JP2008505985A - インターフェロン−αポリペプチドおよび結合体 - Google Patents

インターフェロン−αポリペプチドおよび結合体 Download PDF

Info

Publication number
JP2008505985A
JP2008505985A JP2007527553A JP2007527553A JP2008505985A JP 2008505985 A JP2008505985 A JP 2008505985A JP 2007527553 A JP2007527553 A JP 2007527553A JP 2007527553 A JP2007527553 A JP 2007527553A JP 2008505985 A JP2008505985 A JP 2008505985A
Authority
JP
Japan
Prior art keywords
seq
polypeptide
amino acid
sequence
virus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2007527553A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008505985A5 (enExample
Inventor
フィリップ エー． パッテン，
スリダール ゴビンダラジャン，
スリダール ビスワナサン，
トーベン ラウエスガード ニッセン，
Original Assignee
マキシジェン， インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by マキシジェン， インコーポレイテッド filed Critical マキシジェン， インコーポレイテッド
Publication of JP2008505985A publication Critical patent/JP2008505985A/ja
Publication of JP2008505985A5 publication Critical patent/JP2008505985A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biotechnology (AREA)
  • AIDS & HIV (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
JP2007527553A 2004-05-19 2005-05-18 インターフェロン−αポリペプチドおよび結合体 Pending JP2008505985A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/848,827 US7314613B2 (en) 2002-11-18 2004-05-19 Interferon-alpha polypeptides and conjugates
PCT/US2005/018103 WO2006083276A2 (en) 2004-05-19 2005-05-18 Interferon-alpha polypeptides and conjugates

Publications (2)

Publication Number Publication Date
JP2008505985A true JP2008505985A (ja) 2008-02-28
JP2008505985A5 JP2008505985A5 (enExample) 2008-07-03

Family

ID=36777639

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007527553A Pending JP2008505985A (ja) 2004-05-19 2005-05-18 インターフェロン−αポリペプチドおよび結合体

Country Status (4)

Country Link
US (8) US7314613B2 (enExample)
EP (1) EP1771198A2 (enExample)
JP (1) JP2008505985A (enExample)
WO (1) WO2006083276A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013544803A (ja) * 2010-10-26 2013-12-19 ハンミ サイエンス カンパニー リミテッド 持続型インターフェロンアルファ結合体の液状製剤
JP2014513680A (ja) * 2011-04-21 2014-06-05 バクスター・インターナショナル・インコーポレイテッド ワクチンから抗原を単離し定量する方法

