JP2007513634A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2007513634A5 JP2007513634A5 JP2006544104A JP2006544104A JP2007513634A5 JP 2007513634 A5 JP2007513634 A5 JP 2007513634A5 JP 2006544104 A JP2006544104 A JP 2006544104A JP 2006544104 A JP2006544104 A JP 2006544104A JP 2007513634 A5 JP2007513634 A5 JP 2007513634A5
- Authority
- JP
- Japan
- Prior art keywords
- hbc
- sequence
- residues
- residue
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 21
- 125000000539 amino acid group Chemical group 0.000 claims 20
- 239000002245 particle Substances 0.000 claims 17
- 108090000623 proteins and genes Proteins 0.000 claims 15
- 102000039446 nucleic acids Human genes 0.000 claims 11
- 108020004707 nucleic acids Proteins 0.000 claims 11
- 150000007523 nucleic acids Chemical class 0.000 claims 11
- 108090000765 processed proteins & peptides Proteins 0.000 claims 11
- 235000018102 proteins Nutrition 0.000 claims 11
- 102000004169 proteins and genes Human genes 0.000 claims 11
- 229920001184 polypeptide Polymers 0.000 claims 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims 6
- 241000737598 recombinant Hepatitis B virus Species 0.000 claims 6
- 230000002163 immunogen Effects 0.000 claims 5
- 208000037797 influenza A Diseases 0.000 claims 5
- 230000000295 complement effect Effects 0.000 claims 4
- 102000005741 Metalloproteases Human genes 0.000 claims 2
- 235000018417 cysteine Nutrition 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 102000037865 fusion proteins Human genes 0.000 claims 2
- 108020001507 fusion proteins Proteins 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 239000002054 inoculum Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 229960005486 vaccine Drugs 0.000 claims 2
- 239000004475 Arginine Substances 0.000 claims 1
- 241000700721 Hepatitis B virus Species 0.000 claims 1
- 241000712431 Influenza A virus Species 0.000 claims 1
- 108010006035 Metalloproteases Proteins 0.000 claims 1
- 102000012479 Serine Proteases Human genes 0.000 claims 1
- 108010022999 Serine Proteases Proteins 0.000 claims 1
- 101710102218 Serine protease inhibitor Proteins 0.000 claims 1
- 229940122055 Serine protease inhibitor Drugs 0.000 claims 1
- 101000998548 Yersinia ruckeri Alkaline proteinase inhibitor Proteins 0.000 claims 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
- 230000002934 lysing effect Effects 0.000 claims 1
- 239000003475 metalloproteinase inhibitor Substances 0.000 claims 1
- 239000000203 mixture Chemical group 0.000 claims 1
- 239000003001 serine protease inhibitor Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/732,862 US20040146524A1 (en) | 2002-02-21 | 2003-12-10 | Stabilized immunogenic HBc chimer particles |
| US10/787,734 US7361352B2 (en) | 2001-08-15 | 2004-02-26 | Influenza immunogen and vaccine |
| PCT/US2004/041879 WO2005055957A2 (en) | 2003-12-10 | 2004-12-09 | Influenza immunogen and vaccine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007513634A JP2007513634A (ja) | 2007-05-31 |
| JP2007513634A5 true JP2007513634A5 (enExample) | 2008-02-07 |
Family
ID=34681746
