleotider, som koder for crispr-beslægtede proteiner, og syntetiske sgrna'er, og anvendelsesfremgangsmåder
|
|
WO2015007194A1
(zh)
|
2013-07-16 |
2015-01-22 |
中国科学院上海生命科学研究院 |
植物基因组定点修饰方法
|
|
WO2015010114A1
(en)
|
2013-07-19 |
2015-01-22 |
Larix Bioscience, Llc |
Methods and compositions for producing double allele knock outs
|
|
GB201313235D0
(en)
|
2013-07-24 |
2013-09-04 |
Univ Edinburgh |
Antiviral Compositions Methods and Animals
|
|
US11306328B2
(en)
|
2013-07-26 |
2022-04-19 |
President And Fellows Of Harvard College |
Genome engineering
|
|
CN103388006B
(zh)
|
2013-07-26 |
2015-10-28 |
华东师范大学 |
一种基因定点突变的构建方法
|
|
US10421957B2
(en)
|
2013-07-29 |
2019-09-24 |
Agilent Technologies, Inc. |
DNA assembly using an RNA-programmable nickase
|
|
CA2920253A1
(en)
|
2013-08-02 |
2015-02-05 |
Enevolv, Inc. |
Processes and host cells for genome, pathway, and biomolecular engineering
|
|
ITTO20130669A1
(it)
|
2013-08-05 |
2015-02-06 |
Consiglio Nazionale Ricerche |
Vettore adeno-associato ricombinante muscolo-specifico e suo impiego nel trattamento di patologie muscolari
|
|
US20150044192A1
(en)
|
2013-08-09 |
2015-02-12 |
President And Fellows Of Harvard College |
Methods for identifying a target site of a cas9 nuclease
|
|
WO2015021426A1
(en)
|
2013-08-09 |
2015-02-12 |
Sage Labs, Inc. |
A crispr/cas system-based novel fusion protein and its application in genome editing
|
|
WO2015024017A2
(en)
|
2013-08-16 |
2015-02-19 |
President And Fellows Of Harvard College |
Rna polymerase, methods of purification and methods of use
|
|
WO2015021990A1
(en)
|
2013-08-16 |
2015-02-19 |
University Of Copenhagen |
Rna probing method and reagents
|
|
NO3036326T3
(enExample)
|
2013-08-20 |
2018-03-03 |
|
|
|
US9359599B2
(en)
|
2013-08-22 |
2016-06-07 |
President And Fellows Of Harvard College |
Engineered transcription activator-like effector (TALE) domains and uses thereof
|
|
EP3611268A1
(en)
|
2013-08-22 |
2020-02-19 |
E. I. du Pont de Nemours and Company |
Plant genome modification using guide rna/cas endonuclease systems and methods of use
|
|
WO2015031619A1
(en)
|
2013-08-28 |
2015-03-05 |
Sangamo Biosciences, Inc. |
Compositions for linking dna-binding domains and cleavage domains
|
|
GB201315321D0
(en)
|
2013-08-28 |
2013-10-09 |
Koninklijke Nederlandse Akademie Van Wetenschappen |
Transduction Buffer
|
|
AU2014312123A1
(en)
|
2013-08-29 |
2016-03-17 |
Temple University Of The Commonwealth System Of Higher Education |
Methods and compositions for RNA-guided treatment of HIV infection
|
|
WO2015033293A1
(en)
|
2013-09-04 |
2015-03-12 |
Csir |
Site-specific nuclease single-cell assay targeting gene regulatory elements to silence gene expression
|
|
HRP20240856T1
(hr)
|
2013-09-04 |
2024-10-11 |
KWS SAAT SE & Co. KGaA |
Biljke rezistentne na helminthosporium turcicum
|
|
AU2014315335B2
(en)
|
2013-09-04 |
2017-08-24 |
Corteva Agriscience Llc |
Rapid targeting analysis in crops for determining donor insertion
|
|
WO2015034872A2
(en)
|
2013-09-05 |
2015-03-12 |
Massachusetts Institute Of Technology |
Tuning microbial populations with programmable nucleases
|
|
US9388430B2
(en)
|
2013-09-06 |
2016-07-12 |
President And Fellows Of Harvard College |
Cas9-recombinase fusion proteins and uses thereof
|
|
US9737604B2
(en)
|
2013-09-06 |
2017-08-22 |
President And Fellows Of Harvard College |
Use of cationic lipids to deliver CAS9
|
|
US9340799B2
(en)
|
2013-09-06 |
2016-05-17 |
President And Fellows Of Harvard College |
MRNA-sensing switchable gRNAs
|
|
WO2015040075A1
(en)
|
2013-09-18 |
2015-03-26 |
Genome Research Limited |
Genomic screening methods using rna-guided endonucleases
|
|
EP3988649B1
(en)
|
2013-09-18 |
2024-11-27 |
Kymab Limited |
Methods, cells and organisms
|
|
EP3046932B1
(en)
|
2013-09-20 |
2020-04-29 |
President and Fellows of Harvard College |
Evolved sortases and uses thereof
|
|
AU2014321215B2
(en)
|
2013-09-23 |
2020-07-16 |
Rensselaer Polytechnic Institute |
Nanoparticle-mediated gene delivery, genomic editing and ligand-targeted modification in various cell populations
|
|
US20160237455A1
(en)
|
2013-09-27 |
2016-08-18 |
Editas Medicine, Inc. |
Crispr-related methods and compositions
|
|
US10822606B2
(en)
|
2013-09-27 |
2020-11-03 |
The Regents Of The University Of California |
Optimized small guide RNAs and methods of use
|
|
CA2925050A1
(en)
|
2013-09-30 |
2015-04-02 |
The Regents Of The University Of California |
Identification of cxcr8, a novel chemokine receptor
|
|
WO2015048707A2
(en)
|
2013-09-30 |
2015-04-02 |
Regents Of The University Of Minnesota |
Conferring resistance to geminiviruses in plants using crispr/cas systems
|
|
CN105934512A
(zh)
|
2013-10-02 |
2016-09-07 |
东北大学 |
用于在核基因转移的受体中产生没有发育能力的卵子的方法和组合物
|
|
JP5774657B2
(ja)
|
2013-10-04 |
2015-09-09 |
国立大学法人京都大学 |
エレクトロポレーションを利用した哺乳類の遺伝子改変方法
|
|
CA2932581A1
(en)
|
2013-10-07 |
2015-04-16 |
Northeastern University |
Methods and compositions for ex vivo generation of developmentally competent eggs from germ line cells using autologous cell systems
|
|
WO2015052231A2
(en)
|
2013-10-08 |
2015-04-16 |
Technical University Of Denmark |
Multiplex editing system
|
|
US20150098954A1
(en)
|
2013-10-08 |
2015-04-09 |
Elwha Llc |
Compositions and Methods Related to CRISPR Targeting
|
|
DE102013111099B4
(de)
|
2013-10-08 |
2023-11-30 |
Eberhard Karls Universität Tübingen Medizinische Fakultät |
Permanente Genkorrektur mittels nukleotidmodifizierter messenger RNA
|
|
AU2014333776B2
(en)
|
2013-10-11 |
2021-01-28 |
Cellectis |
Methods and kits for detecting nucleic acid sequences of interest using DNA-binding protein domain
|
|
WO2015057671A1
(en)
|
2013-10-14 |
2015-04-23 |
The Broad Institute, Inc. |
Artificial transcription factors comprising a sliding domain and uses thereof
|
|
KR102357968B1
(ko)
|
2013-10-15 |
2022-02-03 |
더 스크립스 리서치 인스티튜트 |
키메라 항원 수용체 t 세포 스위치 및 이의 용도
|
|
CA2927543C
(en)
|
2013-10-15 |
2021-07-20 |
The California Institute For Biomedical Research |
Peptidic chimeric antigen receptor t cell switches and uses thereof
|
|
WO2015057976A1
(en)
|
2013-10-17 |
2015-04-23 |
Sangamo Biosciences, Inc. |
Delivery methods and compositions for nuclease-mediated genome engineering in hematopoietic stem cells
|
|
US9957526B2
(en)
|
2013-10-17 |
2018-05-01 |
Sangamo Therapeutics, Inc. |
Delivery methods and compositions for nuclease-mediated genome engineering
|
|
US10759764B2
(en)
|
2013-10-18 |
2020-09-01 |
President And Fellows Of Harvard College |
Fluorination of organic compounds
|
|
EP3060658B1
(en)
|
2013-10-25 |
2020-07-15 |
Cellectis |
Design of rare-cutting endonucleases for efficient and specific targeting dna sequences comprising highly repetitive motives
|
|
WO2015065964A1
(en)
|
2013-10-28 |
2015-05-07 |
The Broad Institute Inc. |
Functional genomics using crispr-cas systems, compositions, methods, screens and applications thereof
|
|
WO2015066119A1
(en)
|
2013-10-30 |
2015-05-07 |
North Carolina State University |
Compositions and methods related to a type-ii crispr-cas system in lactobacillus buchneri
|
|
WO2015066638A2
(en)
|
2013-11-04 |
2015-05-07 |
Dow Agrosciences Llc |
Optimal maize loci
|
|
BR102014027442B1
(pt)
|
2013-11-04 |
2022-09-27 |
Dow Agrosciences Llc |
Molécula de ácido nucleico recombinante, uso de uma planta de milho, parte de planta de milho ou célula de planta de milho compreendendo a mesma e método para produzir uma célula vegetal transgênica compreendendo um dna de interesse
|
|
AU2014341928B2
(en)
|
2013-11-04 |
2017-11-30 |
Corteva Agriscience Llc |
A universal donor system for gene targeting
|
|
EP3862434A1
(en)
|
2013-11-04 |
2021-08-11 |
Dow AgroSciences LLC |
Optimal soybean loci
|
|
US10233465B2
(en)
|
2013-11-04 |
2019-03-19 |
Dow Agrosciences Llc |
Optimal soybean loci
|
|
US10752906B2
(en)
|
2013-11-05 |
2020-08-25 |
President And Fellows Of Harvard College |
Precise microbiota engineering at the cellular level
|
|
KR20230054509A
(ko)
|
2013-11-07 |
2023-04-24 |
에디타스 메디신, 인코포레이티드 |
지배적인 gRNA를 이용하는 CRISPR-관련 방법 및 조성물
|
|
US20160282354A1
(en)
|
2013-11-08 |
2016-09-29 |
The Broad Institute, Inc. |
Compositions and methods for selecting a treatment for b-cell neoplasias
|
|
WO2015070193A1
(en)
|
2013-11-11 |
2015-05-14 |
Liu Oliver |
Compositions and methods for targeted gene disruption in prokaryotes
|
|
CN105934524A
(zh)
|
2013-11-11 |
2016-09-07 |
桑格摩生物科学股份有限公司 |
用于治疗亨廷顿氏病的方法和组合物
|
|
DK3492593T3
(da)
|
2013-11-13 |
2021-11-08 |
Childrens Medical Center |
Nukleasemedieret regulering af genekspression
|
|
CA2930590C
(en)
|
2013-11-15 |
2021-02-16 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Engineering neural stem cells using homologous recombination
|
|
WO2015073990A1
(en)
|
2013-11-18 |
2015-05-21 |
Yale University |
Compositions and methods of using transposons
|
|
US20160298096A1
(en)
|
2013-11-18 |
2016-10-13 |
Crispr Therapeutics Ag |
Crispr-cas system materials and methods
|
|
US10787684B2
(en)
|
2013-11-19 |
2020-09-29 |
President And Fellows Of Harvard College |
Large gene excision and insertion
|
|
WO2015075056A1
(en)
|
2013-11-19 |
2015-05-28 |
Thermo Fisher Scientific Baltics Uab |
Programmable enzymes for isolation of specific dna fragments
|
|
US9074199B1
(en)
|
2013-11-19 |
2015-07-07 |
President And Fellows Of Harvard College |
Mutant Cas9 proteins
|
|
CN105960413B
(zh)
|
2013-11-20 |
2020-03-27 |
泰莱托恩基金会 |
人工dna-结合蛋白及其用途
|
|
AU2014351871B2
(en)
|
2013-11-22 |
2020-02-13 |
Cellectis |
Method for generating batches of allogeneic T-cells with averaged potency
|
|
WO2015075195A1
(en)
|
2013-11-22 |
2015-05-28 |
Cellectis |
Method of engineering chemotherapy drug resistant t-cells for immunotherapy
|
|
KR102507624B1
(ko)
|
2013-11-22 |
2023-03-09 |
미나 테라퓨틱스 리미티드 |
C/ebp 알파 짧은 활성화 rna 조성물 및 사용 방법
|
|
CN103642836A
(zh)
|
2013-11-26 |
2014-03-19 |
苏州同善生物科技有限公司 |
一种基于crispr基因敲除技术建立脆性x综合症灵长类动物模型的方法
|
|
CN103614415A
(zh)
|
2013-11-27 |
2014-03-05 |
苏州同善生物科技有限公司 |
一种基于crispr基因敲除技术建立肥胖症大鼠动物模型的方法
|
|
CA2928635C
(en)
|
2013-11-28 |
2022-06-21 |
Horizon Genomics Gmbh |
Somatic haploid human cell line
|
|
EP3757116A1
(en)
|
2013-12-09 |
2020-12-30 |
Sangamo Therapeutics, Inc. |
Methods and compositions for genome engineering
|
|
MX388127B
(es)
|
2013-12-11 |
2025-03-19 |
Regeneron Pharma |
Metodos y composiciones para la modificacion dirigida de un genoma.
|
|
WO2015089364A1
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Crystal structure of a crispr-cas system, and uses thereof
|
|
EP3079726B1
(en)
|
2013-12-12 |
2018-12-05 |
The Broad Institute, Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for targeting disorders and diseases using particle delivery components
|
|
EP3540051B1
(en)
|
2013-12-12 |
2022-08-17 |
The Broad Institute, Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for hsv and viral diseases and disorders.
|
|
EP3080259B1
(en)
|
2013-12-12 |
2023-02-01 |
The Broad Institute, Inc. |
Engineering of systems, methods and optimized guide compositions with new architectures for sequence manipulation
|
|
EP3080271B1
(en)
|
2013-12-12 |
2020-02-12 |
The Broad Institute, Inc. |
Systems, methods and compositions for sequence manipulation with optimized functional crispr-cas systems
|
|
EP3080266B1
(en)
|
2013-12-12 |
2021-02-03 |
The Regents of The University of California |
Methods and compositions for modifying a single stranded target nucleic acid
|
|
SG10201804973TA
(en)
|
2013-12-12 |
2018-07-30 |
Broad Inst Inc |
Compositions and Methods of Use of Crispr-Cas Systems in Nucleotide Repeat Disorders
|
|
US11053481B2
(en)
|
2013-12-12 |
2021-07-06 |
President And Fellows Of Harvard College |
Fusions of Cas9 domains and nucleic acid-editing domains
|
|
BR112016013201B1
(pt)
|
2013-12-12 |
2023-01-31 |
The Broad Institute, Inc. |
Uso de uma composição compreendendo um sistema crispr-cas no tratamento de uma doença genética ocular
|
|
JP2017503485A
(ja)
|
2013-12-12 |
2017-02-02 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
遺伝子産物の発現、構造情報、及び誘導性モジュラーcas酵素を変更するためのcrispr−cas系並びに方法
|
|
EP3080256B1
(en)
|
2013-12-13 |
2018-06-13 |
Cellectis |
Cas9 nuclease platform for microalgae genome engineering
|
|
EP3080275B1
(en)
|
2013-12-13 |
2020-01-15 |
Cellectis |
Method of selection of transformed diatoms using nuclease
|
|
US20150191744A1
(en)
|
2013-12-17 |
2015-07-09 |
University Of Massachusetts |
Cas9 effector-mediated regulation of transcription, differentiation and gene editing/labeling
|
|
AU2014368982B2
(en)
|
2013-12-19 |
2021-03-25 |
Amyris, Inc. |
Methods for genomic integration
|
|
CA2935032C
(en)
|
2013-12-26 |
2024-01-23 |
The General Hospital Corporation |
Multiplex guide rnas
|
|
WO2015103057A1
(en)
|
2013-12-30 |
2015-07-09 |
University Of Pittsburgh - Of The Commonwealth System Of Higher Education |
Fusion genes associated with progressive prostate cancer
|
|
US9963689B2
(en)
|
2013-12-31 |
2018-05-08 |
The Regents Of The University Of California |
Cas9 crystals and methods of use thereof
|
|
CN103668472B
(zh)
|
2013-12-31 |
2014-12-24 |
北京大学 |
利用CRISPR/Cas9系统构建真核基因敲除文库的方法
|
|
AU2015204784B2
(en)
|
2014-01-08 |
2021-01-28 |
President And Fellows Of Harvard College |
RNA-guided gene drives
|
|
EP3094729A1
(en)
|
2014-01-14 |
2016-11-23 |
Lam Therapeutics, Inc. |
Mutagenesis methods
|
|
US10774338B2
(en)
|
2014-01-16 |
2020-09-15 |
The Regents Of The University Of California |
Generation of heritable chimeric plant traits
|
|
WO2015134121A2
(en)
|
2014-01-20 |
2015-09-11 |
President And Fellows Of Harvard College |
Negative selection and stringency modulation in continuous evolution systems
|
|
EP3097194A4
(en)
|
2014-01-21 |
2017-08-23 |
Institute Of Genetics And Developmental Biology, Chinese Academy Of Sciences |
Modified plants
|
|
GB201400962D0
(en)
|
2014-01-21 |
2014-03-05 |
Kloehn Peter C |
Screening for target-specific affinity binders using RNA interference
|
|
EP3096609B1
(en)
|
2014-01-24 |
2021-09-22 |
Children's Medical Center Corporation |
High-throughput mouse model for optimizing antibody affinities
|
|
EP3097212A4
(en)
|
2014-01-24 |
2017-10-04 |
North Carolina State University |
Methods and compositions for sequences guiding cas9 targeting
|
|
US10354746B2
(en)
|
2014-01-27 |
2019-07-16 |
Georgia Tech Research Corporation |
Methods and systems for identifying CRISPR/Cas off-target sites
|
|
CN104805078A
(zh)
|
2014-01-28 |
2015-07-29 |
北京大学 |
用于高效基因组编辑的rna分子的设计、合成及其应用
|
|
US9850525B2
(en)
|
2014-01-29 |
2017-12-26 |
Agilent Technologies, Inc. |
CAS9-based isothermal method of detection of specific DNA sequence
|
|
US20150291969A1
(en)
|
2014-01-30 |
2015-10-15 |
Chromatin, Inc. |
Compositions for reduced lignin content in sorghum and improving cell wall digestibility, and methods of making the same
|
|
US10233456B2
(en)
|
2014-01-30 |
2019-03-19 |
The Board Of Trustees Of The University Of Arkansas |
Method, vectors, cells, seeds and kits for stacking genes into a single genomic site
|
|
WO2015117021A1
(en)
|
2014-01-31 |
2015-08-06 |
Factor Bioscience Inc. |
Methods and products for nucleic acid production and delivery
|
|
GB201401707D0
(en)
|
2014-01-31 |
2014-03-19 |
Sec Dep For Health The |
Adeno-associated viral vectors
|
|
US10072066B2
(en)
|
2014-02-03 |
2018-09-11 |
Sangamo Therapeutics, Inc. |
Methods and compositions for treatment of a beta thalessemia
|
|
WO2015115903A1
(en)
|
2014-02-03 |
2015-08-06 |
Academisch Ziekenhuis Leiden H.O.D.N. Lumc |
Site-specific dna break-induced genome editing using engineered nucleases
|
|
EP4467654A3
(en)
|
2014-02-04 |
2025-02-19 |
Jumpcode Genomics, Inc. |
Genome fractioning
|
|
DK3102680T3
(en)
|
2014-02-07 |
2019-04-08 |
Vib Vzw |
INHIBITION OF NEAT1 FOR TREATMENT OF SOLID TUMORS
|
|
AU2015217208B2
(en)
|
2014-02-11 |
2018-08-30 |
The Regents Of The University Of Colorado, A Body Corporate |
CRISPR enabled multiplexed genome engineering
|
|
WO2015122967A1
(en)
|
2014-02-13 |
2015-08-20 |
Clontech Laboratories, Inc. |
Methods of depleting a target molecule from an initial collection of nucleic acids, and compositions and kits for practicing the same
|
|
JP6673838B2
(ja)
|
2014-02-14 |
2020-04-01 |
セレクティスCellectis |
免疫細胞と病的細胞の両方に存在する抗原を標的とするように操作された、免疫療法のための細胞
|
|
KR20160130392A
(ko)
|
2014-02-18 |
2016-11-11 |
듀크 유니버시티 |
바이러스 복제의 불활성화를 위한 조성물 및 그의 제조 및 사용 방법
|
|
AU2015220765A1
(en)
|
2014-02-20 |
2016-09-01 |
Dsm Ip Assets B.V. |
Phage insensitive Streptococcus thermophilus
|
|
EP3107552B1
(en)
|
2014-02-21 |
2018-03-28 |
Cellectis |
Method for in situ inhibition of regulatory t cells
|
|
WO2015127428A1
(en)
|
2014-02-24 |
2015-08-27 |
Massachusetts Institute Of Technology |
Methods for in vivo genome editing
|
|
JP6606088B2
(ja)
|
2014-02-24 |
2019-11-13 |
サンガモ セラピューティクス, インコーポレイテッド |
ヌクレアーゼ媒介性標的化組み込みのための方法および組成物
|
|
WO2015129686A1
(ja)
|
2014-02-25 |
2015-09-03 |
国立研究開発法人 農業生物資源研究所 |
標的dnaに変異が導入された植物細胞、及びその製造方法
|
|
US11186843B2
(en)
|
2014-02-27 |
2021-11-30 |
Monsanto Technology Llc |
Compositions and methods for site directed genomic modification
|
|
CN103820454B
(zh)
|
2014-03-04 |
2016-03-30 |
上海金卫生物技术有限公司 |
CRISPR-Cas9特异性敲除人PD1基因的方法以及用于特异性靶向PD1基因的sgRNA
|
|
CN103820441B
(zh)
|
2014-03-04 |
2017-05-17 |
黄行许 |
CRISPR‑Cas9特异性敲除人CTLA4基因的方法以及用于特异性靶向CTLA4基因的sgRNA
|
|
WO2015134812A1
(en)
|
2014-03-05 |
2015-09-11 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating usher syndrome and retinitis pigmentosa
|
|
CN111471674A
(zh)
|
2014-03-05 |
2020-07-31 |
国立大学法人神户大学 |
特异性转变靶向dna序列的核酸碱基的基因组序列的修饰方法、及其使用的分子复合体
|
|
EP3553176A1
(en)
|
2014-03-10 |
2019-10-16 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating leber's congenital amaurosis 10 (lca10)
|
|
ES2782125T3
(es)
|
2014-03-11 |
2020-09-10 |
Cellectis |
Método para generar linfocitos T compatibles para trasplante alogénico
|
|
ES2821149T3
(es)
|
2014-03-12 |
2021-04-23 |
Prec Biosciences Inc |
Eliminación del exón del gen de la distrofina mediante nucleasas modificadas genéticamente
|
|
WO2015138870A2
(en)
|
2014-03-13 |
2015-09-17 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for targeted epigenetic modification
|
|
WO2015138855A1
(en)
|
2014-03-14 |
2015-09-17 |
The Regents Of The University Of California |
Vectors and methods for fungal genome engineering by crispr-cas9
|
|
CA2942407C
(en)
|
2014-03-14 |
2023-09-26 |
Cibus Us Llc |
Methods and compositions for increasing efficiency of targeted gene modification using oligonucleotide-mediated gene repair
|
|
AU2015231353B2
(en)
|
2014-03-18 |
2020-11-05 |
Sangamo Therapeutics, Inc. |
Methods and compositions for regulation of zinc finger protein expression
|
|
EP3126498A4
(en)
|
2014-03-20 |
2017-08-23 |
Université Laval |
Crispr-based methods and products for increasing frataxin levels and uses thereof
|
|
CA2939847C
(en)
|
2014-03-21 |
2023-09-05 |
The Board Of Trustees Of The Leland Stanford Junior University |
Genome editing without nucleases
|
|
RS58337B1
(sr)
|
2014-03-24 |
2019-03-29 |
Translate Bio Inc |
Irnk terapija za lečenje očnih oboljenja
|
|
PL3122766T3
(pl)
|
2014-03-24 |
2021-09-13 |
IMMCO Diagnostics, Inc. |
Ulepszone wykrywanie i diagnostyka przeciwciał przeciwjądrowych dla układowych i nieukładowych zaburzeń autoimmunologicznych
|
|
CA2943622A1
(en)
|
2014-03-25 |
2015-10-01 |
Editas Medicine Inc. |
Crispr/cas-related methods and compositions for treating hiv infection and aids
|
|
WO2015148680A1
(en)
|
2014-03-25 |
2015-10-01 |
Ginkgo Bioworks, Inc. |
Methods and genetic systems for cell engineering
|
|
US9609415B2
(en)
|
2014-03-26 |
2017-03-28 |
Bose Corporation |
Headphones with cable management
|
|
WO2015148860A1
(en)
|
2014-03-26 |
2015-10-01 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating beta-thalassemia
|
|
US10349639B2
(en)
|
2014-03-26 |
2019-07-16 |
University Of Maryland, College Park |
Targeted genome editing in zygotes of domestic large animals
|
|
EP3122880B1
(en)
|
2014-03-26 |
2021-05-05 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating sickle cell disease
|
|
WO2015145417A1
(en)
|
2014-03-28 |
2015-10-01 |
Ilan Ziv |
Compounds and methods for trans-membrane delivery of molecules
|
|
US9993563B2
(en)
|
2014-03-28 |
2018-06-12 |
Aposense Ltd. |
Compounds and methods for trans-membrane delivery of molecules
|
|
WO2015153760A2
(en)
|
2014-04-01 |
2015-10-08 |
Sangamo Biosciences, Inc. |
Methods and compositions for prevention or treatment of a nervous system disorder
|
|
WO2015153791A1
(en)
|
2014-04-01 |
2015-10-08 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating herpes simplex virus type 2 (hsv-2)
|
|
WO2015153789A1
(en)
|
2014-04-01 |
2015-10-08 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating herpes simplex virus type 1 (hsv-1)
|
|
EP3540061A1
(en)
|
2014-04-02 |
2019-09-18 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating primary open angle glaucoma
|
|
US10507232B2
(en)
|
2014-04-02 |
2019-12-17 |
University Of Florida Research Foundation, Incorporated |
Materials and methods for the treatment of latent viral infection
|
|
CN103911376B
(zh)
|
2014-04-03 |
2017-02-15 |
黄行许 |
CRISPR‑Cas9靶向敲除乙肝病毒cccDNA及其特异性sgRNA
|
|
WO2015153940A1
(en)
|
2014-04-03 |
2015-10-08 |
Massachusetts Institute Of Technology |
Methods and compositions for the production of guide rna
|
|
CN106460003A
(zh)
|
2014-04-08 |
2017-02-22 |
北卡罗来纳州立大学 |
用于使用crispr相关基因rna引导阻遏转录的方法和组合物
|
|
EP3556858A3
(en)
|
2014-04-09 |
2020-01-22 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating cystic fibrosis
|
|
WO2015157534A1
(en)
|
2014-04-10 |
2015-10-15 |
The Regents Of The University Of California |
Methods and compositions for using argonaute to modify a single stranded target nucleic acid
|
|
WO2015155341A1
(en)
|
2014-04-11 |
2015-10-15 |
Cellectis |
Method for generating immune cells resistant to arginine and/or tryptophan depleted microenvironment
|
|
ES2962509T3
(es)
|
2014-04-14 |
2024-03-19 |
Maxcyte Inc |
Métodos y composiciones para modificar ADN genómico
|
|
WO2015159068A1
(en)
|
2014-04-14 |
2015-10-22 |
Nemesis Bioscience Ltd |
Therapeutic
|
|
CN103923911B
(zh)
|
2014-04-14 |
2016-06-08 |
上海金卫生物技术有限公司 |
CRISPR-Cas9特异性敲除人CCR5基因的方法以及用于特异性靶向CCR5基因的sgRNA
|
|
GB201406970D0
(en)
|
2014-04-17 |
2014-06-04 |
Green Biologics Ltd |
Targeted mutations
|
|
GB201406968D0
(en)
|
2014-04-17 |
2014-06-04 |
Green Biologics Ltd |
Deletion mutants
|
|
WO2015161276A2
(en)
|
2014-04-18 |
2015-10-22 |
Editas Medicine, Inc. |
Crispr-cas-related methods, compositions and components for cancer immunotherapy
|
|
CN105039399A
(zh)
|
2014-04-23 |
2015-11-11 |
复旦大学 |
多能干细胞-遗传性心肌病心肌细胞及其制备方法
|
|
US20170076039A1
(en)
|
2014-04-24 |
2017-03-16 |
Institute For Basic Science |
A Method of Selecting a Nuclease Target Sequence for Gene Knockout Based on Microhomology
|
|
CA2945393C
(en)
|
2014-04-24 |
2021-03-23 |
Board Of Regents, The University Of Texas System |
Application of induced pluripotent stem cells to generate adoptive cell therapy products
|
|
WO2015164748A1
(en)
|
2014-04-24 |
2015-10-29 |
Sangamo Biosciences, Inc. |
Engineered transcription activator like effector (tale) proteins
|
|
WO2015168158A1
(en)
|
2014-04-28 |
2015-11-05 |
Fredy Altpeter |
Targeted genome editing to modify lignin biosynthesis and cell wall composition
|
|
AU2015253536A1
(en)
|
2014-04-28 |
2016-11-17 |
Dow Agrosciences Llc |
Haploid maize transformation
|
|
MX2016014066A
(es)
|
2014-04-28 |
2017-05-03 |
Recombinetics Inc |
Edicion de genes multiples en cerdos.
