JP2012095652A5 - - Google Patents
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- Publication number
- JP2012095652A5 JP2012095652A5 JP2011268598A JP2011268598A JP2012095652A5 JP 2012095652 A5 JP2012095652 A5 JP 2012095652A5 JP 2011268598 A JP2011268598 A JP 2011268598A JP 2011268598 A JP2011268598 A JP 2011268598A JP 2012095652 A5 JP2012095652 A5 JP 2012095652A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- recombinant
- seq
- set forth
- hpv58
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 102000004169 proteins and genes Human genes 0.000 claims 5
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 108020004705 Codon Proteins 0.000 claims 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51921103P | 2003-11-12 | 2003-11-12 | |
| US60/519,211 | 2003-11-12 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006539751A Division JP4912885B2 (ja) | 2003-11-12 | 2004-11-10 | 酵母におけるｈｐｖ５８ｌ１の最適化発現 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012095652A JP2012095652A (ja) | 2012-05-24 |
| JP2012095652A5 true JP2012095652A5 (enExample) | 2013-03-14 |
| JP5616879B2 JP5616879B2 (ja) | 2014-10-29 |
Family
ID=34590374
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006539751A Expired - Lifetime JP4912885B2 (ja) | 2003-11-12 | 2004-11-10 | 酵母におけるｈｐｖ５８ｌ１の最適化発現 |
| JP2011268598A Expired - Lifetime JP5616879B2 (ja) | 2003-11-12 | 2011-12-08 | 酵母におけるｈｐｖ５８ｌ１の最適化発現 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006539751A Expired - Lifetime JP4912885B2 (ja) | 2003-11-12 | 2004-11-10 | 酵母におけるｈｐｖ５８ｌ１の最適化発現 |
Country Status (32)
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7858098B2 (en) * | 2002-12-20 | 2010-12-28 | Glaxosmithkline Biologicals, S.A. | Vaccine |
| US8206950B2 (en) | 2003-06-09 | 2012-06-26 | Animal Technology Institute Taiwan | Fusion antigen used as vaccine and method of making them |
| ES2343255T3 (es) | 2004-03-24 | 2010-07-27 | MERCK SHARP & DOHME CORP. | Expresion optimizada del vph 52 l1 en levadura. |
| US20070243587A1 (en) * | 2006-04-14 | 2007-10-18 | Healthbanks Biotech Co., Ltd. | Using a reverse genetic engineering platform to produce protein vaccines and protein vaccine of avian influenza virus |
| CN101148661B (zh) * | 2006-09-18 | 2013-01-02 | 中国医学科学院基础医学研究所 | 人乳头瘤病毒16型外壳蛋白病毒样颗粒及其制备方法和用途 |
| WO2008112125A1 (en) * | 2007-03-09 | 2008-09-18 | Merck & Co., Inc. | Papillomavirus vaccine compositions |
| EP2154147B1 (en) | 2007-04-29 | 2015-10-07 | Beijing Wantai Biological Pharmacy Enterprise Co., Ltd. | A truncated l1 protein of human papillomavirus 16 |
| DK2147926T3 (en) | 2007-04-29 | 2016-11-28 | Beijing Wantai Biological Pharmacy Entpr Co Ltd | Truncated human papillomavirus type 18 L1 protein |
| WO2008145021A1 (fr) * | 2007-05-29 | 2008-12-04 | Xiamen University | Protéine l1 tronquée du papillomavirus humain de type 6 |
| CN101113417B (zh) * | 2007-06-22 | 2011-04-27 | 山东大学 | Hpv基因酵母体外翻译系统的建立 |
| CN101200696B (zh) * | 2007-11-14 | 2011-07-20 | 山东大学 | 人乳头瘤病毒的酵母增殖模型及建立方法与应用 |
| MY182347A (en) * | 2007-11-23 | 2021-01-20 | Shanghai Zerun Biotechnology Co Ltd | Genes encoding major capsid protein l1 of human papilloma virus and use of the same |
| KR20090073987A (ko) * | 2007-12-31 | 2009-07-03 | 정운원 | 인간유두종바이러스 유전자형 검사를 위한 프라이머, 프로브 및 이를 포함하는 ｄｎａ칩, 이의 검사 방법 및 검사 키트 |
| JP5726727B2 (ja) * | 2008-05-26 | 2015-06-03 | カディラ・ヘルスケア・リミテッド | 麻疹−ヒトパピローマ混合ワクチン |
| US9335868B2 (en) * | 2008-07-31 | 2016-05-10 | Apple Inc. | Capacitive sensor behind black mask |
