JP2012095652A5 - - Google Patents

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Publication number
JP2012095652A5
JP2012095652A5 JP2011268598A JP2011268598A JP2012095652A5 JP 2012095652 A5 JP2012095652 A5 JP 2012095652A5 JP 2011268598 A JP2011268598 A JP 2011268598A JP 2011268598 A JP2011268598 A JP 2011268598A JP 2012095652 A5 JP2012095652 A5 JP 2012095652A5
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JP
Japan
Prior art keywords
protein
recombinant
seq
set forth
hpv58
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2011268598A
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English (en)
Japanese (ja)
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JP5616879B2 (ja
JP2012095652A (ja
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Publication of JP2012095652A publication Critical patent/JP2012095652A/ja
Publication of JP2012095652A5 publication Critical patent/JP2012095652A5/ja
Application granted granted Critical
Publication of JP5616879B2 publication Critical patent/JP5616879B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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JP2011268598A 2003-11-12 2011-12-08 酵母におけるｈｐｖ５８ｌ１の最適化発現 Expired - Lifetime JP5616879B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51921103P 2003-11-12 2003-11-12
US60/519,211 2003-11-12

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2006539751A Division JP4912885B2 (ja) 2003-11-12 2004-11-10 酵母におけるｈｐｖ５８ｌ１の最適化発現

Publications (3)

Publication Number Publication Date
JP2012095652A JP2012095652A (ja) 2012-05-24
JP2012095652A5 true JP2012095652A5 (enExample) 2013-03-14
JP5616879B2 JP5616879B2 (ja) 2014-10-29

Family

ID=34590374

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2006539751A Expired - Lifetime JP4912885B2 (ja) 2003-11-12 2004-11-10 酵母におけるｈｐｖ５８ｌ１の最適化発現
JP2011268598A Expired - Lifetime JP5616879B2 (ja) 2003-11-12 2011-12-08 酵母におけるｈｐｖ５８ｌ１の最適化発現

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2006539751A Expired - Lifetime JP4912885B2 (ja) 2003-11-12 2004-11-10 酵母におけるｈｐｖ５８ｌ１の最適化発現

Country Status (32)

Country Link
US (2) US7498036B2 (enExample)
EP (1) EP1687329B8 (enExample)
JP (2) JP4912885B2 (enExample)
KR (1) KR101170654B1 (enExample)
CN (1) CN1942583B (enExample)
AR (1) AR046835A1 (enExample)
AT (1) ATE452977T1 (enExample)
AU (1) AU2004290032B2 (enExample)
BE (1) BE2015C070I2 (enExample)
BR (1) BRPI0416393B1 (enExample)
CA (1) CA2543928C (enExample)
CY (2) CY1113875T1 (enExample)
DE (1) DE602004024821D1 (enExample)
DK (1) DK1687329T3 (enExample)
ES (1) ES2340287T3 (enExample)
FR (1) FR15C0081I2 (enExample)
HU (1) HUS1500064I1 (enExample)
IL (1) IL175353A (enExample)
IS (1) IS2741B (enExample)
LT (1) LTC1687329I2 (enExample)
LU (1) LU92901I2 (enExample)
MY (1) MY139500A (enExample)
NL (1) NL300775I1 (enExample)
NO (3) NO340633B1 (enExample)
NZ (1) NZ546697A (enExample)
PL (1) PL1687329T3 (enExample)
PT (1) PT1687329E (enExample)
RU (1) RU2370538C2 (enExample)
SI (1) SI1687329T1 (enExample)
TW (1) TWI332988B (enExample)
WO (1) WO2005047315A2 (enExample)
ZA (1) ZA200603106B (enExample)

