AR078253A1 - Metodos para reducir la actividad antivirica en composiciones pcv-2 y composiciones pcv-2 con mejor inmunogenicidad - Google Patents

Metodos para reducir la actividad antivirica en composiciones pcv-2 y composiciones pcv-2 con mejor inmunogenicidad

Info

Publication number
AR078253A1
AR078253A1 ARP100103209A ARP100103209A AR078253A1 AR 078253 A1 AR078253 A1 AR 078253A1 AR P100103209 A ARP100103209 A AR P100103209A AR P100103209 A ARP100103209 A AR P100103209A AR 078253 A1 AR078253 A1 AR 078253A1
Authority
AR
Argentina
Prior art keywords
pcv
antigen
compositions
antiviral activity
immunogenic composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
ARP100103209A
Other languages
English (en)
Inventor
Guosong Zhao
Ali Khazraeinazmpour
Bernd Eichenmueller
Marc Eichmeyer
Gregory Haiwick
Merrill Schaeffer
Caroline Kohler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Vetmedica de C V SA
Boehringer Ingelheim Vetmedica Inc
Original Assignee
Boehringer Ingelheim Vetmedica de C V SA
Boehringer Ingelheim Vetmedica Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
Priority to US23919209P priority Critical
Priority to US30940810P priority
Application filed by Boehringer Ingelheim Vetmedica de C V SA, Boehringer Ingelheim Vetmedica Inc filed Critical Boehringer Ingelheim Vetmedica de C V SA
Publication of AR078253A1 publication Critical patent/AR078253A1/es
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43016553&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR078253(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application status is Pending legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5252Virus inactivated (killed)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5258Virus-like particles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/55Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552Veterinary vaccine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55555Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA Viruses
    • C12N2750/00011MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA Viruses ssDNA Viruses
    • C12N2750/10011Circoviridae
    • C12N2750/10034Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Abstract

Métodos para reducir la actividad antivírica de una composicion que comprende un antígeno PCV-2 al igual que preparaciones antigénicas y composiciones inmunogénicas que comprenden un antígeno PCV-2, en donde se redujo la actividad antivirica. Además, un método para aumentar la inmunogenicidad de una composicion inmunogénica que comprende un antígeno PCV-2 y también una composicion inmunogénica con mayor inmunogenicidad. Reivindicacion 37: La composicion inmunogénica de acuerdo con la reivindicacion 35 o 36, caracterizada porque el antígeno de PCV-2 es una proteína del ORF2 recombinante de circovirus porcino que se expresa en bacterias o células animales. Reivindicacion 38: La composicion inmunogénica de acuerdo con cualquiera de las reivindicaciones 35 a 37, caracterizada porque la proteína del ORF2 de circovirus porcino se puede obtener mediante un proceso que comprende las siguientes etapas: a. expresar el antígeno de PCV-2 2 en una célula huésped; b. recolectar el cultivo celular para obtener el antígeno de PCV-2; c. purificar la recoleccion que comprende el antígeno PCV-2 mediante filtracion en gel; d. mezclar el antígeno de PCV-2 purificado con un adyuvante.
ARP100103209A 2009-09-02 2010-09-01 Metodos para reducir la actividad antivirica en composiciones pcv-2 y composiciones pcv-2 con mejor inmunogenicidad Pending AR078253A1 (es)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US23919209P true 2009-09-02 2009-09-02
US30940810P true 2010-03-01 2010-03-01

Publications (1)

Publication Number Publication Date
AR078253A1 true AR078253A1 (es) 2011-10-26

Family

ID=43016553

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100103209A Pending AR078253A1 (es) 2009-09-02 2010-09-01 Metodos para reducir la actividad antivirica en composiciones pcv-2 y composiciones pcv-2 con mejor inmunogenicidad

Country Status (19)

Country Link
US (1) US9561270B2 (es)
EP (1) EP2473189B1 (es)
JP (1) JP5921435B2 (es)
KR (1) KR101773754B1 (es)
CN (2) CN102573899A (es)
AR (1) AR078253A1 (es)
AU (1) AU2010289431B2 (es)
BR (1) BR112012004698A2 (es)
CA (1) CA2772928C (es)
CO (1) CO6511229A2 (es)
DK (1) DK2473189T3 (es)
ES (1) ES2657812T3 (es)
IN (1) IN2012DN01898A (es)
MX (1) MX340760B (es)
MY (1) MY165831A (es)
RU (1) RU2595395C2 (es)
SG (2) SG10201405406VA (es)
TW (1) TWI627281B (es)
WO (1) WO2011028888A2 (es)

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US7833707B2 (en) 2004-12-30 2010-11-16 Boehringer Ingelheim Vetmedica, Inc. Methods of overexpression and recovery of porcine circovirus type 2 ORF2
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US20100129397A1 (en) 2006-12-11 2010-05-27 Boehringer Ingelheim Vetmedica, Inc. Effective method of treatment of porcine circovirus and lawsonia intracellularis infections
PT2094872T (pt) 2006-12-15 2017-04-27 Boehringer Ingelheim Vetmedica Inc Tratamento de porcos seropositivos para o anticorpo anti-pcv2 com antigénio de pcv2
EP1941903A1 (en) 2007-01-03 2008-07-09 Boehringer Ingelheim Vetmedica Gmbh Prophylaxis and treatment of PRDC
EP1958644A1 (en) 2007-02-13 2008-08-20 Boehringer Ingelheim Vetmedica Gmbh Prevention and treatment of sub-clinical pcvd
US7829274B2 (en) 2007-09-04 2010-11-09 Boehringer Ingelheim Vetmedica, Inc. Reduction of concomitant infections in pigs by the use of PCV2 antigen
EP2242511A4 (en) 2008-01-23 2012-10-24 Boehringer Ingelheim Vetmed Pcv2 mycoplasma hyopneumoniae immunogenic compositions and methods of producing such compositions
TWI627281B (zh) 2009-09-02 2018-06-21 百靈佳殷格翰家畜藥品公司 降低pcv-2組合物殺病毒活性之方法及具有改良免疫原性之pcv-2組合物
CN103102397A (zh) * 2011-11-09 2013-05-15 韩健宝 预防和治疗pcv-2病毒的肽核酸及其制剂
US20140322267A1 (en) * 2013-04-30 2014-10-30 Boehringer Ingelheim Vetmedica, Inc. Orf2 protein of pcv2 subtype a (pcv2a) for use in cross-protection
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KR20160058958A (ko) 2013-10-02 2016-05-25 베링거잉겔하임베트메디카인코퍼레이티드 Pcv2 orf2 단백질 변이체 및 이로 이루어진 바이러스 유사 입자
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