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006544104A Pending JP2007513634A (ja) | 2003-12-10 | 2004-12-09 | インフルエンザ免疫原及びワクチン |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US7361352B2 (enExample) |
| EP (2) | EP1708748A4 (enExample) |
| JP (1) | JP2007513634A (enExample) |
| KR (1) | KR101209484B1 (enExample) |
| CN (1) | CN1913920B (enExample) |
| AU (1) | AU2004296886B2 (enExample) |
| BR (1) | BRPI0417509A (enExample) |
| CA (1) | CA2549104A1 (enExample) |
| IL (1) | IL200341A (enExample) |
| NO (1) | NO20063157L (enExample) |
| WO (1) | WO2005055957A2 (enExample) |
Families Citing this family (87)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7361352B2 (en) * | 2001-08-15 | 2008-04-22 | Acambis, Inc. | Influenza immunogen and vaccine |
| US7351413B2 (en) | 2002-02-21 | 2008-04-01 | Lorantis, Limited | Stabilized HBc chimer particles as immunogens for chronic hepatitis |
| US8101189B2 (en) | 2002-07-05 | 2012-01-24 | Folia Biotech Inc. | Vaccines and immunopotentiating compositions and methods for making and using them |
| NZ540620A (en) * | 2002-12-10 | 2009-03-31 | Lorantis Ltd | Stabilized immunogenic HBc chimer particles |
| US20090162400A1 (en) * | 2004-12-21 | 2009-06-25 | Powell Thomas J | Compositions of influenza viral proteins and methods of use thereof |
| US7700285B1 (en) | 2005-12-29 | 2010-04-20 | Boehringer Ingelheim Vetmedica, Inc. | PCV2 immunogenic compositions and methods of producing such compositions |
| US7833707B2 (en) * | 2004-12-30 | 2010-11-16 | Boehringer Ingelheim Vetmedica, Inc. | Methods of overexpression and recovery of porcine circovirus type 2 ORF2 |
| UA95602C2 (ru) | 2004-12-30 | 2011-08-25 | Берингер Ингельхейм Ветмедика, Инк. | Иммуногенная композиция цвс2 и способы приготовления такой композиции |
| PE20061428A1 (es) | 2005-03-23 | 2007-01-16 | Glaxosmithkline Biolog Sa | Formulacion de vacuna que comprende un adyuvante de emulsion aceite en agua y 3d-mpl |
| US20070160628A1 (en) * | 2005-08-31 | 2007-07-12 | Birkett Ashley J | Stabilized virus-like particles and epitope display systems |
| WO2007052163A2 (en) | 2005-11-01 | 2007-05-10 | Novartis Vaccines And Diagnostics Gmbh & Co Kg | Cell-derived viral vaccines with low levels of residual cell dna by beta-propiolactone treatment |
| US11707520B2 (en) | 2005-11-03 | 2023-07-25 | Seqirus UK Limited | Adjuvanted vaccines with non-virion antigens prepared from influenza viruses grown in cell culture |
| PL2368572T3 (pl) | 2005-11-04 | 2020-11-16 | Seqirus UK Limited | Szczepionki z adjuwantem z niewirionowymi antygenami otrzymane z wirusów grypy hodowanych w hodowli komórkowej |
| US20090220541A1 (en) * | 2005-11-04 | 2009-09-03 | Novartis Vaccines And Diagnostics Srl | Emulsions with free aqueous-phase surfactant for adjuvanting split influenza vaccines |
| EP2275132B1 (en) | 2005-12-29 | 2021-03-03 | Boehringer Ingelheim Animal Health USA Inc. | Multivalent PCV2 immunogenic compositions and methods of producing them |
| MX338626B (es) | 2005-12-29 | 2016-04-26 | Boehringer Ingelheim Vetmed | Uso de una composicion inmunogenica de pcv2 para producir los sintomas clinicos en cerdos. |
