JP2007513634A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2007513634A5 JP2007513634A5 JP2006544104A JP2006544104A JP2007513634A5 JP 2007513634 A5 JP2007513634 A5 JP 2007513634A5 JP 2006544104 A JP2006544104 A JP 2006544104A JP 2006544104 A JP2006544104 A JP 2006544104A JP 2007513634 A5 JP2007513634 A5 JP 2007513634A5
- Authority
- JP
- Japan
- Prior art keywords
- hbc
- sequence
- residues
- residue
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 21
- 125000000539 amino acid group Chemical group 0.000 claims 20
- 239000002245 particle Substances 0.000 claims 17
- 108090000623 proteins and genes Proteins 0.000 claims 15
- 102000039446 nucleic acids Human genes 0.000 claims 11
- 108020004707 nucleic acids Proteins 0.000 claims 11
- 150000007523 nucleic acids Chemical class 0.000 claims 11
- 108090000765 processed proteins & peptides Proteins 0.000 claims 11
- 235000018102 proteins Nutrition 0.000 claims 11
- 102000004169 proteins and genes Human genes 0.000 claims 11
- 229920001184 polypeptide Polymers 0.000 claims 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims 6
- 241000737598 recombinant Hepatitis B virus Species 0.000 claims 6
- 230000002163 immunogen Effects 0.000 claims 5
- 208000037797 influenza A Diseases 0.000 claims 5
- 230000000295 complement effect Effects 0.000 claims 4
- 102000005741 Metalloproteases Human genes 0.000 claims 2
- 235000018417 cysteine Nutrition 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 102000037865 fusion proteins Human genes 0.000 claims 2
- 108020001507 fusion proteins Proteins 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 239000002054 inoculum Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 229960005486 vaccine Drugs 0.000 claims 2
- 239000004475 Arginine Substances 0.000 claims 1
- 241000700721 Hepatitis B virus Species 0.000 claims 1
- 241000712431 Influenza A virus Species 0.000 claims 1
- 108010006035 Metalloproteases Proteins 0.000 claims 1
- 102000012479 Serine Proteases Human genes 0.000 claims 1
- 108010022999 Serine Proteases Proteins 0.000 claims 1
- 101710102218 Serine protease inhibitor Proteins 0.000 claims 1
- 229940122055 Serine protease inhibitor Drugs 0.000 claims 1
- 101000998548 Yersinia ruckeri Alkaline proteinase inhibitor Proteins 0.000 claims 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
- 230000002934 lysing effect Effects 0.000 claims 1
- 239000003475 metalloproteinase inhibitor Substances 0.000 claims 1
- 239000000203 mixture Chemical group 0.000 claims 1
- 239000003001 serine protease inhibitor Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/732,862 US20040146524A1 (en) | 2002-02-21 | 2003-12-10 | Stabilized immunogenic HBc chimer particles |
| US10/787,734 US7361352B2 (en) | 2001-08-15 | 2004-02-26 | Influenza immunogen and vaccine |
| PCT/US2004/041879 WO2005055957A2 (en) | 2003-12-10 | 2004-12-09 | Influenza immunogen and vaccine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007513634A JP2007513634A (ja) | 2007-05-31 |
| JP2007513634A5 true JP2007513634A5 (enExample) | 2008-02-07 |
Family
ID=34681746
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006544104A Pending JP2007513634A (ja) | 2003-12-10 | 2004-12-09 | インフルエンザ免疫原及びワクチン |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US7361352B2 (enExample) |
| EP (2) | EP1708748A4 (enExample) |
| JP (1) | JP2007513634A (enExample) |
| KR (1) | KR101209484B1 (enExample) |
| CN (1) | CN1913920B (enExample) |
