JP2013501038A5 - - Google Patents
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- Publication number
- JP2013501038A5 JP2013501038A5 JP2012523352A JP2012523352A JP2013501038A5 JP 2013501038 A5 JP2013501038 A5 JP 2013501038A5 JP 2012523352 A JP2012523352 A JP 2012523352A JP 2012523352 A JP2012523352 A JP 2012523352A JP 2013501038 A5 JP2013501038 A5 JP 2013501038A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- seq
- vector
- nucleic acid
- hbv
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 38
- 102000039446 nucleic acids Human genes 0.000 claims 32
- 108020004707 nucleic acids Proteins 0.000 claims 32
- 150000007523 nucleic acids Chemical class 0.000 claims 32
- 239000013598 vector Substances 0.000 claims 30
- 230000002163 immunogen Effects 0.000 claims 29
- 125000003275 alpha amino acid group Chemical group 0.000 claims 27
- 125000003729 nucleotide group Chemical group 0.000 claims 25
- 239000002773 nucleotide Substances 0.000 claims 24
- 208000015181 infectious disease Diseases 0.000 claims 16
- 230000002458 infectious effect Effects 0.000 claims 13
- 239000002245 particle Substances 0.000 claims 12
- 125000000539 amino acid group Chemical group 0.000 claims 11
- 238000006467 substitution reaction Methods 0.000 claims 11
- 241000700605 Viruses Species 0.000 claims 9
- 108090000765 processed proteins & peptides Proteins 0.000 claims 9
- 229920001184 polypeptide Polymers 0.000 claims 8
- 102000004196 processed proteins & peptides Human genes 0.000 claims 8
- 230000003612 virological effect Effects 0.000 claims 8
- 238000011282 treatment Methods 0.000 claims 5
- 239000013603 viral vector Substances 0.000 claims 5
- 108700024845 Hepatitis B virus P Proteins 0.000 claims 4
- 102100034349 Integrase Human genes 0.000 claims 4
- 102100034353 Integrase Human genes 0.000 claims 4
- 108010078428 env Gene Products Proteins 0.000 claims 4
- 241000700721 Hepatitis B virus Species 0.000 claims 3
- 206010037742 Rabies Diseases 0.000 claims 3
- 230000002950 deficient Effects 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 208000000419 Chronic Hepatitis B Diseases 0.000 claims 2
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 claims 2
- 206010046865 Vaccinia virus infection Diseases 0.000 claims 2
- 208000016350 chronic hepatitis B virus infection Diseases 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 230000001747 exhibiting effect Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000001575 pathological effect Effects 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 238000011301 standard therapy Methods 0.000 claims 2
- -1 terbivudine Chemical compound 0.000 claims 2
- 208000007089 vaccinia Diseases 0.000 claims 2
- 241000178270 Canarypox virus Species 0.000 claims 1
- 101710132601 Capsid protein Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 101710091045 Envelope protein Proteins 0.000 claims 1
- 241000700662 Fowlpox virus Species 0.000 claims 1
- 108090000288 Glycoproteins Proteins 0.000 claims 1
- 102000003886 Glycoproteins Human genes 0.000 claims 1
- 101100321817 Human parvovirus B19 (strain HV) 7.5K gene Proteins 0.000 claims 1
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 1
- 101710188315 Protein X Proteins 0.000 claims 1
- 241000700618 Vaccinia virus Species 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 229960001997 adefovir Drugs 0.000 claims 1
- WOZSCQDILHKSGG-UHFFFAOYSA-N adefovir depivoxil Chemical compound N1=CN=C2N(CCOCP(=O)(OCOC(=O)C(C)(C)C)OCOC(=O)C(C)(C)C)C=NC2=C1N WOZSCQDILHKSGG-UHFFFAOYSA-N 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 230000036755 cellular response Effects 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229960000980 entecavir Drugs 0.000 claims 1
- YXPVEXCTPGULBZ-WQYNNSOESA-N entecavir hydrate Chemical compound O.C1=NC=2C(=O)NC(N)=NC=2N1[C@H]1C[C@H](O)[C@@H](CO)C1=C YXPVEXCTPGULBZ-WQYNNSOESA-N 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 230000002209 hydrophobic effect Effects 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000005847 immunogenicity Effects 0.000 claims 1
- 239000002955 immunomodulating agent Substances 0.000 claims 1
- 230000002584 immunomodulator Effects 0.000 claims 1
- 229940121354 immunomodulator Drugs 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 229960001627 lamivudine Drugs 0.000 claims 1