| EP2576840B1 (en) | 2010-05-25 | 2018-10-17 | QIAGEN Gaithersburg, Inc. | Fast results hybrid capture assay and associated strategically-truncated probes |
| CN101857870B (zh) * | 2010-06-12 | 2012-09-05 | 上海泽润生物科技有限公司 | Hpv58 l1基因及载体、菌株和表达方法 |
| EP2594579B1 (en) * | 2010-07-16 | 2015-04-15 | Xiamen University | Truncated human papillomavirus type 58 l1 protein |
| CN102154325B (zh) * | 2011-01-01 | 2013-08-21 | 上海生物制品研究所有限责任公司 | 针对人乳头瘤状病毒的疫苗及其制法和用途 |
| EP2722389B1 (en) * | 2011-06-15 | 2018-03-07 | Hong Jin Kim | Method for enhancing the production yield of human papillomavirus l1 protein |
| CN108624614A (zh) * | 2012-03-28 | 2018-10-09 | 北京安百胜生物科技有限公司 | 用汉逊酵母表达系统产生hpv11 l1蛋白的方法 |
| CA2875945A1 (en) | 2012-06-07 | 2013-12-12 | The Children's Hospital Of Philadelphia | Controlled gene expression methods |
| CN103992395B (zh) * | 2013-02-18 | 2018-07-27 | 北京康乐卫士生物技术股份有限公司 | 重组hpv-58型l1的vlp疫苗及其制备方法 |
| CN104120088B (zh) * | 2013-04-26 | 2019-09-24 | 北京安百胜生物科技有限公司 | 用汉逊酵母表达系统产生hpv58 l1蛋白的方法 |
| CN104164374B (zh) * | 2013-05-17 | 2019-10-22 | 北京安百胜生物科技有限公司 | 用汉逊酵母表达系统产生hpv31 l1蛋白的方法 |
| CN104164373B (zh) * | 2013-05-17 | 2019-04-02 | 北京安百胜生物科技有限公司 | 用汉逊酵母表达系统产生hpv68l1蛋白的方法 |
| EP3057612B1 (en) | 2013-10-16 | 2020-05-06 | Merck Sharp & Dohme Corp. | Method of obtaining thermostable dried vaccine formulations |
| EA201790365A1 (ru) * | 2014-09-11 | 2017-07-31 | Кадила Хелзкэр Лимитед | Антигены вируса папилломы человека с хорошими иммунологическими свойствами и содержащая их вакцина |
| CN117187263A (zh) * | 2015-03-30 | 2023-12-08 | 上海泽润生物科技有限公司 | 重组人乳头瘤病毒33亚型蛋白表达 |
| CN104878022A (zh) * | 2015-04-27 | 2015-09-02 | 段青姣 | 编码hpv58l1、hpv52l1蛋白的核苷酸序列及其应用 |
| WO2017092710A1 (zh) * | 2015-12-04 | 2017-06-08 | 厦门大学 | 一种人乳头瘤病毒58型l1蛋白的突变体 |
| US11638754B2 (en) | 2020-02-14 | 2023-05-02 | Merck Sharp & Dohme Llc | HPV vaccine |
| CN113073105B (zh) * | 2021-03-23 | 2023-06-13 | 重庆博唯佰泰生物制药有限公司 | 一种表达hpv 56l1的多核苷酸序列及其表达载体、宿主细胞和应用 |
| CN113549634B (zh) * | 2021-06-07 | 2023-03-31 | 郑州大学 | 编码可溶性hpv58 l1蛋白的基因及其重组质粒的构建与应用 |
| US20230048144A1 (en) | 2021-08-06 | 2023-02-16 | Merck Sharp & Dohme Llc | Hpv vaccine |
| MX2024002144A (es) | 2021-08-19 | 2024-04-23 | Merck Sharp & Dohme Llc | Nueva nanoparticula lipidica termostable y metodos de uso de la misma. |
| TW202513091A (zh) | 2023-06-09 | 2025-04-01 | 美商默沙東有限責任公司 | 用於人類乳突病毒疫苗之奈米乳液佐劑組合物 |
| CN117054647A (zh) * | 2023-07-17 | 2023-11-14 | 广东省一鼎生物技术有限公司 | 一种检测HPV IgG抗体试剂盒及其制备方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5821087A (en) | 1995-03-30 | 1998-10-13 | Merck & Co., Inc. | Production of recombinant human papillomavirus type II protein utilizing papillomavirus 6/11 hybrid DNA |
| IL117591A0 (en) | 1995-03-30 | 1996-07-23 | Merck & Co Inc | Synthetic DNA encoding human papillomavirus type 11 L1 protein |
| JP2001512308A (ja) | 1997-02-07 | 2001-08-21 | メルク エンド カンパニー インコーポレーテッド | 合成ｈｉｖ ｇａｇ遺伝子 |
| EP1002091B1 (en) | 1997-07-09 | 2012-02-29 | Coridon Pty Limited | Nucleic acid sequence and method for selectively expressing a protein in a target cell or tissue |
| PL347472A1 (en) * | 1998-08-14 | 2002-04-08 | Merck & Co Inc | Process for purifying human papillomavirus virus-like particles |
| ATE344052T1 (de) | 1998-08-14 | 2006-11-15 | Merck & Co Inc | Protein-verabreichungssystem, das dem menschlichen papillomavirus ähnliche partikel benützt. |
| SE514982C2 (sv) * | 1999-09-30 | 2001-05-28 | Active Biotech Ab | Bärare innehållande ett huvudkapsidprotein L1 från humant papillomavirus samt dess användning |
| WO2001014416A2 (en) | 1999-08-25 | 2001-03-01 | Merck & Co., Inc. | Synthetic papillomavirus genes optimized for expression in human cells |