| AU (1) | AU2004296886B2 (enExample) |
| BR (1) | BRPI0417509A (enExample) |
| CA (1) | CA2549104A1 (enExample) |
| IL (1) | IL200341A (enExample) |
| NO (1) | NO20063157L (enExample) |
| WO (1) | WO2005055957A2 (enExample) |
Families Citing this family (87)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7361352B2 (en) * | 2001-08-15 | 2008-04-22 | Acambis, Inc. | Influenza immunogen and vaccine |
| US7351413B2 (en) | 2002-02-21 | 2008-04-01 | Lorantis, Limited | Stabilized HBc chimer particles as immunogens for chronic hepatitis |
| US8101189B2 (en) | 2002-07-05 | 2012-01-24 | Folia Biotech Inc. | Vaccines and immunopotentiating compositions and methods for making and using them |
| KR100991679B1 (ko) * | 2002-12-10 | 2010-11-04 | 셀덱스 테라퓨틱스 리미티드 | 안정화 면역원성 ＨＢｃ 키메라 입자 |
| US20090162400A1 (en) * | 2004-12-21 | 2009-06-25 | Powell Thomas J | Compositions of influenza viral proteins and methods of use thereof |
| US7700285B1 (en) | 2005-12-29 | 2010-04-20 | Boehringer Ingelheim Vetmedica, Inc. | PCV2 immunogenic compositions and methods of producing such compositions |
| US7833707B2 (en) | 2004-12-30 | 2010-11-16 | Boehringer Ingelheim Vetmedica, Inc. | Methods of overexpression and recovery of porcine circovirus type 2 ORF2 |
| UA95602C2 (ru) | 2004-12-30 | 2011-08-25 | Берингер Ингельхейм Ветмедика, Инк. | Иммуногенная композиция цвс2 и способы приготовления такой композиции |
| TW200700079A (en) | 2005-03-23 | 2007-01-01 | Glaxosmithkline Biolog Sa | Composition |
| US20070160628A1 (en) * | 2005-08-31 | 2007-07-12 | Birkett Ashley J | Stabilized virus-like particles and epitope display systems |
| ES2359214T5 (es) | 2005-11-01 | 2014-10-08 | Novartis Vaccines And Diagnostics Gmbh | Vacunas virales derivadas de células con niveles reducidos de ADN celular residual por tratamiento con beta-propiolactona |
| US11707520B2 (en) | 2005-11-03 | 2023-07-25 | Seqirus UK Limited | Adjuvanted vaccines with non-virion antigens prepared from influenza viruses grown in cell culture |
| PL1945252T3 (pl) | 2005-11-04 | 2013-11-29 | Seqirus Uk Ltd | Szczepionki zawierające oczyszczone antygeny powierzchniowe otrzymane z wirusów grypy hodowanych w hodowli komórkowej i skwalen jako adiuwant |
| BRPI0618254A2 (pt) * | 2005-11-04 | 2011-08-23 | Novartis Vaccines & Diagnostic | emulsões com agente tensoativo de fase aquosa livre para fornecer adjuvante às vacinas contra influenza dividido |
| PL2371383T3 (pl) | 2005-12-29 | 2016-01-29 | Boehringer Ingelheim Vetmedica Inc | Zastosowanie kompozycji immunogennej do zmniejszania objawów klinicznych u świń |
| US20080226669A1 (en) | 2005-12-29 | 2008-09-18 | Boehringer Ingelheim Vetmedica, Inc. | Multivalent pcv2 immunogenic compositions and methods of producing such compositions |
| EP3011969A1 (en) * | 2006-03-07 | 2016-04-27 | Vaxinnate Corporation | Compositions that include hemagglutinin, methods of making and methods of use thereof |
| WO2007126887A2 (en) * | 2006-03-27 | 2007-11-08 | The Government Of The United States Of America | Immunogenic compositions comprising polynucleotides encoding matrix protein 2 and methods of use |
| WO2007127290A2 (en) * | 2006-04-24 | 2007-11-08 | Protelix, Inc. | Method for producing viral vaccine and therapeutic peptide antigens |
| JP2009543554A (ja) | 2006-07-14 | 2009-12-10 | サノフィ パスツール バイオロジクス カンパニー | ベクターウイルスタンパク質への外来免疫決定基の直接トランスポゾン媒介挿入による組換え型ウイルスワクチンの構築 |
| MX2009000660A (es) | 2006-07-17 | 2009-04-08 | Glaxosmithkline Biolog Sa | Vacuna de influenza. |
