JP2012095652A5 - - Google Patents

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Publication number
JP2012095652A5
JP2012095652A5 JP2011268598A JP2011268598A JP2012095652A5 JP 2012095652 A5 JP2012095652 A5 JP 2012095652A5 JP 2011268598 A JP2011268598 A JP 2011268598A JP 2011268598 A JP2011268598 A JP 2011268598A JP 2012095652 A5 JP2012095652 A5 JP 2012095652A5
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JP
Japan
Prior art keywords
protein
recombinant
seq
set forth
hpv58
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Application number
JP2011268598A
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English (en)
Japanese (ja)
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JP5616879B2 (ja
JP2012095652A (ja
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Publication of JP2012095652A publication Critical patent/JP2012095652A/ja
Publication of JP2012095652A5 publication Critical patent/JP2012095652A5/ja
Application granted granted Critical
Publication of JP5616879B2 publication Critical patent/JP5616879B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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JP2011268598A 2003-11-12 2011-12-08 酵母におけるｈｐｖ５８ｌ１の最適化発現 Expired - Lifetime JP5616879B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51921103P 2003-11-12 2003-11-12
US60/519,211 2003-11-12

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2006539751A Division JP4912885B2 (ja) 2003-11-12 2004-11-10 酵母におけるｈｐｖ５８ｌ１の最適化発現

Publications (3)

Publication Number Publication Date
JP2012095652A JP2012095652A (ja) 2012-05-24
JP2012095652A5 true JP2012095652A5 (enExample) 2013-03-14
JP5616879B2 JP5616879B2 (ja) 2014-10-29

Family

ID=34590374

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2006539751A Expired - Lifetime JP4912885B2 (ja) 2003-11-12 2004-11-10 酵母におけるｈｐｖ５８ｌ１の最適化発現
JP2011268598A Expired - Lifetime JP5616879B2 (ja) 2003-11-12 2011-12-08 酵母におけるｈｐｖ５８ｌ１の最適化発現

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2006539751A Expired - Lifetime JP4912885B2 (ja) 2003-11-12 2004-11-10 酵母におけるｈｐｖ５８ｌ１の最適化発現

Country Status (32)

Country Link
US (2) US7498036B2 (enExample)
EP (1) EP1687329B8 (enExample)
JP (2) JP4912885B2 (enExample)
KR (1) KR101170654B1 (enExample)
CN (1) CN1942583B (enExample)
AR (1) AR046835A1 (enExample)
AT (1) ATE452977T1 (enExample)
AU (1) AU2004290032B2 (enExample)
BE (1) BE2015C070I2 (enExample)
BR (1) BRPI0416393B1 (enExample)
CA (1) CA2543928C (enExample)
CY (2) CY1113875T1 (enExample)
DE (1) DE602004024821D1 (enExample)
DK (1) DK1687329T3 (enExample)
ES (1) ES2340287T3 (enExample)
FR (1) FR15C0081I2 (enExample)
HU (1) HUS1500064I1 (enExample)
IL (1) IL175353A (enExample)
IS (1) IS2741B (enExample)
LT (1) LTC1687329I2 (enExample)
LU (1) LU92901I2 (enExample)
MY (1) MY139500A (enExample)
NL (1) NL300775I2 (enExample)
NO (3) NO340633B1 (enExample)
NZ (1) NZ546697A (enExample)
PL (1) PL1687329T3 (enExample)
PT (1) PT1687329E (enExample)
RU (1) RU2370538C2 (enExample)
SI (1) SI1687329T1 (enExample)
TW (1) TWI332988B (enExample)
WO (1) WO2005047315A2 (enExample)
ZA (1) ZA200603106B (enExample)

