JP2008505985A5 - - Google Patents

Download PDF

Info

Publication number
JP2008505985A5
JP2008505985A5 JP2007527553A JP2007527553A JP2008505985A5 JP 2008505985 A5 JP2008505985 A5 JP 2008505985A5 JP 2007527553 A JP2007527553 A JP 2007527553A JP 2007527553 A JP2007527553 A JP 2007527553A JP 2008505985 A5 JP2008505985 A5 JP 2008505985A5
Authority
JP
Japan
Prior art keywords
seq
polypeptide
virus
conjugate
reducing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2007527553A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008505985A (ja
Filing date
Publication date
Priority claimed from US10/848,827 external-priority patent/US7314613B2/en
Application filed filed Critical
Publication of JP2008505985A publication Critical patent/JP2008505985A/ja
Publication of JP2008505985A5 publication Critical patent/JP2008505985A5/ja
Pending legal-status Critical Current

Links

JP2007527553A 2004-05-19 2005-05-18 インターフェロン−αポリペプチドおよび結合体 Pending JP2008505985A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/848,827 US7314613B2 (en) 2002-11-18 2004-05-19 Interferon-alpha polypeptides and conjugates
PCT/US2005/018103 WO2006083276A2 (en) 2004-05-19 2005-05-18 Interferon-alpha polypeptides and conjugates

Publications (2)

Publication Number Publication Date
JP2008505985A JP2008505985A (ja) 2008-02-28
JP2008505985A5 true JP2008505985A5 (enExample) 2008-07-03

Family

ID=36777639

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007527553A Pending JP2008505985A (ja) 2004-05-19 2005-05-18 インターフェロン−αポリペプチドおよび結合体

Country Status (4)

