JP2012095652A5 - - Google Patents
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- Publication number
- JP2012095652A5 JP2012095652A5 JP2011268598A JP2011268598A JP2012095652A5 JP 2012095652 A5 JP2012095652 A5 JP 2012095652A5 JP 2011268598 A JP2011268598 A JP 2011268598A JP 2011268598 A JP2011268598 A JP 2011268598A JP 2012095652 A5 JP2012095652 A5 JP 2012095652A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- recombinant
- seq
- set forth
- hpv58
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 102000004169 proteins and genes Human genes 0.000 claims 5
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 108020004705 Codon Proteins 0.000 claims 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51921103P | 2003-11-12 | 2003-11-12 | |
| US60/519,211 | 2003-11-12 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006539751A Division JP4912885B2 (ja) | 2003-11-12 | 2004-11-10 | 酵母におけるｈｐｖ５８ｌ１の最適化発現 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012095652A JP2012095652A (ja) | 2012-05-24 |
| JP2012095652A5 true JP2012095652A5 (enExample) | 2013-03-14 |
| JP5616879B2 JP5616879B2 (ja) | 2014-10-29 |
Family
ID=34590374
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006539751A Expired - Lifetime JP4912885B2 (ja) | 2003-11-12 | 2004-11-10 | 酵母におけるｈｐｖ５８ｌ１の最適化発現 |
| JP2011268598A Expired - Lifetime JP5616879B2 (ja) | 2003-11-12 | 2011-12-08 | 酵母におけるｈｐｖ５８ｌ１の最適化発現 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006539751A Expired - Lifetime JP4912885B2 (ja) | 2003-11-12 | 2004-11-10 | 酵母におけるｈｐｖ５８ｌ１の最適化発現 |
Country Status (32)
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7858098B2 (en) * | 2002-12-20 | 2010-12-28 | Glaxosmithkline Biologicals, S.A. | Vaccine |
| US8206950B2 (en) | 2003-06-09 | 2012-06-26 | Animal Technology Institute Taiwan | Fusion antigen used as vaccine and method of making them |
| DK1730175T3 (da) | 2004-03-24 | 2010-08-23 | Merck Sharp & Dohme | Geoptimaliseerde expressie van HPV 52 L1 in gist |
| US20070243587A1 (en) * | 2006-04-14 | 2007-10-18 | Healthbanks Biotech Co., Ltd. | Using a reverse genetic engineering platform to produce protein vaccines and protein vaccine of avian influenza virus |
| CN101148661B (zh) * | 2006-09-18 | 2013-01-02 | 中国医学科学院基础医学研究所 | 人乳头瘤病毒16型外壳蛋白病毒样颗粒及其制备方法和用途 |
| US7709010B2 (en) * | 2007-03-09 | 2010-05-04 | Merck Sharp & Dohme Corp. | Papillomavirus vaccine compositions |
| CN101293918B (zh) | 2007-04-29 | 2013-03-27 | 北京万泰生物药业股份有限公司 | 截短的人乳头瘤病毒16型l1蛋白 |
| US9364529B2 (en) | 2007-04-29 | 2016-06-14 | Beijing Wantai Biological Pharmacy Enterprise Co., Ltd. | Truncated L1 protein of human papillomavirus type 18 |
| US8748127B2 (en) * | 2007-05-29 | 2014-06-10 | Xiamen University | Truncated L1 protein of human papillomavirus type 6 |
| CN101113417B (zh) * | 2007-06-22 | 2011-04-27 | 山东大学 | Hpv基因酵母体外翻译系统的建立 |
| CN101200696B (zh) * | 2007-11-14 | 2011-07-20 | 山东大学 | 人乳头瘤病毒的酵母增殖模型及建立方法与应用 |
| EP2479186B1 (en) * | 2007-11-23 | 2015-08-12 | Shanghai Zerun Biotechnology Co., Ltd. | Genes encoding major capsid protein L1 of human papilloma viruses |
| KR20090073987A (ko) * | 2007-12-31 | 2009-07-03 | 정운원 | 인간유두종바이러스 유전자형 검사를 위한 프라이머, 프로브 및 이를 포함하는 ｄｎａ칩, 이의 검사 방법 및 검사 키트 |
| ES2565846T3 (es) * | 2008-05-26 | 2016-04-07 | Cadila Healthcare Limited | Vacuna combinada contra el sarampión-papiloma humano |
| US9335868B2 (en) * | 2008-07-31 | 2016-05-10 | Apple Inc. | Capacitive sensor behind black mask |
| WO2011149897A1 (en) | 2010-05-25 | 2011-12-01 | Qiagen Gaithersburg, Inc. | Fast results hybrid capture assay and associated strategically-truncated probes |
| CN101857870B (zh) * | 2010-06-12 | 2012-09-05 | 上海泽润生物科技有限公司 | Hpv58 l1基因及载体、菌株和表达方法 |