|
|
WO2015167766A1
(en)
|
2014-04-29 |
2015-11-05 |
Seattle Children's Hospital (dba Seattle Children's Research Institute) |
Ccr5 disruption of cells expressing anti-hiv chimeric antigen receptor (car) derived from broadly neutralizing antibodies
|
|
CN104178506B
(zh)
|
2014-04-30 |
2017-03-01 |
清华大学 |
Taler蛋白通过空间位阻发挥转录抑制作用及其应用
|
|
WO2015165276A1
(zh)
|
2014-04-30 |
2015-11-05 |
清华大学 |
利用tale转录抑制子在哺乳动物细胞中模块化构建合成基因线路的试剂盒
|
|
WO2015168404A1
(en)
|
2014-04-30 |
2015-11-05 |
Massachusetts Institute Of Technology |
Toehold-gated guide rna for programmable cas9 circuitry with rna input
|
|
EP3156493B1
(en)
|
2014-04-30 |
2020-05-06 |
Tsinghua University |
Use of tale transcriptional repressor for modular construction of synthetic gene line in mammalian cell
|
|
BR112016025519A2
(pt)
|
2014-05-01 |
2018-01-16 |
Univ Washington |
engenharia genética in vivo com vetores de adenovírus
|
|
GB201407852D0
(en)
|
2014-05-02 |
2014-06-18 |
Iontas Ltd |
Preparation of libraries od protein variants expressed in eukaryotic cells and use for selecting binding molecules
|
|
WO2015171603A1
(en)
|
2014-05-06 |
2015-11-12 |
Two Blades Foundation |
Methods for producing plants with enhanced resistance to oomycete pathogens
|
|
RU2691102C2
(ru)
|
2014-05-08 |
2019-06-11 |
Сангамо Байосайенсиз, Инк. |
Способы и композиции для лечения болезни хантингтона
|
|
EP3139954A4
(en)
|
2014-05-09 |
2018-02-28 |
Indiana University Research and Technology Corporation |
Methods and compositions for treating hepatitis b virus infections
|
|
EP3140403A4
(en)
|
2014-05-09 |
2017-12-20 |
Université Laval |
Prevention and treatment of alzheimer's disease by genome editing using the crispr/cas system
|
|
US10487336B2
(en)
|
2014-05-09 |
2019-11-26 |
The Regents Of The University Of California |
Methods for selecting plants after genome editing
|
|
WO2015175642A2
(en)
|
2014-05-13 |
2015-11-19 |
Sangamo Biosciences, Inc. |
Methods and compositions for prevention or treatment of a disease
|
|
CN104017821B
(zh)
|
2014-05-16 |
2016-07-06 |
安徽省农业科学院水稻研究所 |
定向编辑颖壳颜色决定基因OsCHI创制褐壳水稻材料的方法
|
|
WO2015173436A1
(en)
|
2014-05-16 |
2015-11-19 |
Vrije Universiteit Brussel |
Genetic correction of myotonic dystrophy type 1
|
|
CN103981212B
(zh)
|
2014-05-16 |
2016-06-01 |
安徽省农业科学院水稻研究所 |
将黄色颖壳的水稻品种的颖壳颜色改为褐色的育种方法
|
|
CN104004782B
(zh)
|
2014-05-16 |
2016-06-08 |
安徽省农业科学院水稻研究所 |
一种延长水稻生育期的育种方法
|
|
CN103981211B
(zh)
|
2014-05-16 |
2016-07-06 |
安徽省农业科学院水稻研究所 |
一种创制闭颖授粉水稻材料的育种方法
|
|
JP2017517256A
(ja)
|
2014-05-20 |
2017-06-29 |
リージェンツ オブ ザ ユニバーシティ オブ ミネソタ |
遺伝子配列を編集する方法
|
|
CA2852593A1
(en)
|
2014-05-23 |
2015-11-23 |
Universite Laval |
Methods for producing dopaminergic neurons and uses thereof
|
|
US10653123B2
(en)
|
2014-05-27 |
2020-05-19 |
Dana-Farber Cancer Institute, Inc. |
Methods and compositions for perturbing gene expression in hematopoietic stem cell lineages in vivo
|
|
KR101815695B1
(ko)
|
2014-05-28 |
2018-01-08 |
기초과학연구원 |
표적 특이적 뉴클레아제를 이용한 표적 dna의 민감한 검출 방법
|
|
US20160060655A1
(en)
|
2014-05-30 |
2016-03-03 |
The Board Of Trustees Of The Leland Stanford Junior University |
Compositions and methods to treat latent viral infections
|
|
EP3152319A4
(en)
|
2014-06-05 |
2017-12-27 |
Sangamo BioSciences, Inc. |
Methods and compositions for nuclease design
|
|
WO2015188191A1
(en)
|
2014-06-06 |
2015-12-10 |
Wong Wilson W |
Dna recombinase circuits for logical control of gene expression
|
|
CA2950178A1
(en)
|
2014-06-06 |
2015-12-10 |
The California Institute For Biomedical Research |
Methods of constructing amino terminal immunoglobulin fusion proteins and compositions thereof
|
|
CN104004778B
(zh)
|
2014-06-06 |
2016-03-02 |
重庆高圣生物医药有限责任公司 |
含有CRISPR/Cas9系统的靶向敲除载体及其腺病毒和应用
|
|
WO2015188135A1
(en)
|
2014-06-06 |
2015-12-10 |
The California Institute For Biomedical Research |
Constant region antibody fusion proteins and compositions thereof
|
|
US20170198307A1
(en)
|
2014-06-06 |
2017-07-13 |
President And Fellows Of Harvard College |
Methods for targeted modification of genomic dna
|
|
BR112016028564A2
(pt)
|
2014-06-06 |
2018-01-30 |
Regeneron Pharma |
método para modificar um locus-alvo em uma célula.
|
|
US11274302B2
(en)
|
2016-08-17 |
2022-03-15 |
Diacarta Ltd |
Specific synthetic chimeric Xenonucleic acid guide RNA; s(XNA-gRNA) for enhancing CRISPR mediated genome editing efficiency
|
|
WO2015191693A2
(en)
|
2014-06-10 |
2015-12-17 |
Massachusetts Institute Of Technology |
Method for gene editing
|
|
MY203868A
(en)
|
2014-06-11 |
2024-07-22 |
Univ Duke |
Compositions and methods for rapid and dynamic flux control using synthetic metabolic valves
|
|
CA2951882A1
(en)
|
2014-06-11 |
2015-12-17 |
Tom E. HOWARD |
Factor viii mutation repair and tolerance induction and related cdnas, compositions, methods and systems
|
|
WO2015191911A2
(en)
|
2014-06-12 |
2015-12-17 |
Clontech Laboratories, Inc. |
Protein enriched microvesicles and methods of making and using the same
|
|
WO2015189693A1
(en)
|
2014-06-12 |
2015-12-17 |
King Abdullah University Of Science And Technology |
Targeted viral-mediated plant genome editing using crispr/cas9
|
|
SG10202002486QA
(en)
|
2014-06-16 |
2020-04-29 |
Univ Johns Hopkins |
Compositions and methods for the expression of crispr guide rnas using the h1 promoter
|
|
WO2015195547A1
(en)
|
2014-06-16 |
2015-12-23 |
University Of Washington |
Methods for controlling stem cell potential and for gene editing in stem cells
|
|
EP3157328B1
(en)
|
2014-06-17 |
2021-08-04 |
Poseida Therapeutics, Inc. |
A method for directing proteins to specific loci in the genome and uses thereof
|
|
CA2952906A1
(en)
|
2014-06-20 |
2015-12-23 |
Cellectis |
Potatoes with reduced granule-bound starch synthase
|
|
IL286474B2
(en)
|
2014-06-23 |
2023-11-01 |
Massachusetts Gen Hospital |
Genome-wide random identification of DSBS assessed by sequencing (guide-sequence)
|
|
MX384887B
(es)
|
2014-06-23 |
2025-03-14 |
Regeneron Pharma |
Ensamblaje de adn mediado por nucleasa.
|
|
WO2015200555A2
(en)
|
2014-06-25 |
2015-12-30 |
Caribou Biosciences, Inc. |
Rna modification to engineer cas9 activity
|
|
GB201411344D0
(en)
|
2014-06-26 |
2014-08-13 |
Univ Leicester |
Cloning
|
|
SG10201911411YA
(en)
|
2014-06-26 |
2020-02-27 |
Regeneron Pharma |
Methods and compositions for targeted genetic modifications and methods of use
|
|
JP6090535B2
(ja)
|
2014-06-30 |
2017-03-08 |
日産自動車株式会社 |
内燃機関
|
|
SG11201610591XA
(en)
|
2014-06-30 |
2017-01-27 |
Kao Corp |
Adhesive sheet for cooling
|
|
US20180187172A1
(en)
|
2014-07-01 |
2018-07-05 |
Board Of Regents, The University Of Texas System |
Regulated gene expression from viral vectors
|
|
EP3164112A1
(en)
|
2014-07-02 |
2017-05-10 |
Shire Human Genetic Therapies, Inc. |
Encapsulation of messenger rna
|
|
EP3167071B1
(en)
|
2014-07-09 |
2020-10-07 |
Gen9, Inc. |
Compositions and methods for site-directed dna nicking and cleaving
|
|
EP2966170A1
(en)
|
2014-07-10 |
2016-01-13 |
Heinrich-Pette-Institut Leibniz-Institut für experimentelle Virologie-Stiftung bürgerlichen Rechts - |
HBV inactivation
|
|
WO2016007347A1
(en)
|
2014-07-11 |
2016-01-14 |
E. I. Du Pont De Nemours And Company |
Compositions and methods for producing plants resistant to glyphosate herbicide
|
|
BR112017000621B1
(pt)
|
2014-07-11 |
2024-03-12 |
Pioneer Hi-Bred International, Inc |
Método para melhorar um traço agronômico de uma planta de milho ou de soja
|
|
CN104109687A
(zh)
|
2014-07-14 |
2014-10-22 |
四川大学 |
运动发酵单胞菌CRISPR-Cas9系统的构建与应用
|
|
US11254933B2
(en)
|
2014-07-14 |
2022-02-22 |
The Regents Of The University Of California |
CRISPR/Cas transcriptional modulation
|
|
MX2017000646A
(es)
|
2014-07-15 |
2017-04-27 |
Juno Therapeutics Inc |
Celulas geneticamente modificadas para terapia celular adoptiva.
|
|
EP3193944B1
(en)
|
2014-07-17 |
2021-04-07 |
University of Pittsburgh - Of the Commonwealth System of Higher Education |
Methods of treating cells containing fusion genes
|
|
US9944933B2
(en)
|
2014-07-17 |
2018-04-17 |
Georgia Tech Research Corporation |
Aptamer-guided gene targeting
|
|
US20160053304A1
(en)
|
2014-07-18 |
2016-02-25 |
Whitehead Institute For Biomedical Research |
Methods Of Depleting Target Sequences Using CRISPR
|
|
US10975406B2
(en)
|
2014-07-18 |
2021-04-13 |
Massachusetts Institute Of Technology |
Directed endonucleases for repeatable nucleic acid cleavage
|
|
US20160053272A1
(en)
|
2014-07-18 |
2016-02-25 |
Whitehead Institute For Biomedical Research |
Methods Of Modifying A Sequence Using CRISPR
|
|
WO2016014565A2
(en)
|
2014-07-21 |
2016-01-28 |
Novartis Ag |
Treatment of cancer using humanized anti-bcma chimeric antigen receptor
|
|
WO2016014409A1
(en)
|
2014-07-21 |
2016-01-28 |
Illumina, Inc. |
Polynucleotide enrichment using crispr-cas systems
|
|
WO2016013183A1
(ja)
|
2014-07-22 |
2016-01-28 |
パナソニックIpマネジメント株式会社 |
複合磁性材料とこれを用いたコイル部品ならびに複合磁性材料の製造方法
|
|
EP3778867A1
(en)
|
2014-07-24 |
2021-02-17 |
DSM IP Assets B.V. |
Phage resistant lactic acid bacteria
|
|
US9816074B2
(en)
|
2014-07-25 |
2017-11-14 |
Sangamo Therapeutics, Inc. |
Methods and compositions for modulating nuclease-mediated genome engineering in hematopoietic stem cells
|
|
US9757420B2
(en)
|
2014-07-25 |
2017-09-12 |
Sangamo Therapeutics, Inc. |
Gene editing for HIV gene therapy
|
|
EP3172316A2
(en)
|
2014-07-25 |
2017-05-31 |
Boehringer Ingelheim International GmbH |
Enhanced reprogramming to ips cells
|
|
EP3194600B1
(en)
|
2014-07-26 |
2019-08-28 |
Consiglio Nazionale Delle Ricerche |
Compositions and methods for treatment of muscular dystrophy
|
|
US9616090B2
(en)
|
2014-07-30 |
2017-04-11 |
Sangamo Biosciences, Inc. |
Gene correction of SCID-related genes in hematopoietic stem and progenitor cells
|
|
AU2015298571B2
(en)
|
2014-07-30 |
2020-09-03 |
President And Fellows Of Harvard College |
Cas9 proteins including ligand-dependent inteins
|
|
FR3024464A1
(fr)
|
2014-07-30 |
2016-02-05 |
Centre Nat Rech Scient |
Ciblage de vecteurs integratifs non-viraux dans les sequences d'adn nucleolaires chez les eucaryotes
|
|
US9850521B2
(en)
|
2014-08-01 |
2017-12-26 |
Agilent Technologies, Inc. |
In vitro assay buffer for Cas9
|
|
US20160076093A1
(en)
|
2014-08-04 |
2016-03-17 |
University Of Washington |
Multiplex homology-directed repair
|
|
EP2982758A1
(en)
|
2014-08-04 |
2016-02-10 |
Centre Hospitalier Universitaire Vaudois (CHUV) |
Genome editing for the treatment of huntington's disease
|
|
CN106536721B
(zh)
|
2014-08-06 |
2020-12-04 |
车医科学大学校产学协力团 |
核酸酶介导的编辑编码hla的基因所产生的免疫相容性细胞
|
|
WO2016021973A1
(ko)
|
2014-08-06 |
2016-02-11 |
주식회사 툴젠 |
캄필로박터 제주니 crispr/cas 시스템 유래 rgen을 이용한 유전체 교정
|
|
WO2016022931A1
(en)
|
2014-08-07 |
2016-02-11 |
The Rockefeller University |
Compositions and methods for transcription-based crispr-cas dna editing
|
|
US9932566B2
(en)
|
2014-08-07 |
2018-04-03 |
Agilent Technologies, Inc. |
CIS-blocked guide RNA
|
|
EP3180034B1
(en)
|
2014-08-11 |
2022-04-20 |
The Board of Regents of The University of Texas System |
Prevention of muscular dystrophy by crispr/cas9-mediated gene editing
|
|
US10513711B2
(en)
|
2014-08-13 |
2019-12-24 |
Dupont Us Holding, Llc |
Genetic targeting in non-conventional yeast using an RNA-guided endonuclease
|
|
CN104178461B
(zh)
|
2014-08-14 |
2017-02-01 |
北京蛋白质组研究中心 |
携带cas9的重组腺病毒及其应用
|
|
CN107429241B
(zh)
|
2014-08-14 |
2025-10-24 |
百奥赛图(北京)医药科技股份有限公司 |
Dna敲入系统
|
|
US9879270B2
(en)
|
2014-08-15 |
2018-01-30 |
Wisconsin Alumni Research Foundation |
Constructs and methods for genome editing and genetic engineering of fungi and protists
|
|
EP3180426B1
(en)
|
2014-08-17 |
2019-12-25 |
The Broad Institute, Inc. |
Genome editing using cas9 nickases
|
|
CA2958292A1
(en)
|
2014-08-19 |
2016-02-25 |
President And Fellows Of Harvard College |
Rna-guided systems for probing and mapping of nucleic acids
|
|
EP3183367B1
(en)
|
2014-08-19 |
2019-06-26 |
Pacific Biosciences Of California, Inc. |
Compositions and methods for enrichment of nucleic acids
|
|
US20190045758A1
(en)
|
2014-08-20 |
2019-02-14 |
Shanghai Institutes For Biological Sciences, Chinese Academy Of Sciences |
Biomarker and Therapeutic Target for Triple Negative Breast Cancer
|
|
KR101946180B1
(ko)
|
2014-08-25 |
2019-02-08 |
지니위브 바이오사이언시스, 인코포레이티드 |
비-복제 형질도입 입자 및 형질도입 입자-기반 리포터 시스템
|
|
BR112017003528A2
(pt)
|
2014-08-26 |
2018-07-10 |
Univ California |
receptores de aba hipersensíveis.
