CA2607651A1 - Evolved interferon-alpha polypeptides - Google Patents
Evolved interferon-alpha polypeptides Download PDFInfo
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- CA2607651A1 CA2607651A1 CA002607651A CA2607651A CA2607651A1 CA 2607651 A1 CA2607651 A1 CA 2607651A1 CA 002607651 A CA002607651 A CA 002607651A CA 2607651 A CA2607651 A CA 2607651A CA 2607651 A1 CA2607651 A1 CA 2607651A1
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- polypeptide
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- 101150091813 shfl gene Proteins 0.000 description 1
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- 238000002741 site-directed mutagenesis Methods 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- BEOOHQFXGBMRKU-UHFFFAOYSA-N sodium cyanoborohydride Chemical compound [Na+].[B-]C#N BEOOHQFXGBMRKU-UHFFFAOYSA-N 0.000 description 1
- IHQKEDIOMGYHEB-UHFFFAOYSA-M sodium dimethylarsinate Chemical compound [Na+].C[As](C)([O-])=O IHQKEDIOMGYHEB-UHFFFAOYSA-M 0.000 description 1
- 238000010532 solid phase synthesis reaction Methods 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
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- 230000006641 stabilisation Effects 0.000 description 1
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- 230000000087 stabilizing effect Effects 0.000 description 1
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- 125000001424 substituent group Chemical group 0.000 description 1
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- 230000002194 synthesizing effect Effects 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 235000007586 terpenes Nutrition 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 150000003573 thiols Chemical class 0.000 description 1
- 206010043554 thrombocytopenia Diseases 0.000 description 1
- 238000012090 tissue culture technique Methods 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
- 230000005030 transcription termination Effects 0.000 description 1
- 230000002103 transcriptional effect Effects 0.000 description 1
- 230000014621 translational initiation Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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- 238000011144 upstream manufacturing Methods 0.000 description 1
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- 201000001862 viral hepatitis Diseases 0.000 description 1
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- 150000003722 vitamin derivatives Chemical class 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- AIDS & HIV (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68276905P | 2005-05-18 | 2005-05-18 | |
| US60/682,769 | 2005-05-18 | ||
| PCT/US2006/019088 WO2007044083A2 (en) | 2005-05-18 | 2006-05-17 | Evolved interferon-alpha polypeptides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2607651A1 true CA2607651A1 (en) | 2007-04-19 |
Family
ID=37943260
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002607651A Abandoned CA2607651A1 (en) | 2005-05-18 | 2006-05-17 | Evolved interferon-alpha polypeptides |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7619067B2 (enExample) |
| EP (1) | EP1888633A4 (enExample) |
| JP (1) | JP2008545393A (enExample) |
| KR (1) | KR20080019619A (enExample) |
| CN (1) | CN101501068A (enExample) |
| AU (1) | AU2006299901A1 (enExample) |
| BR (1) | BRPI0609809A2 (enExample) |
| CA (1) | CA2607651A1 (enExample) |
| IL (1) | IL186880A0 (enExample) |
| MX (1) | MX2007014524A (enExample) |
| WO (1) | WO2007044083A2 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000040715A2 (en) | 1999-01-05 | 2000-07-13 | Trustees Of Boston University | Improved nucleic acid cloning |