| WO2008032219A2 (en) * | 2006-09-11 | 2008-03-20 | Novartis Ag | Making influenza virus vaccines without using eggs |
| US8097419B2 (en) | 2006-09-12 | 2012-01-17 | Longhorn Vaccines & Diagnostics Llc | Compositions and method for rapid, real-time detection of influenza A virus (H1N1) swine 2009 |
| US9481912B2 (en) | 2006-09-12 | 2016-11-01 | Longhorn Vaccines And Diagnostics, Llc | Compositions and methods for detecting and identifying nucleic acid sequences in biological samples |
| US8652782B2 (en) | 2006-09-12 | 2014-02-18 | Longhorn Vaccines & Diagnostics, Llc | Compositions and methods for detecting, identifying and quantitating mycobacterial-specific nucleic acids |
| US8080645B2 (en) * | 2007-10-01 | 2011-12-20 | Longhorn Vaccines & Diagnostics Llc | Biological specimen collection/transport compositions and methods |
| CA2664791A1 (en) | 2006-09-29 | 2008-08-21 | Sanofi Pasteur Biologics Co. | Recombinant rhinovirus vectors |
| ZA200901993B (en) | 2006-09-29 | 2010-07-28 | Sanofi Pasteur Biologics Co | Novel neutralizing immunogen (NIMIV) of rhinovirus and its use for vaccine applicants |
| AU2007317847B2 (en) | 2006-11-07 | 2013-10-31 | Sanofi Pasteur Biologics, Llc | Stabilization of vaccines by lyophilization |
| CA2669485C (en) * | 2006-11-15 | 2017-01-03 | Folia Biotech Inc. | Papaya mosaic virus-based vaccines for influenza |
| WO2008064299A2 (en) * | 2006-11-22 | 2008-05-29 | Boehringer Ingelheim Vetmedica, Inc. | Methods of reducing porcine circovirus-associated disease outbreaks |
| WO2008073464A2 (en) | 2006-12-11 | 2008-06-19 | Boehringer Ingelheim Vetmedica, Inc. | Effective method of treatment of porcine circovirus and lawsonia intracellularis infections |
| ES2625460T5 (es) * | 2006-12-15 | 2020-11-04 | Boehringer Ingelheim Animal Health Usa Inc | Tratamiento de cerdos seropositivos en anticuerpo anti-PCV2 con antígeno de PCV2 |
| EP1941903A1 (en) | 2007-01-03 | 2008-07-09 | Boehringer Ingelheim Vetmedica Gmbh | Prophylaxis and treatment of PRDC |
| US8741849B2 (en) * | 2007-01-10 | 2014-06-03 | Purdue Research Foundation | Kinase inhibitors and uses thereof |
| EP2155228B1 (en) | 2007-01-10 | 2014-04-02 | Purdue Research Foundation | Polypeptide inhibitors of hsp27 kinase and uses therefor |
| EP2117588A4 (en) * | 2007-02-09 | 2011-05-04 | Sanofi Pasteur Biologics Co | VIRAL VECTORS AND METHODS OF USE |
| EP1958644A1 (en) | 2007-02-13 | 2008-08-20 | Boehringer Ingelheim Vetmedica Gmbh | Prevention and treatment of sub-clinical pcvd |
| WO2008118487A2 (en) * | 2007-03-26 | 2008-10-02 | University Of Massachusetts Medical School | Compositions and methods for incresing immunogenicity of glycoprotein vaccines |
| US8071561B2 (en) | 2007-08-16 | 2011-12-06 | Chrontech Pharma Ab | Immunogen platform |
| US20090196915A1 (en) * | 2007-08-21 | 2009-08-06 | Gary Van Nest | Composition and methods of making and using influenza proteins |
| US11041215B2 (en) | 2007-08-24 | 2021-06-22 | Longhorn Vaccines And Diagnostics, Llc | PCR ready compositions and methods for detecting and identifying nucleic acid sequences |
| US9683256B2 (en) | 2007-10-01 | 2017-06-20 | Longhorn Vaccines And Diagnostics, Llc | Biological specimen collection and transport system |
| US10004799B2 (en) | 2007-08-27 | 2018-06-26 | Longhorn Vaccines And Diagnostics, Llc | Composite antigenic sequences and vaccines |