|
|
US9970030B2
(en)
|
2014-08-27 |
2018-05-15 |
Caribou Biosciences, Inc. |
Methods for increasing CAS9-mediated engineering efficiency
|
|
WO2016033298A1
(en)
|
2014-08-28 |
2016-03-03 |
North Carolina State University |
Novel cas9 proteins and guiding features for dna targeting and genome editing
|
|
US10570418B2
(en)
|
2014-09-02 |
2020-02-25 |
The Regents Of The University Of California |
Methods and compositions for RNA-directed target DNA modification
|
|
EP3189140B1
(en)
|
2014-09-05 |
2019-10-23 |
Vilnius University |
Programmable rna shredding by the type iii-a crispr-cas system of streptococcus thermophilus
|
|
WO2016037157A2
(en)
|
2014-09-05 |
2016-03-10 |
The Johns Hopkins University |
Targeting capn9/capns2 activity as a therapeutic strategy for the treatment of myofibroblast differentiation and associated pathologies
|
|
US20170298450A1
(en)
|
2014-09-10 |
2017-10-19 |
The Regents Of The University Of California |
Reconstruction of ancestral cells by enzymatic recording
|
|
WO2016040030A1
(en)
|
2014-09-12 |
2016-03-17 |
E. I. Du Pont De Nemours And Company |
Generation of site-specific-integration sites for complex trait loci in corn and soybean, and methods of use
|
|
CN106795488B
(zh)
|
2014-09-16 |
2021-03-30 |
桑格摩治疗股份有限公司 |
用于造血干细胞中核酸酶介导的基因组工程化和校正的方法和组合物
|
|
US9738646B2
(en)
|
2014-09-16 |
2017-08-22 |
Gilead Sciences, Inc. |
Solid forms of a toll-like receptor modulator
|
|
WO2016049024A2
(en)
|
2014-09-24 |
2016-03-31 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for modeling competition of multiple cancer mutations in vivo
|
|
EP3800260A1
(en)
|
2014-09-24 |
2021-04-07 |
City of Hope |
Adeno-associated virus vector variants for high efficiency genome editing and methods thereof
|
|
WO2016049163A2
(en)
|
2014-09-24 |
2016-03-31 |
The Broad Institute Inc. |
Use and production of chd8+/- transgenic animals with behavioral phenotypes characteristic of autism spectrum disorder
|
|
WO2016049251A1
(en)
|
2014-09-24 |
2016-03-31 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for modeling mutations in leukocytes
|
|
WO2016046635A1
(en)
|
2014-09-25 |
2016-03-31 |
Institut Pasteur |
Methods for characterizing human papillomavirus associated cervical lesions
|
|
WO2016049258A2
(en)
|
2014-09-25 |
2016-03-31 |
The Broad Institute Inc. |
Functional screening with optimized functional crispr-cas systems
|
|
US20160090603A1
(en)
|
2014-09-30 |
2016-03-31 |
Sandia Corporation |
Delivery platforms for the domestication of algae and plants
|
|
WO2016054326A1
(en)
|
2014-10-01 |
2016-04-07 |
The General Hospital Corporation |
Methods for increasing efficiency of nuclease-induced homology-directed repair
|
|
ES3015369T3
(en)
|
2014-10-09 |
2025-05-05 |
Seattle Childrens Hospital Dba Seattle Childrens Res Inst |
Long poly (a) plasmids and methods for introduction of long poly (a) sequences into the plasmid
|
|
EP3204513A2
(en)
|
2014-10-09 |
2017-08-16 |
Life Technologies Corporation |
Crispr oligonucleotides and gene editing
|
|
CA2964234A1
(en)
|
2014-10-10 |
2016-04-14 |
Massachusetts Eye And Ear Infirmary |
Efficient delivery of therapeutic molecules in vitro and in vivo
|
|
EP3204496A1
(en)
|
2014-10-10 |
2017-08-16 |
Editas Medicine, Inc. |
Compositions and methods for promoting homology directed repair
|
|
WO2016061073A1
(en)
|
2014-10-14 |
2016-04-21 |
Memorial Sloan-Kettering Cancer Center |
Composition and method for in vivo engineering of chromosomal rearrangements
|
|
CA2963315A1
(en)
|
2014-10-15 |
2016-04-21 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for generating or maintaining pluripotent cells
|
|
CN104342457A
(zh)
|
2014-10-17 |
2015-02-11 |
杭州师范大学 |
一种将外源基因定点整合到靶标基因的方法
|
|
EP3207139B1
(en)
|
2014-10-17 |
2025-05-07 |
The Penn State Research Foundation |
Methods and compositions for multiplex rna guided genome editing and other rna technologies
|
|
EP3207131B1
(en)
|
2014-10-17 |
2022-09-28 |
Howard Hughes Medical Institute |
Genomic probes
|
|
US10793922B2
(en)
|
2014-10-20 |
2020-10-06 |
Envirologix Inc. |
Compositions and methods for detecting an RNA virus
|
|
US20170306306A1
(en)
|
2014-10-24 |
2017-10-26 |
Life Technologies Corporation |
Compositions and Methods for Enhancing Homologous Recombination
|
|
EP3212788A2
(en)
|
2014-10-27 |
2017-09-06 |
The Broad Institute, Inc. |
Compositions, methods and use of synthetic lethal screening
|
|
CN107075491B
(zh)
|
2014-10-28 |
2021-07-06 |
谷万达公司 |
用于稳定反式剪接的内含肽修饰的蛋白酶的方法和组合物
|
|
WO2016069910A1
(en)
|
2014-10-29 |
2016-05-06 |
Massachusetts Eye And Ear Infirmary |
Methods for efficient delivery of therapeutic molecules in vitro and in vivo
|
|
MA40880A
(fr)
|
2014-10-30 |
2017-09-05 |
Temple Univ Of The Commonwealth |
Éradication guidée par l'arn du virus jc humain et d'autres polyomavirus
|
|
EP4434997A3
(en)
|
2014-10-30 |
2025-01-01 |
President And Fellows Of Harvard College |
Delivery of negatively charged proteins using cationic lipids
|
|
US9816080B2
(en)
|
2014-10-31 |
2017-11-14 |
President And Fellows Of Harvard College |
Delivery of CAS9 via ARRDC1-mediated microvesicles (ARMMs)
|
|
JP6788584B2
(ja)
|
2014-10-31 |
2020-11-25 |
マサチューセッツ インスティテュート オブ テクノロジー |
Crisprについての超並列コンビナトリアル遺伝学
|
|
EP4427809A3
(en)
|
2014-10-31 |
2024-12-04 |
The Trustees of The University of Pennsylvania |
Altering gene expression in car-t cells and uses thereof
|
|
US10435697B2
(en)
|
2014-11-03 |
2019-10-08 |
Nanyang Technological University |
Recombinant expression system that senses pathogenic microorganisms
|
|
CN104504304B
(zh)
|
2014-11-03 |
2017-08-25 |
深圳先进技术研究院 |
一种成簇的规律间隔的短回文重复序列识别方法及装置
|
|
CN104404036B
(zh)
|
2014-11-03 |
2017-12-01 |
赛业(苏州)生物科技有限公司 |
基于CRISPR/Cas9技术的条件性基因敲除方法
|
|
EP3216867B1
(en)
|
2014-11-04 |
2020-04-15 |
National University Corporation Kobe University |
Method for modifying genome sequence to introduce specific mutation to targeted dna sequence by base-removal reaction, and molecular complex used therein
|
|
WO2016073559A1
(en)
|
2014-11-05 |
2016-05-12 |
The Regents Of The University Of California |
Methods for autocatalytic genome editing and neutralizing autocatalytic genome editing
|
|
KR102424721B1
(ko)
|
2014-11-06 |
2022-07-25 |
이 아이 듀폰 디 네모아 앤드 캄파니 |
Rna-유도 엔도뉴클레아제의 세포 내로의 펩티드 매개성 전달
|
|
AU2015342749B2
(en)
|
2014-11-07 |
2022-01-27 |
Editas Medicine, Inc. |
Methods for improving CRISPR/Cas-mediated genome-editing
|
|
ES2706531T3
(es)
|
2014-11-11 |
2019-03-29 |
Illumina Inc |
Amplificación de polinucleótidos empleando sistemas CRISPR-Cas
|
|
US20170369848A1
(en)
|
2014-11-11 |
2017-12-28 |
Q Therapeutics, Inc. |
Engineering mesenchymal stem cells using homologous recombination
|
|
JP6621820B2
(ja)
|
2014-11-14 |
2019-12-18 |
インスティチュート フォー ベーシック サイエンスInstitute For Basic Science |
ゲノムでプログラマブルヌクレアーゼの非標的位置を検出する方法
|
|
US10752674B2
(en)
|
2014-11-15 |
2020-08-25 |
Zumutor Biologics Inc. |
DNA-binding domain of CRISPR system, non-fucosylated and partially fucosylated proteins, and methods thereof
|
|
JP6190995B2
(ja)
|
2014-11-17 |
2017-09-06 |
国立大学法人 東京医科歯科大学 |
簡便で高効率の遺伝子改変非ヒト哺乳動物の作製方法
|
|
US10858662B2
(en)
|
2014-11-19 |
2020-12-08 |
Institute For Basic Science |
Genome editing with split Cas9 expressed from two vectors
|
|
WO2016081924A1
(en)
|
2014-11-20 |
2016-05-26 |
Duke University |
Compositions, systems and methods for cell therapy
|
|
US10227661B2
(en)
|
2014-11-21 |
2019-03-12 |
GeneWeave Biosciences, Inc. |
Sequence-specific detection and phenotype determination
|
|
CA3176380A1
(en)
|
2014-11-21 |
2016-05-26 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for targeted genetic modification using paired guide rnas
|
|
US20180334732A1
(en)
|
2014-11-25 |
2018-11-22 |
Drexel University |
Compositions and methods for hiv quasi-species excision from hiv-1-infected patients
|
|
WO2016084088A1
(en)
|
2014-11-26 |
2016-06-02 |
Ramot At Tel-Aviv University Ltd. |
Targeted elimination of bacterial genes
|
|
US10883111B2
(en)
|
2014-11-27 |
2021-01-05 |
Danziger Innovations Ltd. |
Nucleic acid constructs for genome editing
|
|
GB201421096D0
(en)
|
2014-11-27 |
2015-01-14 |
Imp Innovations Ltd |
Genome editing methods
|
|
US20180105834A1
(en)
|
2014-11-27 |
2018-04-19 |
Institute Of Animal Sciences, Chinese Academy Of Agrigultural Sciences |
A method of site-directed insertion to h11 locus in pigs by using site-directed cutting system
|
|
CN105695485B
(zh)
|
2014-11-27 |
2020-02-21 |
中国科学院上海生命科学研究院 |
一种用于丝状真菌Crispr-Cas系统的Cas9编码基因及其应用
|
|
WO2016089866A1
(en)
|
2014-12-01 |
2016-06-09 |
President And Fellows Of Harvard College |
Rna-guided systems for in vivo gene editing
|
|
WO2016089883A1
(en)
|
2014-12-01 |
2016-06-09 |
Novartis Ag |
Compositions and methods for diagnosis and treatment of prostate cancer
|
|
CN107250148B
(zh)
|
2014-12-03 |
2021-04-16 |
安捷伦科技有限公司 |
具有化学修饰的指导rna
|
|
CN104450774A
(zh)
|
2014-12-04 |
2015-03-25 |
中国农业科学院作物科学研究所 |
一种大豆CRISPR/Cas9体系的构建及其在大豆基因修饰中的应用
|
|
CN107208079B
(zh)
|
2014-12-05 |
2021-06-29 |
应用干细胞有限公司 |
整合转基因的位点定向crispr/重组酶组合物和方法
|
|
CN104531705A
(zh)
|
2014-12-09 |
2015-04-22 |
中国农业大学 |
利用CRISPR-Cas9系统敲除动物myostatin基因的方法
|
|
CN104531704B
(zh)
|
2014-12-09 |
2019-05-21 |
中国农业大学 |
利用CRISPR-Cas9系统敲除动物FGF5基因的方法
|
|
AU2015360502A1
(en)
|
2014-12-10 |
2017-06-29 |
Regents Of The University Of Minnesota |
Genetically modified cells, tissues, and organs for treating disease
|
|
CN107532162A
(zh)
|
2014-12-12 |
2018-01-02 |
托德·M·伍尔夫 |
用于利用寡核苷酸编辑细胞中核酸的组合物和方法
|
|
WO2016094874A1
(en)
|
2014-12-12 |
2016-06-16 |
The Broad Institute Inc. |
Escorted and functionalized guides for crispr-cas systems
|
|
JP6814155B2
(ja)
|
2014-12-12 |
2021-01-13 |
ジュー,ジェイムズ |
対象とする細胞を選択的に除去する方法及び組成物
|
|
WO2016094872A1
(en)
|
2014-12-12 |
2016-06-16 |
The Broad Institute Inc. |
Dead guides for crispr transcription factors
|
|
WO2016094880A1
(en)
|
2014-12-12 |
2016-06-16 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of crispr systems and compositions for genome editing as to hematopoietic stem cells (hscs)
|
|
EP3889260A1
(en)
|
2014-12-12 |
2021-10-06 |
The Broad Institute, Inc. |
Protected guide rnas (pgrnas)
|
|
CN104480144B
(zh)
|
2014-12-12 |
2017-04-12 |
武汉大学 |
用于艾滋病基因治疗的CRISPR/Cas9重组慢病毒载体及其慢病毒
|
|
JP6842417B2
(ja)
|
2014-12-16 |
2021-03-17 |
シー3ジェイ セラピューティクス インコーポレイテッド |
インビトロウイルスゲノム工学のための組成物及びその方法
|
|
US11427829B2
(en)
|
2014-12-16 |
2022-08-30 |
Danisco Us Inc |
Fungal genome modification systems and methods of use
|
|
CA2969384A1
(en)
|
2014-12-17 |
2016-06-23 |
Cellectis |
Inhibitory chimeric antigen receptor (icar or n-car) expressing non-t cell transduction domain
|
|
DK3234134T3
(da)
|
2014-12-17 |
2020-07-27 |
Proqr Therapeutics Ii Bv |
Målrettet rna-redigering
|
|
ES2865268T3
(es)
|
2014-12-17 |
2021-10-15 |
Dupont Us Holding Llc |
Composiciones y métodos para la edición eficaz de genes en E. coli utilizando sistemas de ARN guía/endonucleasa CAS en combinación con moldes de modificación de polinucleótido circulares
|
|
EP3234133B1
(en)
|
2014-12-18 |
2020-11-11 |
Integrated DNA Technologies, Inc. |
Crispr-based compositions and methods of use
|
|
WO2016097751A1
(en)
|
2014-12-18 |
2016-06-23 |
The University Of Bath |
Method of cas9 mediated genome engineering
|
|
CN104745626B
(zh)
|
2014-12-19 |
2018-05-01 |
中国航天员科研训练中心 |
一种条件性基因敲除动物模型的快速构建方法及应用
|
|
EP3234192B1
(en)
|
2014-12-19 |
2021-07-14 |
The Broad Institute, Inc. |
Unbiased identification of double-strand breaks and genomic rearrangement by genome-wide insert capture sequencing
|
|
CA2971444A1
(en)
|
2014-12-20 |
2016-06-23 |
Arc Bio, Llc |
Compositions and methods for targeted depletion, enrichment, and partitioning of nucleic acids using crispr/cas system proteins
|
|
CN104560864B
(zh)
|
2014-12-22 |
2017-08-11 |
中国科学院微生物研究所 |
利用CRISPR‑Cas9系统构建的敲除IFN‑β基因的293T细胞系
|
|
US10190106B2
(en)
|
2014-12-22 |
2019-01-29 |
Univesity Of Massachusetts |
Cas9-DNA targeting unit chimeras
|
|
WO2016106236A1
(en)
|
2014-12-23 |
2016-06-30 |
The Broad Institute Inc. |
Rna-targeting system
|
|
US11053271B2
(en)
|
2014-12-23 |
2021-07-06 |
The Regents Of The University Of California |
Methods and compositions for nucleic acid integration
|
|
AU2015101792A4
(en)
|
2014-12-24 |
2016-01-28 |
Massachusetts Institute Of Technology |
Engineering of systems, methods and optimized enzyme and guide scaffolds for sequence manipulation
|
|
EP3237615B2
(en)
|
2014-12-24 |
2023-07-26 |
The Broad Institute, Inc. |
Crispr having or associated with destabilization domains
|
|
WO2016103233A2
(en)
|
2014-12-24 |
2016-06-30 |
Dana-Farber Cancer Institute, Inc. |
Systems and methods for genome modification and regulation
|
|
CN104651398A
(zh)
|
2014-12-24 |
2015-05-27 |
杭州师范大学 |
利用CRISPR-Cas9特异敲出microRNA基因家族的方法
|
|
EP3239298A4
(en)
|
2014-12-26 |
2018-06-13 |
Riken |
Gene knockout method
|
|
WO2016108926A1
(en)
|
2014-12-30 |
2016-07-07 |
The Broad Institute Inc. |
Crispr mediated in vivo modeling and genetic screening of tumor growth and metastasis
|
|
WO2016109255A1
(en)
|
2014-12-30 |
2016-07-07 |
University Of South Florida |
Methods and compositions for cloning into large vectors
|
|
CN104498493B
(zh)
|
2014-12-30 |
2017-12-26 |
武汉大学 |
CRISPR/Cas9特异性敲除乙型肝炎病毒的方法以及用于特异性靶向HBV DNA的gRNA
|
|
CN104651399B
(zh)
|
2014-12-31 |
2018-11-16 |
广西大学 |
一种利用CRISPR/Cas系统在猪胚胎细胞中实现基因敲除的方法
|
|
CA2972454C
(en)
|
2014-12-31 |
2024-09-10 |
Synthetic Genomics Inc |
Compositions and methods for high efficiency in vivo genome editing
|
|
CN104651392B
(zh)
|
2015-01-06 |
2018-07-31 |
华南农业大学 |
一种利用CRISPR/Cas9系统定点突变P/TMS12-1获得温敏不育系的方法
|
|
WO2016110512A1
(en)
|
2015-01-06 |
2016-07-14 |
Dsm Ip Assets B.V. |
A crispr-cas system for a yeast host cell
|
|
EP3243529B1
(en)
|
2015-01-06 |
2020-09-23 |
Industry-Academic Cooperation Foundation Yonsei University |
Endonuclease targeting blood coagulation factor viii gene and composition for treating hemophilia comprising same
|
|
WO2016110511A1
(en)
|
2015-01-06 |
2016-07-14 |
Dsm Ip Assets B.V. |
A crispr-cas system for a lipolytic yeast host cell
|
|
US11396665B2
(en)
|
2015-01-06 |
2022-07-26 |
Dsm Ip Assets B.V. |
CRISPR-CAS system for a filamentous fungal host cell
|
|
US20180155708A1
(en)
|
2015-01-08 |
2018-06-07 |
President And Fellows Of Harvard College |
Split Cas9 Proteins
|
|
CN104593422A
(zh)
|
2015-01-08 |
2015-05-06 |
中国农业大学 |
一种抗蓝耳病克隆猪的制备方法
|
|
WO2016112351A1
(en)
|
2015-01-09 |
2016-07-14 |
Bio-Rad Laboratories, Inc. |
Detection of genome editing
|
|
WO2016114972A1
(en)
|
2015-01-12 |
2016-07-21 |
The Regents Of The University Of California |
Heterodimeric cas9 and methods of use thereof
|
|
EP3245294A4
(en)
|
2015-01-12 |
2018-05-30 |
Massachusetts Institute of Technology |
Gene editing through microfluidic delivery
|
|
WO2016112963A1
(en)
|
2015-01-13 |
2016-07-21 |
Riboxx Gmbh |
Delivery of biomolecules into cells
|
|
MA41349A
(fr)
|
2015-01-14 |
2017-11-21 |
Univ Temple |
Éradication de l'herpès simplex de type i et d'autres virus de l'herpès associés guidée par arn
|
|
PT3244909T
(pt)
|
2015-01-14 |
2020-01-15 |
Inst Nat Sante Rech Med |
Inibidores de proteassoma no tratamento de um distúrbio relacionado com a acumulação de uma proteína anormal não degradada ou um cancro
|
|
CN107429263A
(zh)
|
2015-01-15 |
2017-12-01 |
斯坦福大学托管董事会 |
调控基因组编辑的方法
|
|
CN104611370A
(zh)
|
2015-01-16 |
2015-05-13 |
深圳市科晖瑞生物医药有限公司 |
一种剔除β2-微球蛋白基因片段的方法
|
|
WO2016116032A1
(en)
|
2015-01-19 |
2016-07-28 |
Institute Of Genetics And Developmental Biology,Chinese Academy Of Sciences |
A method for precise modification of plant via transient gene expression
|
|
CN104725626B
(zh)
|
2015-01-22 |
2016-06-29 |
漳州亚邦化学有限公司 |
一种适用于人造石英石的不饱和树脂的制备方法
|
|
CN105821072A
(zh)
|
2015-01-23 |
2016-08-03 |
深圳华大基因研究院 |
用于DNA组装的CRISPR-Cas9系统及DNA组装方法
|
|
WO2016123071A1
(en)
|
2015-01-26 |
2016-08-04 |
Cold Spring Harbor Laboratory |
Methods of identifying essential protein domains
|
|
US10059940B2
(en)
|
2015-01-27 |
2018-08-28 |
Minghong Zhong |
Chemically ligated RNAs for CRISPR/Cas9-lgRNA complexes as antiviral therapeutic agents
|
|
CN104561095B
(zh)
|
2015-01-27 |
2017-08-22 |
深圳市国创纳米抗体技术有限公司 |
一种能够生产人神经生长因子的转基因小鼠的制备方法
|
|
RU2713328C2
(ru)
|
2015-01-28 |
2020-02-04 |
Пайонир Хай-Бред Интернэшнл, Инк. |
Гибридные днк/рнк-полинуклеотиды crispr и способы применения
|
|
WO2016123243A1
(en)
|
2015-01-28 |
2016-08-04 |
The Regents Of The University Of California |
Methods and compositions for labeling a single-stranded target nucleic acid
|
|
WO2016120480A1
(fr)
|
2015-01-29 |
2016-08-04 |
Meiogenix |
Procede pour induire des recombinaisons meiotiques ciblees
|
|
ES2880473T5
(es)
|
2015-01-30 |
2024-05-09 |
Univ California |
Suministro de proteínas en células hematopoyéticas primarias
|
|
RS61924B1
(sr)
|
2015-02-02 |
2021-06-30 |
Meiragtx Uk Ii Ltd |
Regulacija genske ekspresije putem aptamerom posredovane modulacije alternativnog splajsovanja
|
|
CN104593418A
(zh)
|
2015-02-06 |
2015-05-06 |
中国医学科学院医学实验动物研究所 |
一种人源化大鼠药物评价动物模型建立的方法
|
|
EP3256487A4
(en)
|
2015-02-09 |
2018-07-18 |
Duke University |
Compositions and methods for epigenome editing
|
|
KR101584933B1
(ko)
|
2015-02-10 |
2016-01-13 |
성균관대학교산학협력단 |
항생제 내성 억제용 재조합 벡터 및 이의 용도
|
|
WO2016130697A1
(en)
|
2015-02-11 |
2016-08-18 |
Memorial Sloan Kettering Cancer Center |
Methods and kits for generating vectors that co-express multiple target molecules
|
|
CN104928321B
(zh)
|
2015-02-12 |
2018-06-01 |
中国科学院西北高原生物研究所 |
一种由Crispr/Cas9诱导的鳞片缺失斑马鱼模式及建立方法
|
|
CN104726494B
(zh)
|
2015-02-12 |
2018-10-23 |
中国人民解放军第二军医大学 |
CRISPR-Cas9技术构建染色体易位干细胞及动物模型的方法
|
|
EP3256170B1
(en)
|
2015-02-13 |
2020-09-23 |
University of Massachusetts |
Compositions and methods for transient delivery of nucleases
|
|
US20160244784A1
(en)
|
2015-02-15 |
2016-08-25 |
Massachusetts Institute Of Technology |
Population-Hastened Assembly Genetic Engineering
|
|
WO2016132122A1
(en)
|
2015-02-17 |
2016-08-25 |
University Of Edinburgh |
Assay construct
|
|
CN107406846A
(zh)
|
2015-02-19 |
2017-11-28 |
国立大学法人德岛大学 |
通过电穿孔将Cas9 mRNA导入到哺乳动物的受精卵的方法
|
|
US12129471B2
(en)
|
2015-02-23 |
2024-10-29 |
Vertex Pharmaceuticals Incorporated |
Materials and methods for treatment of human genetic diseases including hemoglobinopathies
|
|
AU2016225178B2
(en)
|
2015-02-23 |
2022-05-05 |
Crispr Therapeutics Ag |
Materials and methods for treatment of hemoglobinopathies
|
|
US20180245073A1
(en)
|
2015-02-23 |
2018-08-30 |
Voyager Therapeutics, Inc. |
Regulatable expression using adeno-associated virus (aav)
|
|
US20160244829A1
(en)
|
2015-02-25 |
2016-08-25 |
University-Industry Foundation, Yonsei University |
Method for target dna enrichment using crispr system
|
|
CN107406858A
(zh)
|
2015-02-25 |
2017-11-28 |
先锋国际良种公司 |
用于指导rna/cas内切核酸酶复合物的调节型表达的组合物和方法
|
|
WO2016135507A1
(en)
|
2015-02-27 |
2016-09-01 |
University Of Edinburgh |
Nucleic acid editing systems
|
|
CN104805099B
(zh)
|
2015-03-02 |
2018-04-13 |
中国人民解放军第二军医大学 |
一种安全编码Cas9蛋白的核酸分子及其表达载体
|
|
KR102598856B1
(ko)
|
2015-03-03 |
2023-11-07 |
더 제너럴 하스피탈 코포레이션 |
변경된 PAM 특이성을 갖는 조작된 CRISPR-Cas9 뉴클레아제
|
|
CN104651401B
(zh)
|
2015-03-05 |
2019-03-08 |
东华大学 |
一种mir-505双等位基因敲除的方法
|
|
CN104673816A
(zh)
|
2015-03-05 |
2015-06-03 |
广东医学院 |
一种pCr-NHEJ载体及其构建方法及其用于细菌基因定点敲除的应用
|
|
US20160264934A1
(en)
|
2015-03-11 |
2016-09-15 |
The General Hospital Corporation |
METHODS FOR MODULATING AND ASSAYING m6A IN STEM CELL POPULATIONS
|
|
US20180271891A1
(en)
|
2015-03-11 |
2018-09-27 |
The Broad Institute Inc. |
Selective treatment of prmt5 dependent cancer
|
|
WO2016141893A1
(zh)
|
2015-03-12 |
2016-09-15 |
中国科学院遗传与发育生物学研究所 |
一种提高植物对入侵的dna病毒的抵御能力的方法
|
|
GB201504223D0
(en)
|
2015-03-12 |
2015-04-29 |
Genome Res Ltd |
Biallelic genetic modification
|
|
CA2979567C
(en)
|
2015-03-13 |
2020-10-13 |
The Jackson Laboratory |