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US8206950B2 (en) 2003-06-09 2012-06-26 Animal Technology Institute Taiwan Fusion antigen used as vaccine and method of making them
MY148656A (en) * 2004-03-24 2013-05-15 Merck Sharp & Dohme Optimized expression of hpv 52 l1 in yeast.
US20070243587A1 (en) * 2006-04-14 2007-10-18 Healthbanks Biotech Co., Ltd. Using a reverse genetic engineering platform to produce protein vaccines and protein vaccine of avian influenza virus
CN101148661B (zh) * 2006-09-18 2013-01-02 中国医学科学院基础医学研究所 人乳头瘤病毒16型外壳蛋白病毒样颗粒及其制备方法和用途
CA2679720A1 (en) * 2007-03-09 2008-09-18 Merck & Co., Inc. Papillomavirus vaccine compositions
US9428555B2 (en) 2007-04-29 2016-08-30 Beijing Wantai Biological Pharmacy Enterprise Co., Ltd. Truncated L1 protein of Human Papillomavirus type 16
WO2008134935A1 (en) 2007-04-29 2008-11-13 Beijing Wantai Biological Pharmacy Enterprise Co., Ltd. Truncated human papillomavirus type 18 l1 proteins
DK2154149T3 (da) * 2007-05-29 2019-10-14 Univ Xiamen En trunkeret l1-protein af human papillomavirus 6
CN101113417B (zh) * 2007-06-22 2011-04-27 山东大学 Hpv基因酵母体外翻译系统的建立
CN101200696B (zh) * 2007-11-14 2011-07-20 山东大学 人乳头瘤病毒的酵母增殖模型及建立方法与应用
EP2479187A1 (en) 2007-11-23 2012-07-25 Shanghai Zerun Biotechnology Co., Ltd. Genes encoding major capsid protein L1 of human papilloma viruses
KR20090073987A (ko) * 2007-12-31 2009-07-03 정운원 인간유두종바이러스 유전자형 검사를 위한 프라이머, 프로브 및 이를 포함하는 ｄｎａ칩, 이의 검사 방법 및 검사 키트
US9623098B2 (en) * 2008-05-26 2017-04-18 Cadila Healthcare Limited Combined measles-human papilloma vaccine
US9335868B2 (en) * 2008-07-31 2016-05-10 Apple Inc. Capacitive sensor behind black mask
JP6153866B2 (ja) 2010-05-25 2017-06-28 キアゲン ガイサーズバーグ アイエヌシー． 迅速なハイブリッド捕捉アッセイ、及び関連する戦略的に切断されたプローブ
CN101857870B (zh) * 2010-06-12 2012-09-05 上海泽润生物科技有限公司 Hpv58 l1基因及载体、菌株和表达方法
CN102336822B (zh) * 2010-07-16 2015-10-14 厦门大学 截短的人乳头瘤病毒58型l1蛋白
CN102154325B (zh) * 2011-01-01 2013-08-21 上海生物制品研究所有限责任公司 针对人乳头瘤状病毒的疫苗及其制法和用途
EP2722389B1 (en) * 2011-06-15 2018-03-07 Hong Jin Kim Method for enhancing the production yield of human papillomavirus l1 protein
CN103361280B (zh) * 2012-03-28 2018-07-24 北京安百胜生物科技有限公司 用汉逊酵母表达系统产生hpv11 l1蛋白的方法
KR102092981B1 (ko) * 2012-06-07 2020-03-24 더 칠드런스 호스피탈 오브 필라델피아 조절된 유전자 발현 방법
CN103992395B (zh) * 2013-02-18 2018-07-27 北京康乐卫士生物技术股份有限公司 重组hpv-58型l1的vlp疫苗及其制备方法
CN104120088B (zh) * 2013-04-26 2019-09-24 北京安百胜生物科技有限公司 用汉逊酵母表达系统产生hpv58 l1蛋白的方法
CN104164373B (zh) * 2013-05-17 2019-04-02 北京安百胜生物科技有限公司 用汉逊酵母表达系统产生hpv68l1蛋白的方法
CN110592133A (zh) * 2013-05-17 2019-12-20 北京安百胜生物科技有限公司 用汉逊酵母表达系统产生hpv31 l1蛋白的方法
EP3057612B1 (en) 2013-10-16 2020-05-06 Merck Sharp & Dohme Corp. Method of obtaining thermostable dried vaccine formulations
CN107002085A (zh) * 2014-09-11 2017-08-01 卡迪拉保健有限公司 具有优异免疫学特性的优异的人乳头瘤病毒抗原和含有其的疫苗
CN117187263A (zh) * 2015-03-30 2023-12-08 上海泽润生物科技有限公司 重组人乳头瘤病毒33亚型蛋白表达
CN104878022A (zh) * 2015-04-27 2015-09-02 段青姣 编码hpv58l1、hpv52l1蛋白的核苷酸序列及其应用
EP3385273A4 (en) * 2015-12-04 2019-08-07 Xiamen University MUTANT OF HUMAN PAPILLOMAIRUS TYPE 58 L1 PROTEIN
JP2023516904A (ja) 2020-02-14 2023-04-21 メルク・シャープ・アンド・ドーム・エルエルシー Ｈｐｖワクチン
CN113073105B (zh) * 2021-03-23 2023-06-13 重庆博唯佰泰生物制药有限公司 一种表达hpv 56l1的多核苷酸序列及其表达载体、宿主细胞和应用
CN113549634B (zh) * 2021-06-07 2023-03-31 郑州大学 编码可溶性hpv58 l1蛋白的基因及其重组质粒的构建与应用
AR126708A1 (es) 2021-08-06 2023-11-08 Merck Sharp & Dohme Llc Vacuna para el vph
JP2024532127A (ja) 2021-08-19 2024-09-05 メルク・シャープ・アンド・ドーム・エルエルシー 熱安定性脂質ナノ粒子およびその使用方法
TW202513091A (zh) 2023-06-09 2025-04-01 美商默沙東有限責任公司 用於人類乳突病毒疫苗之奈米乳液佐劑組合物
CN117054647A (zh) * 2023-07-17 2023-11-14 广东省一鼎生物技术有限公司 一种检测HPV IgG抗体试剂盒及其制备方法