- JTEGQNOMFQHVDC-NKWVEPMBSA-N lamivudine Chemical compound O=C1N=C(N)C=CN1[C@H]1O[C@@H](CO)SC1 JTEGQNOMFQHVDC-NKWVEPMBSA-N 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 239000013600 plasmid vector Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 238000011321 prophylaxis Methods 0.000 claims 1
- 230000010076 replication Effects 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
- 229960004556 tenofovir Drugs 0.000 claims 1
- VCMJCVGFSROFHV-WZGZYPNHSA-N tenofovir disoproxil fumarate Chemical compound OC(=O)\C=C\C(O)=O.N1=CN=C2N(C[C@@H](C)OCP(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C)C=NC2=C1N VCMJCVGFSROFHV-WZGZYPNHSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09305742 | 2009-08-07 | ||
| EP09305742.0 | 2009-08-07 | ||
| PCT/EP2010/061492 WO2011015656A2 (en) | 2009-08-07 | 2010-08-06 | Composition for treating hbv infection |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015232256A Division JP6246778B2 (ja) | 2009-08-07 | 2015-11-27 | Ｈｂｖ感染を治療するための組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013501038A JP2013501038A (ja) | 2013-01-10 |
| JP2013501038A5 true JP2013501038A5 (enExample) | 2013-09-12 |
| JP5897464B2 JP5897464B2 (ja) | 2016-03-30 |
Family
ID=43087099
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012523352A Expired - Fee Related JP5897464B2 (ja) | 2009-08-07 | 2010-08-06 | Ｈｂｖ感染を治療するための組成物 |
| JP2015232256A Expired - Fee Related JP6246778B2 (ja) | 2009-08-07 | 2015-11-27 | Ｈｂｖ感染を治療するための組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015232256A Expired - Fee Related JP6246778B2 (ja) | 2009-08-07 | 2015-11-27 | Ｈｂｖ感染を治療するための組成物 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US9393299B2 (enExample) |
| EP (1) | EP2461826A2 (enExample) |
| JP (2) | JP5897464B2 (enExample) |
| KR (1) | KR20120052352A (enExample) |
| CN (2) | CN105535960B (enExample) |
| BR (1) | BR112012002628B1 (enExample) |
| CA (1) | CA2770075C (enExample) |
| IL (1) | IL217926A (enExample) |
| MX (1) | MX2012001592A (enExample) |
| NZ (1) | NZ598000A (enExample) |
| RU (1) | RU2555346C2 (enExample) |
| SG (1) | SG178254A1 (enExample) |
| TW (1) | TWI555531B (enExample) |
| WO (1) | WO2011015656A2 (enExample) |
| ZA (1) | ZA201200899B (enExample) |
Families Citing this family (44)
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| BR112012002628B1 (pt) * | 2009-08-07 | 2021-09-08 | Transgene Sa | Composição imunogênica, molécula de ácido nucleico, vetor, partícula viral infecciosa, micro-organismo transgênico, composição, usos da composição imunogênica e kit de partes |
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| TWI623618B (zh) * | 2011-07-12 | 2018-05-11 | 傳斯堅公司 | Ｈｂｖ聚合酶突變體 |
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| TWI690322B (zh) | 2012-10-02 | 2020-04-11 | 法商傳斯堅公司 | 含病毒的調配物及其使用 |
| US9946495B2 (en) * | 2013-04-25 | 2018-04-17 | Microsoft Technology Licensing, Llc | Dirty data management for hybrid drives |
| WO2016020538A1 (en) * | 2014-08-08 | 2016-02-11 | Transgene Sa | Hbv vaccine and antibody combination therapy to treat hbv infections |
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| CN106148404B (zh) * | 2015-03-25 | 2020-01-24 | 复旦大学 | 一种人乙型肝炎病毒重组载体及其应用 |
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| CN108779472B (zh) * | 2015-11-04 | 2022-09-09 | 霍欧奇帕生物科技有限公司 | 针对乙型肝炎病毒的疫苗 |
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| DK3402888T3 (da) * | 2016-01-12 | 2020-11-30 | Helmholtz Zentrum Muenchen Deutsches Forschungszentrum Gesundheit & Umwelt Gmbh | Middel og fremgangsmåder til behandling af hbv |
| WO2017180770A1 (en) | 2016-04-13 | 2017-10-19 | Synthetic Genomics, Inc. | Recombinant arterivirus replicon systems and uses thereof |
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| GB201705765D0 (en) * | 2017-04-10 | 2017-05-24 | Univ Oxford Innovation Ltd | HBV vaccine |
| CA3061678A1 (en) | 2017-05-15 | 2018-11-22 | Janssen Vaccines & Prevention B.V. | Stable virus-containing composition |
| US11052147B2 (en) | 2017-05-15 | 2021-07-06 | Janssen Vaccines & Prevention B.V. | Stable virus-containing composition |
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| US11020476B2 (en) | 2017-12-19 | 2021-06-01 | Janssen Sciences Ireland Unlimited Company | Methods and compositions for inducing an immune response against Hepatitis B Virus (HBV) |