| BR112013000996B1 (pt) | 2010-07-16 | 2021-08-10 | Xiamen Innovax Biotech Co., Ltd. | Proteína l1 hpv58 truncada, ácido nucléico isolado, vetor, célula hospedeira, partícula do tipo viral hpv58, composição, composição farmacêutica ou vacina, método para obter uma proteína l1 hpv58 truncada, método para preparar a partícula do tipo viral hpv58, método para preparar uma vacina, e uso da proteína l1 hpv58 truncada |
| CN102154325B (zh) * | 2011-01-01 | 2013-08-21 | 上海生物制品研究所有限责任公司 | 针对人乳头瘤状病毒的疫苗及其制法和用途 |
| AU2012270418B2 (en) * | 2011-06-15 | 2015-08-13 | Posvax Co., Ltd | Method for enhancing the production yield of human papillomavirus L1 protein |
| CN103361280B (zh) * | 2012-03-28 | 2018-07-24 | 北京安百胜生物科技有限公司 | 用汉逊酵母表达系统产生hpv11 l1蛋白的方法 |
| AU2013272283B2 (en) | 2012-06-07 | 2018-02-15 | The Children's Hospital Of Philadelphia | Controlled gene expression methods |
| CN103992395B (zh) * | 2013-02-18 | 2018-07-27 | 北京康乐卫士生物技术股份有限公司 | 重组hpv-58型l1的vlp疫苗及其制备方法 |
| CN110423774A (zh) * | 2013-04-26 | 2019-11-08 | 北京安百胜生物科技有限公司 | 用汉逊酵母表达系统产生hpv58 l1蛋白的方法 |
| CN110592133A (zh) * | 2013-05-17 | 2019-12-20 | 北京安百胜生物科技有限公司 | 用汉逊酵母表达系统产生hpv31 l1蛋白的方法 |
| CN104164373B (zh) * | 2013-05-17 | 2019-04-02 | 北京安百胜生物科技有限公司 | 用汉逊酵母表达系统产生hpv68l1蛋白的方法 |
| WO2015057541A1 (en) | 2013-10-16 | 2015-04-23 | Merck Sharp & Dohme Corp. | Method of obtaining thermostable dried vaccine formulations |
| BR112017004181A2 (pt) * | 2014-09-11 | 2017-12-05 | Cadila Healthcare Ltd | ?gene, vetor, célula hospedeira, partículas similares a vírus, vacina para vírus de papiloma humano, composição imunogênica, adjuvante, método para o preparo de uma vacina de papiloma humano, proteína de capsídeo principal e proteína hpv l1? |
| CN117187263A (zh) * | 2015-03-30 | 2023-12-08 | 上海泽润生物科技有限公司 | 重组人乳头瘤病毒33亚型蛋白表达 |
| CN104878022A (zh) * | 2015-04-27 | 2015-09-02 | 段青姣 | 编码hpv58l1、hpv52l1蛋白的核苷酸序列及其应用 |
| CN106831961B (zh) * | 2015-12-04 | 2019-11-05 | 厦门大学 | 一种人乳头瘤病毒58型l1蛋白的突变体 |
| CR20220395A (es) | 2020-02-14 | 2022-10-27 | Merck Sharp & Dome Llc | Vacuna contra hpv |
| CN113073105B (zh) * | 2021-03-23 | 2023-06-13 | 重庆博唯佰泰生物制药有限公司 | 一种表达hpv 56l1的多核苷酸序列及其表达载体、宿主细胞和应用 |
| CN113549634B (zh) * | 2021-06-07 | 2023-03-31 | 郑州大学 | 编码可溶性hpv58 l1蛋白的基因及其重组质粒的构建与应用 |
| EP4380615A1 (en) | 2021-08-06 | 2024-06-12 | Merck Sharp & Dohme LLC | Hpv vaccine |
| EP4387660A1 (en) | 2021-08-19 | 2024-06-26 | Merck Sharp & Dohme LLC | Thermostable lipid nanoparticle and methods of use thereof |
| US20240408188A1 (en) | 2023-06-09 | 2024-12-12 | Merck Sharp & Dohme Llc | Nanoemulsion adjuvant compositions for human papillomavirus vaccines |
| CN117054647A (zh) * | 2023-07-17 | 2023-11-14 | 广东省一鼎生物技术有限公司 | 一种检测HPV IgG抗体试剂盒及其制备方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5821087A (en) | 1995-03-30 | 1998-10-13 | Merck & Co., Inc. | Production of recombinant human papillomavirus type II protein utilizing papillomavirus 6/11 hybrid DNA |
| IL117591A0 (en) | 1995-03-30 | 1996-07-23 | Merck & Co Inc | Synthetic DNA encoding human papillomavirus type 11 L1 protein |
| DE69836206T2 (de) | 1997-02-07 | 2007-08-23 | Merck & Co., Inc. | Synthetische hiv gag gene |
| EP1002091B1 (en) | 1997-07-09 | 2012-02-29 | Coridon Pty Limited | Nucleic acid sequence and method for selectively expressing a protein in a target cell or tissue |
| JP4440471B2 (ja) * | 1998-08-14 | 2010-03-24 | メルク エンド カムパニー インコーポレーテッド | ヒトパピローマウイルスのウイルス様粒子の精製方法 |
| EP1105157B1 (en) | 1998-08-14 | 2006-11-02 | Merck & Co., Inc. | Protein delivery system using human papillomavirus virus-like particles |
| SE514982C2 (sv) * | 1999-09-30 | 2001-05-28 | Active Biotech Ab | Bärare innehållande ett huvudkapsidprotein L1 från humant papillomavirus samt dess användning |