| US7435562B2 (en) | 2000-07-21 | 2008-10-14 | Modular Genetics, Inc. | Modular vector systems |
| JP2008519602A (ja) | 2004-11-11 | 2008-06-12 | モジュラー ジェネティクス， インコーポレイテッド | 多様性を生じるためのラダーアセンブリおよびシステム |
| US7625555B2 (en) | 2007-06-18 | 2009-12-01 | Novagen Holding Corporation | Recombinant human interferon-like proteins |
| WO2009030066A1 (en) * | 2007-09-04 | 2009-03-12 | Biosteed Gene Expression Tech. Co., Ltd. | Polyethylene glycol modified interferon alpha 2b and preparation method and applicatioins thereof |
| AT506535B1 (de) * | 2008-02-22 | 2010-04-15 | Affiris Forschungs & Entwicklungs Gmbh | Vaccine enthaltend alpha-synuclein-mimotope auf basis von peptiden |
| EA022201B1 (ru) | 2008-04-11 | 2015-11-30 | Мерримак Фармасьютикалз, Инк. | Агент, способный связываться с опухолевой клеткой, содержащий линкер на основе hsa, и его применение |
| US9005599B2 (en) | 2008-04-21 | 2015-04-14 | Tissue Regeneration Therapeutics Inc. | Genetically modified human umbilical cord perivascular cells for prophylaxis against or treatment of biological or chemical agents |
| WO2010142017A1 (en) | 2009-06-09 | 2010-12-16 | Defyrus, Inc . | Administration of interferon for prophylaxis against or treatment of pathogenic infection |
| CN101921330B (zh) * | 2010-06-02 | 2013-07-17 | 北京三元基因工程有限公司 | 重组人干扰素α1b突变体及其制备方法 |
| EP3799880A3 (en) | 2012-03-03 | 2021-06-23 | ImmunGene, Inc. | Engineered antibody-interferon mutant fusion molecules |
| EP3349783B1 (en) * | 2015-09-15 | 2024-01-17 | ILC Therapeutics Ltd | Compositions and methods relating to the treatment of diseases |
| CN108733975B (zh) * | 2018-03-29 | 2021-09-07 | 深圳裕策生物科技有限公司 | 基于二代测序的肿瘤克隆变异检测方法、装置和存储介质 |
| CN111499718B (zh) * | 2019-01-30 | 2022-06-14 | 复旦大学 | 人α干扰素受体结合相关位点突变体及其用途 |
| CN114891088B (zh) * | 2019-06-13 | 2023-07-25 | 江苏科技大学 | 鸭α干扰素及其突变体、制备方法和应用 |
| PL4121092T3 (pl) * | 2020-03-16 | 2024-08-19 | Ilc Therapeutics Ltd | Hybrydowe interferony do leczenia zakażeń wirusowych |
| EP3901168A1 (en) * | 2020-04-21 | 2021-10-27 | Universität Duisburg-Essen | Interferon alpha 2 variants and uses thereof |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6610830B1 (en) * | 1980-07-01 | 2003-08-26 | Hoffman-La Roche Inc. | Microbial production of mature human leukocyte interferons |
| US4414150A (en) * | 1980-11-10 | 1983-11-08 | Genentech, Inc. | Hybrid human leukocyte interferons |
| ES506955A0 (es) | 1980-11-10 | 1983-02-01 | Genentech Inc | Un procedimiento para producir un polipeptido antiviral. |
| EP0098876A1 (en) | 1982-01-19 | 1984-01-25 | Cetus Corporation | Multiclass hybrid interferons |
| US6936694B1 (en) | 1982-05-06 | 2005-08-30 | Intermune, Inc. | Manufacture and expression of large structural genes |
| ATE78262T1 (de) | 1985-06-11 | 1992-08-15 | Ciba Geigy Ag | Hybrid-interferone. |
| JP3496937B2 (ja) | 1990-10-17 | 2004-02-16 | アムジエン・インコーポレーテツド | コンセンサスヒトインターフェロンを含有する細胞増殖障害治療用の医用組成物 |
| US5372808A (en) | 1990-10-17 | 1994-12-13 | Amgen Inc. | Methods and compositions for the treatment of diseases with consensus interferon while reducing side effect |
| US5595732A (en) * | 1991-03-25 | 1997-01-21 | Hoffmann-La Roche Inc. | Polyethylene-protein conjugates |
| US5382657A (en) * | 1992-08-26 | 1995-01-17 | Hoffmann-La Roche Inc. | Peg-interferon conjugates |
| US5780021A (en) * | 1993-03-05 | 1998-07-14 | Georgetown University | Method for treating type 1 diabetes using α-interferon and/or β-i |
| US5574138A (en) * | 1993-03-08 | 1996-11-12 | Immunex Corporation | Epithelium-derived T-cell factor |