| ES2555544T3 (es) | 2006-03-07 | 2016-01-04 | Vaxinnate Corporation | Composiciones que incluyen hemaglutinina, métodos de preparación y métodos de uso de las mismas |
| WO2007126887A2 (en) * | 2006-03-27 | 2007-11-08 | The Government Of The United States Of America | Immunogenic compositions comprising polynucleotides encoding matrix protein 2 and methods of use |
| WO2007127290A2 (en) * | 2006-04-24 | 2007-11-08 | Protelix, Inc. | Method for producing viral vaccine and therapeutic peptide antigens |
| RU2009105099A (ru) * | 2006-07-14 | 2010-08-27 | Санофи Пастер Байолоджикс Ко. (Us) | Конструирование рекомбинантных вирусных вакцин путем прямой транспозон-опосредованной инсерции чужеродных иммунологических детерминант в белки векторного вируса |
| JP5639760B2 (ja) | 2006-07-17 | 2014-12-10 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | インフルエンザワクチン |
| EP3456348B1 (en) * | 2006-09-11 | 2025-03-26 | Seqirus UK Limited | Making influenza virus vaccines without using eggs |
| US8080645B2 (en) | 2007-10-01 | 2011-12-20 | Longhorn Vaccines & Diagnostics Llc | Biological specimen collection/transport compositions and methods |
| US8652782B2 (en) | 2006-09-12 | 2014-02-18 | Longhorn Vaccines & Diagnostics, Llc | Compositions and methods for detecting, identifying and quantitating mycobacterial-specific nucleic acids |
| US9481912B2 (en) | 2006-09-12 | 2016-11-01 | Longhorn Vaccines And Diagnostics, Llc | Compositions and methods for detecting and identifying nucleic acid sequences in biological samples |
| US8097419B2 (en) | 2006-09-12 | 2012-01-17 | Longhorn Vaccines & Diagnostics Llc | Compositions and method for rapid, real-time detection of influenza A virus (H1N1) swine 2009 |
| KR20090096414A (ko) | 2006-09-29 | 2009-09-10 | 사노피 파스테르 바이오로직스 씨오 | 재조합 리노바이러스 벡터 |
| US8652486B2 (en) | 2006-09-29 | 2014-02-18 | Sanofi Pasteur Biologics, Llc | Neutralizing immunogen (NimIV) of rhinovirus and its use for vaccine applications |
| CA2668834C (en) | 2006-11-07 | 2016-10-11 | Sanofi Pasteur Biologics Co. | Stabilization of vaccines by lyophilization |
| DK2069503T3 (da) * | 2006-11-15 | 2016-02-15 | Folia Biotech Inc | Papayamosaikvirus-baserede vacciner mod influenza |
| EP2099927A4 (en) * | 2006-11-22 | 2010-05-05 | Boehringer Ingelheim Vetmed | Methods of reducing porcine circovirus-associated disease outbreaks |
| EP2859900A1 (en) * | 2006-12-11 | 2015-04-15 | Boehringer Ingelheim Vetmedica, Inc. | Effective method of treatment of porcine circovirus and lawsonia intracellularis infections |
| BRPI0721083A2 (pt) * | 2006-12-15 | 2014-02-25 | Boehringer Ingelheim Vetmed | Tratamento de porcos com antígeno de pcv2 |
| EP1941903A1 (en) * | 2007-01-03 | 2008-07-09 | Boehringer Ingelheim Vetmedica Gmbh | Prophylaxis and treatment of PRDC |
| DK2155228T3 (da) | 2007-01-10 | 2014-07-07 | Purdue Research Foundation | Polypeptidinhibitorer af HSP27-kinase og anvendelser herfor |
| EP2117588A4 (en) * | 2007-02-09 | 2011-05-04 | Sanofi Pasteur Biologics Co | VIRAL VECTORS AND METHODS OF USE |
| EP1958644A1 (en) | 2007-02-13 | 2008-08-20 | Boehringer Ingelheim Vetmedica Gmbh | Prevention and treatment of sub-clinical pcvd |
