JP2013501038A5 - - Google Patents
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- JP2013501038A5 JP2013501038A5 JP2012523352A JP2012523352A JP2013501038A5 JP 2013501038 A5 JP2013501038 A5 JP 2013501038A5 JP 2012523352 A JP2012523352 A JP 2012523352A JP 2012523352 A JP2012523352 A JP 2012523352A JP 2013501038 A5 JP2013501038 A5 JP 2013501038A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- seq
- vector
- nucleic acid
- hbv
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000203 mixture Substances 0.000 claims 38
- 102000039446 nucleic acids Human genes 0.000 claims 32
- 108020004707 nucleic acids Proteins 0.000 claims 32
- 150000007523 nucleic acids Chemical class 0.000 claims 32
- 239000013598 vector Substances 0.000 claims 30
- 230000002163 immunogen Effects 0.000 claims 29
- 125000003275 alpha amino acid group Chemical group 0.000 claims 27
- 125000003729 nucleotide group Chemical group 0.000 claims 25
- 239000002773 nucleotide Substances 0.000 claims 24
- 208000015181 infectious disease Diseases 0.000 claims 16
- 230000002458 infectious effect Effects 0.000 claims 13
- 239000002245 particle Substances 0.000 claims 12
- 125000000539 amino acid group Chemical group 0.000 claims 11
- 238000006467 substitution reaction Methods 0.000 claims 11
- 241000700605 Viruses Species 0.000 claims 9
- 108090000765 processed proteins & peptides Proteins 0.000 claims 9
- 229920001184 polypeptide Polymers 0.000 claims 8
- 102000004196 processed proteins & peptides Human genes 0.000 claims 8
- 230000003612 virological effect Effects 0.000 claims 8
- 238000011282 treatment Methods 0.000 claims 5
- 239000013603 viral vector Substances 0.000 claims 5
- 108700024845 Hepatitis B virus P Proteins 0.000 claims 4
- 102100034349 Integrase Human genes 0.000 claims 4
- 102100034353 Integrase Human genes 0.000 claims 4
- 108010078428 env Gene Products Proteins 0.000 claims 4
- 241000700721 Hepatitis B virus Species 0.000 claims 3
- 206010037742 Rabies Diseases 0.000 claims 3
- 230000002950 deficient Effects 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 208000000419 Chronic Hepatitis B Diseases 0.000 claims 2
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 claims 2
- 206010046865 Vaccinia virus infection Diseases 0.000 claims 2
- 208000016350 chronic hepatitis B virus infection Diseases 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 230000001747 exhibiting effect Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000001575 pathological effect Effects 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 238000011301 standard therapy Methods 0.000 claims 2
- -1 terbivudine Chemical compound 0.000 claims 2
- 208000007089 vaccinia Diseases 0.000 claims 2
- 241000178270 Canarypox virus Species 0.000 claims 1
- 101710132601 Capsid protein Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 101710091045 Envelope protein Proteins 0.000 claims 1
- 241000700662 Fowlpox virus Species 0.000 claims 1
- 108090000288 Glycoproteins Proteins 0.000 claims 1
- 102000003886 Glycoproteins Human genes 0.000 claims 1
- 101100321817 Human parvovirus B19 (strain HV) 7.5K gene Proteins 0.000 claims 1
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 1
- 101710188315 Protein X Proteins 0.000 claims 1
- 241000700618 Vaccinia virus Species 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 229960001997 adefovir Drugs 0.000 claims 1
- WOZSCQDILHKSGG-UHFFFAOYSA-N adefovir depivoxil Chemical compound N1=CN=C2N(CCOCP(=O)(OCOC(=O)C(C)(C)C)OCOC(=O)C(C)(C)C)C=NC2=C1N WOZSCQDILHKSGG-UHFFFAOYSA-N 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 230000036755 cellular response Effects 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229960000980 entecavir Drugs 0.000 claims 1