| CA2976814C (en) | 2007-08-27 | 2022-12-13 | Longhorn Vaccines & Diagnostics, Llc | Immunogenic compositions and methods for treating influenza |
| US7829274B2 (en) * | 2007-09-04 | 2010-11-09 | Boehringer Ingelheim Vetmedica, Inc. | Reduction of concomitant infections in pigs by the use of PCV2 antigen |
| US11041216B2 (en) | 2007-10-01 | 2021-06-22 | Longhorn Vaccines And Diagnostics, Llc | Compositions and methods for detecting and quantifying nucleic acid sequences in blood samples |
| EP2195466B1 (en) | 2007-10-01 | 2012-10-10 | Longhorn Vaccines & Diagnostics, LLC | Method of storing biological specimens |
| WO2009079564A2 (en) * | 2007-12-17 | 2009-06-25 | Emory University | Immunogenic compositions and methods of use thereof |
| BRPI0821456A2 (pt) * | 2007-12-31 | 2015-06-16 | Boehring Ingelheim Vetmedica Inc | Partícula similar à pcv2 orf2 com inserção de aminoácido estranho |
| EP2242511A4 (en) | 2008-01-23 | 2012-10-24 | Boehringer Ingelheim Vetmed | IMMUNOGENIC COMPOSITIONS OF MYCOPLASMA HYOPNEUMONIAE PCV2, AND METHODS FOR PRODUCING SUCH COMPOSITIONS |
| US20110110973A1 (en) * | 2008-02-09 | 2011-05-12 | Sanofi Pasteur Biologics Co. | Influenza B Vaccines |
| WO2009128952A2 (en) | 2008-04-18 | 2009-10-22 | Vaxinnate Corporation | Compositions of papillomavirus proteins and methods of use |
| US8329188B2 (en) * | 2008-11-12 | 2012-12-11 | Theraclone Sciences, Inc. | Human M2e peptide immunogens |
| EP2378875B1 (en) * | 2008-12-10 | 2018-05-30 | Purdue Research Foundation | Cell-permeant peptide-based inhibitor of kinases |
| WO2010086743A2 (en) | 2009-02-02 | 2010-08-05 | Chrontech Pharma Ab | Compositions and methods that enhance an immune response |
| EP2396032B1 (en) | 2009-02-10 | 2016-09-28 | Seqirus UK Limited | Influenza vaccines with reduced amounts of squalene |
| BR112012000826B1 (pt) | 2009-07-06 | 2022-07-26 | Variation Biotechnologies Inc | Método para a preparação de vesículas |
| CA2803282C (en) | 2009-07-06 | 2018-05-01 | David E. Anderson | Methods for preparing vesicles and formulations produced therefrom |
| WO2011017132A2 (en) * | 2009-07-27 | 2011-02-10 | Purdue Research, Foundation | Mk2 inhibitor compositions and methods to enhance neurite outgrowth, neuroprotection, and nerve regeneration |
| TWI627281B (zh) | 2009-09-02 | 2018-06-21 | 百靈佳殷格翰家畜藥品公司 | 降低ｐｃｖ－２組合物殺病毒活性之方法及具有改良免疫原性之ｐｃｖ－２組合物 |
| AU2011230491A1 (en) * | 2010-03-26 | 2012-10-18 | Emergent Product Development Gaithersburg Inc. | Ectodomains of influenza Matrix 2 protein, expression system, and uses thereof |
| WO2012006367A2 (en) | 2010-07-06 | 2012-01-12 | Variation Biotechnologies, Inc. | Compositions and methods for treating influenza |
| CA2862864C (en) | 2011-01-13 | 2018-12-11 | Variation Biotechnologies Inc. | Compositions and methods for treating viral infections |
| US20130323280A1 (en) | 2011-01-13 | 2013-12-05 | Variation Biotechnologies, Inc. | Methods for preparing vesicles and formulations produced therefrom |
| EA034702B1 (ru) * | 2011-04-26 | 2020-03-10 | Молекулар Экспресс, Инк. | Липосомные композиции |
| CN103083656A (zh) * | 2011-10-27 | 2013-05-08 | 苏州科贝生物技术有限公司 | 甲型流感病毒保守肽M2e与病毒样颗粒的缀合物及应用 |
| CA2890084C (en) | 2011-11-18 | 2021-05-04 | Maura Ellen Campbell | Synthetic derivatives of mpl and uses thereof |
| EP2802353A4 (en) | 2012-01-12 | 2015-12-02 | Variation Biotechnologies Inc | COMPOSITIONS AND METHOD FOR THE TREATMENT OF VIRUS INFECTIONS |
| EP2806890A4 (en) | 2012-01-26 | 2015-09-02 | Longhorn Vaccines & Diagnostics Llc | COMPOSITIONAL ANTIGEN SEQUENCES AND VACCINES |