A three-component crispr/cas complex system and uses thereof
|
|
AU2016239037B2
(en)
|
2015-03-16 |
2022-04-21 |
Institute Of Genetics And Developmental Biology, Chinese Academy Of Sciences |
Method of applying non-genetic substance to perform site-directed reform of plant genome
|
|
CN106032540B
(zh)
|
2015-03-16 |
2019-10-25 |
中国科学院上海生命科学研究院 |
CRISPR/Cas9核酸内切酶体系的腺相关病毒载体构建及其用途
|
|
CN113846144B
(zh)
|
2015-03-17 |
2023-09-26 |
生物辐射实验室股份有限公司 |
检测基因组编辑
|
|
WO2016149484A2
(en)
|
2015-03-17 |
2016-09-22 |
Temple University Of The Commonwealth System Of Higher Education |
Compositions and methods for specific reactivation of hiv latent reservoir
|
|
MA41382A
(fr)
|
2015-03-20 |
2017-11-28 |
Univ Temple |
Édition génique basée sur le système crispr/endonucléase à induction par tat
|
|
WO2016150855A1
(en)
|
2015-03-20 |
2016-09-29 |
Danmarks Tekniske Universitet |
Crispr/cas9 based engineering of actinomycetal genomes
|
|
CN104726449A
(zh)
|
2015-03-23 |
2015-06-24 |
国家纳米科学中心 |
一种用于预防和/或治疗HIV的CRISPR-Cas9系统及其制备方法和用途
|
|
CN106148416B
(zh)
|
2015-03-24 |
2019-12-17 |
华东师范大学 |
Cyp基因敲除大鼠的培育方法及其肝微粒体的制备方法
|
|
WO2016154596A1
(en)
|
2015-03-25 |
2016-09-29 |
Editas Medicine, Inc. |
Crispr/cas-related methods, compositions and components
|
|
EP3274453B1
(en)
|
2015-03-26 |
2021-01-27 |
Editas Medicine, Inc. |
Crispr/cas-mediated gene conversion
|
|
CA2981509A1
(en)
|
2015-03-30 |
2016-10-06 |
The Board Of Regents Of The Nevada System Of Higher Educ. On Behalf Of The University Of Nevada, La |
Compositions comprising talens and methods of treating hiv
|
|
EP4600366A3
(en)
|
2015-03-31 |
2025-10-22 |
SOHM, Inc. |
Cas 9 retroviral integrase systems for targeted incorporation of a dna sequence into a genome of a cell
|
|
EP3748004A1
(en)
|
2015-04-01 |
2020-12-09 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating duchenne muscular dystrophy and becker muscular dystrophy
|
|
CA3000187A1
(en)
|
2015-04-02 |
2016-10-06 |
Agenovir Corporation |
Gene delivery methods and compositions
|
|
EP4335918A3
(en)
|
2015-04-03 |
2024-04-17 |
Dana-Farber Cancer Institute, Inc. |
Composition and methods of genome editing of b-cells
|
|
CN106434737A
(zh)
|
2015-04-03 |
2017-02-22 |
内蒙古中科正标生物科技有限责任公司 |
基于CRISPR/Cas9技术的单子叶植物基因敲除载体及其应用
|
|
US20170166928A1
(en)
|
2015-04-03 |
2017-06-15 |
Whitehead Institute For Biomedical Research |
Compositions And Methods For Genetically Modifying Yeast
|
|
ES2884838T3
(es)
|
2015-04-06 |
2021-12-13 |
Univ Leland Stanford Junior |
ARN guía químicamente modificados para la regulación génica mediada por CRISPR/CAS
|
|
WO2016164797A1
(en)
|
2015-04-08 |
2016-10-13 |
University Of Pittsburgh - Of The Commonwealth System Of Higher Education |
Activatable crispr/cas9 for spatial and temporal control of genome editing
|
|
EP3284749B1
(en)
|
2015-04-13 |
2024-08-14 |
The University of Tokyo |
Set of polypeptides exhibiting nuclease activity or nickase activity with dependence on light or in presence of drug or suppressing or activating expression of target gene
|
|
US10155938B2
(en)
|
2015-04-14 |
2018-12-18 |
City Of Hope |
Coexpression of CAS9 and TREX2 for targeted mutagenesis
|
|
GB201506509D0
(en)
|
2015-04-16 |
2015-06-03 |
Univ Wageningen |
Nuclease-mediated genome editing
|
|
US11299729B2
(en)
|
2015-04-17 |
2022-04-12 |
President And Fellows Of Harvard College |
Vector-based mutagenesis system
|
|
EP3286322A1
(en)
|
2015-04-21 |
2018-02-28 |
Novartis AG |
Rna-guided gene editing system and uses thereof
|
|
CN104762321A
(zh)
|
2015-04-22 |
2015-07-08 |
东北林业大学 |
基于CRISPR/Cas9系统靶向敲除KHV基因的敲除载体构建方法及其crRNA原件
|
|
CN104805118A
(zh)
|
2015-04-22 |
2015-07-29 |
扬州大学 |
一种苏禽黄鸡胚胎干细胞特定基因进行靶向敲除方法
|
|
JP2018522249A
(ja)
|
2015-04-24 |
2018-08-09 |
エディタス・メディシン、インコーポレイテッド |
Cas9分子/ガイドrna分子複合体の評価
|
|
US20180298340A1
(en)
|
2015-04-24 |
2018-10-18 |
The Regents Of The University Of California |
Systems for detecting, monitoring or treating diseases or conditions using engineered cells and methods for making and using them
|
|
US11268158B2
(en)
|
2015-04-24 |
2022-03-08 |
St. Jude Children's Research Hospital, Inc. |
Assay for safety assessment of therapeutic genetic manipulations, gene therapy vectors and compounds
|
|
EP3289081B1
(en)
|
2015-04-27 |
2019-03-27 |
Genethon |
Compositions and methods for the treatment of nucleotide repeat expansion disorders
|
|
WO2016176191A1
(en)
|
2015-04-27 |
2016-11-03 |
The Trustees Of The University Of Pennsylvania |
Dual aav vector system for crispr/cas9 mediated correction of human disease
|
|
EP3087974A1
(en)
|
2015-04-29 |
2016-11-02 |
Rodos BioTarget GmbH |
Targeted nanocarriers for targeted drug delivery of gene therapeutics
|
|
WO2016176404A1
(en)
|
2015-04-30 |
2016-11-03 |
The Brigham And Women's Hospital, Inc. |
Methods and kits for cloning-free genome editing
|
|
EP4008780A1
(en)
|
2015-04-30 |
2022-06-08 |
The Trustees of Columbia University in the City of New York |
Gene therapy for autosomal dominant diseases
|
|
WO2016179038A1
(en)
|
2015-05-01 |
2016-11-10 |
Spark Therapeutics, Inc. |
ADENO-ASSOCIATED VIRUS-MEDIATED CRISPR-Cas9 TREATMENT OF OCULAR DISEASE
|
|
WO2016179112A1
(en)
|
2015-05-01 |
2016-11-10 |
Precision Biosciences, Inc. |
Precise deletion of chromoscomal sequences in vivo and treatment of nucleotide repeat expansion disorders using engineered nucleases
|
|
CN104894068A
(zh)
|
2015-05-04 |
2015-09-09 |
南京凯地生物科技有限公司 |
一种利用CRISPR/Cas9制备CAR-T细胞的方法
|
|
US11845928B2
(en)
|
2015-05-04 |
2023-12-19 |
Tsinghua University |
Methods and kits for fragmenting DNA
|
|
DE112016002056T5
(de)
|
2015-05-06 |
2018-02-08 |
Snipr Technologies Limited |
Verändern mikrobieller Populationen und Modifizieren von Mikrobiomen
|
|
GB2531454A
(en)
|
2016-01-10 |
2016-04-20 |
Snipr Technologies Ltd |
Recombinogenic nucleic acid strands in situ
|
|
WO2016182893A1
(en)
|
2015-05-08 |
2016-11-17 |
Teh Broad Institute Inc. |
Functional genomics using crispr-cas systems for saturating mutagenesis of non-coding elements, compositions, methods, libraries and applications thereof
|
|
JP7288302B2
(ja)
|
2015-05-08 |
2023-06-07 |
ザ チルドレンズ メディカル センター コーポレーション |
胎児型ヘモグロビン再誘導のための、bcl11aエンハンサー機能性領域を標的とする方法
|
|
EP3294888A1
(en)
|
2015-05-11 |
2018-03-21 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating hiv infection and aids
|
|
EP3294896A1
(en)
|
2015-05-11 |
2018-03-21 |
Editas Medicine, Inc. |
Optimized crispr/cas9 systems and methods for gene editing in stem cells
|
|
KR101785847B1
(ko)
|
2015-05-12 |
2017-10-17 |
연세대학교 산학협력단 |
선형 이중가닥 DNA를 활용한 CRISPR/Cas9 시스템을 이용한 표적 유전체 교정
|
|
KR20170141217A
(ko)
|
2015-05-12 |
2017-12-22 |
상가모 테라퓨틱스, 인코포레이티드 |
유전자 발현의 뉴클레아제-매개된 조절
|
|
US10563226B2
(en)
|
2015-05-13 |
2020-02-18 |
Seattle Children's Hospital |
Enhancing endonuclease based gene editing in primary cells
|
|
JP6587696B2
(ja)
|
2015-05-13 |
2019-10-09 |
ズムトール バイオロジクス、インコーポレイテッド |
アフコシル化タンパク質、前記タンパク質を発現する細胞、及び関連する方法
|
|
US10920221B2
(en)
|
2015-05-13 |
2021-02-16 |
President And Fellows Of Harvard College |
Methods of making and using guide RNA for use with Cas9 systems
|
|
CN105886498A
(zh)
|
2015-05-13 |
2016-08-24 |
沈志荣 |
CRISPR-Cas9特异性敲除人PCSK9基因的方法以及用于特异性靶向PCSK9基因的sgRNA
|
|
US20180291372A1
(en)
|
2015-05-14 |
2018-10-11 |
Massachusetts Institute Of Technology |
Self-targeting genome editing system
|
|
WO2016183448A1
(en)
|
2015-05-14 |
2016-11-17 |
University Of Southern California |
Optimized gene editing utilizing a recombinant endonuclease system
|
|
CN107709555A
(zh)
|
2015-05-15 |
2018-02-16 |
达尔马科恩有限公司 |
用于Cas9介导的基因编辑的合成的单向导RNA
|
|
EP3294877A1
(en)
|
2015-05-15 |
2018-03-21 |
Pioneer Hi-Bred International, Inc. |
Rapid characterization of cas endonuclease systems, pam sequences and guide rna elements
|
|
CN107849547B
(zh)
|
2015-05-16 |
2022-04-19 |
建新公司 |
深内含子突变的基因编辑
|
|
CN104846010B
(zh)
|
2015-05-18 |
2018-07-06 |
安徽省农业科学院水稻研究所 |
一种删除转基因水稻筛选标记基因的方法
|
|
US10662437B2
(en)
|
2015-05-18 |
2020-05-26 |
King Abdullah University Of Science And Technology |
Method of inhibiting plant virus pathogen infections by CRISPR/Cas9-mediated interference
|
|
EP3095870A1
(en)
|
2015-05-19 |
2016-11-23 |
Kws Saat Se |
Methods for the in planta transformation of plants and manufacturing processes and products based and obtainable therefrom
|
|
CN106011104B
(zh)
|
2015-05-21 |
2019-09-27 |
清华大学 |
利用拆分Cas系统进行基因编辑和表达调控方法
|
|
WO2016187904A1
(zh)
|
2015-05-22 |
2016-12-01 |
深圳市第二人民医院 |
CRISPR-Cas9特异性敲除猪CMAH基因的方法及用于特异性靶向CMAH基因的sgRNA
|
|
CN105518135B
(zh)
|
2015-05-22 |
2020-11-24 |
深圳市第二人民医院 |
CRISPR-Cas9特异性敲除猪CMAH基因的方法及用于特异性靶向CMAH基因的sgRNA
|
|
WO2016187717A1
(en)
|
2015-05-26 |
2016-12-01 |
Exerkine Corporation |
Exosomes useful for genome editing
|
|
CN105624146B
(zh)
|
2015-05-28 |
2019-02-15 |
中国科学院微生物研究所 |
基于CRISPR/Cas9和酿酒酵母细胞内源的同源重组的分子克隆方法
|
|
HK1253403A1
(zh)
|
2015-05-28 |
2019-06-14 |
Coda Biotherapeutics |
基因組編輯載體
|
|
CN104894075B
(zh)
|
2015-05-28 |
2019-08-06 |
华中农业大学 |
CRISPR/Cas9和Cre/lox系统编辑伪狂犬病毒基因组制备疫苗方法和应用
|
|
CA3000189A1
(en)
|
2015-05-29 |
2016-12-08 |
Agenovir Corporation |
Compositions and methods to treat viral infections
|
|
US20160346362A1
(en)
|
2015-05-29 |
2016-12-01 |
Agenovir Corporation |
Methods and compositions for treating cytomegalovirus infections
|
|
WO2016196499A1
(en)
|
2015-05-29 |
2016-12-08 |
Clark Atlanta University |
Human cell lines mutant for zic2
|
|
EP3303607A4
(en)
|
2015-05-29 |
2018-10-10 |
North Carolina State University |
Methods for screening bacteria, archaea, algae, and yeast using crispr nucleic acids
|
|
US20160348074A1
(en)
|
2015-05-29 |
2016-12-01 |
Agenovir Corporation |
Methods and compositions for treating cells for transplant
|
|
US10117911B2
(en)
|
2015-05-29 |
2018-11-06 |
Agenovir Corporation |
Compositions and methods to treat herpes simplex virus infections
|
|
WO2016196283A1
(en)
|
2015-05-29 |
2016-12-08 |
Agenovir Corporation |
Antiviral methods and compositions
|
|
CA3000155A1
(en)
|
2015-05-29 |
2016-12-08 |
Agenovir Corporation |
Compositions and methods for cell targeted hpv treatment
|
|
KR102553518B1
(ko)
|
2015-06-01 |
2023-07-07 |
템플 유니버시티-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 |
Hiv 감염의 rna-가이드된 치료를 위한 방법 및 조성물
|
|
WO2016191869A1
(en)
|
2015-06-01 |
2016-12-08 |
The Hospital For Sick Children |
Delivery of structurally diverse polypeptide cargo into mammalian cells by a bacterial toxin
|
|
CN105112445B
(zh)
|
2015-06-02 |
2018-08-10 |
广州辉园苑医药科技有限公司 |
一种基于CRISPR-Cas9基因敲除技术的miR-205基因敲除试剂盒
|
|
EP3303585A4
(en)
|
2015-06-03 |
2018-10-31 |
Board of Regents of the University of Nebraska |
Dna editing using single-stranded dna
|
|
EP3303634B1
(en)
|
2015-06-03 |
2023-08-30 |
The Regents of The University of California |
Cas9 variants and methods of use thereof
|
|
WO2016197133A1
(en)
|
2015-06-04 |
2016-12-08 |
Protiva Biotherapeutics, Inc. |
Delivering crispr therapeutics with lipid nanoparticles
|
|
WO2016197132A1
(en)
|
2015-06-04 |
2016-12-08 |
Protiva Biotherapeutics Inc. |
Treating hepatitis b virus infection using crispr
|
|
CN105039339B
(zh)
|
2015-06-05 |
2017-12-19 |
新疆畜牧科学院生物技术研究所 |
一种以RNA介导的特异性敲除绵羊FecB基因的方法及其专用sgRNA
|
|
EP3334823B1
(en)
|
2015-06-05 |
2024-05-22 |
The Regents of The University of California |
Method and kit for generating crispr/cas guide rnas
|
|
WO2016201047A1
(en)
|
2015-06-09 |
2016-12-15 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for improving transplantation
|
|
US10913787B2
(en)
|
2015-06-10 |
2021-02-09 |
Firmenich Sa |
Method of identifying musk compounds
|
|
EP3726218B1
(en)
|
2015-06-10 |
2023-08-09 |
Firmenich Sa |
Cell lines for screening odorant and aroma receptors
|
|
US20160362667A1
(en)
|
2015-06-10 |
2016-12-15 |
Caribou Biosciences, Inc. |
CRISPR-Cas Compositions and Methods
|
|
WO2016198500A1
(en)
|
2015-06-10 |
2016-12-15 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and compositions for rna-guided treatment of human cytomegalovirus (hcmv) infection
|
|
CN105492608B
(zh)
|
2015-06-11 |
2021-07-23 |
深圳市第二人民医院 |
CRISPR-Cas9特异性敲除猪PDX1基因的方法及用于特异性靶向PDX1基因的sgRNA
|
|
WO2016197360A1
(zh)
|
2015-06-11 |
2016-12-15 |
深圳市第二人民医院 |
CRISPR-Cas9特异性敲除猪GFRA1基因的方法及用于特异性靶向GFRA1基因的sgRNA
|
|
WO2016197355A1
(zh)
|
2015-06-11 |
2016-12-15 |
深圳市第二人民医院 |
CRISPR-Cas9特异性敲除猪SALL1基因的方法及用于特异性靶向SALL1基因的sgRNA
|
|
CN105593367A
(zh)
|
2015-06-11 |
2016-05-18 |
深圳市第二人民医院 |
CRISPR-Cas9特异性敲除猪SLA-1基因的方法及用于特异性靶向SLA-1基因的sgRNA
|
|
WO2016197356A1
(zh)
|
2015-06-11 |
2016-12-15 |
深圳市第二人民医院 |
CRISPR-Cas9特异性敲除猪SLA-2基因的方法及用于特异性靶向SLA-2基因的sgRNA
|
|
CN106414740A
(zh)
|
2015-06-11 |
2017-02-15 |
深圳市第二人民医院 |
CRISPR‑Cas9特异性敲除猪SLA‑3基因的方法及用于特异性靶向SLA‑3基因的sgRNA
|
|
WO2016197358A1
(zh)
|
2015-06-11 |
2016-12-15 |
深圳市第二人民医院 |
CRISPR-Cas9特异性敲除猪FGL2基因的方法及用于特异性靶向FGL2基因的sgRNA
|
|
WO2016197361A1
(zh)
|
2015-06-11 |
2016-12-15 |
深圳市第二人民医院 |
CRISPR-Cas9特异性敲除猪GGTA1基因的方法及用于特异性靶向GGTA1基因的sgRNA
|
|
WO2016197362A1
(zh)
|
2015-06-11 |
2016-12-15 |
深圳市第二人民医院 |
CRISPR-Cas9特异性敲除猪vWF基因的方法及用于特异性靶向vWF基因的sgRNA
|
|
GB201510296D0
(en)
|
2015-06-12 |
2015-07-29 |
Univ Wageningen |
Thermostable CAS9 nucleases
|
|
US20180187190A1
(en)
|
2015-06-12 |
2018-07-05 |
Erasmus University Medical Center Rotterdam |
New crispr assays
|
|
US20180142222A1
(en)
|
2015-06-12 |
2018-05-24 |
The Regents Of The University Of California |
Reporter cas9 variants and methods of use thereof
|
|
CN107922918B
(zh)
|
2015-06-15 |
2022-10-21 |
北卡罗来纳州立大学 |
用于有效递送核酸和基于rna的抗微生物剂的方法和组合物
|
|
WO2016205728A1
(en)
|
2015-06-17 |
2016-12-22 |
Massachusetts Institute Of Technology |
Crispr mediated recording of cellular events
|
|
WO2016205623A1
(en)
|
2015-06-17 |
2016-12-22 |
North Carolina State University |
Methods and compositions for genome editing in bacteria using crispr-cas9 systems
|
|
WO2016205680A1
(en)
|
2015-06-17 |
2016-12-22 |
The Uab Research Foundation |
Crispr/cas9 complex for introducing a functional polypeptide into cells of blood cell lineage
|
|
WO2016205703A1
(en)
|
2015-06-17 |
2016-12-22 |
The Uab Research Foundation |
Crispr/cas9 complex for genomic editing
|
|
WO2016205745A2
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Cell sorting
|
|
AU2016279062A1
(en)
|
2015-06-18 |
2019-03-28 |
Omar O. Abudayyeh |
Novel CRISPR enzymes and systems
|
|
US9790490B2
(en)
|
2015-06-18 |
2017-10-17 |
The Broad Institute Inc. |
CRISPR enzymes and systems
|
|
US9957501B2
(en)
|
2015-06-18 |
2018-05-01 |
Sangamo Therapeutics, Inc. |
Nuclease-mediated regulation of gene expression
|
|
WO2016205759A1
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Engineering and optimization of systems, methods, enzymes and guide scaffolds of cas9 orthologs and variants for sequence manipulation
|
|
US10954513B2
(en)
|
2015-06-18 |
2021-03-23 |
University Of Utah Research Foundation |
RNA-guided transcriptional regulation and methods of using the same for the treatment of back pain
|
|
CA3012631A1
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Novel crispr enzymes and systems
|
|
CN109536474A
(zh)
|
2015-06-18 |
2019-03-29 |
布罗德研究所有限公司 |
降低脱靶效应的crispr酶突变
|
|
US11279928B2
(en)
|
2015-06-29 |
2022-03-22 |
Massachusetts Institute Of Technology |
Compositions comprising nucleic acids and methods of using the same
|
|
GB201511376D0
(en)
|
2015-06-29 |
2015-08-12 |
Ecolab Usa Inc |
Process for the treatment of produced water from chemical enhanced oil recovery
|
|
CA2990699A1
(en)
|
2015-06-29 |
2017-01-05 |
Ionis Pharmaceuticals, Inc. |
Modified crispr rna and modified single crispr rna and uses thereof
|
|
US20180171298A1
(en)
|
2015-06-30 |
2018-06-21 |
Cellectis |
Methods for improving functionality in nk cell by gene inactivation using specific endonuclease
|
|
CN108350446A
(zh)
|
2015-07-02 |
2018-07-31 |
约翰霍普金斯大学 |
基于crispr/cas9的治疗
|
|
CN108026523B
(zh)
|
2015-07-06 |
2021-11-30 |
帝斯曼知识产权资产管理有限公司 |
向导rna组装载体
|
|
US20170009242A1
(en)
|
2015-07-06 |
2017-01-12 |
Whitehead Institute For Biomedical Research |
CRISPR-Mediated Genome Engineering for Protein Depletion
|
|
CN105132451B
(zh)
|
2015-07-08 |
2019-07-23 |
电子科技大学 |
一种CRISPR/Cas9单一转录单元定向修饰骨架载体及其应用
|
|
US20170014449A1
(en)
|
2015-07-13 |
2017-01-19 |
Elwha LLC, a limited liability company of the State of Delaware |
Site-specific epigenetic editing
|
|
WO2017009399A1
(en)
|
2015-07-13 |
2017-01-19 |
Institut Pasteur |
Improving sequence-specific antimicrobials by blocking dna repair
|
|
WO2017011519A1
(en)
|
2015-07-13 |
2017-01-19 |
Sangamo Biosciences, Inc. |
Delivery methods and compositions for nuclease-mediated genome engineering
|
|
EP3323890A4
(en)
|
2015-07-14 |
2019-01-30 |
Fukuoka University |
METHOD OF INDUSTRYING SITE-SPECIFIC RNA MUTATIONS, TARGETED EDITING GUIDE RNA USED IN THE METHOD AND TARGET RNA TARGET EDITING GUIDE RNA COMPLEX
|
|
MA42895A
(fr)
|
2015-07-15 |
2018-05-23 |
Juno Therapeutics Inc |
Cellules modifiées pour thérapie cellulaire adoptive
|
|
EP3322804B1
(en)
|
2015-07-15 |
2021-09-01 |
Rutgers, The State University of New Jersey |
Nuclease-independent targeted gene editing platform and uses thereof
|
|
US20170020922A1
(en)
|
2015-07-16 |
2017-01-26 |
Batu Biologics Inc. |
Gene editing for immunological destruction of neoplasia
|
|
WO2017015101A1
(en)
|
2015-07-17 |
2017-01-26 |
University Of Washington |
Methods for maximizing the efficiency of targeted gene correction
|
|
WO2017015015A1
(en)
|
2015-07-17 |
2017-01-26 |
Emory University |
Crispr-associated protein from francisella and uses related thereto
|
|
WO2017015637A1
(en)
|
2015-07-22 |
2017-01-26 |
Duke University |
High-throughput screening of regulatory element function with epigenome editing technologies
|
|
WO2017015545A1
(en)
|
2015-07-22 |
2017-01-26 |
President And Fellows Of Harvard College |
Evolution of site-specific recombinases
|
|
EP3325668B1
(en)
|
2015-07-23 |
2021-01-06 |
Mayo Foundation for Medical Education and Research |
Editing mitochondrial dna
|
|
ES2948559T3
(es)
|
2015-07-25 |
2023-09-14 |
Habib Frost |
Un sistema, un dispositivo y un método para proporcionar una terapia o una cura para el cáncer y otros estados patológicos
|
|
CN106399360A
(zh)
|
2015-07-27 |
2017-02-15 |
上海药明生物技术有限公司 |
基于crispr技术敲除fut8基因的方法
|
|
WO2017019867A1
(en)
|
2015-07-28 |
2017-02-02 |
Danisco Us Inc |
Genome editing systems and methods of use
|
|
CN105063061B
(zh)
|
2015-07-28 |
2018-10-30 |
华南农业大学 |
一种水稻千粒重基因tgw6突变体及其制备方法与应用
|
|
CN106701808A
(zh)
|
2015-07-29 |
2017-05-24 |
深圳华大基因研究院 |
Dna聚合酶i缺陷型菌株及其构建方法
|
|
WO2017019895A1
(en)
|
2015-07-30 |
2017-02-02 |
President And Fellows Of Harvard College |
Evolution of talens
|
|
GB2557123B
(en)
|
2015-07-31 |
2021-11-03 |
Univ Minnesota |
Modified cells and methods of therapy
|
|
US20200123533A1
(en)
|
2015-07-31 |
2020-04-23 |
The Trustees Of Columbia University In The City Of New York |
High-throughput strategy for dissecting mammalian genetic interactions
|
|
WO2017023974A1
(en)
|
2015-08-03 |
2017-02-09 |
President And Fellows Of Harvard College |
Cas9 genome editing and transcriptional regulation
|
|
WO2017024047A1
(en)
|
2015-08-03 |
2017-02-09 |
Emendobio Inc. |
Compositions and methods for increasing nuclease induced recombination rate in cells
|
|
EP3331905B1
(en)
|
2015-08-06 |
2022-10-05 |
Dana-Farber Cancer Institute, Inc. |
Targeted protein degradation to attenuate adoptive t-cell therapy associated adverse inflammatory responses
|
|
US9580727B1
(en)
|
2015-08-07 |
2017-02-28 |
Caribou Biosciences, Inc. |
Compositions and methods of engineered CRISPR-Cas9 systems using split-nexus Cas9-associated polynucleotides
|
|
CN104962523B
(zh)
|
2015-08-07 |
2018-05-25 |
苏州大学 |
一种测定非同源末端连接修复活性的方法
|
|
AU2016305490B2
(en)
|
2015-08-07 |
2022-07-14 |
Commonwealth Scientific And Industrial Research Organisation |
Method for producing an animal comprising a germline genetic modification
