JP2001514858A5 - - Google Patents
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- Publication number
- JP2001514858A5 JP2001514858A5 JP2000508817A JP2000508817A JP2001514858A5 JP 2001514858 A5 JP2001514858 A5 JP 2001514858A5 JP 2000508817 A JP2000508817 A JP 2000508817A JP 2000508817 A JP2000508817 A JP 2000508817A JP 2001514858 A5 JP2001514858 A5 JP 2001514858A5
- Authority
- JP
- Japan
- Prior art keywords
- conjugate
- region
- protein
- host cell
- expression vector
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 description 4
- 239000013604 expression vector Substances 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 150000007523 nucleic acids Chemical class 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 108700031308 Antennapedia Homeodomain Proteins 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 230000004568 DNA-binding Effects 0.000 description 1
- 102100039869 Histone H2B type F-S Human genes 0.000 description 1
- 108010048671 Homeodomain Proteins Proteins 0.000 description 1
- 102000009331 Homeodomain Proteins Human genes 0.000 description 1
- 101001035372 Homo sapiens Histone H2B type F-S Proteins 0.000 description 1
- 208000026350 Inborn Genetic disease Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 238000001261 affinity purification Methods 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 108020001507 fusion proteins Proteins 0.000 description 1
- 102000037865 fusion proteins Human genes 0.000 description 1
- 108091006104 gene-regulatory proteins Proteins 0.000 description 1
- 102000034356 gene-regulatory proteins Human genes 0.000 description 1
- 208000016361 genetic disease Diseases 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9718609.2 | 1997-09-02 | ||
| GBGB9718609.2A GB9718609D0 (en) | 1997-09-02 | 1997-09-02 | Fusion protein |
| PCT/GB1998/002628 WO1999011809A1 (en) | 1997-09-02 | 1998-09-02 | Conjugates that contain the homeodomain of antennapedia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001514858A JP2001514858A (ja) | 2001-09-18 |
| JP2001514858A5 true JP2001514858A5 (enExample) | 2006-01-05 |
Family
ID=10818419
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000508817A Pending JP2001514858A (ja) | 1997-09-02 | 1998-09-02 | アンテナペディアのホメオドメインを含むコンジュゲート |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7968512B2 (enExample) |
| EP (1) | EP1009847A1 (enExample) |
| JP (1) | JP2001514858A (enExample) |
| AU (1) | AU737829B2 (enExample) |
| BR (1) | BR9811744A (enExample) |
| CA (1) | CA2301157A1 (enExample) |
| GB (1) | GB9718609D0 (enExample) |
| IL (2) | IL134602A0 (enExample) |
| NZ (1) | NZ503007A (enExample) |
| WO (1) | WO1999011809A1 (enExample) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL130160A0 (en) * | 1996-12-02 | 2000-06-01 | Univ Wake Forest | Inactivation of HIV co-receptors as therapy for HIV infection |
| AU1818299A (en) * | 1997-12-10 | 1999-06-28 | Washington University | Anti-pathogen system and methods of use thereof |
| GB9814527D0 (en) | 1998-07-03 | 1998-09-02 | Cyclacel Ltd | Delivery system |
| EP1129064B1 (en) | 1998-11-12 | 2008-01-09 | Invitrogen Corporation | Transfection reagents |
| CA2350919A1 (en) * | 1998-11-13 | 2000-05-25 | Cyclacel Limited | Antennapedia homeodomain helix 3 derived translocation vectors |
| WO2000038733A1 (en) * | 1998-12-24 | 2000-07-06 | Ucb S.A. | Peptidic product, process and composition |
| US6773920B1 (en) | 1999-03-31 | 2004-08-10 | Invitrogen Corporation | Delivery of functional protein sequences by translocating polypeptides |