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US5821087A (en) 1995-03-30 1998-10-13 Merck & Co., Inc. Production of recombinant human papillomavirus type II protein utilizing papillomavirus 6/11 hybrid DNA
IL117591A0 (en) 1995-03-30 1996-07-23 Merck & Co Inc Synthetic DNA encoding human papillomavirus type 11 L1 protein
EE9900343A (et) 1997-02-07 2000-02-15 Merck & Co., Inc. Sünteetiline polünukleotiid, immuunvastuste tekitamise meetod, immunogeenne kompositsioon, anti-HIV immuunvastuste indutseerimise meetod, meetod antigeeni tekitava raku indutseerimiseks ja farmatseutiline kompositsioon
EP1002091B1 (en) 1997-07-09 2012-02-29 Coridon Pty Limited Nucleic acid sequence and method for selectively expressing a protein in a target cell or tissue
HUP0103091A3 (en) * 1998-08-14 2002-03-28 Merck & Co Inc Process for purifying human papillomavirus virus-like particles
EP1105157B1 (en) 1998-08-14 2006-11-02 Merck & Co., Inc. Protein delivery system using human papillomavirus virus-like particles
SE514982C2 (sv) * 1999-09-30 2001-05-28 Active Biotech Ab Bärare innehållande ett huvudkapsidprotein L1 från humant papillomavirus samt dess användning
EP1212358B1 (en) * 1999-08-25 2004-12-15 Merck & Co., Inc. Synthetic papillomavirus genes optimized for expression in human cells
US6436402B1 (en) 1999-10-15 2002-08-20 Merck & Co., Inc. Process for making human papillomavirus virus-like particles with improved properties
US7026443B1 (en) * 1999-12-10 2006-04-11 Epimmune Inc. Inducing cellular immune responses to human Papillomavirus using peptide and nucleic acid compositions
HK1056195B (en) 2000-07-21 2007-06-22 Glaxo Group Limited Codon-optimized papilloma virus sequences
US20040121465A1 (en) * 2002-02-14 2004-06-24 Novavax, Inc. Optimization of gene sequences of virus-like particles for expression in insect cells
KR101080628B1 (ko) * 2003-03-24 2011-11-08 머크 샤프 앤드 돔 코포레이션 효모에서 ｈｐｖ 31 ｌ1의 최적 발현
MY140664A (en) 2003-09-29 2010-01-15 Merck Sharp & Dohme Optimized expression of hpv 45 l1 in yeast

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