JP2008505985A5 - - Google Patents

Download PDF

Info

Publication number
JP2008505985A5
JP2008505985A5 JP2007527553A JP2007527553A JP2008505985A5 JP 2008505985 A5 JP2008505985 A5 JP 2008505985A5 JP 2007527553 A JP2007527553 A JP 2007527553A JP 2007527553 A JP2007527553 A JP 2007527553A JP 2008505985 A5 JP2008505985 A5 JP 2008505985A5
Authority
JP
Japan
Prior art keywords
seq
polypeptide
virus
conjugate
reducing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2007527553A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008505985A (ja
Filing date
Publication date
Priority claimed from US10/848,827 external-priority patent/US7314613B2/en
Application filed filed Critical
Publication of JP2008505985A publication Critical patent/JP2008505985A/ja
Publication of JP2008505985A5 publication Critical patent/JP2008505985A5/ja
Pending legal-status Critical Current

Links

JP2007527553A 2004-05-19 2005-05-18 インターフェロン−αポリペプチドおよび結合体 Pending JP2008505985A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/848,827 US7314613B2 (en) 2002-11-18 2004-05-19 Interferon-alpha polypeptides and conjugates
PCT/US2005/018103 WO2006083276A2 (en) 2004-05-19 2005-05-18 Interferon-alpha polypeptides and conjugates

Publications (2)

Publication Number Publication Date
JP2008505985A JP2008505985A (ja) 2008-02-28
JP2008505985A5 true JP2008505985A5 (enExample) 2008-07-03

Family

ID=36777639

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007527553A Pending JP2008505985A (ja) 2004-05-19 2005-05-18 インターフェロン−αポリペプチドおよび結合体

Country Status (4)

