JP2008545393A5 - - Google Patents
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- Publication number
- JP2008545393A5 JP2008545393A5 JP2008512471A JP2008512471A JP2008545393A5 JP 2008545393 A5 JP2008545393 A5 JP 2008545393A5 JP 2008512471 A JP2008512471 A JP 2008512471A JP 2008512471 A JP2008512471 A JP 2008512471A JP 2008545393 A5 JP2008545393 A5 JP 2008545393A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- polypeptide
- polynucleotide
- host cell
- complex
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920001184 polypeptide Polymers 0.000 claims 22
- 102000004196 processed proteins & peptides Human genes 0.000 claims 22
- 108090000765 processed proteins & peptides Proteins 0.000 claims 22
- 108091033319 polynucleotide Proteins 0.000 claims 8
- 102000040430 polynucleotide Human genes 0.000 claims 8
- 239000002157 polynucleotide Substances 0.000 claims 8
- 238000000034 method Methods 0.000 claims 5
- 230000000840 anti-viral effect Effects 0.000 claims 4
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
- 239000013604 expression vector Substances 0.000 claims 3
- 150000007523 nucleic acids Chemical group 0.000 claims 3
- 239000013598 vector Substances 0.000 claims 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 241000710188 Encephalomyocarditis virus Species 0.000 claims 1
- 239000004698 Polyethylene Substances 0.000 claims 1
- 150000001413 amino acids Chemical group 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 238000002832 anti-viral assay Methods 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- -1 polyethylene Polymers 0.000 claims 1
- 229920000573 polyethylene Polymers 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68276905P | 2005-05-18 | 2005-05-18 | |
| PCT/US2006/019088 WO2007044083A2 (en) | 2005-05-18 | 2006-05-17 | Evolved interferon-alpha polypeptides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008545393A JP2008545393A (ja) | 2008-12-18 |
| JP2008545393A5 true JP2008545393A5 (enExample) | 2009-06-25 |
Family
ID=37943260
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008512471A Pending JP2008545393A (ja) | 2005-05-18 | 2006-05-17 | 進歩したインターフェロンαポリペプチド |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7619067B2 (enExample) |
| EP (1) | EP1888633A4 (enExample) |
| JP (1) | JP2008545393A (enExample) |
| KR (1) | KR20080019619A (enExample) |
| CN (1) | CN101501068A (enExample) |
| AU (1) | AU2006299901A1 (enExample) |
| BR (1) | BRPI0609809A2 (enExample) |
| CA (1) | CA2607651A1 (enExample) |
| IL (1) | IL186880A0 (enExample) |
| MX (1) | MX2007014524A (enExample) |
| WO (1) | WO2007044083A2 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE439437T1 (de) | 1999-01-05 | 2009-08-15 | Univ Boston | Verbessertes klonierungsverfahren |
| US7435562B2 (en) | 2000-07-21 | 2008-10-14 | Modular Genetics, Inc. | Modular vector systems |
| ATE540110T1 (de) | 2004-11-11 | 2012-01-15 | Modular Genetics Inc | Oligonukleotid-leiterkonstruktion und system zur erzeugung von molekularer vielfalt |
| US7625555B2 (en) * | 2007-06-18 | 2009-12-01 | Novagen Holding Corporation | Recombinant human interferon-like proteins |
| EP2186830B1 (en) * | 2007-09-04 | 2012-03-07 | Biosteed Gene Expression Tech. CO., LTD. | Polyethylene glycol modified interferon alpha 2b and preparation method and applicatioins thereof |
| AT506535B1 (de) * | 2008-02-22 | 2010-04-15 | Affiris Forschungs & Entwicklungs Gmbh | Vaccine enthaltend alpha-synuclein-mimotope auf basis von peptiden |
| EA022201B1 (ru) | 2008-04-11 | 2015-11-30 | Мерримак Фармасьютикалз, Инк. | Агент, способный связываться с опухолевой клеткой, содержащий линкер на основе hsa, и его применение |
| AU2009240738B2 (en) | 2008-04-21 | 2014-09-11 | Tissue Regeneration Therapeutics, Inc. | Genetically modified human umbilical cord perivascular cells for prophylaxis against or treatment of biological or chemical agents |
| WO2010142017A1 (en) | 2009-06-09 | 2010-12-16 | Defyrus, Inc . | Administration of interferon for prophylaxis against or treatment of pathogenic infection |
| CN101921330B (zh) * | 2010-06-02 | 2013-07-17 | 北京三元基因工程有限公司 | 重组人干扰素α1b突变体及其制备方法 |
| IN2014DN08236A (enExample) * | 2012-03-03 | 2015-05-15 | Immungene Inc | |
| HRP20240478T1 (hr) | 2015-09-15 | 2024-07-05 | Ilc Therapeutics Ltd | Pripravci i metode vezane za liječenje bolesti |
| CN108733975B (zh) * | 2018-03-29 | 2021-09-07 | 深圳裕策生物科技有限公司 | 基于二代测序的肿瘤克隆变异检测方法、装置和存储介质 |
| CN111499718B (zh) * | 2019-01-30 | 2022-06-14 | 复旦大学 | 人α干扰素受体结合相关位点突变体及其用途 |