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6057287A (en) 1994-01-11 2000-05-02 Dyax Corp. Kallikrein-binding "Kunitz domain" proteins and analogues thereof
EP1141275B1 (en) 1999-01-05 2009-08-12 Trustees Of Boston University Improved nucleic acid cloning
US20040005673A1 (en) 2001-06-29 2004-01-08 Kevin Jarrell System for manipulating nucleic acids
US7435562B2 (en) * 2000-07-21 2008-10-14 Modular Genetics, Inc. Modular vector systems
WO2002008408A2 (en) * 2000-07-21 2002-01-31 Trustees Of Boston University Modular vector systems
ATE528014T1 (de) 2002-06-07 2011-10-15 Dyax Corp Polypeptid mit modifizierten kunitz domains
US7153829B2 (en) 2002-06-07 2006-12-26 Dyax Corp. Kallikrein-inhibitor therapies
US7314613B2 (en) * 2002-11-18 2008-01-01 Maxygen, Inc. Interferon-alpha polypeptides and conjugates
ES2447423T3 (es) * 2003-08-29 2014-03-12 Dyax Corp. Inhibidores de proteasa poli-pegilados
US20070020252A1 (en) * 2003-08-29 2007-01-25 Ladner Robert C Modified protease inhibitors
BRPI0507159A (pt) * 2004-02-02 2007-06-26 Ambrx Inc polipeptìdeos em feixe de quatro hélices humanos modificados e seus usos
US7235530B2 (en) 2004-09-27 2007-06-26 Dyax Corporation Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
CA2590245A1 (en) * 2004-11-11 2006-05-18 Modular Genetics, Inc. Ladder assembly and system for generating diversity
WO2006133088A2 (en) * 2005-06-03 2006-12-14 Ambrx, Inc. Improved human interferon molecules and their uses
WO2008008808A2 (en) * 2006-07-11 2008-01-17 Modular Genetics Inc. Methods of introducing targeted diversity into nucleic acid molecules
AU2007338771A1 (en) * 2006-12-19 2008-07-03 Merrimack Pharmaceuticals, Inc. Coadministration of alpha-fetoprotein and an immunomodulatory agent to treat multiple sclerosis
CN1970572A (zh) * 2006-12-21 2007-05-30 北京三元基因工程有限公司 干扰素α突变体及其聚乙二醇衍生物
WO2008137471A2 (en) * 2007-05-02 2008-11-13 Ambrx, Inc. Modified interferon beta polypeptides and their uses
US7625555B2 (en) 2007-06-18 2009-12-01 Novagen Holding Corporation Recombinant human interferon-like proteins
CN101525381B (zh) * 2008-03-04 2012-04-18 北京百川飞虹生物科技有限公司 一种重组复合干扰素及其表达载体的构建和表达
MX2010011145A (es) 2008-04-11 2011-04-11 Merrimack Pharmaceuticals Inc Enlazadores de la albumina de suero humana y conjugados de la misma.
EP2288359B1 (en) 2008-04-21 2019-10-02 Tissue Regeneration Therapeutics Inc. Genetically modified human umbilical cord perivascular cells for prophylaxis against or treatment of biological or chemical agents
CN102282168A (zh) 2008-11-18 2011-12-14 梅里麦克制药股份有限公司 人血清白蛋白接头以及其结合物
JP2013516389A (ja) 2009-01-06 2013-05-13 ダイアックス コーポレーション カリクレイン阻害剤による粘膜炎治療
US20100284962A1 (en) * 2009-05-06 2010-11-11 Oncopharmacologics, Inc. Modified tumor necrosis factor-beta
BRPI1012951A2 (pt) 2009-06-09 2016-07-26 Defyrus Inc "administração de interferon para profilaxia ou tratamento de infecção por patôgeno"
CN102081018A (zh) * 2009-11-30 2011-06-01 希森美康株式会社 样品的预处理方法及hcv的免疫测定方法
ES2905545T3 (es) 2010-01-06 2022-04-11 Takeda Pharmaceuticals Co Proteínas de unión a calicreína plasmática
WO2011087627A1 (en) * 2010-01-15 2011-07-21 Biolex Therapeutics, Inc Stabilized interferon formulations
IL269565B2 (en) 2011-01-06 2024-06-01 Dyax Corp Plasma kallikrein binding proteins
US20150202287A1 (en) 2012-08-30 2015-07-23 Merrimack Pharmaceuticals, Inc. Combination therapies comprising anti-erbb3 agents
CA2885419A1 (en) 2012-09-19 2014-03-27 Microvascular Tissues, Inc. Compositions and methods for treating and preventing tissue injury and disease
CN105579059B (zh) 2013-09-03 2020-07-31 佐治亚科技研究公司 热稳定的疫苗配制物、工艺和包含疫苗配制物的微针
EP3122782A4 (en) 2014-03-27 2017-09-13 Dyax Corp. Compositions and methods for treatment of diabetic macular edema
CN116077648A (zh) 2015-12-11 2023-05-09 武田药品工业株式会社 血浆激肽释放酶抑制剂及其治疗遗传性血管性水肿发作的用途
CN107046366B (zh) * 2016-02-05 2019-06-04 台达电子企业管理（上海）有限公司 电源变换器及其制备方法
SG10201609616TA (en) * 2016-09-06 2018-04-27 Apple Inc Electronic device with cooling fan

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001025438A2 (en) * 1999-10-07 2001-04-12 Maxygen, Inc. Ifn-alpha homologues
JP2001506855A (ja) * 1996-12-18 2001-05-29 マキシジェン，インコーポレイテッド ポリペプチド操作のための方法および組成物
WO2001095929A2 (en) * 2000-06-16 2001-12-20 Schering Aktiengesellschaft Interferon for treatment of multiple sclerosis
JP2003530070A (ja) * 1999-05-19 2003-10-14 レキシジェン ファーマシューティカルズ コーポレイション Ｆｃ融合タンパク質としてのインターフェロン−αタンパク質の発現および搬出

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6610830B1 (en) * 1980-07-01 2003-08-26 Hoffman-La Roche Inc. Microbial production of mature human leukocyte interferons
ES506955A0 (es) 1980-11-10 1983-02-01 Genentech Inc Un procedimiento para producir un polipeptido antiviral.
US4414150A (en) * 1980-11-10 1983-11-08 Genentech, Inc. Hybrid human leukocyte interferons
WO1983002461A1 (en) 1982-01-19 1983-07-21 Cetus Corp Multiclass hybrid interferons
US6936694B1 (en) 1982-05-06 2005-08-30 Intermune, Inc. Manufacture and expression of large structural genes
EP0205404B1 (en) 1985-06-11 1992-07-15 Ciba-Geigy Ag Hybrid interferons
EP0553294B1 (en) 1990-10-17 1998-12-23 Amgen Inc. The manufacture of compositions for the treatment of cell proliferation disorders
US5372808A (en) 1990-10-17 1994-12-13 Amgen Inc. Methods and compositions for the treatment of diseases with consensus interferon while reducing side effect
US5595732A (en) * 1991-03-25 1997-01-21 Hoffmann-La Roche Inc. Polyethylene-protein conjugates
US5382657A (en) 1992-08-26 1995-01-17 Hoffmann-La Roche Inc. Peg-interferon conjugates
US5780021A (en) * 1993-03-05 1998-07-14 Georgetown University Method for treating type 1 diabetes using α-interferon and/or β-i
US5574138A (en) * 1993-03-08 1996-11-12 Immunex Corporation Epithelium-derived T-cell factor
DK0741577T3 (da) 1994-03-07 2003-02-17 Imperial College Anvendelsen af enterferon, subtype alfa 8, til fremstilling af lægemidler til behandling af virusinfektioner i leveren
US5824784A (en) 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
TW517067B (en) * 1996-05-31 2003-01-11 Hoffmann La Roche Interferon conjugates
WO2000042175A1 (en) 1999-01-14 2000-07-20 Bolder Biotechnology Inc. Methods for making proteins containing free cysteine residues
EP1012184B1 (en) 1997-07-14 2007-10-10 Bolder Biotechnology, Inc. Derivatives of growth hormone and related proteins
WO2000052153A2 (en) 1999-03-02 2000-09-08 Maxygen, Inc. Method to identify ligands for orphan receptors
US20040002474A1 (en) * 1999-10-07 2004-01-01 Maxygen Inc. IFN-alpha homologues
NZ522847A (en) 2000-05-16 2004-11-26 Bolder Biotechnology Inc Methods for refolding proteins containing free cysteine residues
WO2002044197A2 (en) 2000-12-01 2002-06-06 Fish Eleanor N Cytokine receptor binding peptides
KR100459105B1 (ko) 2001-02-15 2004-12-03 선바이오(주) 변형된 인터페론-알파 2ａ 및 2ｂ, 그리고 이들과 ＰＥＧ유도체와의 배합체
RU2005118752A (ru) * 2002-11-15 2006-02-10 Ф.Хоффманн-Ля Рош Аг (Ch) Позиционные изомеры пэгилированного интерферона l-2а (конъюгата пэг-ifn-l-2а)
US7314613B2 (en) * 2002-11-18 2008-01-01 Maxygen, Inc. Interferon-alpha polypeptides and conjugates