Country Link
US (8) US7314613B2 (enExample)
EP (1) EP1771198A2 (enExample)
JP (1) JP2008505985A (enExample)
WO (1) WO2006083276A2 (enExample)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6057287A (en) 1994-01-11 2000-05-02 Dyax Corp. Kallikrein-binding "Kunitz domain" proteins and analogues thereof
ATE439437T1 (de) 1999-01-05 2009-08-15 Univ Boston Verbessertes klonierungsverfahren
US20040005673A1 (en) 2001-06-29 2004-01-08 Kevin Jarrell System for manipulating nucleic acids
US7435562B2 (en) * 2000-07-21 2008-10-14 Modular Genetics, Inc. Modular vector systems
US20030017552A1 (en) * 2000-07-21 2003-01-23 Jarrell Kevin A. Modular vector systems
CA2488558C (en) 2002-06-07 2013-08-20 Dyax Corp. Prevention and reduction of blood loss
US7153829B2 (en) 2002-06-07 2006-12-26 Dyax Corp. Kallikrein-inhibitor therapies
US7314613B2 (en) * 2002-11-18 2008-01-01 Maxygen, Inc. Interferon-alpha polypeptides and conjugates
DK1663281T3 (en) * 2003-08-29 2014-03-17 Dyax Corp POLY-PEGYLED PROTEASE INHIBITORS
EP1663279A4 (en) * 2003-08-29 2009-02-18 Dyax Corp MODIFIED PROTEASE INHIBITORS
US8778880B2 (en) * 2004-02-02 2014-07-15 Ambrx, Inc. Human growth hormone modified at position 35
US7235530B2 (en) 2004-09-27 2007-06-26 Dyax Corporation Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
ATE540110T1 (de) * 2004-11-11 2012-01-15 Modular Genetics Inc Oligonukleotid-leiterkonstruktion und system zur erzeugung von molekularer vielfalt
CA2609205A1 (en) * 2005-06-03 2006-12-14 Ambrx, Inc. Improved human interferon molecules and their uses
WO2008008808A2 (en) * 2006-07-11 2008-01-17 Modular Genetics Inc. Methods of introducing targeted diversity into nucleic acid molecules
CA2673398A1 (en) * 2006-12-19 2008-07-03 Merrimack Pharmaceuticals, Inc. Coadministration of alpha-fetoprotein and an immunomodulatory agent to treat multiple sclerosis
CN1970572A (zh) * 2006-12-21 2007-05-30 北京三元基因工程有限公司 干扰素α突变体及其聚乙二醇衍生物
EP2076533B1 (en) * 2007-05-02 2014-10-08 Ambrx, Inc. Modified interferon beta polypeptides and their uses
US7625555B2 (en) 2007-06-18 2009-12-01 Novagen Holding Corporation Recombinant human interferon-like proteins
CN101525381B (zh) * 2008-03-04 2012-04-18 北京百川飞虹生物科技有限公司 一种重组复合干扰素及其表达载体的构建和表达
EA022201B1 (ru) 2008-04-11 2015-11-30 Мерримак Фармасьютикалз, Инк. Агент, способный связываться с опухолевой клеткой, содержащий линкер на основе hsa, и его применение
AU2009240738B2 (en) 2008-04-21 2014-09-11 Tissue Regeneration Therapeutics, Inc. Genetically modified human umbilical cord perivascular cells for prophylaxis against or treatment of biological or chemical agents
JP5677972B2 (ja) 2008-11-18 2015-02-25 メリマック ファーマシューティカルズ インコーポレーティッド ヒト血清アルブミンリンカーおよびそのコンジュゲート
US8637454B2 (en) 2009-01-06 2014-01-28 Dyax Corp. Treatment of mucositis with kallikrein inhibitors
US20100284962A1 (en) * 2009-05-06 2010-11-11 Oncopharmacologics, Inc. Modified tumor necrosis factor-beta
WO2010142017A1 (en) 2009-06-09 2010-12-16 Defyrus, Inc . Administration of interferon for prophylaxis against or treatment of pathogenic infection
CN102081018A (zh) * 2009-11-30 2011-06-01 希森美康株式会社 样品的预处理方法及hcv的免疫测定方法
RS62853B1 (sr) 2010-01-06 2022-02-28 Takeda Pharmaceuticals Co Proteini koji vezuju kalikrein plazme
WO2011087627A1 (en) * 2010-01-15 2011-07-21 Biolex Therapeutics, Inc Stabilized interferon formulations
KR101303388B1 (ko) * 2010-10-26 2013-09-03 한미사이언스 주식회사 지속형 인터페론 알파 결합체의 액상 제제
AU2012204202A1 (en) 2011-01-06 2013-07-11 Dyax Corp. Plasma kallikrein binding proteins
JP6232373B2 (ja) * 2011-04-21 2017-11-15 ナノセラピューティクス・インコーポレイテッドＮａｎｏｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． ワクチンから抗原を単離し定量する方法
US20150202287A1 (en) 2012-08-30 2015-07-23 Merrimack Pharmaceuticals, Inc. Combination therapies comprising anti-erbb3 agents
ES2710921T3 (es) 2012-09-19 2019-04-29 Microvascular Tissues Inc Composiciones para tratar y prevenir lesión y enfermedad tisular
CA2923010C (en) 2013-09-03 2022-08-30 Georgia Tech Research Corporation Thermally stable vaccine formulations and microneedles
AU2015235967B2 (en) 2014-03-27 2020-10-22 Takeda Pharmaceutical Company Limited Compositions and methods for treatment of diabetic macular edema
CN116077648A (zh) 2015-12-11 2023-05-09 武田药品工业株式会社 血浆激肽释放酶抑制剂及其治疗遗传性血管性水肿发作的用途
CN107046366B (zh) * 2016-02-05 2019-06-04 台达电子企业管理（上海）有限公司 电源变换器及其制备方法
SG10201609616TA (en) * 2016-09-06 2018-04-27 Apple Inc Electronic device with cooling fan
MX2022008649A (es) 2020-01-13 2022-09-23 Takeda Pharmaceuticals Co Inhibidores de calicreina plasmatica y sus usos para tratar episodios de angioedema hereditario pediatrico.