- YXPVEXCTPGULBZ-WQYNNSOESA-N entecavir hydrate Chemical compound O.C1=NC=2C(=O)NC(N)=NC=2N1[C@H]1C[C@H](O)[C@@H](CO)C1=C YXPVEXCTPGULBZ-WQYNNSOESA-N 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 230000002209 hydrophobic effect Effects 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000005847 immunogenicity Effects 0.000 claims 1
- 239000002955 immunomodulating agent Substances 0.000 claims 1
- 230000002584 immunomodulator Effects 0.000 claims 1
- 229940121354 immunomodulator Drugs 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 229960001627 lamivudine Drugs 0.000 claims 1
- JTEGQNOMFQHVDC-NKWVEPMBSA-N lamivudine Chemical compound O=C1N=C(N)C=CN1[C@H]1O[C@@H](CO)SC1 JTEGQNOMFQHVDC-NKWVEPMBSA-N 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 239000013600 plasmid vector Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 238000011321 prophylaxis Methods 0.000 claims 1
- 230000010076 replication Effects 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
- 229960004556 tenofovir Drugs 0.000 claims 1
- VCMJCVGFSROFHV-WZGZYPNHSA-N tenofovir disoproxil fumarate Chemical compound OC(=O)\C=C\C(O)=O.N1=CN=C2N(C[C@@H](C)OCP(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C)C=NC2=C1N VCMJCVGFSROFHV-WZGZYPNHSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09305742.0 | 2009-08-07 | ||
| EP09305742 | 2009-08-07 | ||
| PCT/EP2010/061492 WO2011015656A2 (en) | 2009-08-07 | 2010-08-06 | Composition for treating hbv infection |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015232256A Division JP6246778B2 (ja) | 2009-08-07 | 2015-11-27 | Ｈｂｖ感染を治療するための組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013501038A JP2013501038A (ja) | 2013-01-10 |
| JP2013501038A5 true JP2013501038A5 (enExample) | 2013-09-12 |
| JP5897464B2 JP5897464B2 (ja) | 2016-03-30 |
Family
ID=43087099
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012523352A Expired - Fee Related JP5897464B2 (ja) | 2009-08-07 | 2010-08-06 | Ｈｂｖ感染を治療するための組成物 |
| JP2015232256A Expired - Fee Related JP6246778B2 (ja) | 2009-08-07 | 2015-11-27 | Ｈｂｖ感染を治療するための組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015232256A Expired - Fee Related JP6246778B2 (ja) | 2009-08-07 | 2015-11-27 | Ｈｂｖ感染を治療するための組成物 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US9393299B2 (enExample) |
| EP (1) | EP2461826A2 (enExample) |
| JP (2) | JP5897464B2 (enExample) |
| KR (1) | KR20120052352A (enExample) |
| CN (2) | CN102573903B (enExample) |
| BR (1) | BR112012002628B1 (enExample) |
| CA (1) | CA2770075C (enExample) |
| IL (1) | IL217926A (enExample) |
| MX (1) | MX2012001592A (enExample) |
| NZ (1) | NZ598000A (enExample) |
| RU (1) | RU2555346C2 (enExample) |
| SG (1) | SG178254A1 (enExample) |
| TW (1) | TWI555531B (enExample) |
| WO (1) | WO2011015656A2 (enExample) |
| ZA (1) | ZA201200899B (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20120052352A (ko) * | 2009-08-07 | 2012-05-23 | 트랜스진 에스.에이. | Ｈｂｖ 감염을 치료하는 조성물 |
| EA030381B1 (ru) * | 2011-06-14 | 2018-07-31 | Глоубиммьюн, Инк. | Иммунотерапевтическая композиция, ее применения и способы лечения или профилактики инфекции, вызванной вирусом гепатита дельта |
| TWI575070B (zh) | 2011-07-12 | 2017-03-21 | 傳斯堅公司 | Ｈｂｖ聚合酶突變體 |
| WO2014009433A1 (en) | 2012-07-10 | 2014-01-16 | Transgene Sa | Mycobacterium resuscitation promoting factor for use as adjuvant |
| TWI690322B (zh) | 2012-10-02 | 2020-04-11 | 法商傳斯堅公司 | 含病毒的調配物及其使用 |
| US9946495B2 (en) * | 2013-04-25 | 2018-04-17 | Microsoft Technology Licensing, Llc | Dirty data management for hybrid drives |
| WO2016020538A1 (en) * | 2014-08-08 | 2016-02-11 | Transgene Sa | Hbv vaccine and antibody combination therapy to treat hbv infections |
| WO2016131945A1 (en) | 2015-02-20 | 2016-08-25 | Transgene Sa | Combination product with autophagy modulator |
| CN114262380A (zh) | 2015-03-18 | 2022-04-01 | 欧姆尼赛特有限公司 | 包含经修饰的α病毒表面糖蛋白与肿瘤相关抗原的融合蛋白及其方法 |