| US6335160B1 (en) * | 1995-02-17 | 2002-01-01 | Maxygen, Inc. | Methods and compositions for polypeptide engineering |
| DK0741577T3 (da) | 1994-03-07 | 2003-02-17 | Imperial College | Anvendelsen af enterferon, subtype alfa 8, til fremstilling af lægemidler til behandling af virusinfektioner i leveren |
| US5824784A (en) | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
| TW517067B (en) | 1996-05-31 | 2003-01-11 | Hoffmann La Roche | Interferon conjugates |
| ATE375363T1 (de) | 1997-07-14 | 2007-10-15 | Bolder Biotechnology Inc | Derivate des wachstumshormons und verwandte proteine |
| NZ513077A (en) | 1999-01-14 | 2004-03-26 | Bolder Biotechnology Inc | Methods for making proteins containing free cysteine residues |
| AU3725600A (en) | 1999-03-02 | 2000-09-21 | Maxygen, Inc. | Surrogate orphan ligands for orphan receptors |
| CN1361793A (zh) | 1999-05-19 | 2002-07-31 | 利思进药品公司 | 干扰素－α蛋白作为Fc融合蛋白的表达和运输 |
| CA2385045A1 (en) * | 1999-10-07 | 2001-04-12 | Maxygen, Inc. | Ifn-alpha homologues |
| US20040002474A1 (en) * | 1999-10-07 | 2004-01-01 | Maxygen Inc. | IFN-alpha homologues |
| NZ522847A (en) | 2000-05-16 | 2004-11-26 | Bolder Biotechnology Inc | Methods for refolding proteins containing free cysteine residues |
| AU2002223350A1 (en) | 2000-12-01 | 2002-06-11 | Eleanor N. Fish | Cytokine receptor binding peptides |
| KR100459105B1 (ko) | 2001-02-15 | 2004-12-03 | 선바이오(주) | 변형된 인터페론-알파 2ａ 및 2ｂ, 그리고 이들과 ＰＥＧ유도체와의 배합체 |
| DE60307881T2 (de) * | 2002-11-15 | 2007-03-08 | F. Hoffmann-La Roche Ag | Positionelle isomeren von pegyliertem interferon alpha 2a |
| AU2003297285A1 (en) * | 2002-11-18 | 2004-06-15 | Maxygen, Inc. | Interferon-alpha polypeptides and conjugates |
| BRPI0511196A (pt) | 2004-05-19 | 2007-12-04 | Maxygen Inc | polipeptìdeo isolado ou recombinante, conjugado, composição, célula hospedeira, vetor, métodos para preparar um polipeptìdeo, para preparar um conjugado, para reduzir o número de cópias de um vìrus em células infectadas com o vìrus, para reduzir o nìvel de rna hcv, dna hbv e rna hiv no soro de um paciente infectado com hcv, hbv e hiv, e, uso do polipeptìdeo, do conjugado ou da composição |
-
2006
- 2006-05-17 US US11/383,798 patent/US7619067B2/en not_active Expired - Fee Related
- 2006-05-17 CN CNA2006800222000A patent/CN101501068A/zh active Pending
- 2006-05-17 KR KR1020077029196A patent/KR20080019619A/ko not_active Withdrawn
- 2006-05-17 CA CA002607651A patent/CA2607651A1/en not_active Abandoned
- 2006-05-17 MX MX2007014524A patent/MX2007014524A/es unknown
- 2006-05-17 WO PCT/US2006/019088 patent/WO2007044083A2/en not_active Ceased
- 2006-05-17 AU AU2006299901A patent/AU2006299901A1/en not_active Abandoned
- 2006-05-17 EP EP06836068A patent/EP1888633A4/en not_active Withdrawn
- 2006-05-17 JP JP2008512471A patent/JP2008545393A/ja active Pending
- 2006-05-17 BR BRPI0609809-6A patent/BRPI0609809A2/pt not_active Application Discontinuation
-
2007
- 2007-10-24 IL IL186880A patent/IL186880A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007044083A2 (en) | 2007-04-19 |
| KR20080019619A (ko) | 2008-03-04 |
| MX2007014524A (es) | 2008-02-07 |
| EP1888633A2 (en) | 2008-02-20 |
| BRPI0609809A2 (pt) | 2011-10-11 |
| US7619067B2 (en) | 2009-11-17 |
| IL186880A0 (en) | 2008-02-09 |
| AU2006299901A1 (en) | 2007-04-19 |
| EP1888633A4 (en) | 2010-01-27 |
| CN101501068A (zh) | 2009-08-05 |
| WO2007044083A3 (en) | 2009-04-16 |
| US20080226597A1 (en) | 2008-09-18 |
| JP2008545393A (ja) | 2008-12-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |