JP2013501038A5 - - Google Patents
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- Publication number
- JP2013501038A5 JP2013501038A5 JP2012523352A JP2012523352A JP2013501038A5 JP 2013501038 A5 JP2013501038 A5 JP 2013501038A5 JP 2012523352 A JP2012523352 A JP 2012523352A JP 2012523352 A JP2012523352 A JP 2012523352A JP 2013501038 A5 JP2013501038 A5 JP 2013501038A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- seq
- vector
- nucleic acid
- hbv
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000203 mixture Substances 0.000 claims 38
- 102000039446 nucleic acids Human genes 0.000 claims 32
- 108020004707 nucleic acids Proteins 0.000 claims 32
- 150000007523 nucleic acids Chemical class 0.000 claims 32
- 239000013598 vector Substances 0.000 claims 30
- 230000002163 immunogen Effects 0.000 claims 29
- 125000003275 alpha amino acid group Chemical group 0.000 claims 27
- 125000003729 nucleotide group Chemical group 0.000 claims 25
- 239000002773 nucleotide Substances 0.000 claims 24
- 208000015181 infectious disease Diseases 0.000 claims 16
- 230000002458 infectious effect Effects 0.000 claims 13
- 239000002245 particle Substances 0.000 claims 12
- 125000000539 amino acid group Chemical group 0.000 claims 11
- 238000006467 substitution reaction Methods 0.000 claims 11
- 241000700605 Viruses Species 0.000 claims 9
- 108090000765 processed proteins & peptides Proteins 0.000 claims 9
- 229920001184 polypeptide Polymers 0.000 claims 8
- 102000004196 processed proteins & peptides Human genes 0.000 claims 8
- 230000003612 virological effect Effects 0.000 claims 8
- 238000011282 treatment Methods 0.000 claims 5
- 239000013603 viral vector Substances 0.000 claims 5
- 108700024845 Hepatitis B virus P Proteins 0.000 claims 4
- 102100034349 Integrase Human genes 0.000 claims 4
- 102100034353 Integrase Human genes 0.000 claims 4
- 108010078428 env Gene Products Proteins 0.000 claims 4
- 241000700721 Hepatitis B virus Species 0.000 claims 3
- 206010037742 Rabies Diseases 0.000 claims 3
- 230000002950 deficient Effects 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 208000000419 Chronic Hepatitis B Diseases 0.000 claims 2
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 claims 2
- 206010046865 Vaccinia virus infection Diseases 0.000 claims 2
- 208000016350 chronic hepatitis B virus infection Diseases 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 230000001747 exhibiting effect Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000001575 pathological effect Effects 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 238000011301 standard therapy Methods 0.000 claims 2
- -1 terbivudine Chemical compound 0.000 claims 2
- 208000007089 vaccinia Diseases 0.000 claims 2
- 241000178270 Canarypox virus Species 0.000 claims 1
- 101710132601 Capsid protein Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 101710091045 Envelope protein Proteins 0.000 claims 1
- 241000700662 Fowlpox virus Species 0.000 claims 1
- 108090000288 Glycoproteins Proteins 0.000 claims 1
- 102000003886 Glycoproteins Human genes 0.000 claims 1
- 101100321817 Human parvovirus B19 (strain HV) 7.5K gene Proteins 0.000 claims 1
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 1
- 101710188315 Protein X Proteins 0.000 claims 1
- 241000700618 Vaccinia virus Species 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 229960001997 adefovir Drugs 0.000 claims 1
- WOZSCQDILHKSGG-UHFFFAOYSA-N adefovir depivoxil Chemical compound N1=CN=C2N(CCOCP(=O)(OCOC(=O)C(C)(C)C)OCOC(=O)C(C)(C)C)C=NC2=C1N WOZSCQDILHKSGG-UHFFFAOYSA-N 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 230000036755 cellular response Effects 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229960000980 entecavir Drugs 0.000 claims 1
