ZA200603106B - Optimized expression of HPV 58 L1 in yeast - Google Patents

Optimized expression of HPV 58 L1 in yeast Download PDF

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Publication number
ZA200603106B
ZA200603106B ZA200603106A ZA200603106A ZA200603106B ZA 200603106 B ZA200603106 B ZA 200603106B ZA 200603106 A ZA200603106 A ZA 200603106A ZA 200603106 A ZA200603106 A ZA 200603106A ZA 200603106 B ZA200603106 B ZA 200603106B
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South Africa
Prior art keywords
vlps
hpv
yeast
protein
vaccine
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ZA200603106A
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English (en)
Inventor
Janine T Bryan
Michelle K Brownlow
Loren D Schultz
Wang Xin-Min
Kathrin U Jansen
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Merck & Co Inc
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Publication of ZA200603106B publication Critical patent/ZA200603106B/en

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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/01—DNA viruses
    • C07K14/025—Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
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    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P31/12—Antivirals
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
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    • A61K2039/525—Virus
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20023—Virus like particles [VLP]
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    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2800/00—Nucleic acids vectors
    • C12N2800/22—Vectors comprising a coding region that has been codon optimised for expression in a respective host

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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
ZA200603106A 2003-11-12 2006-04-19 Optimized expression of HPV 58 L1 in yeast ZA200603106B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US51921103P 2003-11-12 2003-11-12

Publications (1)

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ZA200603106B true ZA200603106B (en) 2007-09-26

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ZA200603106A ZA200603106B (en) 2003-11-12 2006-04-19 Optimized expression of HPV 58 L1 in yeast

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CN104120088B (zh) * 2013-04-26 2019-09-24 北京安百胜生物科技有限公司 用汉逊酵母表达系统产生hpv58 l1蛋白的方法
CN104164373B (zh) * 2013-05-17 2019-04-02 北京安百胜生物科技有限公司 用汉逊酵母表达系统产生hpv68l1蛋白的方法
CN110592133A (zh) * 2013-05-17 2019-12-20 北京安百胜生物科技有限公司 用汉逊酵母表达系统产生hpv31 l1蛋白的方法
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CN1942583B (zh) 2010-10-27
CN1942583A (zh) 2007-04-04
DE602004024821D1 (de) 2010-02-04
CY2015051I1 (el) 2016-06-22
US20070036824A1 (en) 2007-02-15
IL175353A0 (en) 2006-09-05
FR15C0081I1 (fr) 2016-08-01
NO340633B1 (no) 2017-05-15
BRPI0416393B1 (pt) 2021-06-29
CY2015051I2 (el) 2016-06-22
HUS1500064I1 (hu) 2016-02-29
WO2005047315A3 (en) 2006-09-28
JP2008500019A (ja) 2008-01-10
NL300775I1 (enExample) 2015-12-29
JP5616879B2 (ja) 2014-10-29
US7976848B2 (en) 2011-07-12
CA2543928C (en) 2011-04-05
NL300775I2 (enExample) 2015-12-29
AU2004290032A1 (en) 2005-05-26
NO2017058I1 (no) 2017-11-10
RU2370538C2 (ru) 2009-10-20
NO2022052I1 (no) 2022-11-30
US7498036B2 (en) 2009-03-03
JP2012095652A (ja) 2012-05-24
EP1687329A2 (en) 2006-08-09
PL1687329T3 (pl) 2010-06-30
PT1687329E (pt) 2010-02-26
NO20062674L (no) 2006-06-09
JP4912885B2 (ja) 2012-04-11
WO2005047315A2 (en) 2005-05-26
EP1687329B1 (en) 2009-12-23
FR15C0081I2 (fr) 2016-11-25
LU92901I2 (fr) 2016-03-08
AU2004290032B2 (en) 2009-02-05
BE2015C070I2 (enExample) 2023-12-18
KR20060122852A (ko) 2006-11-30
ATE452977T1 (de) 2010-01-15
AR046835A1 (es) 2005-12-28
CY1113875T1 (el) 2016-06-22
ES2340287T3 (es) 2010-06-01
US20100272749A1 (en) 2010-10-28
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