| CN104244984B (zh) | 2012-01-27 | 2020-03-31 | 变异生物技术公司 | 用于治疗剂的方法和组合物 |
| WO2013134636A1 (en) | 2012-03-09 | 2013-09-12 | Purdue Research Foundation | Compositions and methods for delivery of kinase inhibiting peptides |
| US8932598B2 (en) | 2012-08-28 | 2015-01-13 | Vaxinnate Corporation | Fusion proteins and methods of use |
| WO2014039661A1 (en) * | 2012-09-05 | 2014-03-13 | Stryker Corporation | Patient support |
| US10117923B2 (en) | 2012-11-07 | 2018-11-06 | Vacplanta Limited | Production of an immunogen using a plant virus |
| WO2014074509A1 (en) * | 2012-11-07 | 2014-05-15 | Vacplanta Limted | Production of an immunogen using a plant virus |
| DK3052516T3 (da) | 2013-10-02 | 2020-03-23 | Boehringer Ingelheim Animal Health Usa Inc | PCV2-ORF2-proteinvariant og viruslignende partikler sammensat deraf |
| GB201402890D0 (en) | 2014-02-18 | 2014-04-02 | Iqur Ltd | Vaccines based on hepatitis B Core antigens |
| GB201421692D0 (en) * | 2014-12-05 | 2015-01-21 | Iquar Ltd | Vaccines based on hepatitis B core antigens |
| CA2985652C (en) | 2015-05-14 | 2020-03-10 | Gerald W. FISHER | Rapid methods for the extraction of nucleic acids from biological samples |
| CN113164445A (zh) | 2018-08-02 | 2021-07-23 | 得克萨斯系统大学评议会 | Tlr1/2激动剂地普罗考姆的佐剂作用协同增效检查点抑制性抗体以消除疾病 |
| US20220356538A1 (en) * | 2019-09-24 | 2022-11-10 | The Penn State Research Foundation | Hepatitis b virus mutants with increased covalently closed circular dna |
| US12485166B2 (en) | 2020-02-06 | 2025-12-02 | Longhorn Vaccines And Diagnostics, Llc | Vaccines for the treatment and prevention of zoonotic infections |
| EP4103283A4 (en) | 2020-03-26 | 2024-02-28 | Provectus Pharmatech, Inc. | NEW USES OF HALOGENATED XANTHENES IN ONCOLOGY AND VIROLOGY |
| US11938182B2 (en) | 2020-03-26 | 2024-03-26 | Provectus Pharmatech, Inc. | Halogenated xanthenes as vaccine adjuvants |
| WO2022087122A1 (en) | 2020-10-20 | 2022-04-28 | Longhorn Vaccines And Diagnostics, Llc | Immunogenic antigens |
| WO2022187132A1 (en) * | 2021-03-04 | 2022-09-09 | Longhorn Vaccines And Diagnostics, Llc | Vaccines for the treatment and prevention of zoonotic infections |
Family Cites Families (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4767842A (en) | 1973-05-07 | 1988-08-30 | The Ohio State University | Antigenic modification of polypeptides |
| US4888170A (en) | 1981-10-22 | 1989-12-19 | Research Corporation | Vaccines obtained from antigenic gene products of recombinant genes |
| US4436727A (en) | 1982-05-26 | 1984-03-13 | Ribi Immunochem Research, Inc. | Refined detoxified endotoxin product |
| US4977092A (en) * | 1985-06-26 | 1990-12-11 | Amgen | Expression of exogenous polypeptides and polypeptide products including hepatitis B surface antigen in yeast cells |
| US4539205A (en) | 1982-11-09 | 1985-09-03 | Scripps Clinic And Research Foundation | Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives |
| US4643992A (en) | 1982-11-09 | 1987-02-17 | Scripps Clinic And Research Foundation | Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives |
| US4987237A (en) | 1983-08-26 | 1991-01-22 | Ribi Immunochem Research, Inc. | Derivatives of monophosphoryl lipid A |
| US5093318A (en) | 1983-11-01 | 1992-03-03 | Scripps Clinic And Research Foundation | Immunostimulating guanosine derivatives and their pharmaceutical compositions |
| US5011828A (en) | 1985-11-15 | 1991-04-30 | Michael Goodman | Immunostimulating guanine derivatives, compositions and methods |