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US8206950B2 (en) * 2003-06-09 2012-06-26 Animal Technology Institute Taiwan Fusion antigen used as vaccine and method of making them
ATE466022T1 (de) 2004-03-24 2010-05-15 Merck Sharp & Dohme Optimierte expression von hpv-52-l1 in hefe
US20070243587A1 (en) * 2006-04-14 2007-10-18 Healthbanks Biotech Co., Ltd. Using a reverse genetic engineering platform to produce protein vaccines and protein vaccine of avian influenza virus
CN101148661B (zh) * 2006-09-18 2013-01-02 中国医学科学院基础医学研究所 人乳头瘤病毒16型外壳蛋白病毒样颗粒及其制备方法和用途
AU2008226974B2 (en) * 2007-03-09 2013-08-15 Merck Sharp & Dohme Llc Papillomavirus vaccine compositions
EP2154147B1 (en) 2007-04-29 2015-10-07 Beijing Wantai Biological Pharmacy Enterprise Co., Ltd. A truncated l1 protein of human papillomavirus 16
EP2147926B1 (en) 2007-04-29 2016-08-24 Beijing Wantai Biological Pharmacy Enterprise Co., Ltd. Truncated human papillomavirus type 18 l1 proteins
EP2154149B1 (en) * 2007-05-29 2019-07-10 Xiamen University A truncated l1 protein of human papillomavirus 6
CN101113417B (zh) * 2007-06-22 2011-04-27 山东大学 Hpv基因酵母体外翻译系统的建立
CN101200696B (zh) * 2007-11-14 2011-07-20 山东大学 人乳头瘤病毒的酵母增殖模型及建立方法与应用
WO2009076824A1 (zh) 2007-11-23 2009-06-25 Shanghai Zerun Biotechnology Co., Ltd. 人乳头状瘤病毒主要衣壳蛋白l1基因及其用途
KR20090073987A (ko) * 2007-12-31 2009-07-03 정운원 인간유두종바이러스 유전자형 검사를 위한 프라이머, 프로브 및 이를 포함하는 ｄｎａ칩, 이의 검사 방법 및 검사 키트
BRPI0909547A2 (pt) * 2008-05-26 2019-03-06 Cadila Healthcare Ltd. vacina combinada de sarampo - hpv, vetor e hospedero
US9335868B2 (en) * 2008-07-31 2016-05-10 Apple Inc. Capacitive sensor behind black mask
CA2799205A1 (en) 2010-05-25 2011-12-01 Qiagen Gaithersburg, Inc. Fast results hybrid capture assay and associated strategically-truncated probes
CN101857870B (zh) * 2010-06-12 2012-09-05 上海泽润生物科技有限公司 Hpv58 l1基因及载体、菌株和表达方法
EP2594579B1 (en) * 2010-07-16 2015-04-15 Xiamen University Truncated human papillomavirus type 58 l1 protein
CN102154325B (zh) * 2011-01-01 2013-08-21 上海生物制品研究所有限责任公司 针对人乳头瘤状病毒的疫苗及其制法和用途
CN103717741B (zh) * 2011-06-15 2016-04-13 中央大学校产学协力团 用于提高人乳头瘤病毒l1蛋白产量的方法
CN103361280B (zh) * 2012-03-28 2018-07-24 北京安百胜生物科技有限公司 用汉逊酵母表达系统产生hpv11 l1蛋白的方法
AU2013272283B2 (en) 2012-06-07 2018-02-15 The Children's Hospital Of Philadelphia Controlled gene expression methods
CN103992395B (zh) * 2013-02-18 2018-07-27 北京康乐卫士生物技术股份有限公司 重组hpv-58型l1的vlp疫苗及其制备方法
CN110423774A (zh) * 2013-04-26 2019-11-08 北京安百胜生物科技有限公司 用汉逊酵母表达系统产生hpv58 l1蛋白的方法
CN104164374B (zh) * 2013-05-17 2019-10-22 北京安百胜生物科技有限公司 用汉逊酵母表达系统产生hpv31 l1蛋白的方法
CN104164373B (zh) * 2013-05-17 2019-04-02 北京安百胜生物科技有限公司 用汉逊酵母表达系统产生hpv68l1蛋白的方法
WO2015057541A1 (en) 2013-10-16 2015-04-23 Merck Sharp & Dohme Corp. Method of obtaining thermostable dried vaccine formulations
EP3191505A2 (en) * 2014-09-11 2017-07-19 Cadila Healthcare Limited Superior human papilloma virus antigens with superior immunological properties and vaccine containing it
CN106148359A (zh) * 2015-03-30 2016-11-23 上海泽润生物科技有限公司 重组人乳头瘤病毒33亚型蛋白表达
CN104878022A (zh) * 2015-04-27 2015-09-02 段青姣 编码hpv58l1、hpv52l1蛋白的核苷酸序列及其应用
EP3385273A4 (en) * 2015-12-04 2019-08-07 Xiamen University MUTANT OF HUMAN PAPILLOMAIRUS TYPE 58 L1 PROTEIN
US12673103B2 (en) 2020-02-14 2026-07-07 Merck Sharp & Dohme Llc HPV vaccine
CN113073105B (zh) * 2021-03-23 2023-06-13 重庆博唯佰泰生物制药有限公司 一种表达hpv 56l1的多核苷酸序列及其表达载体、宿主细胞和应用
CN113549634B (zh) * 2021-06-07 2023-03-31 郑州大学 编码可溶性hpv58 l1蛋白的基因及其重组质粒的构建与应用
WO2023014853A1 (en) 2021-08-06 2023-02-09 Merck Sharp & Dohme Llc Hpv vaccine
AR126813A1 (es) 2021-08-19 2023-11-15 Merck Sharp & Dohme Llc Nueva nanopartícula lipídica termostable y métodos de uso de la misma
CR20250529A (es) 2023-06-09 2026-01-12 Merck Sharp & Dohme Llc Composiciones adyuvantes en nanoemulsión para vacunas contra el papilomavirus humano
CN117054647A (zh) * 2023-07-17 2023-11-14 广东省一鼎生物技术有限公司 一种检测HPV IgG抗体试剂盒及其制备方法