Country Link
US (8) US7314613B2 (enExample)
EP (1) EP1771198A2 (enExample)
JP (1) JP2008505985A (enExample)
WO (1) WO2006083276A2 (enExample)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6057287A (en) 1994-01-11 2000-05-02 Dyax Corp. Kallikrein-binding "Kunitz domain" proteins and analogues thereof
JP2002537762A (ja) * 1999-01-05 2002-11-12 トラスティーズ オブ ボストン ユニバーシティ 改良型核酸クローニング
US20040005673A1 (en) * 2001-06-29 2004-01-08 Kevin Jarrell System for manipulating nucleic acids
WO2002008408A2 (en) * 2000-07-21 2002-01-31 Trustees Of Boston University Modular vector systems
US7435562B2 (en) * 2000-07-21 2008-10-14 Modular Genetics, Inc. Modular vector systems
US7153829B2 (en) 2002-06-07 2006-12-26 Dyax Corp. Kallikrein-inhibitor therapies
DK2311432T3 (en) 2002-06-07 2015-02-02 Dyax Corp Modified Kunitz domain polypeptides and their use in reducing ischemia or the onset of a systemic inflammatory response associated with a surgical procedure
US7314613B2 (en) * 2002-11-18 2008-01-01 Maxygen, Inc. Interferon-alpha polypeptides and conjugates
AU2004268144A1 (en) * 2003-08-29 2005-03-10 Dyax Corp. Modified protease inhibitors
AU2004268145B2 (en) * 2003-08-29 2010-09-16 Takeda Pharmaceutical Company Limited Poly-PEGylated protease inhibitors
CN103755800B (zh) * 2004-02-02 2016-02-24 Ambrx公司 经修饰的人类生长激素多肽与其用途
US7235530B2 (en) 2004-09-27 2007-06-26 Dyax Corporation Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
US7485423B2 (en) * 2004-11-11 2009-02-03 Modular Genetics, Inc. Ladder assembly and system for generating diversity
WO2006133088A2 (en) * 2005-06-03 2006-12-14 Ambrx, Inc. Improved human interferon molecules and their uses
US20080014616A1 (en) * 2006-07-11 2008-01-17 Kevin Jarrell Methods of introducing targeted diversity into nucleic acid molecules
KR20090104041A (ko) * 2006-12-19 2009-10-05 메리맥 파마슈티컬즈, 인크. 다발성 경화증을 치료하기 위한 α페토프로테인 및 면역조절제의 병용투여
CN1970572A (zh) 2006-12-21 2007-05-30 北京三元基因工程有限公司 干扰素α突变体及其聚乙二醇衍生物
KR20100019467A (ko) * 2007-05-02 2010-02-18 암브룩스, 인코포레이티드 변형된 인터페론 베타 폴리펩티드 및 그의 용도
US7625555B2 (en) * 2007-06-18 2009-12-01 Novagen Holding Corporation Recombinant human interferon-like proteins
CN101525381B (zh) * 2008-03-04 2012-04-18 北京百川飞虹生物科技有限公司 一种重组复合干扰素及其表达载体的构建和表达
BRPI0911652A2 (pt) 2008-04-11 2015-08-04 Merrimack Pharmaceuticals Inc Ligantes de albumina sérica humana e seus conjugados
KR20170005148A (ko) 2008-04-21 2017-01-11 티슈 리제너레이션 쎄라퓨틱스, 인코포레이티드 생물학적 또는 화학적 물질에 대한 예방 또는 치료를 위한 유전적으로 변형된 인간 탯줄 혈관주위 세포
CN102282168A (zh) 2008-11-18 2011-12-14 梅里麦克制药股份有限公司 人血清白蛋白接头以及其结合物
US8637454B2 (en) 2009-01-06 2014-01-28 Dyax Corp. Treatment of mucositis with kallikrein inhibitors
US20100284962A1 (en) * 2009-05-06 2010-11-11 Oncopharmacologics, Inc. Modified tumor necrosis factor-beta
WO2010142017A1 (en) 2009-06-09 2010-12-16 Defyrus, Inc . Administration of interferon for prophylaxis against or treatment of pathogenic infection
CN102081018A (zh) * 2009-11-30 2011-06-01 希森美康株式会社 样品的预处理方法及hcv的免疫测定方法
ES2688093T3 (es) 2010-01-06 2018-10-30 Dyax Corp. Proteínas de unión a calicreína plasmática
WO2011087627A1 (en) * 2010-01-15 2011-07-21 Biolex Therapeutics, Inc Stabilized interferon formulations
KR101303388B1 (ko) 2010-10-26 2013-09-03 한미사이언스 주식회사 지속형 인터페론 알파 결합체의 액상 제제
IL269565B2 (en) 2011-01-06 2024-06-01 Dyax Corp Plasma kallikrein binding proteins
KR101960928B1 (ko) * 2011-04-21 2019-07-17 올로지 바이오서비시즈, 인크. 백신으로부터 항원을 단리하고 정량하기 위한 방법
WO2014036520A1 (en) 2012-08-30 2014-03-06 Merrimack Pharmaceuticals, Inc. Combination therapies comprising anti-erbb3 agents
EP3476410B1 (en) 2012-09-19 2021-08-18 MicroVascular Tissues, Inc. Compositions and methods for treating and preventing tissue injury and disease
RU2720808C2 (ru) 2013-09-03 2020-05-13 Джорджия Тек Рисёч Корпорейшн Термостабильные препараты вакцин и микроиглы
EP3122782A4 (en) 2014-03-27 2017-09-13 Dyax Corp. Compositions and methods for treatment of diabetic macular edema
BR112018011622A2 (pt) 2015-12-11 2018-11-27 Dyax Corp método para tratar ataque de angioedema hereditário (hae) ou reduzir a taxa de ataque de hae
CN107046366B (zh) * 2016-02-05 2019-06-04 台达电子企业管理（上海）有限公司 电源变换器及其制备方法
SG10201609616TA (en) * 2016-09-06 2018-04-27 Apple Inc Electronic device with cooling fan
CA3167336A1 (en) 2020-01-13 2021-07-22 Takeda Pharmaceutical Company Limited Plasma kallikrein inhibitors and uses thereof for treating pediatric hereditary angioedema attack

