AU2006299901A1 - Evolved interferon-alpha polypeptides - Google Patents
Evolved interferon-alpha polypeptides Download PDFInfo
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- AU2006299901A1 AU2006299901A1 AU2006299901A AU2006299901A AU2006299901A1 AU 2006299901 A1 AU2006299901 A1 AU 2006299901A1 AU 2006299901 A AU2006299901 A AU 2006299901A AU 2006299901 A AU2006299901 A AU 2006299901A AU 2006299901 A1 AU2006299901 A1 AU 2006299901A1
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- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
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- 230000008929 regeneration Effects 0.000 description 1
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- 230000032537 response to toxin Effects 0.000 description 1
- 210000003705 ribosome Anatomy 0.000 description 1
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- 102200114146 rs61748123 Human genes 0.000 description 1
- 235000019515 salmon Nutrition 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
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- 238000010008 shearing Methods 0.000 description 1
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- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
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- IHQKEDIOMGYHEB-UHFFFAOYSA-M sodium dimethylarsinate Chemical compound [Na+].C[As](C)([O-])=O IHQKEDIOMGYHEB-UHFFFAOYSA-M 0.000 description 1
- 238000010532 solid phase synthesis reaction Methods 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
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- 230000006641 stabilisation Effects 0.000 description 1
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- 208000003265 stomatitis Diseases 0.000 description 1
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- BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical compound OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
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- 230000002194 synthesizing effect Effects 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 235000007586 terpenes Nutrition 0.000 description 1
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- 229930101283 tetracycline Natural products 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 150000003573 thiols Chemical class 0.000 description 1
- 206010043554 thrombocytopenia Diseases 0.000 description 1
- 238000012090 tissue culture technique Methods 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
- 102000014898 transaminase activity proteins Human genes 0.000 description 1
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 239000001226 triphosphate Substances 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68276905P | 2005-05-18 | 2005-05-18 | |
| US60/682,769 | 2005-05-18 | ||
| PCT/US2006/019088 WO2007044083A2 (en) | 2005-05-18 | 2006-05-17 | Evolved interferon-alpha polypeptides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2006299901A1 true AU2006299901A1 (en) | 2007-04-19 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2006299901A Abandoned AU2006299901A1 (en) | 2005-05-18 | 2006-05-17 | Evolved interferon-alpha polypeptides |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7619067B2 (enExample) |
| EP (1) | EP1888633A4 (enExample) |
| JP (1) | JP2008545393A (enExample) |
| KR (1) | KR20080019619A (enExample) |
| CN (1) | CN101501068A (enExample) |
| AU (1) | AU2006299901A1 (enExample) |
| BR (1) | BRPI0609809A2 (enExample) |