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| KR20200111729A (ko) | 2018-01-19 | 2020-09-29 | 얀센 파마슈티칼즈, 인코포레이티드 | 재조합 레플리콘 시스템을 이용한 면역 반응 유도 및 증진 |
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| KR102234027B1 (ko) * | 2018-05-09 | 2021-03-31 | 서울대학교산학협력단 | B형 간염 바이러스 유래 폴리펩티드 및 이의 항바이러스 용도 |
| US12331076B2 (en) | 2018-10-08 | 2025-06-17 | Janssen Pharmaceuticals, Inc. | Alphavirus-based replicons for administration of biotherapeutics |
| KR20220041080A (ko) * | 2019-06-18 | 2022-03-31 | 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 | B형 간염 바이러스(hbv) 백신 및 항-pd-1 또는 항-pc-l1 항체의 조합 |
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| US8007805B2 (en) * | 2003-08-08 | 2011-08-30 | Paladin Labs, Inc. | Chimeric antigens for breaking host tolerance to foreign antigens |
| DE10339927A1 (de) * | 2003-08-29 | 2005-03-24 | Rhein Biotech Gesellschaft für neue Biotechnologische Prozesse und Produkte mbH | Zusammensetzung zur Prophylaxe/Therapie von HBV-Infektionen und HBV-vermittelten Erkrankungen |
| JP2007509614A (ja) * | 2003-10-21 | 2007-04-19 | メルボルン ヘルス | Ｈｂｖ変種の検出および適用 |
| GB0328753D0 (en) | 2003-12-11 | 2004-01-14 | Royal Veterinary College The | Hepatitis B vaccines |
| ATE421534T1 (de) | 2004-11-08 | 2009-02-15 | Transgene Sa | Aus teilen bestehendes kit für die durchführung einer antitumorbehandlung oder antiviralen behandlung in einem säugetier |
| EP1764369A1 (de) | 2005-09-16 | 2007-03-21 | Rhein Biotech Gesellschaft für neue biotechnologische Prozesse und Produkte mbH | Vakzine enthaltend trunkiertes HBV core protein plus Saponin-basierendes Adjuvants |
| GB0522578D0 (en) | 2005-11-04 | 2005-12-14 | King S College London | Ribozymal nucleic acid |
| US8211444B2 (en) * | 2006-03-09 | 2012-07-03 | Transgene S.A. | Hepatitis C virus non structural fusion protein |
| BRPI0713711A2 (pt) * | 2006-06-20 | 2012-10-30 | Transgene Sa | vacina viral recombinante, kit para vacinação, e, método para usar pelo menos um composto |
| CN101573449B (zh) * | 2006-08-14 | 2013-09-18 | 浦项工大产学协力团 | 用于治疗慢性乙型肝炎的dna疫苗及其制备方法 |
| BRPI0810305A2 (pt) * | 2007-05-15 | 2018-07-10 | Transgene Sa | "vetor, molécula de ácido nucléico substancialmente isolada, célula hospedeira, composição farmacêutica, uso de uma molécula de ácido nucléico, uso de um vetor, uso de uma célula hospedeira e uso de uma composição" |
| WO2009092612A1 (en) * | 2008-01-25 | 2009-07-30 | Universitätsklinikum Heidelberg | Hydrophobic modified pres-derived peptides of hepatitis b virus (hbv) and their use as vehicles for the specific delivery of compounds to the liver |
| BR112012002628B1 (pt) * | 2009-08-07 | 2021-09-08 | Transgene Sa | Composição imunogênica, molécula de ácido nucleico, vetor, partícula viral infecciosa, micro-organismo transgênico, composição, usos da composição imunogênica e kit de partes |
| US10076570B2 (en) * | 2009-08-07 | 2018-09-18 | Transgene S.A. | Composition for treating HBV infection |
-
2010
- 2010-08-06 BR BR112012002628-3A patent/BR112012002628B1/pt not_active IP Right Cessation
- 2010-08-06 KR KR1020127005033A patent/KR20120052352A/ko not_active Ceased
- 2010-08-06 SG SG2012007845A patent/SG178254A1/en unknown
- 2010-08-06 MX MX2012001592A patent/MX2012001592A/es active IP Right Grant
- 2010-08-06 WO PCT/EP2010/061492 patent/WO2011015656A2/en not_active Ceased
- 2010-08-06 CA CA2770075A patent/CA2770075C/en active Active
- 2010-08-06 CN CN201510884240.7A patent/CN105535960B/zh active Active
- 2010-08-06 CN CN201080042650.2A patent/CN102573903B/zh active Active
- 2010-08-06 US US13/388,826 patent/US9393299B2/en not_active Expired - Fee Related
- 2010-08-06 TW TW099126293A patent/TWI555531B/zh active
- 2010-08-06 JP JP2012523352A patent/JP5897464B2/ja not_active Expired - Fee Related
- 2010-08-06 RU RU2012107671/15A patent/RU2555346C2/ru active
- 2010-08-06 EP EP10737945A patent/EP2461826A2/en not_active Ceased
- 2010-08-06 NZ NZ598000A patent/NZ598000A/xx not_active IP Right Cessation
-
2012
- 2012-02-02 IL IL217926A patent/IL217926A/en active IP Right Grant
- 2012-02-07 ZA ZA2012/00899A patent/ZA201200899B/en unknown
-
2015
- 2015-11-27 JP JP2015232256A patent/JP6246778B2/ja not_active Expired - Fee Related
-
2016
- 2016-07-06 US US15/203,046 patent/US20170072047A1/en not_active Abandoned
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