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6610830B1 (en) * 1980-07-01 2003-08-26 Hoffman-La Roche Inc. Microbial production of mature human leukocyte interferons
US4414150A (en) * 1980-11-10 1983-11-08 Genentech, Inc. Hybrid human leukocyte interferons
ES506955A0 (es) 1980-11-10 1983-02-01 Genentech Inc Un procedimiento para producir un polipeptido antiviral.
EP0098876A1 (en) 1982-01-19 1984-01-25 Cetus Corporation Multiclass hybrid interferons
US6936694B1 (en) 1982-05-06 2005-08-30 Intermune, Inc. Manufacture and expression of large structural genes
ATE78262T1 (de) 1985-06-11 1992-08-15 Ciba Geigy Ag Hybrid-interferone.
US5372808A (en) 1990-10-17 1994-12-13 Amgen Inc. Methods and compositions for the treatment of diseases with consensus interferon while reducing side effect
ES2128348T3 (es) 1990-10-17 1999-05-16 Amgen Inc Obtencion de composiciones para el tratamiento de alteraciones de la proliferacion celular.
US5595732A (en) * 1991-03-25 1997-01-21 Hoffmann-La Roche Inc. Polyethylene-protein conjugates
US5382657A (en) 1992-08-26 1995-01-17 Hoffmann-La Roche Inc. Peg-interferon conjugates
US5780021A (en) * 1993-03-05 1998-07-14 Georgetown University Method for treating type 1 diabetes using α-interferon and/or β-i
US5574138A (en) * 1993-03-08 1996-11-12 Immunex Corporation Epithelium-derived T-cell factor
US6335160B1 (en) * 1995-02-17 2002-01-01 Maxygen, Inc. Methods and compositions for polypeptide engineering
ATE227133T1 (de) 1994-03-07 2002-11-15 Imperial College Verwendung von interferon-alpha 8 subtype zur herstellung von medikamenten zur behandlung von viralinfektionen der leber
US5824784A (en) 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
TW517067B (en) 1996-05-31 2003-01-11 Hoffmann La Roche Interferon conjugates
IL133974A0 (en) 1997-07-14 2001-04-30 Bolder Biotechnology Inc Derivatives of growth hormone and related proteins
ATE526401T1 (de) 1999-01-14 2011-10-15 Bolder Biotechnology Inc Verfahren zur herstellung von proteinen mit freien cysteinresten
AU3725600A (en) 1999-03-02 2000-09-21 Maxygen, Inc. Surrogate orphan ligands for orphan receptors
DE60035871T2 (de) * 1999-05-19 2008-06-05 Merck Patent Gmbh Expression und export von interferon-alpha proteinen als fc fusionsproteine
EP1238082A2 (en) 1999-10-07 2002-09-11 Maxygen, Inc. Ifn-alpha homologues
US20040002474A1 (en) * 1999-10-07 2004-01-01 Maxygen Inc. IFN-alpha homologues
CN1318443C (zh) 2000-05-16 2007-05-30 博尔德生物技术公司 含游离半胱氨酸残基的蛋白重折叠的方法
US20020025304A1 (en) * 2000-06-16 2002-02-28 Croze Edward M. Novel interferon for the treatment of multiple sclerosis
AU2002223350A1 (en) 2000-12-01 2002-06-11 Eleanor N. Fish Cytokine receptor binding peptides
KR100459105B1 (ko) 2001-02-15 2004-12-03 선바이오(주) 변형된 인터페론-알파 2ａ 및 2ｂ, 그리고 이들과 ＰＥＧ유도체와의 배합체
MXPA05005178A (es) 2002-11-15 2005-07-22 Hoffmann La Roche Isomeros posicionales del interferon alfa 2a (ifn) pegilado con una porcion de polietilenglicol grande (peg).
US7314613B2 (en) * 2002-11-18 2008-01-01 Maxygen, Inc. Interferon-alpha polypeptides and conjugates

Similar Documents

Publication Publication Date Title
JP2008505985A5 (enExample)
JP2008507298A5 (enExample)
JP6290193B2 (ja) ペグ化ｏｘｍ変異体
RU2006145020A (ru) Полипептиды и конъюгаты интерферона-альфа
JP2013501038A5 (enExample)
RU2012107671A (ru) Композиция для лечения инфекции вирусом гепатита в
JP2008529558A5 (enExample)
JP2001514858A5 (enExample)
JP2010533171A5 (enExample)
JPH09511404A (ja) 呼吸器多核体ウイルスプロテインｇのペプチド断片、免疫原的薬剤、それを含む医薬組成物、および製造法
JP2006506097A5 (enExample)
JP2008504850A5 (enExample)
CN104788556A (zh) 人胰岛素类似物及其酰化衍生物
CN102558362A (zh) 一种用于治疗糖尿病的融合蛋白及其制备方法
CN112552413B (zh) 新型冠状病毒重组蛋白亚单位疫苗
US20250223592A1 (en) Compositions and methods for circular rna affinity purification
JP2003503355A5 (enExample)
CN1223605C (zh) 抑制sars冠状病毒的多肽药物及其衍生物和其应用
CN108864292B (zh) 一种干扰素重组融合蛋白及其应用
CN103923209A (zh) 一种Lambda干扰素突变体及聚乙二醇衍生物
AU704594B2 (en) Production of recombinant peptides as natural hydrophobic peptide analogues
JPS6299399A (ja) ヒトγ−インタ−フエロンの生物活性誘導体
JP2005512518A5 (enExample)
JP2011521648A5 (enExample)
CN105085658B (zh) 一种白细胞介素29突变体及聚乙二醇衍生物