| JP2002539839A (ja) * | 1999-03-31 | 2002-11-26 | インヴィトロゲン・コーポレーション | 転位ポリペプチドによる機能性タンパク質配列の送達 |
| US6372494B1 (en) | 1999-05-14 | 2002-04-16 | Advanced Tissue Sciences, Inc. | Methods of making conditioned cell culture medium compositions |
| WO2001049832A2 (en) * | 2000-01-07 | 2001-07-12 | Artemis Pharmaceuticals Gmbh | Transduction of recombinases for inducible gene targeting |
| EP1118668A1 (en) * | 2000-01-07 | 2001-07-25 | ARTEMIS Pharmaceuticals GmbH | Transduction of recombinases for inducible gene targeting |
| GB0003284D0 (en) * | 2000-02-15 | 2000-04-05 | Secr Defence Brit | Anti-viral therapy |
| JP2004528266A (ja) * | 2000-04-12 | 2004-09-16 | インプリクス リミテッド | 薬物送達用組成物 |
| DE10027777A1 (de) * | 2000-06-07 | 2001-12-13 | Otogene Ag | Transfektionsverfahren |
| GB0015090D0 (en) * | 2000-06-20 | 2000-08-09 | Implyx Ltd | Gene-activating conjugates |
| KR100374050B1 (ko) * | 2000-07-26 | 2003-03-03 | 최수영 | 세포침투성 융합단백질, 이를 코딩하는 재조합폴리뉴클레오타이드 및 발현벡터 |
| WO2002020737A2 (en) * | 2000-09-07 | 2002-03-14 | Vanderbilt University | Genome engineering by cell-permeable dna site-specific recombinases |
| US6472176B2 (en) * | 2000-12-14 | 2002-10-29 | Genvec, Inc. | Polynucleotide encoding chimeric protein and related vector, cell, and method of expression thereof |
| US7442686B2 (en) | 2001-04-12 | 2008-10-28 | Bioaxone Therapeutique Inc. | Treatment of macular degeneration with ADP-ribosyl transferase fusion protein therapeutic compositions |
| CA2367636C (en) | 2001-04-12 | 2010-05-04 | Lisa Mckerracher | Fusion proteins |
| CA2452865A1 (en) * | 2001-06-07 | 2002-12-12 | Skinmedica, Inc. | Conditioned cell culture media and uses thereof |
| GB0124391D0 (en) * | 2001-10-11 | 2001-11-28 | Gene Expression Technologies L | Control of gene expression |
| US20050136040A1 (en) * | 2001-10-11 | 2005-06-23 | Imperial College Innovations Limited | Control of gene expression using a complex of an oligonucleotide and a regulatory peptide |
| ITRM20030376A1 (it) | 2003-07-31 | 2005-02-01 | Univ Roma | Procedimento per l'isolamento e l'espansione di cellule staminali cardiache da biopsia. |
| US11660317B2 (en) | 2004-11-08 | 2023-05-30 | The Johns Hopkins University | Compositions comprising cardiosphere-derived cells for use in cell therapy |
| DE102007041655A1 (de) | 2007-09-03 | 2009-03-05 | Medicyte Gmbh | Vermehrung von primären Zellen und deren Verwendung |
| US8119366B2 (en) | 2007-10-05 | 2012-02-21 | Trojan Technologies, Ltd. | Antennapedia-dominant negative mastermind-like construct |
| US20100266592A1 (en) * | 2009-04-14 | 2010-10-21 | Trojan Technologies, Ltd. | Therapeutic antennapedia-antibody molecules and methods of use thereof |
| US9845457B2 (en) | 2010-04-30 | 2017-12-19 | Cedars-Sinai Medical Center | Maintenance of genomic stability in cultured stem cells |
| DE102010041958A1 (de) | 2010-10-04 | 2012-04-05 | Medicyte Gmbh | Geeignete Hepatozyten für in-vitro Genotoxitätstests |
| US20140296154A1 (en) * | 2011-05-06 | 2014-10-02 | Yale University | Method of preventing development of psoriatic lesions |
| AU2012271781C1 (en) * | 2011-06-13 | 2017-09-21 | The Board Of Trustees Of The University Of Illinois | Peptide compositions and methods for treating lung injury, asthma, anaphylaxis, angioedema, systemic vascular permeability syndromes, and nasal congestion |
| EP2841086B1 (en) | 2012-04-09 | 2018-09-26 | Case Western Reserve University | Compositions for use in treating neural injury by inhibiting the activity of lar family phosphatases |