| WO2008118487A2 (en) * | 2007-03-26 | 2008-10-02 | University Of Massachusetts Medical School | Compositions and methods for incresing immunogenicity of glycoprotein vaccines |
| JP5703466B2 (ja) * | 2007-08-07 | 2015-04-22 | パーデュー・リサーチ・ファウンデーションPurdue Research Foundation | キナーゼ阻害薬およびその使用 |
| WO2009022236A2 (en) * | 2007-08-16 | 2009-02-19 | Tripep Ab | Immunogen platform |
| CA2697049A1 (en) * | 2007-08-21 | 2009-02-26 | Dynavax Technologies Corporation | Composition and methods of making and using influenza proteins |
| US9683256B2 (en) | 2007-10-01 | 2017-06-20 | Longhorn Vaccines And Diagnostics, Llc | Biological specimen collection and transport system |
| US11041215B2 (en) | 2007-08-24 | 2021-06-22 | Longhorn Vaccines And Diagnostics, Llc | PCR ready compositions and methods for detecting and identifying nucleic acid sequences |
| EP3058954B1 (en) * | 2007-08-27 | 2017-03-01 | Longhorn Vaccines and Diagnostics, LLC | Immunogenic compositions and methods |
| US10004799B2 (en) | 2007-08-27 | 2018-06-26 | Longhorn Vaccines And Diagnostics, Llc | Composite antigenic sequences and vaccines |
| US7829274B2 (en) | 2007-09-04 | 2010-11-09 | Boehringer Ingelheim Vetmedica, Inc. | Reduction of concomitant infections in pigs by the use of PCV2 antigen |
| DK2195466T3 (da) | 2007-10-01 | 2013-01-14 | Longhorn Vaccines & Diagnostics Llc | Fremgangsmåde til opbevaring af biologiske prøver |
| US11041216B2 (en) | 2007-10-01 | 2021-06-22 | Longhorn Vaccines And Diagnostics, Llc | Compositions and methods for detecting and quantifying nucleic acid sequences in blood samples |
| WO2009079564A2 (en) * | 2007-12-17 | 2009-06-25 | Emory University | Immunogenic compositions and methods of use thereof |
| JP2011508595A (ja) * | 2007-12-31 | 2011-03-17 | ベーリンガー インゲルハイム フェトメディカ インコーポレイテッド | 外来性アミノ酸の挿入を含むpcv2orf2ウイルス様粒子 |
| JP5613061B2 (ja) * | 2008-01-23 | 2014-10-22 | ベーリンガー インゲルハイム フェトメディカ インコーポレイテッド | Pcv2マイコプラズマ・ハイオニューモニエ免疫原性組成物および前記組成物の製造方法 |
| WO2009099678A1 (en) | 2008-02-09 | 2009-08-13 | Sanofi Pasteur Biologics Co. | Influenza b vaccines |
| AU2009236585B2 (en) | 2008-04-18 | 2013-03-07 | Vaxinnate Corporation | Deletion mutants of flagellin and methods of use |
| WO2010056796A1 (en) * | 2008-11-12 | 2010-05-20 | Theraclone Sciences, Inc. | Human m2e peptide immunogens |
| AU2009324661A1 (en) * | 2008-12-10 | 2011-07-07 | Purdue Research Foundation | Cell-permeant peptide-based inhibitor of kinases |
| WO2010086743A2 (en) | 2009-02-02 | 2010-08-05 | Chrontech Pharma Ab | Compositions and methods that enhance an immune response |
| AU2010212550B2 (en) | 2009-02-10 | 2016-03-10 | Seqirus UK Limited | Influenza vaccines with reduced amounts of squalene |
| CN102482666B (zh) | 2009-07-06 | 2017-02-08 | 变异生物技术公司 | 制备囊泡的方法和由其产生的制剂 |
| CA2803282C (en) | 2009-07-06 | 2018-05-01 | David E. Anderson | Methods for preparing vesicles and formulations produced therefrom |
| WO2011017132A2 (en) * | 2009-07-27 | 2011-02-10 | Purdue Research, Foundation | Mk2 inhibitor compositions and methods to enhance neurite outgrowth, neuroprotection, and nerve regeneration |
| TWI627281B (zh) | 2009-09-02 | 2018-06-21 | 百靈佳殷格翰家畜藥品公司 | 降低pcv-2組合物殺病毒活性之方法及具有改良免疫原性之pcv-2組合物 |