| US4818527A (en) * | 1986-12-09 | 1989-04-04 | Scripps Clinic And Research Foundation | T cell epitopes of the hepatitis B virus nucleocapsid protein |
| US4882145A (en) * | 1986-12-09 | 1989-11-21 | Scripps Clinic And Research Foundation | T cell epitopes of the hepatitis B virus nucleocapsid protein |
| US5143726A (en) * | 1986-12-09 | 1992-09-01 | The Scripps Research Institute | T cell epitopes of the hepatitis B virus nucleocapsid protein |
| US4976958A (en) * | 1987-02-26 | 1990-12-11 | Scripps Clinic And Research Foundation | Mycobacterial recombinants and peptides |
| US5057540A (en) | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
| US5387744A (en) | 1987-06-04 | 1995-02-07 | Washington University | Avirulent microbes and uses therefor: Salmonella typhi |
| JPH04501801A (ja) | 1988-09-06 | 1992-04-02 | ワシントン ユニバーシティ | トランスジェニック植物による経口的免疫化 |
| US5023179A (en) | 1988-11-14 | 1991-06-11 | Eric Lam | Promoter enhancer element for gene expression in plant roots |
| US5110732A (en) | 1989-03-14 | 1992-05-05 | The Rockefeller University | Selective gene expression in plants |
| JPH0832638B2 (ja) | 1989-05-25 | 1996-03-29 | カイロン コーポレイション | サブミクロン油滴乳剤を含んで成るアジュバント製剤 |
| NZ235315A (en) | 1989-09-19 | 1991-09-25 | Wellcome Found | Chimaeric hepadnavirus core antigen proteins and their construction |
| US5618988A (en) | 1990-03-02 | 1997-04-08 | Amoco Corporation | Enhanced carotenoid accumulation in storage organs of genetically engineered plants |
| CA2055447C (en) | 1990-03-02 | 2006-12-19 | Rodney Lee Ausich | Biosynthesis of carotenoids in genetically engineered hosts |
| US5057588A (en) | 1990-03-09 | 1991-10-15 | Hoechst Celanese Corp. | Vinylidene cyanide alternating copolymers |
| US5709879A (en) | 1990-06-29 | 1998-01-20 | Chiron Corporation | Vaccine compositions containing liposomes |
| NZ253137A (en) | 1992-06-25 | 1996-08-27 | Smithkline Beecham Biolog | Vaccine comprising antigen and/or antigenic composition, qs21 (quillaja saponaria molina extract) and 3 de-o-acylated monophosphoryl lipid a. |
| US5297441A (en) | 1992-08-14 | 1994-03-29 | The Boeing Company | Apparatus for supporting a test specimen for compression testing |
| EP0689454B2 (en) | 1993-03-23 | 2005-02-23 | SMITHKLINE BEECHAM BIOLOGICALS s.a. | Vaccine compositions containing 3-o deacylated monophosphoryl lipid a |
| GB9326253D0 (en) | 1993-12-23 | 1994-02-23 | Smithkline Beecham Biolog | Vaccines |
| DE69535905D1 (de) | 1994-07-15 | 2009-02-26 | Coley Pharm Group Inc | Immunomodulatorische Oligonukleotide |
| UA56132C2 (uk) | 1995-04-25 | 2003-05-15 | Смітклайн Бічем Байолоджікалс С.А. | Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини |
| JP3701761B2 (ja) * | 1997-01-08 | 2005-10-05 | 本田技研工業株式会社 | 車両用シート |
| US6355257B1 (en) | 1997-05-08 | 2002-03-12 | Corixa Corporation | Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors |
| US7063967B2 (en) | 1997-05-08 | 2006-06-20 | Corixa Corporation | Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors |
| US6303347B1 (en) | 1997-05-08 | 2001-10-16 | Corixa Corporation | Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors |
| US6113918A (en) | 1997-05-08 | 2000-09-05 | Ribi Immunochem Research, Inc. | Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors |
| BR9809149A (pt) | 1997-05-20 | 2000-08-01 | Galenica Pharmaceuticals Inc | Análogos de triterpeno saponina dotados de adjuvante e atividade imonoestimulatória |