| CN114891088B (zh) * | 2019-06-13 | 2023-07-25 | 江苏科技大学 | 鸭α干扰素及其突变体、制备方法和应用 |
| JP2023517525A (ja) * | 2020-03-16 | 2023-04-26 | アイエルシー セラピューティクス リミテッド | ウイルス感染を治療するためのハイブリッドインターフェロン |
| EP3901168A1 (en) * | 2020-04-21 | 2021-10-27 | Universität Duisburg-Essen | Interferon alpha 2 variants and uses thereof |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6610830B1 (en) * | 1980-07-01 | 2003-08-26 | Hoffman-La Roche Inc. | Microbial production of mature human leukocyte interferons |
| ES506955A0 (es) | 1980-11-10 | 1983-02-01 | Genentech Inc | Un procedimiento para producir un polipeptido antiviral. |
| US4414150A (en) * | 1980-11-10 | 1983-11-08 | Genentech, Inc. | Hybrid human leukocyte interferons |
| EP0098876A1 (en) | 1982-01-19 | 1984-01-25 | Cetus Corporation | Multiclass hybrid interferons |
| US6936694B1 (en) | 1982-05-06 | 2005-08-30 | Intermune, Inc. | Manufacture and expression of large structural genes |
| ATE78262T1 (de) | 1985-06-11 | 1992-08-15 | Ciba Geigy Ag | Hybrid-interferone. |
| ES2128348T3 (es) | 1990-10-17 | 1999-05-16 | Amgen Inc | Obtencion de composiciones para el tratamiento de alteraciones de la proliferacion celular. |
| US5372808A (en) | 1990-10-17 | 1994-12-13 | Amgen Inc. | Methods and compositions for the treatment of diseases with consensus interferon while reducing side effect |
| US5595732A (en) * | 1991-03-25 | 1997-01-21 | Hoffmann-La Roche Inc. | Polyethylene-protein conjugates |
| US5382657A (en) | 1992-08-26 | 1995-01-17 | Hoffmann-La Roche Inc. | Peg-interferon conjugates |
| US5780021A (en) * | 1993-03-05 | 1998-07-14 | Georgetown University | Method for treating type 1 diabetes using α-interferon and/or β-i |
| US5574138A (en) * | 1993-03-08 | 1996-11-12 | Immunex Corporation | Epithelium-derived T-cell factor |
| US6335160B1 (en) * | 1995-02-17 | 2002-01-01 | Maxygen, Inc. | Methods and compositions for polypeptide engineering |
| ATE227133T1 (de) | 1994-03-07 | 2002-11-15 | Imperial College | Verwendung von interferon-alpha 8 subtype zur herstellung von medikamenten zur behandlung von viralinfektionen der leber |
| US5824784A (en) | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
| TW517067B (en) | 1996-05-31 | 2003-01-11 | Hoffmann La Roche | Interferon conjugates |
| IL133974A0 (en) | 1997-07-14 | 2001-04-30 | Bolder Biotechnology Inc | Derivatives of growth hormone and related proteins |
| ATE526401T1 (de) | 1999-01-14 | 2011-10-15 | Bolder Biotechnology Inc | Verfahren zur herstellung von proteinen mit freien cysteinresten |
| AU3725600A (en) | 1999-03-02 | 2000-09-21 | Maxygen, Inc. | Surrogate orphan ligands for orphan receptors |
| DE60035871T2 (de) | 1999-05-19 | 2008-06-05 | Merck Patent Gmbh | Expression und export von interferon-alpha proteinen als fc fusionsproteine |
| EP1238082A2 (en) * | 1999-10-07 | 2002-09-11 | Maxygen, Inc. | Ifn-alpha homologues |
| US20040002474A1 (en) * | 1999-10-07 | 2004-01-01 | Maxygen Inc. | IFN-alpha homologues |
| CN1318443C (zh) | 2000-05-16 | 2007-05-30 | 博尔德生物技术公司 | 含游离半胱氨酸残基的蛋白重折叠的方法 |
| AU2002223350A1 (en) | 2000-12-01 | 2002-06-11 | Eleanor N. Fish | Cytokine receptor binding peptides |
| KR100459105B1 (ko) | 2001-02-15 | 2004-12-03 | 선바이오(주) | 변형된 인터페론-알파 2ａ 및 2ｂ, 그리고 이들과 ＰＥＧ유도체와의 배합체 |
| MXPA05005178A (es) | 2002-11-15 | 2005-07-22 | Hoffmann La Roche | Isomeros posicionales del interferon alfa 2a (ifn) pegilado con una porcion de polietilenglicol grande (peg). |
| WO2004046365A2 (en) * | 2002-11-18 | 2004-06-03 | Maxygen, Inc. | Interferon-alpha polypeptides and conjugates |
| US7318918B2 (en) | 2004-05-19 | 2008-01-15 | Maxygen, Inc. | Interferon-alpha polypeptides and conjugates |
-
2006
- 2006-05-17 BR BRPI0609809-6A patent/BRPI0609809A2/pt not_active Application Discontinuation
- 2006-05-17 US US11/383,798 patent/US7619067B2/en not_active Expired - Fee Related
- 2006-05-17 MX MX2007014524A patent/MX2007014524A/es unknown
- 2006-05-17 WO PCT/US2006/019088 patent/WO2007044083A2/en not_active Ceased
- 2006-05-17 KR KR1020077029196A patent/KR20080019619A/ko not_active Withdrawn
- 2006-05-17 CA CA002607651A patent/CA2607651A1/en not_active Abandoned
- 2006-05-17 EP EP06836068A patent/EP1888633A4/en not_active Withdrawn
- 2006-05-17 JP JP2008512471A patent/JP2008545393A/ja active Pending
- 2006-05-17 AU AU2006299901A patent/AU2006299901A1/en not_active Abandoned
- 2006-05-17 CN CNA2006800222000A patent/CN101501068A/zh active Pending
-
2007
- 2007-10-24 IL IL186880A patent/IL186880A0/en unknown
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