| CN106148404B (zh) * | 2015-03-25 | 2020-01-24 | 复旦大学 | 一种人乙型肝炎病毒重组载体及其应用 |
| WO2016167369A1 (ja) * | 2015-04-16 | 2016-10-20 | 国立研究開発法人産業技術総合研究所 | Ｂ型肝炎ウイルス分泌阻害剤 |
| CN115948467A (zh) * | 2015-11-04 | 2023-04-11 | 霍欧奇帕生物科技有限公司 | 针对乙型肝炎病毒的疫苗 |
| CA3003548A1 (en) | 2015-11-12 | 2017-05-18 | Hookipa Biotech Ag | Arenavirus particles as cancer vaccines |
| US9963751B2 (en) | 2015-11-24 | 2018-05-08 | The Penn State Research Foundation | Compositions and methods for identifying agents to reduce hepatitis B virus covalently closed circular DNA |
| CN116732101A (zh) * | 2016-01-12 | 2023-09-12 | 德国亥姆霍兹慕尼黑中心健康与环境研究中心（有限公司） | 用于治疗hbv的手段和方法 |
| US10538786B2 (en) | 2016-04-13 | 2020-01-21 | Janssen Pharmaceuticals, Inc. | Recombinant arterivirus replicon systems and uses thereof |
| CA3026054A1 (en) | 2016-05-30 | 2017-12-07 | Geovax Inc. | Compositions and methods for generating an immune response to hepatitis b virus |
| BR112018075855A2 (pt) * | 2016-06-15 | 2019-04-02 | Oxford University Innovation Limited | sistema de vetor viral adeno-associado com dupla sobreposição para a expressão abc4a |
| EP3276006A1 (en) * | 2016-07-27 | 2018-01-31 | Theravectys | Lentiviral vectors for expression of hepatitis b virus (hbv) antigens |
| EP3522920A2 (en) | 2016-10-10 | 2019-08-14 | Transgene SA | Immunotherapeutic product and mdsc modulator combination therapy |
| EP3526332B1 (en) | 2016-10-17 | 2024-06-26 | Janssen Pharmaceuticals, Inc. | Recombinant virus replicon systems and uses thereof |
| CA3045650A1 (en) | 2016-12-05 | 2018-06-14 | Janssen Pharmaceuticals, Inc. | Compositions and methods for enhancing gene expression |
| GB201705765D0 (en) * | 2017-04-10 | 2017-05-24 | Univ Oxford Innovation Ltd | HBV vaccine |
| CA3061678A1 (en) | 2017-05-15 | 2018-11-22 | Janssen Vaccines & Prevention B.V. | Stable virus-containing composition |
| KR102658198B1 (ko) | 2017-05-15 | 2024-04-16 | 얀센 백신스 앤드 프리벤션 비.브이. | 안정한 바이러스 함유 조성물 |
| GB201721069D0 (en) | 2017-12-15 | 2018-01-31 | Glaxosmithkline Biologicals Sa | Hepatitis B Immunisation regimen and compositions |
| EA202091517A1 (ru) | 2017-12-19 | 2020-11-03 | Янссен Сайенсиз Айрлэнд Анлимитед Компани | Способы и устройство для доставки вакцин против вируса гепатита b (hbv) |
| US11021692B2 (en) | 2017-12-19 | 2021-06-01 | Janssen Sciences Ireland Unlimited Company | Hepatitis B virus (HBV) vaccines and uses thereof |
| MX2020006471A (es) * | 2017-12-19 | 2020-09-22 | Janssen Sciences Ireland Unlimited Co | Metodos y composiciones para inducir una respuesta inmune contra el virus de hepatitis b (hbv). |
| CA3085492A1 (en) * | 2017-12-19 | 2019-06-27 | Janssen Sciences Ireland Unlimited Company | Methods and apparatus for the delivery of hepatitis b virus (hbv) vaccines |
| US11020476B2 (en) | 2017-12-19 | 2021-06-01 | Janssen Sciences Ireland Unlimited Company | Methods and compositions for inducing an immune response against Hepatitis B Virus (HBV) |
| BR112020014525A2 (pt) | 2018-01-19 | 2020-12-08 | Janssen Pharmaceuticals, Inc. | Induzir e intensificar respostas imunes utilizando sistemas de replicon recombinantes |
| IL277128B2 (en) | 2018-03-06 | 2025-11-01 | Precigen Inc | Hepatitis b vaccines and uses of the same |
| KR102234027B1 (ko) * | 2018-05-09 | 2021-03-31 | 서울대학교산학협력단 | B형 간염 바이러스 유래 폴리펩티드 및 이의 항바이러스 용도 |
| US12331076B2 (en) | 2018-10-08 | 2025-06-17 | Janssen Pharmaceuticals, Inc. | Alphavirus-based replicons for administration of biotherapeutics |
| CA3143679A1 (en) * | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and hbv-targeting rnai |
| EP3986454A1 (en) * | 2019-06-18 | 2022-04-27 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and anti-pd-1 or anti-pd-l1 antibody |