| US6080725A (en) | 1997-05-20 | 2000-06-27 | Galenica Pharmaceuticals, Inc. | Immunostimulating and vaccine compositions employing saponin analog adjuvants and uses thereof |
| DE69832706T2 (de) * | 1997-08-05 | 2006-08-10 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. | Immunschützendes influenzaantigen und dessen verwendung zur impfung |
| GB9718901D0 (en) | 1997-09-05 | 1997-11-12 | Smithkline Beecham Biolog | Vaccine |
| US6024961A (en) | 1997-11-14 | 2000-02-15 | Washington University | Recombinant avirulent immunogenic S typhi having rpos positive phenotype |
| CA2314934C (en) | 1997-12-16 | 2006-08-29 | Chiron Corporation | Use of microparticles combined with submicron oil-in-water emulsions |
| NZ506245A (en) | 1998-02-12 | 2003-08-29 | Immune Complex Corp | Strategically modified hepatitis b core proteins and their derivatives |
| HUP0101619A3 (en) | 1998-04-09 | 2003-11-28 | Smithkline Beecham Biolog | Adjuvant compositions |
| US5990085A (en) * | 1998-05-04 | 1999-11-23 | Michigan State University | Inhibin-HBc fusion protein |
| DK1075276T3 (da) | 1998-05-07 | 2008-02-11 | Corixa Corp | Adjuvanssammensætning og fremgangsmåder til dens anvendelse |
| AU770225B2 (en) | 1998-12-04 | 2004-02-19 | Biogen Idec Ma Inc. | HBV core antigen particles with multiple immunogenic components attached via peptide ligands |
| ATE324448T1 (de) | 1999-10-08 | 2006-05-15 | Celltech Pharma Europ Ltd | Design von immunogene |
| WO2001041759A1 (en) | 1999-12-10 | 2001-06-14 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for modulation of oocyte activation |
| ES2260235T3 (es) | 2000-06-22 | 2006-11-01 | Ucb Pharma Limited | Modificacion del antigeno "core" de la hepatitis b. |
| US6942866B2 (en) | 2000-08-16 | 2005-09-13 | Apovia, Inc. | Malaria immunogen and vaccine |
| US20030138769A1 (en) | 2000-08-16 | 2003-07-24 | Birkett Ashley J. | Immunogenic HBc chimer particles having enhanced stability |
| US7361352B2 (en) * | 2001-08-15 | 2008-04-22 | Acambis, Inc. | Influenza immunogen and vaccine |
| US20030202982A1 (en) * | 2001-08-15 | 2003-10-30 | Birkett Ashley J. | Influenza immunogen and vaccine |
| US20030175863A1 (en) * | 2001-08-15 | 2003-09-18 | Birkett Ashley J. | Influenza immunogen and vaccine |
| US20030198645A1 (en) * | 2002-02-21 | 2003-10-23 | Mark Page | Stabilized HBc chimer particles as therapeutic vaccine for chronic hepatitis |
-
2004
- 2004-02-26 US US10/787,734 patent/US7361352B2/en not_active Expired - Fee Related
- 2004-12-09 BR BRPI0417509-3A patent/BRPI0417509A/pt not_active IP Right Cessation
- 2004-12-09 JP JP2006544104A patent/JP2007513634A/ja active Pending
- 2004-12-09 EP EP04814103A patent/EP1708748A4/en not_active Withdrawn
- 2004-12-09 AU AU2004296886A patent/AU2004296886B2/en not_active Ceased
- 2004-12-09 WO PCT/US2004/041879 patent/WO2005055957A2/en not_active Ceased
- 2004-12-09 EP EP11182824A patent/EP2425848A3/en not_active Withdrawn
- 2004-12-09 CN CN2004800414514A patent/CN1913920B/zh not_active Expired - Fee Related
- 2004-12-09 CA CA002549104A patent/CA2549104A1/en not_active Abandoned
-
2006
- 2006-06-09 KR KR1020067011453A patent/KR101209484B1/ko not_active Expired - Fee Related
- 2006-07-07 NO NO20063157A patent/NO20063157L/no not_active Application Discontinuation
- 2006-08-24 US US11/509,382 patent/US8017127B2/en not_active Expired - Fee Related
-
2009
- 2009-08-11 IL IL200341A patent/IL200341A/en not_active IP Right Cessation