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001506855A (ja) * 1996-12-18 2001-05-29 マキシジェン，インコーポレイテッド ポリペプチド操作のための方法および組成物
JP2003530070A (ja) * 1999-05-19 2003-10-14 レキシジェン ファーマシューティカルズ コーポレイション Ｆｃ融合タンパク質としてのインターフェロン−αタンパク質の発現および搬出
WO2001025438A2 (en) * 1999-10-07 2001-04-12 Maxygen, Inc. Ifn-alpha homologues
WO2001095929A2 (en) * 2000-06-16 2001-12-20 Schering Aktiengesellschaft Interferon for treatment of multiple sclerosis

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
JPN6009051033, Ｊ Ｃｅｌｌ Ｐｈｙｓ．， １８２ （２０００） ｐ．９７−１０８ *
JPN6009051037, Ｄｒｕｇｓ， ５０［５］ （１９９５） ｐ．８７３−８９６ *
JPN6009051041, Ｄｒｕｇｓ， ６１［１５］ （２００１） ｐ．２２６３−２２８８ *
JPN6009051043, Ｃａｎ Ｊ Ｃｈｅｍ．， ８０ （２００２） ｐ．１１６６−１１７３ *
JPN6009051045, Ｊ Ｉｎｔｅｒｆｅｒｏｎ Ｒｅｓ．， １２ （１９９２） ｐ．２５７−２６６ *
JPN6009051047, Ｎａｔ Ｂｉｏｔｅｃｈ．， １７ （１９９９） ｐ．７９３−７９７ *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013544803A (ja) * 2010-10-26 2013-12-19 ハンミ サイエンス カンパニー リミテッド 持続型インターフェロンアルファ結合体の液状製剤
US9669105B2 (en) 2010-10-26 2017-06-06 Hanmi Science Co., Ltd. Liquid formulations of long-acting interferon alpha conjugates
JP2014513680A (ja) * 2011-04-21 2014-06-05 バクスター・インターナショナル・インコーポレイテッド ワクチンから抗原を単離し定量する方法

Also Published As

Publication number Publication date
US20090011465A1 (en) 2009-01-08
WO2006083276A3 (en) 2009-04-16
EP1771198A2 (en) 2007-04-11
US7504097B2 (en) 2009-03-17
US7488473B2 (en) 2009-02-10
US7498152B1 (en) 2009-03-03
WO2006083276A2 (en) 2006-08-10
US7488589B2 (en) 2009-02-10
US7488801B2 (en) 2009-02-10
US20090017501A1 (en) 2009-01-15
US20090042252A1 (en) 2009-02-12
US7314613B2 (en) 2008-01-01
US20090017502A1 (en) 2009-01-15
US20090017500A1 (en) 2009-01-15
US20070274950A1 (en) 2007-11-29
US20070065407A1 (en) 2007-03-22
US20080227149A1 (en) 2008-09-18

Similar Documents

Publication Publication Date Title
US7314613B2 (en) Interferon-alpha polypeptides and conjugates
US7541163B2 (en) Interferon-alpha polypeptides and conjugates
US20040219131A1 (en) Interferon-alpha polypeptides and conjugates
EP1888633A2 (en) Evolved interferon-alpha polypeptides
ZA200503782B (en) Interferon-alpha polypeptides and conjugates
KR20070022279A (ko) 인터페론-알파 폴리펩티드 및 컨쥬게이트

Legal Events

Date Code Title Description
A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20080515

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20080515

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20091006

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20100427