| CN103118709A (zh) * | 2010-03-26 | 2013-05-22 | 新兴产品开发盖瑟斯堡有限公司 | 流感病毒基质2蛋白的胞外域、其表达系统和应用 |
| CN103096922B (zh) | 2010-07-06 | 2019-08-06 | 变异生物技术公司 | 用于治疗流行性感冒的组合物和方法 |
| BR112013017939B1 (pt) | 2011-01-13 | 2022-11-16 | Variation Biotechnologies Inc | Composição imunogênica liofilizada termoestável, uso e método para preparação da mesma |
| US20130323280A1 (en) | 2011-01-13 | 2013-12-05 | Variation Biotechnologies, Inc. | Methods for preparing vesicles and formulations produced therefrom |
| EP2701734B1 (en) * | 2011-04-26 | 2019-09-25 | Molecular Express, Inc. | Liposomal formulations |
| CN103083656A (zh) * | 2011-10-27 | 2013-05-08 | 苏州科贝生物技术有限公司 | 甲型流感病毒保守肽M2e与病毒样颗粒的缀合物及应用 |
| US20140328876A1 (en) | 2011-11-18 | 2014-11-06 | Variation Biotechnologies Inc. | Synthetic derivatives of mpl and uses thereof |
| EP2802353A4 (en) | 2012-01-12 | 2015-12-02 | Variation Biotechnologies Inc | COMPOSITIONS AND METHOD FOR THE TREATMENT OF VIRUS INFECTIONS |
| WO2013112916A1 (en) | 2012-01-26 | 2013-08-01 | Longhorn Vaccines And Diagnostics, Llc | Composite antigenic sequences and vaccines |
| CN104244984B (zh) | 2012-01-27 | 2020-03-31 | 变异生物技术公司 | 用于治疗剂的方法和组合物 |
| WO2013134636A1 (en) | 2012-03-09 | 2013-09-12 | Purdue Research Foundation | Compositions and methods for delivery of kinase inhibiting peptides |
| US8932598B2 (en) | 2012-08-28 | 2015-01-13 | Vaxinnate Corporation | Fusion proteins and methods of use |
| EP2892490B1 (en) * | 2012-09-05 | 2020-05-06 | Stryker Corporation | Patient support |
| US20150274784A1 (en) * | 2012-11-07 | 2015-10-01 | Vacplanta Limted | Production of an Immunogen Using a Plant Virus |
| US10117923B2 (en) | 2012-11-07 | 2018-11-06 | Vacplanta Limited | Production of an immunogen using a plant virus |
| US9505808B2 (en) | 2013-10-02 | 2016-11-29 | Boehringer Ingelheim Vetmedica, Inc. | PCV2 ORF2 protein variant and virus like particles composed thereof |
| GB201402890D0 (en) | 2014-02-18 | 2014-04-02 | Iqur Ltd | Vaccines based on hepatitis B Core antigens |
| GB201421692D0 (en) * | 2014-12-05 | 2015-01-21 | Iquar Ltd | Vaccines based on hepatitis B core antigens |
| US9976136B2 (en) | 2015-05-14 | 2018-05-22 | Longhorn Vaccines And Diagnostics, Llc | Rapid methods for the extraction of nucleic acids from biological samples |
| BR112021001992A2 (pt) | 2018-08-02 | 2021-05-04 | The Board Of Regents Of The University Of Texas System | efeito adjuvante do agonista tlr1/2 diprovocim sinergiza com anticorpos inibidores de checkpoint para eliminar doença |
| US20220356538A1 (en) * | 2019-09-24 | 2022-11-10 | The Penn State Research Foundation | Hepatitis b virus mutants with increased covalently closed circular dna |
| US12485166B2 (en) | 2020-02-06 | 2025-12-02 | Longhorn Vaccines And Diagnostics, Llc | Vaccines for the treatment and prevention of zoonotic infections |
| US11938182B2 (en) | 2020-03-26 | 2024-03-26 | Provectus Pharmatech, Inc. | Halogenated xanthenes as vaccine adjuvants |
| EP4103283A4 (en) | 2020-03-26 | 2024-02-28 | Provectus Pharmatech, Inc. | NEW USES OF HALOGENATED XANTHENES IN ONCOLOGY AND VIROLOGY |