|
|
WO2017025323A1
(en)
|
2015-08-11 |
2017-02-16 |
Cellectis |
Cells for immunotherapy engineered for targeting cd38 antigen and for cd38 gene inactivation
|
|
CN105255937A
(zh)
|
2015-08-14 |
2016-01-20 |
西北农林科技大学 |
一种真核细胞III型启动子表达CRISPR sgRNA的方法及其应用
|
|
CA2994883A1
(en)
|
2015-08-14 |
2017-02-23 |
Institute Of Genetics And Developmental Biology, Chinese Academy Of Scnces |
Method for obtaining glyphosate-resistant rice by site-directed nucleotide substitution
|
|
CA2995983A1
(en)
|
2015-08-19 |
2017-02-23 |
Arc Bio, Llc |
Capture of nucleic acids using a nucleic acid-guided nuclease-based system
|
|
US11339408B2
(en)
|
2015-08-20 |
2022-05-24 |
Applied Stemcell, Inc. |
Nuclease with enhanced efficiency of genome editing
|
|
CN105112519A
(zh)
|
2015-08-20 |
2015-12-02 |
郑州大学 |
一种基于crispr的大肠杆菌o157:h7菌株检测试剂盒及检测方法
|
|
CN105177126B
(zh)
|
2015-08-21 |
2018-12-04 |
东华大学 |
一种利用荧光pcr技术对小鼠的分型鉴定方法
|
|
JP6905755B2
(ja)
|
2015-08-25 |
2021-07-21 |
デューク ユニバーシティ |
Rnaガイド型エンドヌクレアーゼを使用してゲノム工学における特異性を改善する組成物および方法
|
|
CN106480083B
(zh)
|
2015-08-26 |
2021-12-14 |
中国科学院分子植物科学卓越创新中心 |
CRISPR/Cas9介导的大片段DNA拼接方法
|
|
US9512446B1
(en)
|
2015-08-28 |
2016-12-06 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases
|
|
AU2016316845B2
(en)
|
2015-08-28 |
2022-03-10 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases
|
|
US9926546B2
(en)
|
2015-08-28 |
2018-03-27 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases
|
|
US10526590B2
(en)
|
2015-08-31 |
2020-01-07 |
Agilent Technologies, Inc. |
Compounds and methods for CRISPR/Cas-based genome editing by homologous recombination
|
|
CN105087620B
(zh)
|
2015-08-31 |
2017-12-29 |
中国农业大学 |
一种过表达猪共刺激受体4‑1bb载体及其应用
|
|
US20170058272A1
(en)
|
2015-08-31 |
2017-03-02 |
Caribou Biosciences, Inc. |
Directed nucleic acid repair
|
|
AU2016316027B2
(en)
|
2015-09-01 |
2022-04-07 |
Dana-Farber Cancer Institute Inc. |
Systems and methods for selection of gRNA targeting strands for Cas9 localization
|
|
EP3344756B1
(en)
|
2015-09-02 |
2025-11-05 |
University of Massachusetts |
Detection of gene loci with crispr arrayed repeats and/or polychromatic single guide ribonucleic acids
|
|
WO2017040786A1
(en)
|
2015-09-04 |
2017-03-09 |
Massachusetts Institute Of Technology |
Multilayer genetic safety kill circuits based on single cas9 protein and multiple engineered grna in mammalian cells
|
|
CN105400810B
(zh)
|
2015-09-06 |
2019-05-07 |
吉林大学 |
采用敲除技术建立低磷性佝偻病模型的方法
|
|
EP3347464B1
(en)
|
2015-09-08 |
2024-01-24 |
University of Massachusetts |
Dnase h activity of neisseria meningitidis cas9
|
|
SG11201801809VA
(en)
|
2015-09-09 |
2018-04-27 |
Univ Kobe Nat Univ Corp |
Method for modifying genome sequence that specifically converts nucleobase of targeted dna sequence, and molecular complex used in said method
|
|
JP6664693B2
(ja)
|
2015-09-09 |
2020-03-13 |
国立大学法人神戸大学 |
標的化したdna配列の核酸塩基を特異的に変換する、グラム陽性菌のゲノム配列の変換方法、及びそれに用いる分子複合体
|
|
WO2017044776A1
(en)
|
2015-09-10 |
2017-03-16 |
Texas Tech University System |
Single-guide rna (sgrna) with improved knockout efficiency
|
|
US20170072025A1
(en)
|
2015-09-10 |
2017-03-16 |
Youhealth Biotech, Limited |
Methods and compositions for the treatment of glaucoma
|
|
CN105274144A
(zh)
|
2015-09-14 |
2016-01-27 |
徐又佳 |
通过CRISPR/Cas9技术得到敲除铁调素基因斑马鱼的制备方法
|
|
US10301613B2
(en)
|
2015-09-15 |
2019-05-28 |
Arizona Board Of Regents On Behalf Of Arizona State University |
Targeted remodeling of prokaryotic genomes using CRISPR-nickases
|
|
CN105210981B
(zh)
|
2015-09-15 |
2018-09-28 |
中国科学院生物物理研究所 |
建立可应用于人类疾病研究的雪貂模型的方法及其应用
|
|
CN105112422B
(zh)
|
2015-09-16 |
2019-11-08 |
中山大学 |
基因miR408和UCL在培育高产水稻中的应用
|
|
WO2017049129A2
(en)
|
2015-09-18 |
2017-03-23 |
President And Fellows Of Harvard College |
Methods of making guide rna
|
|
CN105132427B
(zh)
|
2015-09-21 |
2019-01-08 |
新疆畜牧科学院生物技术研究所 |
一种以RNA介导的特异性敲除双基因获得基因编辑绵羊的方法及其专用sgRNA
|
|
EP3353298B1
(en)
|
2015-09-21 |
2023-09-13 |
Arcturus Therapeutics, Inc. |
Allele selective gene editing and uses thereof
|
|
EP3352795B1
(en)
|
2015-09-21 |
2020-08-12 |
The Regents of The University of California |
Compositions and methods for target nucleic acid modification
|
|
SI3352776T1
(sl)
|
2015-09-23 |
2025-08-29 |
Sangamo Therapeutics, Inc. |
Represorji Htt in njihove uporabe
|
|
JP2018532402A
(ja)
|
2015-09-24 |
2018-11-08 |
クリスパー セラピューティクス アーゲー |
Rnaプログラム可能エンドヌクレアーゼの新規のファミリーならびにゲノム編集および他の適用におけるそれらの使用
|
|
CA2999500A1
(en)
|
2015-09-24 |
2017-03-30 |
Editas Medicine, Inc. |
Use of exonucleases to improve crispr/cas-mediated genome editing
|
|
WO2017053762A1
(en)
|
2015-09-24 |
2017-03-30 |
Sigma-Aldrich Co. Llc |
Methods and reagents for molecular proximity detection using rna-guided nucleic acid binding proteins
|
|
KR101795999B1
(ko)
|
2015-09-25 |
2017-11-09 |
전남대학교산학협력단 |
Crispr/cas9 시스템을 이용한 베타2-마이크로글로불린 유전자 제거용 시발체
|
|
KR101745863B1
(ko)
|
2015-09-25 |
2017-06-12 |
전남대학교산학협력단 |
Crispr/cas9 시스템을 이용한 프로히비틴2 유전자 제거용 시발체
|
|
WO2017053729A1
(en)
|
2015-09-25 |
2017-03-30 |
The Board Of Trustees Of The Leland Stanford Junior University |
Nuclease-mediated genome editing of primary cells and enrichment thereof
|
|
US20180258411A1
(en)
|
2015-09-25 |
2018-09-13 |
Tarveda Therapeutics, Inc. |
Compositions and methods for genome editing
|
|
EP3147363B1
(en)
|
2015-09-26 |
2019-10-16 |
B.R.A.I.N. Ag |
Activation of taste receptor genes in mammalian cells using crispr-cas-9
|
|
JP2018527943A
(ja)
|
2015-09-28 |
2018-09-27 |
テンプル ユニバーシティー オブ ザ コモンウェルス システム オブ ハイヤー エデュケーション |
Rna誘導性の、hiv感染の処置のための、方法および組成物
|
|
JP2018532403A
(ja)
|
2015-09-29 |
2018-11-08 |
アジェノビア コーポレーション |
送達方法および組成物
|
|
US20170087225A1
(en)
|
2015-09-29 |
2017-03-30 |
Agenovir Corporation |
Compositions and methods for latent viral transcription regulation
|
|
US20170088828A1
(en)
|
2015-09-29 |
2017-03-30 |
Agenovir Corporation |
Compositions and methods for treatment of latent viral infections
|
|
CN105177038B
(zh)
|
2015-09-29 |
2018-08-24 |
中国科学院遗传与发育生物学研究所 |
一种高效定点编辑植物基因组的CRISPR/Cas9系统
|
|
US20170088587A1
(en)
|
2015-09-29 |
2017-03-30 |
Agenovir Corporation |
Antiviral fusion proteins and genes
|
|
CN105331627B
(zh)
|
2015-09-30 |
2019-04-02 |
华中农业大学 |
一种利用内源CRISPR-Cas系统进行原核生物基因组编辑的方法
|
|
WO2017059241A1
(en)
|
2015-10-02 |
2017-04-06 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Lentiviral protein delivery system for rna-guided genome editing
|
|
CA3004710A1
(en)
|
2015-10-06 |
2017-04-13 |
The Children's Hospital Of Philadelphia |
Compositions and methods for treating fragile x syndrome and related syndromes
|
|
US10760081B2
(en)
|
2015-10-07 |
2020-09-01 |
New York University |
Compositions and methods for enhancing CRISPR activity by POLQ inhibition
|
|
WO2017062886A1
(en)
|
2015-10-08 |
2017-04-13 |
Cellink Corporation |
Battery interconnects
|
|
IL297017A
(en)
|
2015-10-08 |
2022-12-01 |
Harvard College |
Multiplexed genome editing
|
|
WO2017062855A1
(en)
|
2015-10-09 |
2017-04-13 |
Monsanto Technology Llc |
Novel rna-guided nucleases and uses thereof
|
|
CA3004713A1
(en)
|
2015-10-09 |
2017-04-13 |
The Children's Hospital Of Philadelphia |
Compositions and methods for treating huntington's disease and related disorders
|
|
FI4144844T3
(fi)
|
2015-10-12 |
2025-11-24 |
Dupont Us Holding Llc |
Suojatut dna-templaatit geenimuokkaukseen ja homologisen rekombinaation lisäämiseen soluissa ja niiden käyttömenetelmät
|
|
EP4089175A1
(en)
|
2015-10-13 |
2022-11-16 |
Duke University |
Genome engineering with type i crispr systems in eukaryotic cells
|
|
US10829787B2
(en)
|
2015-10-14 |
2020-11-10 |
Life Technologies Corporation |
Ribonucleoprotein transfection agents
|
|
CN105400779A
(zh)
|
2015-10-15 |
2016-03-16 |
芜湖医诺生物技术有限公司 |
嗜热链球菌CRISPR-Cas9系统识别的人CCR5基因的靶序列和sgRNA及其应用
|
|
CN108431225A
(zh)
|
2015-10-16 |
2018-08-21 |
阿斯特拉捷利康股份公司 |
细胞基因组的诱导型修饰
|
|
CN108778343A
(zh)
|
2015-10-16 |
2018-11-09 |
天普大学-联邦高等教育系统 |
利用cpf1进行rna向导的基因编辑的方法和组合物
|
|
FR3042506B1
(fr)
|
2015-10-16 |
2018-11-30 |
IFP Energies Nouvelles |
Outil genetique de transformation de bacteries clostridium
|
|
WO2017070169A1
(en)
|
2015-10-19 |
2017-04-27 |
The Methodist Hospital |
Crispr-cas9 delivery to hard-to-transfect cells via membrane deformation
|
|
CN105331607A
(zh)
|
2015-10-19 |
2016-02-17 |
芜湖医诺生物技术有限公司 |
嗜热链球菌CRISPR-Cas9系统识别的人CCR5基因的靶序列和sgRNA及其应用
|
|
JP7059179B2
(ja)
|
2015-10-20 |
2022-04-25 |
アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル |
遺伝子操作のための方法及び製品
|
|
CN105316324A
(zh)
|
2015-10-20 |
2016-02-10 |
芜湖医诺生物技术有限公司 |
嗜热链球菌CRISPR-Cas9系统识别的人CXCR4基因的靶序列和sgRNA及其应用
|
|
CN105331608A
(zh)
|
2015-10-20 |
2016-02-17 |
芜湖医诺生物技术有限公司 |
脑膜炎双球菌CRISPR-Cas9系统识别的人CXCR4基因的靶序列和sgRNA及其应用
|
|
CN105331609A
(zh)
|
2015-10-20 |
2016-02-17 |
芜湖医诺生物技术有限公司 |
脑膜炎双球菌CRISPR-Cas9系统识别的人CCR5基因的靶序列和sgRNA及其应用
|
|
KR20180069832A
(ko)
|
2015-10-20 |
2018-06-25 |
파이어니어 하이 부렛드 인터내쇼날 인코포레이팃드 |
유도 cas 시스템을 통한 비기능성 유전자 산물에 대한 기능 회복 및 이용 방법
|
|
CN105316337A
(zh)
|
2015-10-20 |
2016-02-10 |
芜湖医诺生物技术有限公司 |
嗜热链球菌CRISPR-Cas9系统识别的人CXCR4基因的靶序列和sgRNA及其应用
|
|
AU2016341919A1
(en)
|
2015-10-21 |
2018-04-19 |
Editas Medicine, Inc. |
CRISPR/CAS-related methods and compositions for treating hepatitis b virus
|
|
KR102761827B1
(ko)
|
2015-10-22 |
2025-02-03 |
더 브로드 인스티튜트, 인코퍼레이티드 |
타입 vi-b crispr 효소 및 시스템
|
|
CN105219799A
(zh)
|
2015-10-22 |
2016-01-06 |
天津吉诺沃生物科技有限公司 |
一种基于CRISPR/Cas系统的多年生黑麦草的育种方法
|
|
US12043852B2
(en)
|
2015-10-23 |
2024-07-23 |
President And Fellows Of Harvard College |
Evolved Cas9 proteins for gene editing
|
|
EP3350327B1
(en)
|
2015-10-23 |
2018-09-26 |
Caribou Biosciences, Inc. |
Engineered crispr class 2 cross-type nucleic-acid targeting nucleic acids
|
|
EP3159407A1
(en)
|
2015-10-23 |
2017-04-26 |
Silence Therapeutics (London) Ltd |
Guide rnas, methods and uses
|
|
TW201715041A
(zh)
|
2015-10-26 |
2017-05-01 |
國立清華大學 |
細菌基因編輯方法
|
|
US9988637B2
(en)
|
2015-10-26 |
2018-06-05 |
National Tsing Hua Univeristy |
Cas9 plasmid, genome editing system and method of Escherichia coli
|
|
US10280411B2
(en)
|
2015-10-27 |
2019-05-07 |
Pacific Biosciences of California, In.c |
Methods, systems, and reagents for direct RNA sequencing
|
|
EP3673732A3
(en)
|
2015-10-27 |
2020-07-29 |
Recombinetics, Inc. |
Engineering of humanized car t-cells and platelets by genetic complementation
|
|
ES3040945T3
(en)
|
2015-10-28 |
2025-11-06 |
Vertex Pharma |
Materials and methods for treatment of duchenne muscular dystrophy
|
|
EP3368054A4
(en)
|
2015-10-28 |
2019-07-03 |
Voyager Therapeutics, Inc. |
REGULATORY EXPRESSION USING THE ADENO-ASSOCIATED VIRUS (AAV)
|
|
MY189674A
(en)
|
2015-10-28 |
2022-02-24 |
Sangamo Therapeutics Inc |
Liver-specific constructs, factor viii expression cassettes and methods of use thereof
|
|
WO2017074962A1
(en)
|
2015-10-30 |
2017-05-04 |
Brandeis University |
Modified cas9 compositions and methods of use
|
|
CA3001711A1
(en)
|
2015-10-30 |
2017-05-04 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating herpes simplex virus
|
|
CN105238806B
(zh)
|
2015-11-02 |
2018-11-27 |
中国科学院天津工业生物技术研究所 |
一种用于微生物的CRISPR/Cas9基因编辑载体的构建及其应用
|
|
CN105316327B
(zh)
|
2015-11-03 |
2019-01-29 |
中国农业科学院作物科学研究所 |
小麦TaAGO4a基因CRISPR/Cas9载体及其应用
|
|
KR20250141836A
(ko)
|
2015-11-04 |
2025-09-29 |
페이트 세러퓨틱스, 인코포레이티드 |
만능 세포의 유전자 조작
|
|
WO2017079428A1
(en)
|
2015-11-04 |
2017-05-11 |
President And Fellows Of Harvard College |
Site specific germline modification
|
|
EP3370741B1
(en)
|
2015-11-04 |
2025-10-08 |
The Trustees of the University of Pennsylvania |
Methods and compositions for gene editing in hematopoietic stem cells
|
|
GB2544270A
(en)
|
2015-11-05 |
2017-05-17 |
Fundació Centre De Regulació Genòmica |
Nucleic acids, peptides and methods
|
|
AU2016348782A1
(en)
|
2015-11-05 |
2018-05-31 |
Cellectis |
Process of gene-editing of cells isolated from a subject suffering from a metabolic disease affecting the erythroid lineage, cells obtained by said process and uses thereof.
|
|
CA3004497A1
(en)
|
2015-11-06 |
2017-05-11 |
The Jackson Laboratory |
Large genomic dna knock-in and uses thereof
|
|
WO2017078751A1
(en)
|
2015-11-06 |
2017-05-11 |
The Methodist Hospital |
Micoluidic cell deomailiy assay for enabling rapid and efficient kinase screening via the crispr-cas9 system
|
|
WO2017081097A1
(en)
|
2015-11-09 |
2017-05-18 |
Ifom Fondazione Istituto Firc Di Oncologia Molecolare |
Crispr-cas sgrna library
|
|
EP3374501B1
(en)
|
2015-11-11 |
2023-07-12 |
Lonza Ltd |
Crispr-associated (cas) proteins with reduced immunogenicity
|
|
EP3374494A4
(en)
|
2015-11-11 |
2019-05-01 |
Coda Biotherapeutics, Inc. |
CRISPR COMPOSITIONS AND METHODS OF USE FOR GENE THERAPY
|
|
WO2017083368A1
(en)
|
2015-11-12 |
2017-05-18 |
Pfizer Inc. |
Tissue-specific genome engineering using crispr-cas9
|
|
US20170191047A1
(en)
|
2015-11-13 |
2017-07-06 |
University Of Georgia Research Foundation, Inc. |
Adenosine-specific rnase and methods of use
|
|
KR101885901B1
(ko)
|
2015-11-13 |
2018-08-07 |
기초과학연구원 |
5' 말단의 인산기가 제거된 rna를 포함하는 리보핵산단백질 전달용 조성물
|
|
US11306308B2
(en)
|
2015-11-13 |
2022-04-19 |
Massachusetts Institute Of Technology |
High-throughput CRISPR-based library screening
|
|
KR102877920B1
(ko)
|
2015-11-16 |
2025-10-30 |
더 리서치 인스티튜트 앳 네이션와이드 칠드런스 하스피탈 |
티틴-기반 근증 및 다른 티틴성병증의 치료를 위한 물질 및 방법
|
|
US11905521B2
(en)
|
2015-11-17 |
2024-02-20 |
The Chinese University Of Hong Kong |
Methods and systems for targeted gene manipulation
|
|
AU2016359629B2
(en)
|
2015-11-23 |
2023-03-09 |
Ranjan BATRA |
Tracking and manipulating cellular RNA via nuclear delivery of CRISPR/Cas9
|
|
CN105602987A
(zh)
|
2015-11-23 |
2016-05-25 |
深圳市默赛尔生物医学科技发展有限公司 |
一种高效的dc细胞xbp1基因敲除方法
|
|
US20170145438A1
(en)
|
2015-11-24 |
2017-05-25 |
University Of South Carolina |
Viral Vectors for Gene Editing
|
|
US10240145B2
(en)
|
2015-11-25 |
2019-03-26 |
The Board Of Trustees Of The Leland Stanford Junior University |
CRISPR/Cas-mediated genome editing to treat EGFR-mutant lung cancer
|
|
WO2017090724A1
(ja)
|
2015-11-25 |
2017-06-01 |
国立大学法人 群馬大学 |
Dnaメチル化編集用キットおよびdnaメチル化編集方法
|
|
WO2017091510A1
(en)
|
2015-11-27 |
2017-06-01 |
The Regents Of The University Of California |
Compositions and methods for the production of hydrocarbons, hydrogen and carbon monoxide using engineered azotobacter strains
|
|
CN105505979A
(zh)
|
2015-11-28 |
2016-04-20 |
湖北大学 |
一种以CRISPR/Cas9基因编辑技术打靶Badh2基因获得香稻品系的方法
|
|
CN106811479B
(zh)
|
2015-11-30 |
2019-10-25 |
中国农业科学院作物科学研究所 |
利用CRISPR/Cas9系统定点修饰ALS基因获得抗除草剂水稻的系统及其应用
|
|
WO2017095111A1
(ko)
|
2015-11-30 |
2017-06-08 |
기초과학연구원 |
F. novicida 유래 Cas9을 포함하는 유전체 교정용 조성물
|
|
CN105296518A
(zh)
|
2015-12-01 |
2016-02-03 |
中国农业大学 |
一种用于CRISPR/Cas9技术的同源臂载体构建方法
|
|
RU2634395C1
(ru)
|
2015-12-01 |
2017-10-26 |
Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Балтийский Федеральный Университет имени Иммануила Канта" (БФУ им. И. Канта) |
Генетическая конструкция на основе системы редактирования генома crispr/cas9, кодирующая нуклеазу cas9, специфически импортируемую в митохондрии клеток человека
|
|
EP3383168A4
(en)
|
2015-12-02 |
2019-05-08 |
Ceres, Inc. |
METHOD FOR THE GENETIC MODIFICATION OF PLANTS
|
|
WO2017096041A1
(en)
|
2015-12-02 |
2017-06-08 |
The Regents Of The University Of California |
Compositions and methods for modifying a target nucleic acid
|
|
WO2017093370A1
(en)
|
2015-12-03 |
2017-06-08 |
Technische Universität München |
T-cell specific genome editing
|
|
CN105779449B
(zh)
|
2015-12-04 |
2018-11-27 |
新疆农业大学 |
一种棉花启动子GbU6-5PS及应用
|
|
CN105779448B
(zh)
|
2015-12-04 |
2018-11-27 |
新疆农业大学 |
一种棉花启动子GbU6-7PS及应用
|
|
JP2018536436A
(ja)
|
2015-12-04 |
2018-12-13 |
ノバルティス アーゲー |
免疫腫瘍学のための組成物および方法
|
|
CN105462968B
(zh)
|
2015-12-07 |
2018-10-16 |
北京信生元生物医学科技有限公司 |
一种靶向apoCⅢ的CRISPR-Cas9系统及其应用
|
|
CN106845151B
(zh)
|
2015-12-07 |
2019-03-26 |
中国农业大学 |
CRISPR-Cas9系统sgRNA作用靶点的筛选方法及装置
|
|
RU2018124657A
(ru)
|
2015-12-09 |
2020-01-09 |
Эксижн Биотерапевтикс, Инк. |
Способы редактирования генов и композиции для устранения риска активации вируса jc и пмл (прогрессирующая мультифокальная лейкоэнцефалопатия) во время иммуносупрессивной терапии
|
|
CN105463003A
(zh)
|
2015-12-11 |
2016-04-06 |
扬州大学 |
一种消除卡那霉素耐药基因活性的重组载体及其构建方法
|
|
EP3387134B1
(en)
|
2015-12-11 |
2020-10-14 |
Danisco US Inc. |
Methods and compositions for enhanced nuclease-mediated genome modification and reduced off-target site effects
|
|
CN105296537A
(zh)
|
2015-12-12 |
2016-02-03 |
西南大学 |
一种基于睾丸内注射的基因定点编辑技术
|
|
CN105400773B
(zh)
|
2015-12-14 |
2018-06-26 |
同济大学 |
应用于大规模筛选癌症基因的CRISPR/Cas9富集测序方法
|
|
WO2017105350A1
(en)
|
2015-12-14 |
2017-06-22 |
Cellresearch Corporation Pte Ltd |
A method of generating a mammalian stem cell carrying a transgene, a mammalian stem cell generated by the method and pharmaceuticals uses of the mammalian stem cell
|
|
NO343153B1
(en)
|
2015-12-17 |
2018-11-19 |
Hydra Systems As |
A method of assessing the integrity status of a barrier plug
|
|
WO2017106616A1
(en)
|
2015-12-17 |
2017-06-22 |
The Regents Of The University Of Colorado, A Body Corporate |
Varicella zoster virus encoding regulatable cas9 nuclease
|
|
CN105463027A
(zh)
|
2015-12-17 |
2016-04-06 |
中国农业大学 |
一种高肌肉量及肥厚型心肌病模型克隆猪的制备方法
|
|
FI3390632T3
(fi)
|
2015-12-18 |
2025-11-25 |
Danisco Us Inc |
Menetelmät ja koostumukset polymeraasi ii (pol-ii) -pohjaisen opas-rna:n ilmentämiseen
|
|
US11761007B2
(en)
|
2015-12-18 |
2023-09-19 |
The Scripps Research Institute |
Production of unnatural nucleotides using a CRISPR/Cas9 system
|
|
ES2983043T3
(es)
|
2015-12-18 |
2024-10-21 |
Sangamo Therapeutics Inc |
Alteración dirigida del receptor de células T
|
|
CN109072218B
(zh)
|
2015-12-18 |
2023-04-18 |
国立研究开发法人科学技术振兴机构 |
基因修饰非人生物、卵细胞、受精卵以及目的基因的修饰方法
|
|
WO2017106569A1
(en)
|
2015-12-18 |
2017-06-22 |
The Regents Of The University Of California |
Modified site-directed modifying polypeptides and methods of use thereof
|
|
US12110490B2
(en)
|
2015-12-18 |
2024-10-08 |
The Broad Institute, Inc. |
CRISPR enzymes and systems
|
|
CN108699132B
(zh)
|
2015-12-18 |
2023-08-11 |
桑格摩生物治疗股份有限公司 |
Mhc细胞受体的靶向破坏
|
|
EP3390631B1
(en)
|
2015-12-18 |
2020-04-08 |
Danisco US Inc. |
Methods and compositions for t-rna based guide rna expression
|
|
US11684665B2
(en)
|
2015-12-22 |
2023-06-27 |
CureVac SE |
Method for producing RNA molecule compositions
|
|
WO2017112620A1
(en)
|
2015-12-22 |
2017-06-29 |
North Carolina State University |
Methods and compositions for delivery of crispr based antimicrobials
|
|
US20210260219A1
(en)
|
2015-12-23 |
2021-08-26 |
Crispr Therapeutics Ag |
Materials and methods for treatment of amyotrophic lateral sclerosis and/or frontal temporal lobular degeneration
|
|
CN105543270A
(zh)
|
2015-12-24 |
2016-05-04 |
中国农业科学院作物科学研究所 |
双抗性CRISPR/Cas9载体及应用
|
|
CN105543266A
(zh)
|
2015-12-25 |
2016-05-04 |
安徽大学 |
一种维吉尼亚链霉菌IBL14中的CRISPR-Cas系统及应用其进行基因编辑的方法
|
|
CN105505976A
(zh)
|
2015-12-25 |
2016-04-20 |
安徽大学 |
一种维吉尼亚链霉菌ibl14产青霉素重组菌株的构建方法
|
|
EA201891532A1
(ru)
|
2015-12-28 |
2019-01-31 |
Новартис Аг |
Композиции и способы лечения гемоглобинопатий
|
|
AU2016380351B2
(en)
|
2015-12-29 |
2023-04-06 |
Monsanto Technology Llc |
Novel CRISPR-associated transposases and uses thereof
|
|
CN105441451B
(zh)
|
2015-12-31 |
2019-03-22 |
暨南大学 |
一种特异靶向人ABCB1基因的sgRNA导向序列及应用
|
|
CN105567735A
(zh)
|
2016-01-05 |
2016-05-11 |
华东师范大学 |
一种凝血因子基因突变的定点修复载体系统及方法
|
|
WO2017118720A1
(en)
|
2016-01-08 |
2017-07-13 |
Novozymes A/S |
Genome editing in bacillus host cells
|
|
CN105647922A
(zh)
|
2016-01-11 |
2016-06-08 |
中国人民解放军疾病预防控制所 |
基于一种新gRNA序列的CRISPR-Cas9系统在制备乙肝治疗药物中的应用
|
|
US11441146B2
(en)
|
2016-01-11 |
2022-09-13 |
Christiana Care Health Services, Inc. |
Compositions and methods for improving homogeneity of DNA generated using a CRISPR/Cas9 cleavage system
|
|
US11427837B2
(en)
|