| CA (1) | CA2607651A1 (enExample) |
| IL (1) | IL186880A0 (enExample) |
| MX (1) | MX2007014524A (enExample) |
| WO (1) | WO2007044083A2 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU774306B2 (en) | 1999-01-05 | 2004-06-24 | Trustees Of Boston University | Improved nucleic acid cloning |
| US7435562B2 (en) | 2000-07-21 | 2008-10-14 | Modular Genetics, Inc. | Modular vector systems |
| JP2008519602A (ja) | 2004-11-11 | 2008-06-12 | モジュラー ジェネティクス， インコーポレイテッド | 多様性を生じるためのラダーアセンブリおよびシステム |
| US7625555B2 (en) * | 2007-06-18 | 2009-12-01 | Novagen Holding Corporation | Recombinant human interferon-like proteins |
| ATE548382T1 (de) * | 2007-09-04 | 2012-03-15 | Biosteed Gene Expression Tech Co Ltd | Polyethylenglykolmodifiziertes interferon alpha 2b und herstellungsverfahren und anwendungen davon |
| AT506535B1 (de) * | 2008-02-22 | 2010-04-15 | Affiris Forschungs & Entwicklungs Gmbh | Vaccine enthaltend alpha-synuclein-mimotope auf basis von peptiden |
| EP2860260A1 (en) | 2008-04-11 | 2015-04-15 | Merrimack Pharmaceuticals, Inc. | Human serum albumin linkers and conjugates thereof |
| JP5773366B2 (ja) | 2008-04-21 | 2015-09-02 | ティシュー リジェネレイション セラピューティックス、インコーポレイテッド | 生物学的又は化学的作用物質に対する予防又はそれらの治療のために遺伝子改変されたヒト臍帯血管周囲細胞 |
| JP5908397B2 (ja) | 2009-06-09 | 2016-04-26 | デフィルス、インコーポレイテッドＤｅｆｙｒｕｓ， Ｉｎｃ． | 病原体感染を予防又は治療するためのインターフェロン投与 |
| CN101921330B (zh) * | 2010-06-02 | 2013-07-17 | 北京三元基因工程有限公司 | 重组人干扰素α1b突变体及其制备方法 |
| IN2014DN08236A (enExample) * | 2012-03-03 | 2015-05-15 | Immungene Inc | |
| EP3349783B1 (en) | 2015-09-15 | 2024-01-17 | ILC Therapeutics Ltd | Compositions and methods relating to the treatment of diseases |
| CN108733975B (zh) * | 2018-03-29 | 2021-09-07 | 深圳裕策生物科技有限公司 | 基于二代测序的肿瘤克隆变异检测方法、装置和存储介质 |
| CN111499718B (zh) * | 2019-01-30 | 2022-06-14 | 复旦大学 | 人α干扰素受体结合相关位点突变体及其用途 |
| CN114853875B (zh) * | 2019-06-13 | 2023-07-25 | 江苏科技大学 | 鸭α干扰素及其突变体、制备方法和应用 |
| CN115697377A (zh) * | 2020-03-16 | 2023-02-03 | Ilc医疗有限公司 | 涉及治疗疾病的组合物和方法 |
| EP3901168A1 (en) * | 2020-04-21 | 2021-10-27 | Universität Duisburg-Essen | Interferon alpha 2 variants and uses thereof |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6610830B1 (en) | 1980-07-01 | 2003-08-26 | Hoffman-La Roche Inc. | Microbial production of mature human leukocyte interferons |
| ES8302778A1 (es) | 1980-11-10 | 1983-02-01 | Genentech Inc | Un procedimiento para producir un polipeptido antiviral. |
| US4414150A (en) | 1980-11-10 | 1983-11-08 | Genentech, Inc. | Hybrid human leukocyte interferons |
| WO1983002461A1 (en) | 1982-01-19 | 1983-07-21 | Cetus Corp | Multiclass hybrid interferons |
| US6936694B1 (en) | 1982-05-06 | 2005-08-30 | Intermune, Inc. | Manufacture and expression of large structural genes |
| US4885166A (en) | 1985-06-11 | 1989-12-05 | Ciba-Geigy Corporation | Hybrid interferons |
| SG52537A1 (en) | 1990-10-17 | 1998-09-28 | Amgen Inc | Methods and compositions for the treatment of cell proliferation disorders |
| US5372808A (en) | 1990-10-17 | 1994-12-13 | Amgen Inc. | Methods and compositions for the treatment of diseases with consensus interferon while reducing side effect |
| US5595732A (en) | 1991-03-25 | 1997-01-21 | Hoffmann-La Roche Inc. | Polyethylene-protein conjugates |
| US5382657A (en) | 1992-08-26 | 1995-01-17 | Hoffmann-La Roche Inc. | Peg-interferon conjugates |
| US5780021A (en) * | 1993-03-05 | 1998-07-14 | Georgetown University | Method for treating type 1 diabetes using α-interferon and/or β-i |