| WO2022087122A1 (en) | 2020-10-20 | 2022-04-28 | Longhorn Vaccines And Diagnostics, Llc | Immunogenic antigens |
| CA3212672A1 (en) * | 2021-03-04 | 2022-09-09 | Longhorn Vaccines And Diagnostics, Llc | Vaccines for the treatment and prevention of zoonotic infections |
Family Cites Families (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4767842A (en) | 1973-05-07 | 1988-08-30 | The Ohio State University | Antigenic modification of polypeptides |
| US4888170A (en) | 1981-10-22 | 1989-12-19 | Research Corporation | Vaccines obtained from antigenic gene products of recombinant genes |
| US4436727A (en) | 1982-05-26 | 1984-03-13 | Ribi Immunochem Research, Inc. | Refined detoxified endotoxin product |
| US4977092A (en) * | 1985-06-26 | 1990-12-11 | Amgen | Expression of exogenous polypeptides and polypeptide products including hepatitis B surface antigen in yeast cells |
| US4643992A (en) | 1982-11-09 | 1987-02-17 | Scripps Clinic And Research Foundation | Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives |
| US4539205A (en) | 1982-11-09 | 1985-09-03 | Scripps Clinic And Research Foundation | Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives |
| US4987237A (en) | 1983-08-26 | 1991-01-22 | Ribi Immunochem Research, Inc. | Derivatives of monophosphoryl lipid A |
| US5093318A (en) | 1983-11-01 | 1992-03-03 | Scripps Clinic And Research Foundation | Immunostimulating guanosine derivatives and their pharmaceutical compositions |
| US5011828A (en) | 1985-11-15 | 1991-04-30 | Michael Goodman | Immunostimulating guanine derivatives, compositions and methods |
| US4818527A (en) * | 1986-12-09 | 1989-04-04 | Scripps Clinic And Research Foundation | T cell epitopes of the hepatitis B virus nucleocapsid protein |
| US4882145A (en) * | 1986-12-09 | 1989-11-21 | Scripps Clinic And Research Foundation | T cell epitopes of the hepatitis B virus nucleocapsid protein |
| US5143726A (en) * | 1986-12-09 | 1992-09-01 | The Scripps Research Institute | T cell epitopes of the hepatitis B virus nucleocapsid protein |
| US4976958A (en) * | 1987-02-26 | 1990-12-11 | Scripps Clinic And Research Foundation | Mycobacterial recombinants and peptides |
| US5057540A (en) | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
| US5387744A (en) | 1987-06-04 | 1995-02-07 | Washington University | Avirulent microbes and uses therefor: Salmonella typhi |
| IL91525A0 (en) | 1988-09-06 | 1990-04-29 | Univ Washington | Transgenic plants,pharmaceutical compositions containing the same and methods for the preparation thereof |
| US5023179A (en) | 1988-11-14 | 1991-06-11 | Eric Lam | Promoter enhancer element for gene expression in plant roots |
| US5110732A (en) | 1989-03-14 | 1992-05-05 | The Rockefeller University | Selective gene expression in plants |
| WO1990014837A1 (en) | 1989-05-25 | 1990-12-13 | Chiron Corporation | Adjuvant formulation comprising a submicron oil droplet emulsion |
| NZ235315A (en) | 1989-09-19 | 1991-09-25 | Wellcome Found | Chimaeric hepadnavirus core antigen proteins and their construction |
| US5618988A (en) | 1990-03-02 | 1997-04-08 | Amoco Corporation | Enhanced carotenoid accumulation in storage organs of genetically engineered plants |