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US5821087A (en) 1995-03-30 1998-10-13 Merck & Co., Inc. Production of recombinant human papillomavirus type II protein utilizing papillomavirus 6/11 hybrid DNA
IL117591A0 (en) 1995-03-30 1996-07-23 Merck & Co Inc Synthetic DNA encoding human papillomavirus type 11 L1 protein
EE9900343A (et) 1997-02-07 2000-02-15 Merck & Co., Inc. Sünteetiline polünukleotiid, immuunvastuste tekitamise meetod, immunogeenne kompositsioon, anti-HIV immuunvastuste indutseerimise meetod, meetod antigeeni tekitava raku indutseerimiseks ja farmatseutiline kompositsioon
CA2296067C (en) 1997-07-09 2008-10-07 The University Of Queensland Nucleic acid sequence and method for selectively expressing a protein in a target cell or tissue
EP1105466B1 (en) * 1998-08-14 2006-04-26 Merck & Co., Inc. Process for purifying human papillomavirus virus-like particles
DE69933875T2 (de) 1998-08-14 2007-05-31 Merck & Co., Inc. Protein-verabreichungssystem, das dem menschlichen papillomavirus ähnliche partikel benützt.
SE514982C2 (sv) * 1999-09-30 2001-05-28 Active Biotech Ab Bärare innehållande ett huvudkapsidprotein L1 från humant papillomavirus samt dess användning
ES2233437T3 (es) * 1999-08-25 2005-06-16 MERCK & CO., INC. Genes sinteticos del papilomavirus optimizados para expresion en celulas humanas.
US6436402B1 (en) * 1999-10-15 2002-08-20 Merck & Co., Inc. Process for making human papillomavirus virus-like particles with improved properties
US7026443B1 (en) * 1999-12-10 2006-04-11 Epimmune Inc. Inducing cellular immune responses to human Papillomavirus using peptide and nucleic acid compositions
NZ523683A (en) 2000-07-21 2004-08-27 Glaxo Group Ltd Codon-optimized papilloma virus sequences
WO2003068804A2 (en) * 2002-02-14 2003-08-21 Novavax, Inc. Novel insect cell line
RU2356943C2 (ru) * 2003-03-24 2009-05-27 Мерк Энд Ко., Инк. Молекула нуклеиновой кислоты, кодирующая hpv31 l1, экспрессирующий вектор, клетка-хозяин, вирусоподобная частица и способ ее получения, вакцина, фармацевтическая композиция и способы с их использованием
MY140664A (en) 2003-09-29 2010-01-15 Merck Sharp & Dohme Optimized expression of hpv 45 l1 in yeast

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