2016-01-12 |
2022-08-30 |
The Regents Of The University Of California |
Compositions and methods for enhanced genome editing
|
|
CA3011458A1
(en)
|
2016-01-14 |
2017-07-20 |
The Brigham And Women's Hospital, Inc. |
Genome editing for treating glioblastoma
|
|
CA3011484A1
(en)
|
2016-01-14 |
2017-07-20 |
Memphis Meats, Inc. |
Methods for extending the replicative capacity of somatic cells during an ex vivo cultivation process
|
|
WO2017124086A1
(en)
|
2016-01-15 |
2017-07-20 |
The Jackson Laboratory |
Genetically modified non-human mammals by multi-cycle electroporation of cas9 protein
|
|
CN105567738A
(zh)
|
2016-01-18 |
2016-05-11 |
南开大学 |
使用基因组编辑技术CRISPR-Cas9诱导CCR5Δ32缺失的方法
|
|
WO2017126987A1
(ru)
|
2016-01-18 |
2017-07-27 |
Анатолий Викторович ЗАЗУЛЯ |
Эритроциты для направленного транспорта лекарственного средства
|
|
CN105567734A
(zh)
|
2016-01-18 |
2016-05-11 |
丹弥优生物技术(湖北)有限公司 |
一种基因组dna序列精准编辑方法
|
|
WO2017127807A1
(en)
|
2016-01-22 |
2017-07-27 |
The Broad Institute Inc. |
Crystal structure of crispr cpf1
|
|
CN108603196A
(zh)
|
2016-01-25 |
2018-09-28 |
酶切生物技术公司 |
Rna向导的对人类jc病毒和其他多瘤病毒的根除
|
|
CN105543228A
(zh)
|
2016-01-25 |
2016-05-04 |
宁夏农林科学院 |
一种快速将水稻转化为香稻的方法
|
|
CN105567689B
(zh)
|
2016-01-25 |
2019-04-09 |
重庆威斯腾生物医药科技有限责任公司 |
CRISPR/Cas9靶向敲除人TCAB1基因及其特异性gRNA
|
|
JP2019506156A
(ja)
|
2016-01-25 |
2019-03-07 |
エクシジョン バイオセラピューティクス インコーポレイテッド |
Hiv感染症のrna誘導型治療のための方法及び組成物
|
|
EP3199632A1
(en)
|
2016-01-26 |
2017-08-02 |
ACIB GmbH |
Temperature-inducible crispr/cas system
|
|
CN105567688A
(zh)
|
2016-01-27 |
2016-05-11 |
武汉大学 |
一种可用于艾滋病基因治疗的CRISPR/SaCas9系统
|
|
AU2017211395B2
(en)
|
2016-01-29 |
2024-04-18 |
The Trustees Of Princeton University |
Split inteins with exceptional splicing activity
|
|
CA3013179A1
(en)
|
2016-01-30 |
2017-08-03 |
Bonac Corporation |
Artificial single guide rna and use thereof
|
|
CN105647968B
(zh)
|
2016-02-02 |
2019-07-23 |
浙江大学 |
一种CRISPR/Cas9工作效率快速测试系统及其应用
|
|
CN107022562B
(zh)
|
2016-02-02 |
2020-07-17 |
中国种子集团有限公司 |
利用CRISPR/Cas9系统对玉米基因定点突变的方法
|
|
US11845933B2
(en)
|
2016-02-03 |
2023-12-19 |
Massachusetts Institute Of Technology |
Structure-guided chemical modification of guide RNA and its applications
|
|
CN105671083B
(zh)
|
2016-02-03 |
2017-09-29 |
安徽柯顿生物科技有限公司 |
PD‑1基因重组病毒质粒及构建、重组逆转录病毒Lenti‑PD‑1‑Puro及包装与应用
|
|
US11208652B2
(en)
|
2016-02-04 |
2021-12-28 |
President And Fellows Of Harvard College |
Mitochondrial genome editing and regulation
|
|
WO2017136629A1
(en)
|
2016-02-05 |
2017-08-10 |
Regents Of The University Of Minnesota |
Vectors and system for modulating gene expression
|
|
WO2017139264A1
(en)
|
2016-02-09 |
2017-08-17 |
President And Fellows Of Harvard College |
Dna-guided gene editing and regulation
|
|
JP6998313B2
(ja)
|
2016-02-11 |
2022-02-04 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
細胞のゲノムにおける変異ジストロフィン遺伝子を修飾する方法及び組成物
|
|
RU2016104674A
(ru)
|
2016-02-11 |
2017-08-16 |
Анатолий Викторович Зазуля |
Устройство модификации эритроцита с механизмом направленного транспорта лекарственного средства для функций генной терапии crispr/cas9
|
|
EP3417062B1
(en)
|
2016-02-15 |
2024-06-26 |
Temple University - Of The Commonwealth System of Higher Education |
Excision of retroviral nucleic acid sequences
|
|
CN105647962A
(zh)
|
2016-02-15 |
2016-06-08 |
浙江大学 |
运用CRISPR-Cas9系统敲除水稻MIRNA393b茎环序列的基因编辑方法
|
|
US9896696B2
(en)
|
2016-02-15 |
2018-02-20 |
Benson Hill Biosystems, Inc. |
Compositions and methods for modifying genomes
|
|
CA3014792A1
(en)
|
2016-02-16 |
2017-08-24 |
Carnegie Mellon University |
Compositions for enhancing targeted gene editing and methods of use thereof
|
|
CN105594664B
(zh)
|
2016-02-16 |
2018-10-02 |
湖南师范大学 |
一种基因敲除选育stat1a基因缺失型斑马鱼的方法
|
|
CN105647969B
(zh)
|
2016-02-16 |
2020-12-15 |
湖南师范大学 |
一种基因敲除选育stat1a基因缺失型斑马鱼的方法
|
|
CN105624187A
(zh)
|
2016-02-17 |
2016-06-01 |
天津大学 |
酿酒酵母基因组定点突变的方法
|
|
US11326161B2
(en)
|
2016-02-18 |
2022-05-10 |
President And Fellows Of Harvard College |
Methods and systems of molecular recording by CRISPR-Cas system
|
|
US20170275665A1
(en)
|
2016-02-24 |
2017-09-28 |
Board Of Regents, The University Of Texas System |
Direct crispr spacer acquisition from rna by a reverse-transcriptase-cas1 fusion protein
|
|
CN105646719B
(zh)
|
2016-02-24 |
2019-12-20 |
无锡市妇幼保健院 |
一种高效定点转基因的工具及其应用
|
|
WO2017147446A1
(en)
|
2016-02-25 |
2017-08-31 |
Agenovir Corporation |
Viral and oncoviral nuclease treatment
|
|
WO2017147278A1
(en)
|
2016-02-25 |
2017-08-31 |
The Children's Medical Center Corporation |
Customized class switch of immunoglobulin genes in lymphoma and hybridoma by crispr/cas9 technology
|
|
US20170247703A1
(en)
|
2016-02-25 |
2017-08-31 |
Agenovir Corporation |
Antiviral nuclease methods
|
|
US20170246260A1
(en)
|
2016-02-25 |
2017-08-31 |
Agenovir Corporation |
Modified antiviral nuclease
|
|
EP3420089B1
(en)
|
2016-02-26 |
2021-12-29 |
LanzaTech NZ, Inc. |
Crispr/cas systems for c-1 fixing bacteria
|
|
US10538750B2
(en)
|
2016-02-29 |
2020-01-21 |
Agilent Technologies, Inc. |
Methods and compositions for blocking off-target nucleic acids from cleavage by CRISPR proteins
|
|
US11447768B2
(en)
|
2016-03-01 |
2022-09-20 |
University Of Florida Research Foundation, Incorporated |
Molecular cell diary system
|
|
CN105671070B
(zh)
|
2016-03-03 |
2019-03-19 |
江南大学 |
一种用于枯草芽孢杆菌基因组编辑的CRISPRCas9系统及其构建方法
|
|
SG11201807538PA
(en)
|
2016-03-04 |
2018-09-27 |
Editas Medicine Inc |
Crispr-cpf1-related methods, compositions and components for cancer immunotherapy
|
|
CN107177591A
(zh)
|
2016-03-09 |
2017-09-19 |
北京大学 |
利用CRISPR技术编辑CCR5基因的sgRNA序列及其用途
|
|
CN105821039B
(zh)
|
2016-03-09 |
2020-02-07 |
李旭 |
联合免疫基因抑制HBV复制的特异性sgRNA、表达载体及其应用
|
|
CN105821040B
(zh)
|
2016-03-09 |
2018-12-14 |
李旭 |
联合免疫基因抑制高危型HPV表达的sgRNA、基因敲除载体及其应用
|
|
CN105861547A
(zh)
|
2016-03-10 |
2016-08-17 |
黄捷 |
身份证号码永久嵌入基因组的方法
|
|
EP3699280A3
(en)
|
2016-03-11 |
2020-11-18 |
Pioneer Hi-Bred International, Inc. |
Novel cas9 systems and methods of use
|
|
IL313038A
(en)
|
2016-03-14 |
2024-07-01 |
Editas Medicine Inc |
Methods and preparations related to CRISPR/CAS - for the treatment of diseases in the hemoglobin cell
|
|
US20180112234A9
(en)
|
2016-03-14 |
2018-04-26 |
Intellia Therapeutics, Inc. |
Methods and compositions for gene editing
|
|
EP3430332B1
(en)
|
2016-03-15 |
2020-01-01 |
Carrier Corporation |
Refrigerated sales cabinet
|
|
CA3029735A1
(en)
|
2016-03-15 |
2017-09-21 |
University Of Massachusetts |
Anti-crispr compounds and methods of use
|
|
EP3219799A1
(en)
|
2016-03-17 |
2017-09-20 |
IMBA-Institut für Molekulare Biotechnologie GmbH |
Conditional crispr sgrna expression
|
|
US20200291370A1
(en)
|
2016-03-18 |
2020-09-17 |
President And Fellows Of Harvard College |
Mutant Cas Proteins
|
|
EP3433363A1
(en)
|
2016-03-25 |
2019-01-30 |
Editas Medicine, Inc. |
Genome editing systems comprising repair-modulating enzyme molecules and methods of their use
|
|
EP3433364A1
(en)
|
2016-03-25 |
2019-01-30 |
Editas Medicine, Inc. |
Systems and methods for treating alpha 1-antitrypsin (a1at) deficiency
|
|
CN106047803A
(zh)
|
2016-03-28 |
2016-10-26 |
青岛市胶州中心医院 |
CRISPR/Cas9靶向敲除兔BMP2基因的细胞模型及其应用
|
|
WO2017172644A2
(en)
|
2016-03-28 |
2017-10-05 |
The Charles Stark Draper Laboratory, Inc. |
Bacteria identification and antibiotic susceptibility profiling device
|
|
LT3436077T
(lt)
|
2016-03-30 |
2025-06-25 |
Intellia Therapeutics, Inc. |
Lipidų nanodalelių vaisto formos, skirtos crispr/cas komponentams
|
|
WO2017173004A1
(en)
|
2016-03-30 |
2017-10-05 |
Mikuni Takayasu |
A method for in vivo precise genome editing
|
|
US20190093128A1
(en)
|
2016-03-31 |
2019-03-28 |
The Regents Of The University Of California |
Methods for genome editing in zygotes
|
|
GB2565461B
(en)
|
2016-03-31 |
2022-04-13 |
Harvard College |
Methods and compositions for the single tube preparation of sequencing libraries using Cas9
|
|
US10301619B2
(en)
|
2016-04-01 |
2019-05-28 |
New England Biolabs, Inc. |
Compositions and methods relating to synthetic RNA polynucleotides created from synthetic DNA oligonucleotides
|
|
CN106167525B
(zh)
|
2016-04-01 |
2019-03-19 |
北京康明百奥新药研发有限公司 |
筛选超低岩藻糖细胞系的方法和应用
|
|
KR20180132705A
(ko)
|
2016-04-04 |
2018-12-12 |
에테하 취리히 |
단백질 생산 및 라이브러리(Library) 생성을 위한 포유동물 세포주
|
|
WO2017176529A1
(en)
|
2016-04-06 |
2017-10-12 |
Temple Univesity-Of The Commonwealth System Of Higher Education |
Compositions for eradicating flavivirus infections in subjects
|
|
CN105802980A
(zh)
|
2016-04-08 |
2016-07-27 |
北京大学 |
Gateway兼容性CRISPR/Cas9系统及其应用
|
|
CN106399306B
(zh)
|
2016-04-12 |
2019-11-05 |
西安交通大学第一附属医院 |
靶向人lncRNA-UCA1抑制膀胱癌的sgRNA、基因载体及其应用
|
|
WO2017180915A2
(en)
|
2016-04-13 |
2017-10-19 |
Duke University |
Crispr/cas9-based repressors for silencing gene targets in vivo and methods of use
|
|
WO2017180711A1
(en)
|
2016-04-13 |
2017-10-19 |
Editas Medicine, Inc. |
Grna fusion molecules, gene editing systems, and methods of use thereof
|
|
EP4047092B1
(en)
|
2016-04-13 |
2025-07-30 |
Editas Medicine, Inc. |
Cas9 fusion molecules, gene editing systems, and methods of use thereof
|
|
EP3442596A1
(en)
|
2016-04-14 |
2019-02-20 |
Université de Lausanne |
Treatment and/or prevention of dna-triplet repeat diseases or disorders
|
|
EP3443085B1
(en)
|
2016-04-14 |
2022-09-14 |
BOCO Silicon Valley, Inc. |
Genome editing of human neural stem cells using nucleases
|
|
CN105821116A
(zh)
|
2016-04-15 |
2016-08-03 |
扬州大学 |
一种绵羊mstn基因定向敲除及其影响成肌分化的检测方法
|
|
US12065667B2
(en)
|
2016-04-16 |
2024-08-20 |
Ohio State Innovation Foundation |
Modified Cpf1 MRNA, modified guide RNA, and uses thereof
|
|
WO2017184334A1
(en)
|
2016-04-18 |
2017-10-26 |
The Board Of Regents Of The University Of Texas System |
Generation of genetically engineered animals by crispr/cas9 genome editing in spermatogonial stem cells
|
|
EP3445852A1
(en)
|
2016-04-18 |
2019-02-27 |
Ruprecht-Karls-Universität Heidelberg |
Means and methods for inactivating therapeutic dna in a cell
|
|
KR102424476B1
(ko)
|
2016-04-19 |
2022-07-25 |
더 브로드 인스티튜트, 인코퍼레이티드 |
신규한 crispr 효소 및 시스템
|
|
CN106086062A
(zh)
|
2016-04-19 |
2016-11-09 |
上海市农业科学院 |
一种获得番茄基因组定点敲除突变体的方法
|
|
WO2017189308A1
(en)
|
2016-04-19 |
2017-11-02 |
The Broad Institute Inc. |
Novel crispr enzymes and systems
|
|
US11286478B2
(en)
|
2016-04-19 |
2022-03-29 |
The Broad Institute, Inc. |
Cpf1 complexes with reduced indel activity
|
|
CN105886616B
(zh)
|
2016-04-20 |
2020-08-07 |
广东省农业科学院农业生物基因研究中心 |
一种用于猪基因编辑的高效特异性sgRNA识别位点引导序列及其筛选方法
|
|
CN105821075B
(zh)
|
2016-04-22 |
2017-09-12 |
湖南农业大学 |
一种茶树咖啡因合成酶CRISPR/Cas9基因组编辑载体的构建方法
|
|
CN107304435A
(zh)
|
2016-04-22 |
2017-10-31 |
中国科学院青岛生物能源与过程研究所 |
一种Cas9/RNA系统及其应用
|
|
US11248216B2
(en)
|
2016-04-25 |
2022-02-15 |
The Regents Of The University Of California |
Methods and compositions for genomic editing
|
|
CN105861552B
(zh)
|
2016-04-25 |
2019-10-11 |
西北农林科技大学 |
一种T7 RNA聚合酶介导的CRISPR/Cas9基因编辑系统的构建方法
|
|
CN107326046A
(zh)
|
2016-04-28 |
2017-11-07 |
上海邦耀生物科技有限公司 |
一种提高外源基因同源重组效率的方法
|
|
CN109477109B
(zh)
|
2016-04-29 |
2022-09-23 |
萨勒普塔医疗公司 |
靶向人lmna的寡核苷酸类似物
|
|
US11608499B2
(en)
|
2016-04-29 |
2023-03-21 |
Basf Plant Science Company Gmbh |
Methods for modification of target nucleic acids
|
|
CN105821049B
(zh)
|
2016-04-29 |
2019-06-04 |
中国农业大学 |
一种Fbxo40基因敲除猪的制备方法
|
|
CN105886534A
(zh)
|
2016-04-29 |
2016-08-24 |
苏州溯源精微生物科技有限公司 |
一种抑制肿瘤转移的方法
|
|
SG11201810755TA
(en)
|
2016-05-01 |
2019-01-30 |
Neemo Inc |
Harnessing heterologous and endogenous crispr-cas machineries for efficient markerless genome editing in clostridium
|
|
WO2017192573A1
(en)
|
2016-05-02 |
2017-11-09 |
Massachusetts Institute Of Technology |
Nanoparticle conjugates of highly potent toxins and intraperitoneal administration of nanoparticles for treating or imaging cancer
|
|
CN105950639A
(zh)
|
2016-05-04 |
2016-09-21 |
广州美格生物科技有限公司 |
金黄色葡萄球菌CRISPR/Cas9系统的制备及其在构建小鼠模型中的应用
|
|
EP3452101A2
(en)
|
2016-05-04 |
2019-03-13 |
CureVac AG |
Rna encoding a therapeutic protein
|
|
WO2017191210A1
(en)
|
2016-05-04 |
2017-11-09 |
Novozymes A/S |
Genome editing by crispr-cas9 in filamentous fungal host cells
|
|
CN105907785B
(zh)
|
2016-05-05 |
2020-02-07 |
苏州吉玛基因股份有限公司 |
化学合成的crRNA用于CRISPR/Cpf1系统在基因编辑中的应用
|
|
CN106244591A
(zh)
|
2016-08-23 |
2016-12-21 |
苏州吉玛基因股份有限公司 |
修饰crRNA在CRISPR/Cpf1基因编辑系统中的应用
|
|
WO2017192172A1
(en)
|
2016-05-05 |
2017-11-09 |
Temple University - Of The Commonwealth System Of Higher Education |
Rna guided eradication of varicella zoster virus
|
|
WO2017190664A1
(zh)
|
2016-05-05 |
2017-11-09 |
苏州吉玛基因股份有限公司 |
化学合成的crRNA和修饰crRNA在CRISPR/Cpf1基因编辑系统中的应用
|
|
ES2957660T3
(es)
|
2016-05-05 |
2024-01-23 |
Univ Duke |
Composiciones relacionadas con crispr/cas para tratar la distrofia muscular de duchenne
|
|
CA3022319A1
(en)
|
2016-05-06 |
2017-11-09 |
Tod M. Woolf |
Improved methods for genome editing with and without programmable nucleases
|
|
CN105985985B
(zh)
|
2016-05-06 |
2019-12-31 |
苏州大学 |
Crispr技术编辑并用igf优化的异体间充质干细胞的制备方法及在治疗心梗中应用
|
|
US20190161743A1
(en)
|
2016-05-09 |
2019-05-30 |
President And Fellows Of Harvard College |
Self-Targeting Guide RNAs in CRISPR System
|
|
JP2019519250A
(ja)
|
2016-05-10 |
2019-07-11 |
ユナイテッド ステイツ ガバメント アズ リプレゼンテッド バイ ザ デパートメント オブ ベテランズ アフェアーズUnited States Government As Represented By The Department Of Veterans Affairs |
Hiv−1感染と複製に必須な遺伝子を切断するcrispr/casの構築物のレンチウィルスによる送達
|
|
CN105861554B
(zh)
|
2016-05-10 |
2020-01-31 |
华南农业大学 |
一种基于对Rbmy基因进行编辑来实现动物性别控制的方法和应用
|
|
CN107365786A
(zh)
|
2016-05-12 |
2017-11-21 |
中国科学院微生物研究所 |
一种将spacer序列克隆至CRISPR-Cas9系统中的方法及其应用
|
|
US20190345483A1
(en)
|
2016-05-12 |
2019-11-14 |
President And Fellows Of Harvard College |
AAV Split Cas9 Genome Editing and Transcriptional Regulation
|
|
US20200325483A1
(en)
|
2016-05-12 |
2020-10-15 |
Brian P. Hanley |
Safe delivery of crispr and other gene therapies to large fractions of somatic cells in humans and animals
|
|
KR101922989B1
(ko)
|
2016-05-13 |
2018-11-28 |
연세대학교 산학협력단 |
CRISPR/Retron 시스템을 이용한 유전체상의 치환 변이 생성과 추적 방법
|
|
CN106011171B
(zh)
|
2016-05-18 |
2019-10-11 |
西北农林科技大学 |
一种利用CRISPR/Cas9技术基于SSA修复的基因无缝编辑方法
|
|
CN105838733A
(zh)
|
2016-05-18 |
2016-08-10 |
云南省农业科学院花卉研究所 |
Cas9 介导的香石竹基因编辑载体和应用
|
|
CN105907758B
(zh)
|
2016-05-18 |
2020-06-05 |
世翱(上海)生物医药科技有限公司 |
CRISPR-Cas9引导序列及其引物、转基因表达载体及其构建方法
|
|
WO2017201476A1
(en)
|
2016-05-20 |
2017-11-23 |
Regeneron Pharmaceuticals, Inc. |
Methods for breaking immunological tolerance using multiple guide rnas
|
|
CN106446600B
(zh)
|
2016-05-20 |
2019-10-18 |
同济大学 |
一种基于CRISPR/Cas9的sgRNA的设计方法
|
|
US20190201551A1
(en)
|
2016-05-23 |
2019-07-04 |
Washington University |
Pulmonary targeted cas9/crispr for in vivo editing of disease genes
|
|
US20190300867A1
(en)
|
2016-05-23 |
2019-10-03 |
The Trustees Of Columbia University In The City Of New York |
Bypassing the pam requirement of the crispr-cas system
|
|
CN105950560B
(zh)
|
2016-05-24 |
2019-07-23 |
苏州系统医学研究所 |
人源化pd-l1肿瘤细胞系及具有该细胞系的动物模型与应用
|
|
CN106011167B
(zh)
|
2016-05-27 |
2019-11-01 |
上海交通大学 |
雄性不育基因OsDPW2的应用及水稻育性恢复的方法
|
|
WO2017207589A1
(en)
|
2016-06-01 |
2017-12-07 |
Kws Saat Se |
Hybrid nucleic acid sequences for genome engineering
|
|
US20190100732A1
(en)
|
2016-06-02 |
2019-04-04 |
Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. |
Assay for the removal of methyl-cytosine residues from dna
|
|
CA3026321C
(en)
|
2016-06-02 |
2023-10-03 |
Sigma-Aldrich Co. Llc |
Using programmable dna binding proteins to enhance targeted genome modification
|
|
EP3463290A4
(en)
|
2016-06-03 |
2019-10-30 |
Temple University - Of The Commonwealth System of Higher Education |
REGULATION OF THE NEGATIVE RECONSTITUTION OF HIV-1 BY GENETIZATION STRATEGY
|
|
US11140883B2
(en)
|
2016-06-03 |
2021-10-12 |
Auburn University |
Gene editing of reproductive hormones to sterilize aquatic animals
|
|
CN106119275A
(zh)
|
2016-06-07 |
2016-11-16 |
湖北大学 |
基于CRISPR/Cas9技术将非糯性水稻株系改造成糯性株系的打靶载体和方法
|
|
US20190256844A1
(en)
|
2016-06-07 |
2019-08-22 |
Temple University - Of The Commonwealth System Of Higher Education |
Rna guided compositions for preventing and treating hepatitis b virus infections
|
|
US10767175B2
(en)
|
2016-06-08 |
2020-09-08 |
Agilent Technologies, Inc. |
High specificity genome editing using chemically modified guide RNAs
|
|
CN106086008B
(zh)
|
2016-06-10 |
2019-03-12 |
中国农业科学院植物保护研究所 |
烟粉虱MED隐种TRP基因的CRISPR/cas9系统及其应用
|
|
US11779657B2
(en)
|
2016-06-10 |
2023-10-10 |
City Of Hope |
Compositions and methods for mitochondrial genome editing
|
|
AU2017286122A1
(en)
|
2016-06-14 |
2018-11-22 |
Pioneer Hi-Bred International, Inc. |
Use of Cpf1 endonuclease for plant genome modifications
|
|
CN106434752A
(zh)
|
2016-06-14 |
2017-02-22 |
南通大学附属医院 |
敲除Wnt3a基因的过程及其验证方法
|
|
CN106167821A
(zh)
|
2016-06-16 |
2016-11-30 |
郑州大学 |
一种金黄色葡萄球菌crispr位点检测试剂盒及检测方法
|
|
CN105950633B
(zh)
|
2016-06-16 |
2019-05-03 |
复旦大学 |
基因OsARF4在控制水稻粒长和千粒重中的应用
|
|
CN106167808A
(zh)
|
2016-06-16 |
2016-11-30 |
郑州大学 |
一种基于CRISPR/Cas9技术消除mecA质粒的方法
|
|
WO2017219033A1
(en)
|
2016-06-17 |
2017-12-21 |
Montana State University |
Bidirectional targeting for genome editing
|
|
WO2017216771A2
(en)
|
2016-06-17 |
2017-12-21 |
Genesis Technologies Limited |
Crispr-cas system, materials and methods
|
|
JP7267013B2
(ja)
|
2016-06-17 |
2023-05-01 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
Vi型crisprオルソログ及び系
|
|
CN105950626B
(zh)
|
2016-06-17 |
2018-09-28 |
新疆畜牧科学院生物技术研究所 |
基于CRISPR/Cas9获得不同毛色绵羊的方法及靶向ASIP基因的sgRNA
|
|
IL263595B2
(en)
|
2016-06-20 |
2023-11-01 |
Keygene Nv |
A method for targeted modification of DNA in plant cells
|
|
WO2017223107A1
(en)
|
2016-06-20 |
2017-12-28 |
Unity Biotechnology, Inc. |
Genome modifying enzyme therapy for diseases modulated by senescent cells
|
|
US20170362635A1
(en)
|
2016-06-20 |
2017-12-21 |
University Of Washington |
Muscle-specific crispr/cas9 editing of genes
|
|
CA3018430A1
(en)
|
2016-06-20 |
2017-12-28 |
Pioneer Hi-Bred International, Inc. |
Novel cas systems and methods of use
|
|
CN106148370A
(zh)
|
2016-06-21 |
2016-11-23 |
苏州瑞奇生物医药科技有限公司 |
肥胖症大鼠动物模型和构建方法
|
|
EP3475416A4
(en)
|
2016-06-22 |
2020-04-29 |
Icahn School of Medicine at Mount Sinai |
VIRAL DELIVERY OF RNA USING SELF-CLeavING RIBOZYMES AND CRISPR-BASED APPLICATIONS
|
|
WO2017220751A1
(en)
|
2016-06-22 |
2017-12-28 |
Proqr Therapeutics Ii B.V. |
Single-stranded rna-editing oligonucleotides
|
|
CN106119283A
(zh)
|
2016-06-24 |
2016-11-16 |
广西壮族自治区水牛研究所 |
一种利用CRISPR‑Cas9靶向敲除MSTN基因的方法
|
|
CN105925608A
(zh)
|
2016-06-24 |
2016-09-07 |
广西壮族自治区水牛研究所 |
一种利用CRISPR-Cas9靶向敲除ALK6基因的方法
|
|
CN106047877B
(zh)
|
2016-06-24 |
2019-01-11 |
中山大学附属第一医院 |
一种靶向敲除FTO基因的sgRNA及CRISPR/Cas9慢病毒系统与应用
|
|
CN106148286B
(zh)
|
2016-06-29 |
2019-10-29 |
牛刚 |
一种用于检测热原的细胞模型的构建方法和细胞模型及热原检测试剂盒
|
|
WO2018005691A1
(en)
|
2016-06-29 |
2018-01-04 |
The Regents Of The University Of California |
Efficient genetic screening method
|
|
EP3478840A1
(en)
|
2016-06-29 |
2019-05-08 |
Crispr Therapeutics AG |
Compositions and methods for gene editing
|
|
US20210222164A1
(en)
|
2016-06-29 |
2021-07-22 |
The Broad Institute, Inc. |
Crispr-cas systems having destabilization domain
|
|
US10927383B2
(en)
|
2016-06-30 |
2021-02-23 |
Ethris Gmbh |
Cas9 mRNAs
|
|
US20180004537A1
(en)
|
2016-07-01 |
2018-01-04 |
Microsoft Technology Licensing, Llc |
Molecular State Machines
|
|
US10892034B2
(en)
|
2016-07-01 |
2021-01-12 |
Microsoft Technology Licensing, Llc |
Use of homology direct repair to record timing of a molecular event
|
|
US10669558B2
(en)
|
2016-07-01 |
2020-06-02 |
Microsoft Technology Licensing, Llc |
Storage through iterative DNA editing
|
|
MX2019000262A
(es)
|
2016-07-05 |
2019-05-27 |
Univ Johns Hopkins |
Composiciones basadas en crispr/cas9 y metodos para el tratamiento de degeneraciones retinianas.