| US6436402B1 (en) | 1999-10-15 | 2002-08-20 | Merck & Co., Inc. | Process for making human papillomavirus virus-like particles with improved properties |
| US7026443B1 (en) * | 1999-12-10 | 2006-04-11 | Epimmune Inc. | Inducing cellular immune responses to human Papillomavirus using peptide and nucleic acid compositions |
| PT1301614E (pt) | 2000-07-21 | 2007-02-28 | Group Limited Glaxo | Sequências de codão optimizado do vírus do papiloma |
| WO2003068163A2 (en) * | 2002-02-14 | 2003-08-21 | Novavax, Inc. | Optimization of gene sequences of chimeric virus-like particles for expression in insect cells |
| CA2519112C (en) | 2003-03-24 | 2012-09-11 | Merck & Co., Inc. | Optimized expression of hpv 31 l1 in yeast |
| MY140664A (en) * | 2003-09-29 | 2010-01-15 | Merck Sharp & Dohme | Optimized expression of hpv 45 l1 in yeast |
-
2004
- 2004-11-09 MY MYPI20044678A patent/MY139500A/en unknown
- 2004-11-10 AT AT04810619T patent/ATE452977T1/de active
- 2004-11-10 ES ES04810619T patent/ES2340287T3/es not_active Expired - Lifetime
- 2004-11-10 JP JP2006539751A patent/JP4912885B2/ja not_active Expired - Lifetime
- 2004-11-10 SI SI200431328T patent/SI1687329T1/sl unknown
- 2004-11-10 CN CN2004800332355A patent/CN1942583B/zh not_active Expired - Lifetime
- 2004-11-10 DE DE602004024821T patent/DE602004024821D1/de not_active Expired - Lifetime
- 2004-11-10 KR KR1020067009199A patent/KR101170654B1/ko not_active Expired - Lifetime
- 2004-11-10 AR ARP040104141A patent/AR046835A1/es active IP Right Grant
- 2004-11-10 BR BRPI0416393-1A patent/BRPI0416393B1/pt not_active IP Right Cessation
- 2004-11-10 US US10/579,111 patent/US7498036B2/en not_active Expired - Lifetime
- 2004-11-10 AU AU2004290032A patent/AU2004290032B2/en active Active
- 2004-11-10 PT PT04810619T patent/PT1687329E/pt unknown
- 2004-11-10 NZ NZ546697A patent/NZ546697A/en not_active IP Right Cessation
- 2004-11-10 DK DK04810619.9T patent/DK1687329T3/da active
- 2004-11-10 CA CA2543928A patent/CA2543928C/en not_active Expired - Lifetime
- 2004-11-10 PL PL04810619T patent/PL1687329T3/pl unknown
- 2004-11-10 WO PCT/US2004/037372 patent/WO2005047315A2/en not_active Ceased
- 2004-11-10 EP EP04810619A patent/EP1687329B8/en not_active Expired - Lifetime
- 2004-11-10 RU RU2006120402/13A patent/RU2370538C2/ru active
- 2004-11-11 TW TW093134524A patent/TWI332988B/zh not_active IP Right Cessation
-
2006
- 2006-04-19 ZA ZA200603106A patent/ZA200603106B/en unknown
- 2006-04-21 IS IS8425A patent/IS2741B/is unknown
- 2006-05-01 IL IL175353A patent/IL175353A/en active IP Right Grant
- 2006-06-09 NO NO20062674A patent/NO340633B1/no active Protection Beyond IP Right Term
-
2009
- 2009-01-26 US US12/321,797 patent/US7976848B2/en not_active Expired - Lifetime
-
2010
- 2010-03-19 CY CY20101100258T patent/CY1113875T1/el unknown
-
2011
- 2011-12-08 JP JP2011268598A patent/JP5616879B2/ja not_active Expired - Lifetime
-
2015
- 2015-11-30 NL NL300775C patent/NL300775I2/nl unknown
- 2015-12-02 HU HUS1500064C patent/HUS1500064I1/hu unknown
- 2015-12-04 FR FR15C0081C patent/FR15C0081I2/fr active Active
- 2015-12-07 CY CY2015051C patent/CY2015051I2/el unknown
- 2015-12-08 LU LU92901C patent/LU92901I2/xx unknown
- 2015-12-08 LT LTPA2015048C patent/LTC1687329I2/lt unknown
- 2015-12-09 BE BE2015C070C patent/BE2015C070I2/nl unknown
-
2017
- 2017-11-10 NO NO2017058C patent/NO2017058I1/no unknown
-
2022
- 2022-11-30 NO NO2022052C patent/NO2022052I1/no unknown
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