| ATE284898T1 (de) * | 1999-08-25 | 2005-01-15 | Merck & Co Inc | Synthetische papillomavirus gene, welche für expression in menschlichen zellen optimiert sind |
| US6436402B1 (en) | 1999-10-15 | 2002-08-20 | Merck & Co., Inc. | Process for making human papillomavirus virus-like particles with improved properties |
| US7026443B1 (en) * | 1999-12-10 | 2006-04-11 | Epimmune Inc. | Inducing cellular immune responses to human Papillomavirus using peptide and nucleic acid compositions |
| WO2002008435A1 (en) | 2000-07-21 | 2002-01-31 | Glaxo Group Limited | Codon-optimized papilloma virus sequences |
| WO2003068993A1 (en) * | 2002-02-14 | 2003-08-21 | Novavax, Inc. | Method for isolation and purification of expressed gene products in vitro |
| ATE546529T1 (de) | 2003-03-24 | 2012-03-15 | Merck Sharp & Dohme | Optimierte expression von hpv 31 l1 in hefe |
| MY140664A (en) | 2003-09-29 | 2010-01-15 | Merck Sharp & Dohme | Optimized expression of hpv 45 l1 in yeast |
-
2004
- 2004-11-09 MY MYPI20044678A patent/MY139500A/en unknown
- 2004-11-10 CA CA2543928A patent/CA2543928C/en not_active Expired - Lifetime
- 2004-11-10 AT AT04810619T patent/ATE452977T1/de active
- 2004-11-10 ES ES04810619T patent/ES2340287T3/es not_active Expired - Lifetime
- 2004-11-10 PL PL04810619T patent/PL1687329T3/pl unknown
- 2004-11-10 DE DE602004024821T patent/DE602004024821D1/de not_active Expired - Lifetime
- 2004-11-10 EP EP04810619A patent/EP1687329B8/en not_active Expired - Lifetime
- 2004-11-10 JP JP2006539751A patent/JP4912885B2/ja not_active Expired - Lifetime
- 2004-11-10 BR BRPI0416393-1A patent/BRPI0416393B1/pt not_active IP Right Cessation
- 2004-11-10 NZ NZ546697A patent/NZ546697A/en not_active IP Right Cessation
- 2004-11-10 RU RU2006120402/13A patent/RU2370538C2/ru active
- 2004-11-10 AU AU2004290032A patent/AU2004290032B2/en active Active
- 2004-11-10 WO PCT/US2004/037372 patent/WO2005047315A2/en not_active Ceased
- 2004-11-10 KR KR1020067009199A patent/KR101170654B1/ko not_active Expired - Lifetime
- 2004-11-10 US US10/579,111 patent/US7498036B2/en not_active Expired - Lifetime
- 2004-11-10 PT PT04810619T patent/PT1687329E/pt unknown
- 2004-11-10 SI SI200431328T patent/SI1687329T1/sl unknown
- 2004-11-10 DK DK04810619.9T patent/DK1687329T3/da active
- 2004-11-10 AR ARP040104141A patent/AR046835A1/es active IP Right Grant
- 2004-11-10 CN CN2004800332355A patent/CN1942583B/zh not_active Expired - Lifetime
- 2004-11-11 TW TW093134524A patent/TWI332988B/zh not_active IP Right Cessation
-
2006
- 2006-04-19 ZA ZA200603106A patent/ZA200603106B/en unknown
- 2006-04-21 IS IS8425A patent/IS2741B/is unknown
- 2006-05-01 IL IL175353A patent/IL175353A/en active IP Right Grant
- 2006-06-09 NO NO20062674A patent/NO340633B1/no active Protection Beyond IP Right Term
-
2009
- 2009-01-26 US US12/321,797 patent/US7976848B2/en not_active Expired - Lifetime
-
2010
- 2010-03-19 CY CY20101100258T patent/CY1113875T1/el unknown
-
2011
- 2011-12-08 JP JP2011268598A patent/JP5616879B2/ja not_active Expired - Lifetime
-
2015
- 2015-11-30 NL NL300775C patent/NL300775I1/nl unknown
- 2015-12-02 HU HUS1500064C patent/HUS1500064I1/hu unknown
- 2015-12-04 FR FR15C0081C patent/FR15C0081I2/fr active Active
- 2015-12-07 CY CY2015051C patent/CY2015051I1/el unknown
- 2015-12-08 LU LU92901C patent/LU92901I2/xx unknown
- 2015-12-08 LT LTPA2015048C patent/LTC1687329I2/lt unknown
- 2015-12-09 BE BE2015C070C patent/BE2015C070I2/nl unknown
-
2017
- 2017-11-10 NO NO2017058C patent/NO2017058I1/no unknown
-
2022
- 2022-11-30 NO NO2022052C patent/NO2022052I1/no unknown
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