|
|
CN109312353A
(zh)
|
2016-07-06 |
2019-02-05 |
诺维信公司 |
通过crispr-抑制来改善微生物
|
|
CN106191057B
(zh)
|
2016-07-06 |
2018-12-25 |
中山大学 |
一种用于敲除人CYP2E1基因的sgRNA序列、CYP2E1基因缺失细胞株的构建方法及其应用
|
|
CN106051058A
(zh)
|
2016-07-07 |
2016-10-26 |
上海格昆机电科技有限公司 |
用于航天贮箱和粒子治疗仪的旋转机架及其传动机构
|
|
CN107586777A
(zh)
|
2016-07-08 |
2018-01-16 |
上海吉倍生物技术有限公司 |
人PDCD1基因sgRNA的用途及其相关药物
|
|
WO2018009822A1
(en)
|
2016-07-08 |
2018-01-11 |
Ohio State Innovation Foundation |
Modified nucleic acids, hybrid guide rnas, and uses thereof
|
|
CN106047930B
(zh)
|
2016-07-12 |
2020-05-19 |
北京百奥赛图基因生物技术有限公司 |
一种PS1基因条件性敲除flox大鼠的制备方法
|
|
JP2019520069A
(ja)
|
2016-07-13 |
2019-07-18 |
ディーエスエム アイピー アセッツ ビー.ブイ.Dsm Ip Assets B.V. |
藻類宿主細胞用のcrispr−casシステム
|
|
US11674158B2
(en)
|
2016-07-15 |
2023-06-13 |
Salk Institute For Biological Studies |
Methods and compositions for genome editing in non-dividing cells
|
|
US20190330659A1
(en)
|
2016-07-15 |
2019-10-31 |
Zymergen Inc. |
Scarless dna assembly and genome editing using crispr/cpf1 and dna ligase
|
|
CN106191062B
(zh)
|
2016-07-18 |
2019-06-14 |
广东华南疫苗股份有限公司 |
一种tcr-/pd-1-双阴性t细胞及其构建方法
|
|
CN106191061B
(zh)
|
2016-07-18 |
2019-06-18 |
暨南大学 |
一种特异靶向人ABCG2基因的sgRNA导向序列及其应用
|
|
CN106190903B
(zh)
|
2016-07-18 |
2019-04-02 |
华中农业大学 |
鸭疫里氏杆菌Cas9基因缺失突变株及其应用
|
|
CN106434651B
(zh)
|
2016-07-19 |
2021-05-18 |
广西大学 |
根癌农杆菌和CRISPR-Cas9介导的基因定点插入失活方法及其应用
|
|
EP3487523B1
(en)
|
2016-07-19 |
2023-09-06 |
Duke University |
Therapeutic applications of cpf1-based genome editing
|
|
JP2019520844A
(ja)
|
2016-07-21 |
2019-07-25 |
マックスサイト インコーポレーティッド |
ゲノムdnaを改変するための方法および組成物
|
|
CN106191064B
(zh)
|
2016-07-22 |
2019-06-07 |
中国农业大学 |
一种制备mc4r基因敲除猪的方法
|
|
WO2018015444A1
(en)
|
2016-07-22 |
2018-01-25 |
Novozymes A/S |
Crispr-cas9 genome editing with multiple guide rnas in filamentous fungi
|
|
CN106191107B
(zh)
|
2016-07-22 |
2020-03-20 |
湖南农业大学 |
一种降低水稻籽粒落粒性的分子改良方法
|
|
EP3488001A1
(en)
|
2016-07-25 |
2019-05-29 |
Mayo Foundation for Medical Education and Research |
Treating cancer
|
|
EP3491133A4
(en)
|
2016-07-26 |
2020-05-06 |
The General Hospital Corporation |
VARIANTS OF CRISPR OF PREVOTELLA AND FRANCISELLA 1 (CPF1)
|
|
CN106222193B
(zh)
|
2016-07-26 |
2019-09-20 |
浙江大学 |
一种重组载体及无转基因基因编辑植株的筛选方法
|
|
WO2018018979A1
(zh)
|
2016-07-26 |
2018-02-01 |
浙江大学 |
植物重组载体及无转基因成分的基因编辑植株的筛选方法
|
|
CN106191099A
(zh)
|
2016-07-27 |
2016-12-07 |
苏州泓迅生物科技有限公司 |
一种基于CRISPR‑Cas9系统的酿酒酵母基因组并行多重编辑载体及其应用
|
|
CN106086061A
(zh)
|
2016-07-27 |
2016-11-09 |
苏州泓迅生物科技有限公司 |
一种基于CRISPR‑Cas9系统的酿酒酵母基因组编辑载体及其应用
|
|
CN106191124B
(zh)
|
2016-07-29 |
2019-10-11 |
中国科学院重庆绿色智能技术研究院 |
一种利用鱼卵保存液提高CRISPR-Cas9基因编辑和传代效率的鱼类育种方法
|
|
CN106434748A
(zh)
|
2016-07-29 |
2017-02-22 |
中国科学院重庆绿色智能技术研究院 |
一种热激诱导型 Cas9 酶转基因斑马鱼的研制及应用
|
|
CN106191113B
(zh)
|
2016-07-29 |
2020-01-14 |
中国农业大学 |
一种mc3r基因敲除猪的制备方法
|
|
CN106191114B
(zh)
|
2016-07-29 |
2020-02-11 |
中国科学院重庆绿色智能技术研究院 |
利用CRISPR-Cas9系统敲除鱼类MC4R基因的育种方法
|
|
GB201613135D0
(en)
|
2016-07-29 |
2016-09-14 |
Medical Res Council |
Genome editing
|
|
CN106434688A
(zh)
|
2016-08-01 |
2017-02-22 |
云南纳博生物科技有限公司 |
一种水稻直立密穗dep1基因人工定点突变体及其应用
|
|
WO2018026723A1
(en)
|
2016-08-01 |
2018-02-08 |
University Of Pittsburgh - Of The Commonwealth System Of Higher Education |
Human induced pluripotent stem cells for high efficiency genetic engineering
|
|
CN106011150A
(zh)
|
2016-08-01 |
2016-10-12 |
云南纳博生物科技有限公司 |
一种水稻穗粒数Gn1a基因人工定点突变体及其应用
|
|
WO2018025206A1
(en)
|
2016-08-02 |
2018-02-08 |
Kyoto University |
Method for genome editing
|
|
WO2018026976A1
(en)
|
2016-08-02 |
2018-02-08 |
Editas Medicine, Inc. |
Compositions and methods for treating cep290 associated disease
|
|
KR20250103795A
(ko)
|
2016-08-03 |
2025-07-07 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
아데노신 핵염기 편집제 및 그의 용도
|
|
CN106282241A
(zh)
|
2016-08-05 |
2017-01-04 |
无锡市第二人民医院 |
通过CRISPR/Cas9得到敲除bmp2a基因的斑马鱼的方法
|
|
CN109804066A
(zh)
|
2016-08-09 |
2019-05-24 |
哈佛大学的校长及成员们 |
可编程cas9-重组酶融合蛋白及其用途
|
|
KR101710026B1
(ko)
|
2016-08-10 |
2017-02-27 |
주식회사 무진메디 |
Cas9 단백질 및 가이드 RNA의 혼성체를 함유하는 나노 리포좀 전달체 조성물
|
|
CN106222203A
(zh)
|
2016-08-10 |
2016-12-14 |
云南纳博生物科技有限公司 |
利用CRISPR/Cas技术获得家蚕丝素重链基因突变体及突变方法和应用
|
|
CN106172238B
(zh)
|
2016-08-12 |
2019-01-22 |
中南大学 |
miR-124基因敲除小鼠动物模型的构建方法和应用
|
|
CN106222177B
(zh)
|
2016-08-13 |
2018-06-26 |
江苏集萃药康生物科技有限公司 |
一种靶向人STAT6的CRISPR-Cas9系统及其用于治疗过敏性疾病的应用
|
|
US20210000091A1
(en)
|
2016-08-17 |
2021-01-07 |
The Regents Of The University Of California |
Split Trans-Complementing Gene-Drive System for Suppressing Aedes Aegypti Mosquitos
|
|
US12431216B2
(en)
|
2016-08-17 |
2025-09-30 |
Broad Institute, Inc. |
Methods for identifying class 2 crispr-cas systems
|
|
US11810649B2
(en)
|
2016-08-17 |
2023-11-07 |
The Broad Institute, Inc. |
Methods for identifying novel gene editing elements
|
|
IL264872B2
(en)
|
2016-08-18 |
2025-02-01 |
Univ California |
CRISPR-CAS genome engineering using a modular AAV delivery system
|
|
WO2018035423A1
(en)
|
2016-08-19 |
2018-02-22 |
Bluebird Bio, Inc. |
Genome editing enhancers
|
|
US20190185850A1
(en)
|
2016-08-20 |
2019-06-20 |
Avellino Lab Usa, Inc. |
Single guide rna/crispr/cas9 systems, and methods of use thereof
|
|
CN106191116B
(zh)
|
2016-08-22 |
2019-10-08 |
西北农林科技大学 |
基于CRISPR/Cas9的外源基因敲入整合系统及其建立方法和应用
|
|
CN106191071B
(zh)
|
2016-08-22 |
2018-09-04 |
广州资生生物科技有限公司 |
一种CRISPR-Cas9系统及其用于治疗乳腺癌疾病的应用
|
|
CN106086028B
(zh)
|
2016-08-23 |
2019-04-23 |
中国农业科学院作物科学研究所 |
一种通过基因组编辑提高水稻抗性淀粉含量的方法及其专用sgRNA
|
|
CN106244555A
(zh)
|
2016-08-23 |
2016-12-21 |
广州医科大学附属第三医院 |
一种提高基因打靶的效率的方法及β‑球蛋白基因位点的碱基原位修复方法
|
|
US10975393B2
(en)
|
2016-08-24 |
2021-04-13 |
Sangamo Therapeutics, Inc. |
Engineered target specific nucleases
|
|
SG11201901531TA
(en)
|
2016-08-24 |
2019-03-28 |
Sangamo Therapeutics Inc |
Regulation of gene expression using engineered nucleases
|
|
KR101856345B1
(ko)
|
2016-08-24 |
2018-06-20 |
경상대학교산학협력단 |
CRISPR/Cas9 시스템을 이용하여 APOBEC3H 및 APOBEC3CH 이중-넉아웃 고양이를 제조하는 방법
|
|
CN106244609A
(zh)
|
2016-08-24 |
2016-12-21 |
浙江理工大学 |
一种调节pi3k‑akt信号通路的非编码基因的筛选系统及筛选方法
|
|
US11542509B2
(en)
|
2016-08-24 |
2023-01-03 |
President And Fellows Of Harvard College |
Incorporation of unnatural amino acids into proteins using base editing
|
|
CN106109417A
(zh)
|
2016-08-24 |
2016-11-16 |
李因传 |
一种肝细胞膜仿生脂质体药物载体、制作方法及其应用
|
|
CN106544357B
(zh)
|
2016-08-25 |
2018-08-21 |
湖南杂交水稻研究中心 |
一种培育镉低积累籼稻品种的方法
|
|
CN106318973B
(zh)
|
2016-08-26 |
2019-09-13 |
深圳市第二人民医院 |
一种基于CRISPR-Cas9的基因调控装置及基因调控方法
|
|
CN107784200B
(zh)
|
2016-08-26 |
2020-11-06 |
深圳华大生命科学研究院 |
一种筛选新型CRISPR-Cas系统的方法和装置
|
|
CN106350540A
(zh)
|
2016-08-26 |
2017-01-25 |
苏州系统医学研究所 |
一种由慢病毒介导的高效可诱导型CRISPR/Cas9基因敲除载体及其应用
|
|
CN106399375A
(zh)
|
2016-08-31 |
2017-02-15 |
南京凯地生物科技有限公司 |
利用CRISPR/Cas9敲除人PD‑1基因构建靶向CD19CAR‑T细胞的方法
|
|
CN106399367A
(zh)
|
2016-08-31 |
2017-02-15 |
深圳市卫光生物制品股份有限公司 |
提高crispr介导的同源重组效率的方法
|
|
CN106480097A
(zh)
|
2016-10-13 |
2017-03-08 |
南京凯地生物科技有限公司 |
利用CRISPR/Cas9技术敲除人PD‑1基因构建可靶向MSLN新型CAR‑T细胞的方法及其应用
|
|
CN107794272B
(zh)
|
2016-09-06 |
2021-10-12 |
中国科学院上海营养与健康研究所 |
一种高特异性的crispr基因组编辑体系
|
|
US20180105806A1
(en)
|
2016-09-07 |
2018-04-19 |
Massachusetts Institute Of Technology |
Method for rna-guided endonuclease-based dna assembly
|
|
CN106367435B
(zh)
|
2016-09-07 |
2019-11-08 |
电子科技大学 |
一种水稻miRNA定向敲除的方法
|
|
CN106399311A
(zh)
|
2016-09-07 |
2017-02-15 |
同济大学 |
用于Chip‑seq全基因组结合谱的内源蛋白标记的方法
|
|
WO2018049075A1
(en)
|
2016-09-07 |
2018-03-15 |
Flagship Pioneering, Inc. |
Methods and compositions for modulating gene expression
|
|
CN106399377A
(zh)
|
2016-09-07 |
2017-02-15 |
同济大学 |
一种基于CRISPR/Cas9高通量技术筛选药物靶点基因的方法
|
|
WO2018049168A1
(en)
|
2016-09-09 |
2018-03-15 |
The Board Of Trustees Of The Leland Stanford Junior University |
High-throughput precision genome editing
|
|
CN107574179B
(zh)
|
2016-09-09 |
2018-07-10 |
康码(上海)生物科技有限公司 |
一种为克鲁维酵母优化的CRISPR/Cas9高效基因编辑系统
|
|
WO2018051347A1
(en)
|
2016-09-14 |
2018-03-22 |
Yeda Research And Development Co. Ltd. |
Crisp-seq, an integrated method for massively parallel single cell rna-seq and crispr pooled screens
|
|
CN106318934B
(zh)
|
2016-09-21 |
2020-06-05 |
上海交通大学 |
胡萝卜β(1,2)木糖转移酶的基因全序列及用于转染双子叶植物的CRISPR/CAS9的质粒构建
|
|
US20180127786A1
(en)
|
2016-09-23 |
2018-05-10 |
Casebia Therapeutics Limited Liability Partnership |
Compositions and methods for gene editing
|
|
EP3516056B1
(en)
|
2016-09-23 |
2024-11-27 |
DSM IP Assets B.V. |
A guide-rna expression system for a host cell
|
|
CN106957858A
(zh)
|
2016-09-23 |
2017-07-18 |
西北农林科技大学 |
一种利用CRISPR/Cas9系统共同敲除绵羊MSTN、ASIP、BCO2基因的方法
|
|
US9580698B1
(en)
|
2016-09-23 |
2017-02-28 |
New England Biolabs, Inc. |
Mutant reverse transcriptase
|
|
US11319546B2
(en)
|
2016-09-28 |
2022-05-03 |
Cellivery Therapeutics, Inc. |
Cell-permeable (CP)-Cas9 recombinant protein and uses thereof
|
|
CN110023494A
(zh)
|
2016-09-30 |
2019-07-16 |
加利福尼亚大学董事会 |
Rna指导的核酸修饰酶及其使用方法
|
|
JP7306696B2
(ja)
|
2016-09-30 |
2023-07-11 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
Rna誘導型核酸修飾酵素及びその使用方法
|
|
CN106480027A
(zh)
|
2016-09-30 |
2017-03-08 |
重庆高圣生物医药有限责任公司 |
CRISPR/Cas9 靶向敲除人PD‑1基因及其特异性gRNA
|
|
WO2018064516A1
(en)
|
2016-09-30 |
2018-04-05 |
Monsanto Technology Llc |
Method for selecting target sites for site-specific genome modification in plants
|
|
CN107880132B
(zh)
|
2016-09-30 |
2022-06-17 |
北京大学 |
一种融合蛋白及使用其进行同源重组的方法
|
|
CN107881184B
(zh)
|
2016-09-30 |
2021-08-27 |
中国科学院分子植物科学卓越创新中心 |
一种基于Cpf1的DNA体外拼接方法
|
|
EP3518981A4
(en)
|
2016-10-03 |
2020-06-10 |
President and Fellows of Harvard College |
THERAPEUTIC RNA DELIVERY THROUGH ARRDC1 MICROVESICLES
|
|
WO2018067846A1
(en)
|
2016-10-05 |
2018-04-12 |
President And Fellows Of Harvard College |
Methods of crispr mediated genome modulation in v. natriegens
|
|
US10669539B2
(en)
|
2016-10-06 |
2020-06-02 |
Pioneer Biolabs, Llc |
Methods and compositions for generating CRISPR guide RNA libraries
|
|
CA3039409A1
(en)
|
2016-10-07 |
2018-04-12 |
Integrated Dna Technologies, Inc. |
S. pyogenes cas9 mutant genes and polypeptides encoded by same
|
|
CN106479985A
(zh)
|
2016-10-09 |
2017-03-08 |
上海吉玛制药技术有限公司 |
病毒介导的Cpf1蛋白在CRISPR/Cpf1基因编辑系统中的应用
|
|
IT201600102542A1
(it)
|
2016-10-12 |
2018-04-12 |
Univ Degli Studi Di Trento |
Plasmide e sistema lentivirale contenente un circuito autolimitante della Cas9 che ne incrementa la sicurezza.
