CN101921330B - 重组人干扰素α1b突变体及其制备方法 - Google Patents
重组人干扰素α1b突变体及其制备方法 Download PDFInfo
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- CN101921330B CN101921330B CN 201010189352 CN201010189352A CN101921330B CN 101921330 B CN101921330 B CN 101921330B CN 201010189352 CN201010189352 CN 201010189352 CN 201010189352 A CN201010189352 A CN 201010189352A CN 101921330 B CN101921330 B CN 101921330B
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名称 | 比活性(IU/mg) |
IFNα1b | (0.89±0.07)×107 |
IFNα1b/31K | (1.55±0.27)×107 |
IFNα1b/26L/27F/31K | (4.61±0.33)×107 |
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CN 201010189352 CN101921330B (zh) | 2010-06-02 | 2010-06-02 | 重组人干扰素α1b突变体及其制备方法 |
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CN101921330A CN101921330A (zh) | 2010-12-22 |
CN101921330B true CN101921330B (zh) | 2013-07-17 |
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Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
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CN102219848B (zh) * | 2011-05-25 | 2014-01-22 | 浙江海正药业股份有限公司 | 重组人干扰素β-1a的纯化方法 |
EP2527424A1 (en) * | 2011-05-26 | 2012-11-28 | Richter-Helm Bio Tec GmbH & Co. KG | Recombinant expression of soluble Interferon |
CN102716469B (zh) * | 2012-07-07 | 2013-09-11 | 北京三元基因工程有限公司 | 干扰素α的干粉吸入剂 |
CN103641905B (zh) * | 2013-12-12 | 2015-04-01 | 北京三元基因工程有限公司 | 干扰素α1b突变体及其与人血清白蛋白的融合蛋白 |
CN105087626A (zh) * | 2015-05-21 | 2015-11-25 | 苏州欧赛微科生物医药科技有限公司 | 表达和分泌人干扰素α2b的乳杆菌菌株及其用途 |
CN107556376B (zh) * | 2017-09-08 | 2018-09-28 | 上海华新生物高技术有限公司 | 一种干扰素α-2b突变体及其制备方法和应用 |
CN116251174B (zh) * | 2022-12-23 | 2023-09-29 | 北京三元基因药业股份有限公司 | 一种包含人干扰素α1b吸入溶液的药物组件 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007044083A2 (en) * | 2005-05-18 | 2007-04-19 | Maxygen, Inc. | Evolved interferon-alpha polypeptides |
CN101547935A (zh) * | 2006-12-21 | 2009-09-30 | 北京三元基因工程有限公司 | 干扰素α突变体及其聚乙二醇衍生物 |
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Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2007044083A2 (en) * | 2005-05-18 | 2007-04-19 | Maxygen, Inc. | Evolved interferon-alpha polypeptides |
CN101547935A (zh) * | 2006-12-21 | 2009-09-30 | 北京三元基因工程有限公司 | 干扰素α突变体及其聚乙二醇衍生物 |
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