| DE69132769T2 (de) | 1990-03-02 | 2002-04-18 | Bp Corp. North America Inc., Chicago | Biosynthese von carotinoiden in genetisch hergestellten wirtszellen |
| US5057588A (en) | 1990-03-09 | 1991-10-15 | Hoechst Celanese Corp. | Vinylidene cyanide alternating copolymers |
| US5709879A (en) | 1990-06-29 | 1998-01-20 | Chiron Corporation | Vaccine compositions containing liposomes |
| CA2138997C (en) | 1992-06-25 | 2003-06-03 | Jean-Paul Prieels | Vaccine composition containing adjuvants |
| US5297441A (en) | 1992-08-14 | 1994-03-29 | The Boeing Company | Apparatus for supporting a test specimen for compression testing |
| SG48309A1 (en) | 1993-03-23 | 1998-04-17 | Smithkline Beecham Biolog | Vaccine compositions containing 3-0 deacylated monophosphoryl lipid a |
| GB9326253D0 (en) | 1993-12-23 | 1994-02-23 | Smithkline Beecham Biolog | Vaccines |
| WO1996002555A1 (en) | 1994-07-15 | 1996-02-01 | The University Of Iowa Research Foundation | Immunomodulatory oligonucleotides |
| UA56132C2 (uk) | 1995-04-25 | 2003-05-15 | Смітклайн Бічем Байолоджікалс С.А. | Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини |
| JP3701761B2 (ja) * | 1997-01-08 | 2005-10-05 | 本田技研工業株式会社 | 車両用シート |
| US6355257B1 (en) | 1997-05-08 | 2002-03-12 | Corixa Corporation | Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors |
| US6303347B1 (en) | 1997-05-08 | 2001-10-16 | Corixa Corporation | Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors |
| US6113918A (en) | 1997-05-08 | 2000-09-05 | Ribi Immunochem Research, Inc. | Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors |
| US7063967B2 (en) | 1997-05-08 | 2006-06-20 | Corixa Corporation | Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors |
| US6080725A (en) | 1997-05-20 | 2000-06-27 | Galenica Pharmaceuticals, Inc. | Immunostimulating and vaccine compositions employing saponin analog adjuvants and uses thereof |
| WO1998052573A1 (en) | 1997-05-20 | 1998-11-26 | Galenica Pharmaceuticals, Inc. | Triterpene saponin analogs having adjuvant and immunostimulatory activity |
| WO1999007839A2 (en) | 1997-08-05 | 1999-02-18 | Vlaams Interuniversitair Instituut Voor Biotechnologie | Immunoprotective influenza antigen and its use in vaccination |
| GB9718901D0 (en) | 1997-09-05 | 1997-11-12 | Smithkline Beecham Biolog | Vaccine |
| US6024961A (en) | 1997-11-14 | 2000-02-15 | Washington University | Recombinant avirulent immunogenic S typhi having rpos positive phenotype |
| ATE215385T1 (de) | 1997-12-16 | 2002-04-15 | Chiron Corp | Verwendung von mikropartikeln mit submikron öl/wasser emulsionen |
| ATE249240T1 (de) | 1998-02-12 | 2003-09-15 | Immune Complex Corp | Strategisch modifizierte hepatitis b kernproteine und ihre derivate |
| WO1999052549A1 (en) | 1998-04-09 | 1999-10-21 | Smithkline Beecham Biologicals S.A. | Adjuvant compositions |
| US5990085A (en) * | 1998-05-04 | 1999-11-23 | Michigan State University | Inhibin-HBc fusion protein |
| HK1039072A1 (zh) | 1998-05-07 | 2002-04-12 | 科里克萨有限公司 | 佐剂组合物及其使用方法 |
| KR100715954B1 (ko) | 1998-12-04 | 2007-05-09 | 바이오겐 아이덱 엠에이 인코포레이티드 | 펩티드 리간드에 의하여 부착된 다중 면역원성 성분을보유한 hbv 코어 항원 입자 |
| JP2003511075A (ja) | 1999-10-08 | 2003-03-25 | セルテック ファーマ ユアロップ リミテッド | 免疫原の設計 |
| WO2001041759A1 (en) | 1999-12-10 | 2001-06-14 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for modulation of oocyte activation |
| EP1294893B1 (en) | 2000-06-22 | 2006-03-15 | UCB Pharma Limited | Modification of hepatitis b core antigen |
| US20030138769A1 (en) | 2000-08-16 | 2003-07-24 | Birkett Ashley J. | Immunogenic HBc chimer particles having enhanced stability |
| US6942866B2 (en) | 2000-08-16 | 2005-09-13 | Apovia, Inc. | Malaria immunogen and vaccine |
| US20030175863A1 (en) * | 2001-08-15 | 2003-09-18 | Birkett Ashley J. | Influenza immunogen and vaccine |
| US7361352B2 (en) * | 2001-08-15 | 2008-04-22 | Acambis, Inc. | Influenza immunogen and vaccine |
| US20030202982A1 (en) * | 2001-08-15 | 2003-10-30 | Birkett Ashley J. | Influenza immunogen and vaccine |
| US20030198645A1 (en) * | 2002-02-21 | 2003-10-23 | Mark Page | Stabilized HBc chimer particles as therapeutic vaccine for chronic hepatitis |
-
2004
- 2004-02-26 US US10/787,734 patent/US7361352B2/en not_active Expired - Fee Related
- 2004-12-09 EP EP04814103A patent/EP1708748A4/en not_active Withdrawn
- 2004-12-09 JP JP2006544104A patent/JP2007513634A/ja active Pending
- 2004-12-09 EP EP11182824A patent/EP2425848A3/en not_active Withdrawn
- 2004-12-09 AU AU2004296886A patent/AU2004296886B2/en not_active Ceased
- 2004-12-09 CA CA002549104A patent/CA2549104A1/en not_active Abandoned
- 2004-12-09 WO PCT/US2004/041879 patent/WO2005055957A2/en not_active Ceased
- 2004-12-09 BR BRPI0417509-3A patent/BRPI0417509A/pt not_active IP Right Cessation
- 2004-12-09 CN CN2004800414514A patent/CN1913920B/zh not_active Expired - Fee Related
-
2006
- 2006-06-09 KR KR1020067011453A patent/KR101209484B1/ko not_active Expired - Fee Related
- 2006-07-07 NO NO20063157A patent/NO20063157L/no not_active Application Discontinuation
- 2006-08-24 US US11/509,382 patent/US8017127B2/en not_active Expired - Fee Related
-
2009
- 2009-08-11 IL IL200341A patent/IL200341A/en not_active IP Right Cessation
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2025004002A5 (enExample) | ||
| JP2005120106A5 (enExample) | ||
| JP2012095652A5 (enExample) | ||
| JP2020500015A5 (enExample) | ||
| JP2013501038A5 (enExample) | ||
| JP2009540801A5 (enExample) | ||
| JP2009509535A5 (enExample) | ||
| JP2004532033A5 (enExample) | ||
| JP2018171063A5 (enExample) | ||
| JP2018537087A5 (enExample) | ||
| JP2014506790A5 (enExample) | ||
| JP2013531477A5 (enExample) | ||
| JP2020508667A5 (enExample) | ||
| JP2022062113A5 (enExample) | ||
| JP2011087580A5 (enExample) | ||
| JP2014239686A5 (enExample) | ||
| JP2008543314A5 (enExample) | ||
| JP2002510494A5 (enExample) | ||
| JP2013502226A5 (enExample) | ||
| JP2014507154A5 (enExample) | ||
| JP2016503655A5 (enExample) | ||
| JP2020517260A5 (enExample) | ||
| BRPI0417509A (pt) | molécula de proteìna quimérica de núcleo de vìrus da hepatite b (hbc) recombinante, partìculas, vacina ou inóculo, ácido nucleico, molécula de ácido nucleico recombinante, e, célula hospedeira | |
| WO2024078621A1 (zh) | 一种pht纳米孔突变体蛋白及其应用 | |
| JP2005509420A5 (enExample) |