| WO2013184527A1 (en) | 2012-06-05 | 2013-12-12 | Capricor, Inc. | Optimized methods for generation of cardiac stem cells from cardiac tissue and their use in cardiac therapy |
| JP6433896B2 (ja) | 2012-08-13 | 2018-12-05 | シーダーズ−サイナイ・メディカル・センターＣｅｄａｒｓ−Ｓｉｎａｉ Ｍｅｄｉｃａｌ Ｃｅｎｔｅｒ | 組織再生のためのエキソソームおよびマイクロリボ核酸 |
| DK3007729T3 (da) * | 2013-06-11 | 2019-09-30 | Portage Pharmaceuticals Ltd | Struktur, fremstilling og anvendelser af humanderiverede cellegennemtrængelige peptider, der er konjugeret med specifikke biologisk aktive cargo-peptider |
| EP2927685A1 (en) | 2014-04-02 | 2015-10-07 | Medicyte GmbH | Suitable hepatocytes for in-vitro hepatitis tests |
| WO2016011203A1 (en) | 2014-07-15 | 2016-01-21 | Life Technologies Corporation | Compositions with lipid aggregates and methods for efficient delivery of molecules to cells |
| JP6878274B2 (ja) | 2014-10-03 | 2021-05-26 | シーダーズ−サイナイ・メディカル・センターＣｅｄａｒｓ−Ｓｉｎａｉ Ｍｅｄｉｃａｌ Ｃｅｎｔｅｒ | 筋ジストロフィーの処置における心筋球由来細胞およびこのような細胞によって分泌されたエキソソーム |
| KR20170122762A (ko) | 2015-03-02 | 2017-11-06 | 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 | 혈관신생 억제용 펩타이드 |
| WO2017123662A1 (en) | 2016-01-11 | 2017-07-20 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction |
| WO2017177178A1 (en) | 2016-04-07 | 2017-10-12 | Case Western Reserve University | Tdp-43 mitochondrial localization inhibitor for the treatment of neurodegenerative disease |
| WO2017210652A1 (en) | 2016-06-03 | 2017-12-07 | Cedars-Sinai Medical Center | Cdc-derived exosomes for treatment of ventricular tachyarrythmias |
| EP3515459A4 (en) | 2016-09-20 | 2020-08-05 | Cedars-Sinai Medical Center | CELLS DERIVED FROM CARDIOSPHERES AND THEIR EXTRACELLULAR VESICLES TO DELAY OR REVERSE AGING AND AGE-RELATED DISORDERS |
| CA3059910A1 (en) | 2017-04-19 | 2018-10-25 | Cedars-Sinai Medical Center | Methods and compositions for treating skeletal muscular dystrophy |
| US20200230205A1 (en) | 2017-07-11 | 2020-07-23 | Case Western Reserve University | Compositions and methods for treating myelin disorders |
| EP3727351A4 (en) | 2017-12-20 | 2021-10-06 | Cedars-Sinai Medical Center | MANIPULATED EXTRACELLULAR VESICLES FOR ENHANCED RELEASE INTO TISSUE |
| WO2019152549A1 (en) | 2018-02-05 | 2019-08-08 | Cedars-Sinai Medical Center | Methods for therapeutic use of exosomes and y-rnas |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2739621B1 (fr) * | 1995-10-05 | 1997-12-05 | Centre Nat Rech Scient | Peptides utilisables comme vecteurs pour l'adressage intracellulaire de molecules actives |
-
1997
- 1997-09-02 GB GBGB9718609.2A patent/GB9718609D0/en active Pending
-
1998
- 1998-09-02 IL IL13460298A patent/IL134602A0/xx active IP Right Grant
- 1998-09-02 AU AU88776/98A patent/AU737829B2/en not_active Ceased
- 1998-09-02 WO PCT/GB1998/002628 patent/WO1999011809A1/en not_active Ceased
- 1998-09-02 CA CA002301157A patent/CA2301157A1/en not_active Abandoned
- 1998-09-02 NZ NZ503007A patent/NZ503007A/xx not_active IP Right Cessation
- 1998-09-02 EP EP98940453A patent/EP1009847A1/en not_active Withdrawn
- 1998-09-02 JP JP2000508817A patent/JP2001514858A/ja active Pending
- 1998-09-02 BR BR9811744-0A patent/BR9811744A/pt not_active Application Discontinuation
-
2000
- 2000-02-17 IL IL134602A patent/IL134602A/en not_active IP Right Cessation
-
2004
- 2004-02-27 US US10/789,403 patent/US7968512B2/en not_active Expired - Lifetime
-
2011
- 2011-06-24 US US13/168,167 patent/US8735340B2/en not_active Expired - Fee Related
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