|
|
CN106434663A
(zh)
|
2016-10-12 |
2017-02-22 |
遵义医学院 |
CRISPR/Cas9靶向敲除人ezrin基因增强子关键区的方法及其特异性gRNA
|
|
US20190365862A1
(en)
|
2016-10-12 |
2019-12-05 |
Temple University - Of The Commonwealth System Of Higher Education |
Combination therapies for eradicating flavivirus infections in subjects
|
|
KR20240064734A
(ko)
|
2016-10-14 |
2024-05-13 |
더 제너럴 하스피탈 코포레이션 |
후성적으로 조절되는 부위-특이적 뉴클레아제
|
|
AU2017342543B2
(en)
|
2016-10-14 |
2024-06-27 |
President And Fellows Of Harvard College |
AAV delivery of nucleobase editors
|
|
CN106434782B
(zh)
|
2016-10-14 |
2020-01-10 |
南京工业大学 |
一种产顺式-4-羟脯氨酸的方法
|
|
US20190330620A1
(en)
|
2016-10-14 |
2019-10-31 |
Emendobio Inc. |
Rna compositions for genome editing
|
|
SG10201913505WA
(en)
|
2016-10-17 |
2020-02-27 |
Univ Nanyang Tech |
Truncated crispr-cas proteins for dna targeting
|
|
US10640810B2
(en)
|
2016-10-19 |
2020-05-05 |
Drexel University |
Methods of specifically labeling nucleic acids using CRISPR/Cas
|
|
WO2018081504A1
(en)
|
2016-10-28 |
2018-05-03 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating herpes simplex virus
|
|
US20180127759A1
(en)
|
2016-10-28 |
2018-05-10 |
Massachusetts Institute Of Technology |
Dynamic genome engineering
|
|
US20180119141A1
(en)
|
2016-10-28 |
2018-05-03 |
Massachusetts Institute Of Technology |
Crispr/cas global regulator screening platform
|
|
WO2018079134A1
(ja)
|
2016-10-31 |
2018-05-03 |
株式会社江口高周波 |
リアクトル
|
|
WO2018081728A1
(en)
|
2016-10-31 |
2018-05-03 |
Emendobio Inc. |
Compositions for genome editing
|
|
WO2018085288A1
(en)
|
2016-11-01 |
2018-05-11 |
President And Fellows Of Harvard College |
Inhibitors of rna guided nucleases and uses thereof
|
|
WO2018083606A1
(en)
|
2016-11-01 |
2018-05-11 |
Novartis Ag |
Methods and compositions for enhancing gene editing
|
|
GB201618507D0
(en)
|
2016-11-02 |
2016-12-14 |
Stichting Voor De Technische Wetenschappen And Wageningen Univ |
Microbial genome editing
|
|
WO2018085414A1
(en)
|
2016-11-02 |
2018-05-11 |
President And Fellows Of Harvard College |
Engineered guide rna sequences for in situ detection and sequencing
|
|
CN106544353A
(zh)
|
2016-11-08 |
2017-03-29 |
宁夏医科大学总医院 |
一种利用CRISPR‑Cas9清除鲍曼不动杆菌耐药性基因的方法
|
|
CN106755088A
(zh)
|
2016-11-11 |
2017-05-31 |
广东万海细胞生物科技有限公司 |
一种自体car‑t细胞制备方法及应用
|
|
WO2018089664A1
(en)
|
2016-11-11 |
2018-05-17 |
The Regents Of The University Of California |
Variant rna-guided polypeptides and methods of use
|
|
CN106566838B
(zh)
|
2016-11-14 |
2019-11-01 |
上海伯豪生物技术有限公司 |
一种基于CRISPR-Cas9技术的miR-126全长基因敲除试剂盒及其应用
|
|
EP3538661A4
(en)
|
2016-11-14 |
2020-04-15 |
Institute Of Genetics And Developmental Biology, Chinese Academy Of Sciences |
METHOD FOR BASIC PROCESSING IN PLANTS
|
|
CN106554969A
(zh)
|
2016-11-15 |
2017-04-05 |
陕西理工学院 |
基于抑菌杀菌的多靶点CRISPR/Cas9表达载体
|
|
US11485760B2
(en)
|
2016-11-16 |
2022-11-01 |
The Regents Of The University Of California |
Inhibitors of CRISPR-Cas9
|
|
CN106754912B
(zh)
|
2016-11-16 |
2019-11-08 |
上海交通大学 |
一类定向清除肝细胞中HBVcccDNA的质粒及制剂
|
|
US20180282722A1
(en)
|
2016-11-21 |
2018-10-04 |
Massachusetts Institute Of Technology |
Chimeric DNA:RNA Guide for High Accuracy Cas9 Genome Editing
|
|
CN106480067A
(zh)
|
2016-11-21 |
2017-03-08 |
中国农业科学院烟草研究所 |
烟草NtNAC096基因控制烟草衰老的应用
|
|
JP2019535287A
(ja)
|
2016-11-22 |
2019-12-12 |
インテグレイテツド・デイー・エヌ・エイ・テクノロジーズ・インコーポレイテツド |
Crispr/cpf1システム及び方法
|
|
CA3044531A1
(en)
|
2016-11-28 |
2018-05-31 |
The Board Of Regents Of The University Of Texas System |
Prevention of muscular dystrophy by crispr/cpf1-mediated gene editing
|
|
CN106755091A
(zh)
|
2016-11-28 |
2017-05-31 |
中国人民解放军第三军医大学第附属医院 |
基因敲除载体,mh7a细胞nlrp1基因敲除方法
|
|
CN106480036B
(zh)
|
2016-11-30 |
2019-04-09 |
华南理工大学 |
一种具有启动子功能的dna片段及其应用
|
|
US20200056206A1
(en)
|
2016-12-01 |
2020-02-20 |
UNIVERSITé LAVAL |
Crispr-based treatment of friedreich ataxia
|
|
CN107043779B
(zh)
|
2016-12-01 |
2020-05-12 |
中国农业科学院作物科学研究所 |
一种CRISPR/nCas9介导的定点碱基替换在植物中的应用
|
|
CN106834323A
(zh)
|
2016-12-01 |
2017-06-13 |
安徽大学 |
一种基于维吉尼亚链霉菌IBL14基因cas7‑5‑3的基因编辑方法
|
|
US9816093B1
(en)
|
2016-12-06 |
2017-11-14 |
Caribou Biosciences, Inc. |
Engineered nucleic acid-targeting nucleic acids
|
|
CN106701830B
(zh)
|
2016-12-07 |
2020-01-03 |
湖南人文科技学院 |
一种敲除猪胚胎p66shc基因的方法
|
|
WO2018103686A1
(zh)
|
2016-12-07 |
2018-06-14 |
中国科学院上海生命科学研究院 |
叶绿体基因组编辑方法
|
|
CN106544351B
(zh)
|
2016-12-08 |
2019-09-10 |
江苏省农业科学院 |
CRISPR-Cas9体外敲除耐药基因mcr-1的方法及其专用细胞穿透肽
|
|
US11192929B2
(en)
|
2016-12-08 |
2021-12-07 |
Regents Of The University Of Minnesota |
Site-specific DNA base editing using modified APOBEC enzymes
|
|
CN110291198B
(zh)
|
2016-12-08 |
2024-11-26 |
因特利亚治疗公司 |
经修饰的指导rna
|
|
JP7228514B2
(ja)
|
2016-12-09 |
2023-02-24 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
Crisprエフェクターシステムベースの診断法
|
|
WO2018107103A1
(en)
|
2016-12-09 |
2018-06-14 |
The Broad Institute, Inc. |
Crispr-systems for modifying a trait of interest in a plant
|
|
WO2018111947A1
(en)
|
2016-12-12 |
2018-06-21 |
Integrated Dna Technologies, Inc. |
Genome editing enhancement
|
|
WO2018111946A1
(en)
|
2016-12-12 |
2018-06-21 |
Integrated Dna Technologies, Inc. |
Genome editing detection
|
|
CN107893074A
(zh)
|
2016-12-13 |
2018-04-10 |
广东赤萌医疗科技有限公司 |
一种用于敲除CXCR4基因的gRNA、表达载体、敲除系统、试剂盒
|
|
CA3046824A1
(en)
|
2016-12-14 |
2018-06-21 |
Wageningen Universiteit |
Thermostable cas9 nucleases
|
|
WO2018109101A1
(en)
|
2016-12-14 |
2018-06-21 |
Wageningen Universiteit |
Thermostable cas9 nucleases
|
|
KR101748575B1
(ko)
|
2016-12-16 |
2017-06-20 |
주식회사 엠젠플러스 |
Ins 유전자 녹아웃 당뇨병 또는 당뇨병 합병증 동물모델 및 이의 제조방법
|
|
WO2018112336A1
(en)
|
2016-12-16 |
2018-06-21 |
Ohio State Innovation Foundation |
Systems and methods for dna-guided rna cleavage
|
|
CN106755026A
(zh)
|
2016-12-18 |
2017-05-31 |
吉林大学 |
sgRNA表达载体的构建及牙釉质钙化不全模型的建立
|
|
WO2018112446A2
(en)
|
2016-12-18 |
2018-06-21 |
Selonterra, Inc. |
Use of apoe4 motif-mediated genes for diagnosis and treatment of alzheimer's disease
|
|
GB2572918B
(en)
|
2016-12-23 |
2023-02-15 |
Harvard College |
Gene editing of PCSK9
|
|
WO2018119359A1
(en)
|
2016-12-23 |
2018-06-28 |
President And Fellows Of Harvard College |
Editing of ccr5 receptor gene to protect against hiv infection
|
|
CN107354173A
(zh)
|
2016-12-26 |
2017-11-17 |
浙江省医学科学院 |
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|
|
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(zh)
|
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郑州大学 |
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|
|
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(zh)
|
2016-12-27 |
2017-06-13 |
安徽省农业科学院畜牧兽医研究所 |
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|
|
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(zh)
|
2016-12-27 |
2017-05-31 |
安徽省农业科学院畜牧兽医研究所 |
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|
|
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(zh)
|
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2020-04-03 |
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|
|
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(zh)
|
2016-12-30 |
2017-06-20 |
重庆高圣生物医药有限责任公司 |
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|
|
CN106755077A
(zh)
|
2016-12-30 |
2017-05-31 |
华智水稻生物技术有限公司 |
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|
|
CN106701763B
(zh)
|
2016-12-30 |
2019-07-19 |
重庆高圣生物医药有限责任公司 |
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|
|
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(zh)
|
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|
|
CN106701818B
(zh)
|
2017-01-09 |
2020-04-24 |
湖南杂交水稻研究中心 |
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|
|
CN107012164B
(zh)
|
2017-01-11 |
2023-03-03 |
电子科技大学 |
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|
|
EP3568476A1
(en)
|
2017-01-11 |
2019-11-20 |
Oxford University Innovation Limited |
Crispr rna
|
|
US20180258418A1
(en)
|
2017-01-17 |
2018-09-13 |
Institute For Basic Science |
Method of identifying genome-wide off-target sites of base editors by detecting single strand breaks in genomic dna
|
|
CN107058372A
(zh)
|
2017-01-18 |
2017-08-18 |
四川农业大学 |
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|
|
JP2020513783A
(ja)
|
2017-01-18 |
2020-05-21 |
エクシジョン バイオセラピューティクス インコーポレイテッド |
Crispr
|
|
CN106701823A
(zh)
|
2017-01-18 |
2017-05-24 |
上海交通大学 |
生产无岩藻糖单克隆抗体的cho细胞系建立及其应用
|
|
CN106801056A
(zh)
|
2017-01-24 |
2017-06-06 |
中国科学院广州生物医药与健康研究院 |
一种sgRNA及其构建的慢病毒载体和应用
|
|
US20190352626A1
(en)
|
2017-01-30 |
2019-11-21 |
KWS SAAT SE & Co. KGaA |
Repair template linkage to endonucleases for genome engineering
|
|
TWI608100B
(zh)
|
2017-02-03 |
2017-12-11 |
國立清華大學 |
Cas9表達質體、大腸桿菌基因剪輯系統及其方法
|
|
TW201839136A
(zh)
|
2017-02-06 |
2018-11-01 |
瑞士商諾華公司 |
治療血色素異常症之組合物及方法
|
|
WO2018148246A1
(en)
|
2017-02-07 |
2018-08-16 |
Massachusetts Institute Of Technology |
Methods and compositions for rna-guided genetic circuits
|
|
AU2018218280B2
(en)
|
2017-02-07 |
2024-10-17 |
The Regents Of The University Of California |
Gene therapy for haploinsufficiency
|
|
WO2018148647A2
(en)
|
2017-02-10 |
2018-08-16 |
Lajoie Marc Joseph |
Genome editing reagents and their use
|
|
IT201700016321A1
(it)
|
2017-02-14 |
2018-08-14 |
Univ Degli Studi Di Trento |
Mutanti di cas9 ad alta specificita' e loro applicazioni.
|
|
US20200063127A1
(en)
|
2017-02-15 |
2020-02-27 |
Massachusetts Institute Of Technology |
Dna writers, molecular recorders and uses thereof
|
|
JP7688478B2
(ja)
|
2017-02-15 |
2025-06-04 |
キージーン ナムローゼ フェンノートシャップ |
植物細胞における標的遺伝子変化の方法
|
|
CN106957855B
(zh)
|
2017-02-16 |
2020-04-17 |
上海市农业科学院 |
使用CRISPR/Cas9技术靶向敲除水稻矮杆基因SD1的方法
|
|
WO2018152418A1
(en)
|
2017-02-17 |
2018-08-23 |
Temple University - Of The Commonwealth System Of Higher Education |
Gene editing therapy for hiv infection via dual targeting of hiv genome and ccr5
|
|
WO2018149418A1
(en)
|
2017-02-20 |
2018-08-23 |
Institute Of Genetics And Developmental Biology, Chinese Academy Of Sciences |
Genome editing system and method
|
|
EP3585807A1
(en)
|
2017-02-22 |
2020-01-01 |
CRISPR Therapeutics AG |
Materials and methods for treatment of early onset parkinson's disease (park1) and other synuclein, alpha (snca) gene related conditions or disorders
|
|
WO2018156372A1
(en)
|
2017-02-22 |
2018-08-30 |
The Regents Of The University Of California |
Genetically modified non-human animals and products thereof
|
|
US11559588B2
(en)
|
2017-02-22 |
2023-01-24 |
Crispr Therapeutics Ag |
Materials and methods for treatment of Spinocerebellar Ataxia Type 1 (SCA1) and other Spinocerebellar Ataxia Type 1 Protein (ATXN1) gene related conditions or disorders
|
|
US11920148B2
(en)
|
2017-02-22 |
2024-03-05 |
Crispr Therapeutics Ag |
Compositions and methods for gene editing
|
|
CA3053709A1
(en)
|
2017-02-22 |
2018-08-30 |
Crispr Therapeutics Ag |
Compositions and methods for treatment of proprotein convertase subtilisin/kexin type 9 (pcsk9)-related disorders
|
|
WO2018154459A1
(en)
|
2017-02-22 |
2018-08-30 |
Crispr Therapeutics Ag |
Materials and methods for treatment of primary hyperoxaluria type 1 (ph1) and other alanine-glyoxylate aminotransferase (agxt) gene related conditions or disorders
|
|
US20200216857A1
(en)
|
2017-02-22 |
2020-07-09 |
Crispr Therapeutics Ag |
Materials and methods for treatment of spinocerebellar ataxia type 2 (sca2) and other spinocerebellar ataxia type 2 protein (atxn2) gene related conditions or disorders
|
|
EP3585896A1
(en)
|
2017-02-22 |
2020-01-01 |
CRISPR Therapeutics AG |
Materials and methods for treatment of merosin-deficient cogenital muscular dystrophy (mdcmd) and other laminin, alpha 2 (lama2) gene related conditions or disorders
|
|
EP3585897A1
(en)
|
2017-02-22 |
2020-01-01 |
CRISPR Therapeutics AG |
Materials and methods for treatment of dystrophic epidermolysis bullosa (deb) and other collagen type vii alpha 1 chain (col7a1) gene related conditions or disorders
|
|
US20190380314A1
(en)
|
2017-02-23 |
2019-12-19 |
President And Fellows Of Harvard College |
Methods of Genetic Modification of a Cell
|
|
CN106868031A
(zh)
|
2017-02-24 |
2017-06-20 |
北京大学 |
一种基于分级组装的多个sgRNA串联并行表达的克隆方法及应用
|
|
WO2018161009A1
(en)
|
2017-03-03 |
2018-09-07 |
Yale University |
Aav-mediated direct in vivo crispr screen in glioblastoma
|
|
US11111492B2
(en)
|
2017-03-06 |
2021-09-07 |
Florida State University Research Foundation, Inc. |
Genome engineering methods using a cytosine-specific Cas9
|
|
EP3592853A1
(en)
|
2017-03-09 |
2020-01-15 |
President and Fellows of Harvard College |
Suppression of pain by gene editing
|
|
KR20190127797A
(ko)
*
|
2017-03-10 |
2019-11-13 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
시토신에서 구아닌으로의 염기 편집제
|
|
WO2018170015A1
(en)
|
2017-03-14 |
2018-09-20 |
The Regents Of The University Of California |
Engineering crispr cas9 immune stealth
|
|
CN106978428A
(zh)
|
2017-03-15 |
2017-07-25 |
上海吐露港生物科技有限公司 |
一种Cas蛋白特异结合靶标DNA、调控靶标基因转录的方法及试剂盒
|
|
BR112019019087A2
(pt)
|
2017-03-15 |
2020-05-12 |
The Broad Institute, Inc. |
Diagnóstico baseado em sistema efetor de crispr para detecção de vírus
|
|
CN106906242A
(zh)
|
2017-03-16 |
2017-06-30 |
重庆高圣生物医药有限责任公司 |
一种提高CRIPSR/Cas9靶向敲除基因产生非同源性末端接合效率的方法
|
|
EP3600382A4
(en)
|
2017-03-21 |
2020-12-30 |
Anthony P. Shuber |
TREATMENT OF CANCER WITH CAS ENDONUCLEASE COMPLEXES
|
|
CA3057192A1
(en)
|
2017-03-23 |
2018-09-27 |
President And Fellows Of Harvard College |
Nucleobase editors comprising nucleic acid programmable dna binding proteins
|
|
CN107012213A
(zh)
|
2017-03-24 |
2017-08-04 |
南开大学 |
结直肠癌的生物标记物
|
|
US10876101B2
(en)
|
2017-03-28 |
2020-12-29 |
Locanabio, Inc. |
CRISPR-associated (Cas) protein
|
|
CN106947780A
(zh)
|
2017-03-28 |
2017-07-14 |
扬州大学 |
一种兔mstn基因的编辑方法
|
|
CN106906240A
(zh)
|
2017-03-29 |
2017-06-30 |
浙江大学 |
运用CRISPR‑Cas9系统敲除大麦VE合成通路中的关键基因HPT的方法
|
|
KR102758434B1
(ko)
|
2017-03-30 |
2025-01-21 |
고쿠리츠 다이가쿠 호진 교토 다이가쿠 |
게놈 편집에 의한 엑손 스키핑 유도 방법
|
|
CN108660161B
(zh)
|
2017-03-31 |
2023-05-09 |
中国科学院脑科学与智能技术卓越创新中心 |
基于CRISPR/Cas9技术的制备无嵌合基因敲除动物的方法
|
|
CN107058358B
(zh)
|
2017-04-01 |
2020-06-09 |
中国科学院微生物研究所 |
一种双spacer序列识别切割CRISPR-Cas9载体构建及其在疣孢菌中的应用
|
|
CN106967726B
(zh)
|
2017-04-05 |
2020-12-29 |
华南农业大学 |
一种创建亚洲栽培稻与非洲栽培稻种间杂种亲和系的方法和应用
|
|
US9938288B1
(en)
|
2017-04-05 |
2018-04-10 |
President And Fellows Of Harvard College |
Macrocyclic compound and uses thereof
|
|
CN107142282A
(zh)
|
2017-04-06 |
2017-09-08 |
中山大学 |
一种利用CRISPR/Cas9在哺乳动物细胞中实现大片段DNA定点整合的方法
|
|
CN107034229A
(zh)
|
2017-04-07 |
2017-08-11 |
江苏贝瑞利生物科技有限公司 |
一种植物中高效筛选CRISPR/CAS9基因编辑系统候选sgRNA系统及应用
|
|
ES2880366T3
(es)
|
2017-04-11 |
2021-11-24 |
Hoffmann La Roche |
Retrotranscriptasa mutante con un incremento en la estabilidad térmica así como productos, procedimientos y usos que involucran la misma
|
|
CN107058320B
(zh)
|
2017-04-12 |
2019-08-02 |
南开大学 |
Il7r基因缺失斑马鱼突变体的制备及其应用
|
|
CN106916852B
(zh)
|
2017-04-13 |
2020-12-04 |
上海科技大学 |
一种碱基编辑系统及其构建和应用方法
|
|
CN108728476A
(zh)
|
2017-04-14 |
2018-11-02 |
复旦大学 |
一种利用crispr系统产生多样性抗体文库的方法
|
|
CN107298701B
(zh)
|
2017-04-18 |
2020-10-30 |
上海大学 |
玉米转录因子ZmbZIP22及其应用
|
|
CN106957844A
(zh)
|
2017-04-20 |
2017-07-18 |
华侨大学 |
一种能有效敲除HTLV‑1病毒基因组的CRISPR/Cas9的gRNA序列
|
|
US12058986B2
(en)
|
2017-04-20 |
2024-08-13 |
Egenesis, Inc. |
Method for generating a genetically modified pig with inactivated porcine endogenous retrovirus (PERV) elements
|
|
EP3612551B1
(en)
|
2017-04-21 |
2024-09-04 |
The General Hospital Corporation |
Variants of cpf1 (cas12a) with altered pam specificity
|
|
WO2018195555A1
(en)
|
2017-04-21 |
2018-10-25 |
The Board Of Trustees Of The Leland Stanford Junior University |
Crispr/cas 9-mediated integration of polynucleotides by sequential homologous recombination of aav donor vectors
|
|
US11530405B2
(en)
|
2017-04-24 |
2022-12-20 |
Dupont Nutrition Biosciences Aps |
Anti-CRISPR genes and proteins and methods of use
|
|
CN107043775B
(zh)
|
2017-04-24 |
2020-06-16 |
中国农业科学院生物技术研究所 |
一种能促进棉花侧根发育的sgRNA及其应用
|
|
US20180312822A1
(en)
|
2017-04-26 |
2018-11-01 |
10X Genomics, Inc. |
Mmlv reverse transcriptase variants
|
|
CN206970581U
(zh)
|
2017-04-26 |
2018-02-06 |
重庆威斯腾生物医药科技有限责任公司 |
一种用于辅助CRISPR/cas9基因敲除的试剂盒
|
|
WO2018197020A1
(en)
|
2017-04-27 |
2018-11-01 |
Novozymes A/S |
Genome editing by crispr-cas9 using short donor oligonucleotides
|
|
US20200407737A1
(en)
|
2017-05-03 |
2020-12-31 |
KWS SAAT SE & Co. KGaA |
Use of crispr-cas endonucleases for plant genome engineering
|
|
JP7292213B2
(ja)
|
2017-05-04 |
2023-06-16 |
ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア |
Crispr/cpf1を用いる、t細胞における遺伝子編集のための組成物および方法
|
|
CN107012174A
(zh)
|
2017-05-04 |
2017-08-04 |
昆明理工大学 |
CRISPR/Cas9技术在获得家蚕锌指蛋白基因突变体中的应用
|
|
CN107254485A
(zh)
|
2017-05-08 |
2017-10-17 |
南京农业大学 |
一种能够快速构建植物基因定点敲除载体的新反应体系
|
|
CN107129999A
(zh)
|
2017-05-09 |
2017-09-05 |
福建省农业科学院畜牧兽医研究所 |
利用稳转CRISPR/Cas9系统对病毒基因组进行靶向编辑的方法
|
|
WO2018208755A1
(en)
|
2017-05-09 |
2018-11-15 |
The Regents Of The University Of California |
Compositions and methods for tagging target proteins in proximity to a nucleotide sequence of interest
|
|
JP7398279B2
(ja)
|
2017-05-10 |
2023-12-14 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
Crispr/cas9核送達による細胞rnaの狙いを定めた編集
|
|
WO2018209158A2
(en)
|
2017-05-10 |
2018-11-15 |
Editas Medicine, Inc. |
Crispr/rna-guided nuclease systems and methods
|
|
CN107130000B
(zh)
|
2017-05-12 |
2019-12-17 |
浙江卫未生物医药科技有限公司 |
一种同时敲除KRAS基因和EGFR基因的CRISPR-Cas9系统及其应用
|
|
WO2018209320A1
(en)
|
2017-05-12 |
2018-11-15 |
President And Fellows Of Harvard College |
Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation
|
|
CN107012250B
(zh)
|
2017-05-16 |
2021-01-29 |
上海交通大学 |
一种适用于CRISPR/Cas9系统的基因组DNA片段编辑精准度的分析方法及应用
|
|
US11692184B2
(en)
|
2017-05-16 |
2023-07-04 |
The Regents Of The University Of California |
Thermostable RNA-guided endonucleases and methods of use thereof
|
|
CN106987570A
(zh)
|
2017-05-16 |
2017-07-28 |
上海交通大学 |
一种Cas9核酸酶R780A及其用途
|
|
CN107326042A
(zh)
|
2017-05-16 |
2017-11-07 |
上海交通大学 |
水稻tms10基因的定点敲除系统及其应用
|
|
CN106947750B
(zh)
|
2017-05-16 |
2020-12-08 |
上海交通大学 |
一种Cas9核酸酶Q920P及其用途
|
|
CN106957830B
(zh)
|
2017-05-16 |
2020-12-25 |
上海交通大学 |
一种Cas9核酸酶ΔF916及其用途
|
|
CN106967697B
(zh)
|
2017-05-16 |
2021-03-26 |
上海交通大学 |
一种Cas9核酸酶G915F及其用途
|
|
CN106916820B
(zh)
|
2017-05-16 |
2019-09-27 |
吉林大学 |
能有效编辑猪ROSA26基因的sgRNA及其应用
|
|
CN106957831B
(zh)
|
2017-05-16 |
2021-03-12 |
上海交通大学 |
一种Cas9核酸酶K918A及其用途
|
|
CN106939303B
(zh)
|
2017-05-16 |
2021-02-23 |
上海交通大学 |
一种Cas9核酸酶R919P及其用途
|
|
US11591620B2
(en)
|
2017-05-18 |
2023-02-28 |
Cargill, Incorporated |
Genome editing system
|
|
US12297436B2
(en)
|
2017-05-18 |
2025-05-13 |
The Broad Institute, Inc. |
Systems, methods, and compositions for targeted nucleic acid editing
|
|
CN111417727A
(zh)
|
2017-05-18 |
2020-07-14 |
博德研究所 |
用于靶向核酸编辑的系统、方法和组合物
|
|
EP3625359A4
(en)
|
2017-05-18 |
2021-03-03 |
Children's National Medical Center |
APTAMERIC AND NUCLEIC ACID PAYLOAD COMPOSITIONS AND METHODS OF USE
|
|
CN107236737A
(zh)
|
2017-05-19 |
2017-10-10 |
上海交通大学 |
特异靶向拟南芥ILK2基因的sgRNA序列及其应用
|
|
CN107043787B
(zh)
|
2017-05-19 |
2017-12-26 |
南京医科大学 |
一种基于CRISPR/Cas9获得MARF1定点突变小鼠模型的构建方法和应用
|
|
WO2018217852A1
(en)
|
2017-05-23 |
2018-11-29 |
Gettysburg College |
Crispr based tool for characterizing bacterial serovar diversity
|
|
CN107034188B
(zh)
|
2017-05-24 |
2018-07-24 |
中山大学附属口腔医院 |
一种靶向骨的外泌体载体、CRISPR/Cas9基因编辑系统及应用
|
|
WO2018218188A2
(en)
|
2017-05-25 |
2018-11-29 |
The General Hospital Corporation |
Base editors with improved precision and specificity
|
|
CN107177625B
(zh)
|
2017-05-26 |
2021-05-25 |
中国农业科学院植物保护研究所 |
一种定点突变的人工载体系统及定点突变方法
|
|
EP3630975B1
(en)
|
2017-05-26 |
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|
|
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|
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|
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|
|
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|
|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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(en)
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|
|
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(zh)
|
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|
|
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|
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|
|
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|
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|
|
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|
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|
|
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(en)
|
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|
|
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(zh)
|
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|
|
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|
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|
|
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|
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|
|
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|
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|
|
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(en)
|
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|
|
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(zh)
|
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|
|
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(en)
|
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|
|
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(ko)
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(zh)
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(de)
|
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Massachusetts Institute Of Technology |
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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|
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|
|
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|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(ja)
|
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|
|
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|
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|
|
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|
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|