| US5574138A (en) * | 1993-03-08 | 1996-11-12 | Immunex Corporation | Epithelium-derived T-cell factor |
| US6335160B1 (en) | 1995-02-17 | 2002-01-01 | Maxygen, Inc. | Methods and compositions for polypeptide engineering |
| ATE227133T1 (de) | 1994-03-07 | 2002-11-15 | Imperial College | Verwendung von interferon-alpha 8 subtype zur herstellung von medikamenten zur behandlung von viralinfektionen der leber |
| US5824784A (en) | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
| TW517067B (en) | 1996-05-31 | 2003-01-11 | Hoffmann La Roche | Interferon conjugates |
| US6608183B1 (en) | 1997-07-14 | 2003-08-19 | Bolder Biotechnology, Inc. | Derivatives of growth hormone and related proteins |
| BR0008759B1 (pt) | 1999-01-14 | 2014-03-11 | Bolder Biotechnology Inc | Métodos para a produção de proteinas contendo resíduos de cisteina livre |
| WO2000052153A2 (en) | 1999-03-02 | 2000-09-08 | Maxygen, Inc. | Method to identify ligands for orphan receptors |
| ATE369384T1 (de) | 1999-05-19 | 2007-08-15 | Emd Lexigen Res Ct Corp | Expression und export von interferon-alpha proteinen als fc fusionsproteine |
| US20040002474A1 (en) | 1999-10-07 | 2004-01-01 | Maxygen Inc. | IFN-alpha homologues |
| EP1238082A2 (en) * | 1999-10-07 | 2002-09-11 | Maxygen, Inc. | Ifn-alpha homologues |
| NZ522847A (en) | 2000-05-16 | 2004-11-26 | Bolder Biotechnology Inc | Methods for refolding proteins containing free cysteine residues |
| AU2002223350A1 (en) | 2000-12-01 | 2002-06-11 | Eleanor N. Fish | Cytokine receptor binding peptides |
| KR100459105B1 (ko) | 2001-02-15 | 2004-12-03 | 선바이오(주) | 변형된 인터페론-알파 2ａ 및 2ｂ, 그리고 이들과 ＰＥＧ유도체와의 배합체 |
| RU2005118752A (ru) | 2002-11-15 | 2006-02-10 | Ф.Хоффманн-Ля Рош Аг (Ch) | Позиционные изомеры пэгилированного интерферона l-2а (конъюгата пэг-ifn-l-2а) |
| WO2004046365A2 (en) | 2002-11-18 | 2004-06-03 | Maxygen, Inc. | Interferon-alpha polypeptides and conjugates |
| WO2005113592A2 (en) | 2004-05-19 | 2005-12-01 | Maxygen, Inc. | Interferon-alpha polypeptides and conjugates |
-
2006
- 2006-05-17 CN CNA2006800222000A patent/CN101501068A/zh active Pending
- 2006-05-17 BR BRPI0609809-6A patent/BRPI0609809A2/pt not_active Application Discontinuation
- 2006-05-17 AU AU2006299901A patent/AU2006299901A1/en not_active Abandoned
- 2006-05-17 MX MX2007014524A patent/MX2007014524A/es unknown
- 2006-05-17 CA CA002607651A patent/CA2607651A1/en not_active Abandoned
- 2006-05-17 KR KR1020077029196A patent/KR20080019619A/ko not_active Withdrawn
- 2006-05-17 WO PCT/US2006/019088 patent/WO2007044083A2/en not_active Ceased
- 2006-05-17 EP EP06836068A patent/EP1888633A4/en not_active Withdrawn
- 2006-05-17 JP JP2008512471A patent/JP2008545393A/ja active Pending
- 2006-05-17 US US11/383,798 patent/US7619067B2/en not_active Expired - Fee Related
-
2007
- 2007-10-24 IL IL186880A patent/IL186880A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL186880A0 (en) | 2008-02-09 |
| WO2007044083A3 (en) | 2009-04-16 |
| EP1888633A4 (en) | 2010-01-27 |
| KR20080019619A (ko) | 2008-03-04 |
| EP1888633A2 (en) | 2008-02-20 |
| WO2007044083A2 (en) | 2007-04-19 |
| CN101501068A (zh) | 2009-08-05 |
| CA2607651A1 (en) | 2007-04-19 |
| BRPI0609809A2 (pt) | 2011-10-11 |
| US20080226597A1 (en) | 2008-09-18 |
| US7619067B2 (en) | 2009-11-17 |
| MX2007014524A (es) | 2008-02-07 |
| JP2008545393A (ja) | 2008-12-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1 | Application lapsed section 142(2)(a) - no request for examination in relevant period |