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6610830B1 (en) 1980-07-01 2003-08-26 Hoffman-La Roche Inc. Microbial production of mature human leukocyte interferons
ES506955A0 (es) 1980-11-10 1983-02-01 Genentech Inc Un procedimiento para producir un polipeptido antiviral.
US4414150A (en) 1980-11-10 1983-11-08 Genentech, Inc. Hybrid human leukocyte interferons
IT1167610B (it) 1982-01-19 1987-05-13 Cetus Corp Interfreron ibrido multiclasse, composizione farmaceutica che lo contiene e procedimento di produzione
US6936694B1 (en) 1982-05-06 2005-08-30 Intermune, Inc. Manufacture and expression of large structural genes
DE3685996T2 (de) 1985-06-11 1993-01-14 Ciba Geigy Ag Hybrid-interferone.
US5372808A (en) 1990-10-17 1994-12-13 Amgen Inc. Methods and compositions for the treatment of diseases with consensus interferon while reducing side effect
WO1992006707A1 (en) 1990-10-17 1992-04-30 Amgen Inc. Methods and compositions for the treatment of cell proliferation disorders
US5595732A (en) 1991-03-25 1997-01-21 Hoffmann-La Roche Inc. Polyethylene-protein conjugates
US5382657A (en) 1992-08-26 1995-01-17 Hoffmann-La Roche Inc. Peg-interferon conjugates
US5780021A (en) * 1993-03-05 1998-07-14 Georgetown University Method for treating type 1 diabetes using α-interferon and/or β-i
US5574138A (en) 1993-03-08 1996-11-12 Immunex Corporation Epithelium-derived T-cell factor
US6335160B1 (en) 1995-02-17 2002-01-01 Maxygen, Inc. Methods and compositions for polypeptide engineering
JP4001379B2 (ja) 1994-03-07 2007-10-31 インペリアル カレッジ オブ サイエンス，テクノロジー アンド メディシン ウィルス感染を治療する薬剤の調製におけるインターフェロンのサブタイプの使用
US5824784A (en) 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
TW517067B (en) 1996-05-31 2003-01-11 Hoffmann La Roche Interferon conjugates
CN1269805A (zh) 1997-07-14 2000-10-11 博尔德生物技术公司 生长激素和相关蛋白的衍生物
JP2002534119A (ja) 1999-01-14 2002-10-15 ボルダー バイオテクノロジー， インコーポレイテッド 自由システイン残基を有するタンパク質の生産方法
AU3725600A (en) 1999-03-02 2000-09-21 Maxygen, Inc. Surrogate orphan ligands for orphan receptors
KR20020018197A (ko) 1999-05-19 2002-03-07 추후보정 Ｆｃ 융합 단백질로서의 인터페론-알파 단백질의 발현 및분비
US20040002474A1 (en) 1999-10-07 2004-01-01 Maxygen Inc. IFN-alpha homologues
CA2385045A1 (en) 1999-10-07 2001-04-12 Maxygen, Inc. Ifn-alpha homologues
IL152804A0 (en) 2000-05-16 2003-06-24 Bolder Biotechnology Inc Methods for refolding proteins containing free cysteine residues
US20020025304A1 (en) * 2000-06-16 2002-02-28 Croze Edward M. Novel interferon for the treatment of multiple sclerosis
WO2002044197A2 (en) 2000-12-01 2002-06-06 Fish Eleanor N Cytokine receptor binding peptides
KR100459105B1 (ko) 2001-02-15 2004-12-03 선바이오(주) 변형된 인터페론-알파 2ａ 및 2ｂ, 그리고 이들과 ＰＥＧ유도체와의 배합체
AU2003293668A1 (en) 2002-11-15 2004-06-15 F. Hoffmann-La Roche Ag Positional isomers of peg ifn alpha 2a
US7314613B2 (en) * 2002-11-18 2008-01-01 Maxygen, Inc. Interferon-alpha polypeptides and conjugates

Similar Documents

Publication Publication Date Title
JP2008507298A5 (enExample)
JP6290193B2 (ja) ペグ化ｏｘｍ変異体
RU2006145020A (ru) Полипептиды и конъюгаты интерферона-альфа
JP2013501038A5 (enExample)
RU2012107671A (ru) Композиция для лечения инфекции вирусом гепатита в
JP2008529558A5 (enExample)
JP2001514858A5 (enExample)
JP5407044B2 (ja) インターフェロンα変異体およびそのポリエチレングリコール誘導体
JP2010533171A5 (enExample)
JPH09511404A (ja) 呼吸器多核体ウイルスプロテインｇのペプチド断片、免疫原的薬剤、それを含む医薬組成物、および製造法
JP2006506097A5 (enExample)
CN104788556A (zh) 人胰岛素类似物及其酰化衍生物
US20260092098A1 (en) Human a interferon receptor binding-related site mutant and use thereof
RU2005118998A (ru) Полипептиды и конъюгаты альфа-интерферона
US20250223592A1 (en) Compositions and methods for circular rna affinity purification
CN102558362A (zh) 一种用于治疗糖尿病的融合蛋白及其制备方法
CN112552413A (zh) 新型冠状病毒重组蛋白亚单位疫苗
JP2003503355A5 (enExample)
CN1223605C (zh) 抑制sars冠状病毒的多肽药物及其衍生物和其应用
CN103923209B (zh) 一种Lambda干扰素突变体及聚乙二醇衍生物
CN108864292B (zh) 一种干扰素重组融合蛋白及其应用
RU2010125695A (ru) Гены, кодирующие главный капсидный белок l1 вируса папилломы человека, и их применение
JP2005512518A5 (enExample)
JP2011521648A5 (enExample)
CN105085658A (zh) 一种白细胞介素29突变体及聚乙二醇衍生物