| PH12022550490A1 (en) * | 2019-08-29 | 2023-02-06 | Triad Nat Security Llc | Hepatitis b virus vaccines |
| KR20220074917A (ko) | 2019-09-30 | 2022-06-03 | 길리애드 사이언시즈, 인코포레이티드 | Hbv 백신 및 hbv를 치료하는 방법 |
| JP2023505304A (ja) | 2019-12-07 | 2023-02-08 | アイエスエー ファーマシューティカルズ ビー．ヴイ． | Ｂ型肝炎ウイルスに関連する疾患の治療 |
| WO2022012539A1 (zh) * | 2020-07-17 | 2022-01-20 | 养生堂有限公司 | 一种细胞穿膜肽及其应用 |
| CN114107377A (zh) * | 2020-08-31 | 2022-03-01 | 复旦大学附属华山医院 | 一种乙肝病毒载体及其应用 |
| WO2024223299A2 (en) | 2023-04-26 | 2024-10-31 | Isa Pharmaceuticals B.V. | Methods of treating cancer by administering immunogenic compositions and a pd-1 inhibitor |
| WO2025226656A1 (en) * | 2024-04-23 | 2025-10-30 | Modernatx, Inc. | Hepatitis b virus mrna vaccines |
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| DE10339927A1 (de) * | 2003-08-29 | 2005-03-24 | Rhein Biotech Gesellschaft für neue Biotechnologische Prozesse und Produkte mbH | Zusammensetzung zur Prophylaxe/Therapie von HBV-Infektionen und HBV-vermittelten Erkrankungen |
| US7875423B2 (en) * | 2003-10-21 | 2011-01-25 | Melbourne Health | HBV variants detection and application |
| GB0328753D0 (en) * | 2003-12-11 | 2004-01-14 | Royal Veterinary College The | Hepatitis B vaccines |
| WO2006048768A2 (en) | 2004-11-08 | 2006-05-11 | Transgene S.A. | Kit of parts designed for implementing an antitumoral or antiviral treatment in a mammal |
| EP1764369A1 (de) * | 2005-09-16 | 2007-03-21 | Rhein Biotech Gesellschaft für neue biotechnologische Prozesse und Produkte mbH | Vakzine enthaltend trunkiertes HBV core protein plus Saponin-basierendes Adjuvants |
| GB0522578D0 (en) | 2005-11-04 | 2005-12-14 | King S College London | Ribozymal nucleic acid |
| MX2008011361A (es) * | 2006-03-09 | 2008-09-15 | Transgene Sa | Proteina de fusion no-estructural del virus de hepatitis c. |
| EP2029169A2 (en) * | 2006-06-20 | 2009-03-04 | Transgene S.A. | Recombinant viral vaccine |
| EP2057268B1 (en) * | 2006-08-14 | 2014-08-13 | Postech Foundation | A dna vaccine for curing chronic hepatitis b and a method of preparing same |
| JP5474767B2 (ja) * | 2007-05-15 | 2014-04-16 | トランジェーヌ、ソシエテ、アノニム | 多重遺伝子発現のためのベクター |
| CN102015753A (zh) * | 2008-01-25 | 2011-04-13 | 海德堡吕布莱希特-卡尔斯大学 | 乙肝病毒(HBV)的疏水性修饰的preS-衍生肽及其作为载体将化合物特异性递送到肝脏的用途 |
| KR20120052352A (ko) * | 2009-08-07 | 2012-05-23 | 트랜스진 에스.에이. | Ｈｂｖ 감염을 치료하는 조성물 |
| US10076570B2 (en) * | 2009-08-07 | 2018-09-18 | Transgene S.A. | Composition for treating HBV infection |
-
2010
- 2010-08-06 KR KR1020127005033A patent/KR20120052352A/ko not_active Ceased
- 2010-08-06 EP EP10737945A patent/EP2461826A2/en not_active Ceased
- 2010-08-06 CA CA2770075A patent/CA2770075C/en active Active
- 2010-08-06 SG SG2012007845A patent/SG178254A1/en unknown
- 2010-08-06 RU RU2012107671/15A patent/RU2555346C2/ru active
- 2010-08-06 TW TW099126293A patent/TWI555531B/zh active
- 2010-08-06 MX MX2012001592A patent/MX2012001592A/es active IP Right Grant
- 2010-08-06 JP JP2012523352A patent/JP5897464B2/ja not_active Expired - Fee Related
- 2010-08-06 WO PCT/EP2010/061492 patent/WO2011015656A2/en not_active Ceased
- 2010-08-06 BR BR112012002628-3A patent/BR112012002628B1/pt not_active IP Right Cessation
- 2010-08-06 CN CN201080042650.2A patent/CN102573903B/zh active Active
- 2010-08-06 CN CN201510884240.7A patent/CN105535960B/zh active Active
- 2010-08-06 US US13/388,826 patent/US9393299B2/en not_active Expired - Fee Related
- 2010-08-06 NZ NZ598000A patent/NZ598000A/xx not_active IP Right Cessation
-
2012
- 2012-02-02 IL IL217926A patent/IL217926A/en active IP Right Grant
- 2012-02-07 ZA ZA2012/00899A patent/ZA201200899B/en unknown
-
2015
- 2015-11-27 JP JP2015232256A patent/JP6246778B2/ja not_active Expired - Fee Related
-
2016
- 2016-07-06 US US15/203,046 patent/US20170072047A1/en not_active Abandoned
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