- YXPVEXCTPGULBZ-WQYNNSOESA-N entecavir hydrate Chemical compound O.C1=NC=2C(=O)NC(N)=NC=2N1[C@H]1C[C@H](O)[C@@H](CO)C1=C YXPVEXCTPGULBZ-WQYNNSOESA-N 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 230000002209 hydrophobic effect Effects 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000005847 immunogenicity Effects 0.000 claims 1
- 239000002955 immunomodulating agent Substances 0.000 claims 1
- 230000002584 immunomodulator Effects 0.000 claims 1
- 229940121354 immunomodulator Drugs 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 229960001627 lamivudine Drugs 0.000 claims 1
- JTEGQNOMFQHVDC-NKWVEPMBSA-N lamivudine Chemical compound O=C1N=C(N)C=CN1[C@H]1O[C@@H](CO)SC1 JTEGQNOMFQHVDC-NKWVEPMBSA-N 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 239000013600 plasmid vector Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 238000011321 prophylaxis Methods 0.000 claims 1
- 230000010076 replication Effects 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
- 229960004556 tenofovir Drugs 0.000 claims 1
- VCMJCVGFSROFHV-WZGZYPNHSA-N tenofovir disoproxil fumarate Chemical compound OC(=O)\C=C\C(O)=O.N1=CN=C2N(C[C@@H](C)OCP(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C)C=NC2=C1N VCMJCVGFSROFHV-WZGZYPNHSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09305742.0 | 2009-08-07 | ||
| EP09305742 | 2009-08-07 | ||
| PCT/EP2010/061492 WO2011015656A2 (en) | 2009-08-07 | 2010-08-06 | Composition for treating hbv infection |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015232256A Division JP6246778B2 (ja) | 2009-08-07 | 2015-11-27 | Ｈｂｖ感染を治療するための組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013501038A JP2013501038A (ja) | 2013-01-10 |
| JP2013501038A5 true JP2013501038A5 (enExample) | 2013-09-12 |
| JP5897464B2 JP5897464B2 (ja) | 2016-03-30 |
Family
ID=43087099
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012523352A Expired - Fee Related JP5897464B2 (ja) | 2009-08-07 | 2010-08-06 | Ｈｂｖ感染を治療するための組成物 |
| JP2015232256A Expired - Fee Related JP6246778B2 (ja) | 2009-08-07 | 2015-11-27 | Ｈｂｖ感染を治療するための組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015232256A Expired - Fee Related JP6246778B2 (ja) | 2009-08-07 | 2015-11-27 | Ｈｂｖ感染を治療するための組成物 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US9393299B2 (enExample) |
| EP (1) | EP2461826A2 (enExample) |
| JP (2) | JP5897464B2 (enExample) |
| KR (1) | KR20120052352A (enExample) |
| CN (2) | CN105535960B (enExample) |
| BR (1) | BR112012002628B1 (enExample) |
| CA (1) | CA2770075C (enExample) |
| IL (1) | IL217926A (enExample) |
| MX (1) | MX2012001592A (enExample) |
| NZ (1) | NZ598000A (enExample) |
| RU (1) | RU2555346C2 (enExample) |
| SG (1) | SG178254A1 (enExample) |
| TW (1) | TWI555531B (enExample) |
| WO (1) | WO2011015656A2 (enExample) |
| ZA (1) | ZA201200899B (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CA2770075C (en) * | 2009-08-07 | 2021-08-24 | Perrine Martin | Composition for treating hbv infection |
| WO2012174220A1 (en) | 2011-06-14 | 2012-12-20 | Globeimmune, Inc. | Yeast-based compositions and methods for the treatment or prevention of hepatitis delta virus infection |
| TWI575070B (zh) * | 2011-07-12 | 2017-03-21 | 傳斯堅公司 | Ｈｂｖ聚合酶突變體 |
| WO2014009433A1 (en) | 2012-07-10 | 2014-01-16 | Transgene Sa | Mycobacterium resuscitation promoting factor for use as adjuvant |
| TWI690322B (zh) | 2012-10-02 | 2020-04-11 | 法商傳斯堅公司 | 含病毒的調配物及其使用 |
| US9946495B2 (en) * | 2013-04-25 | 2018-04-17 | Microsoft Technology Licensing, Llc | Dirty data management for hybrid drives |
| WO2016020538A1 (en) * | 2014-08-08 | 2016-02-11 | Transgene Sa | Hbv vaccine and antibody combination therapy to treat hbv infections |
| WO2016131945A1 (en) | 2015-02-20 | 2016-08-25 | Transgene Sa | Combination product with autophagy modulator |
| MX2017011732A (es) | 2015-03-18 | 2018-08-15 | Omnicyte | Proteínas de fusión que comprenden glicoproteínas de la superficie del virus alfa modificado y antígeno asociado al tumor y métodos de los mismos. |
| CN106148404B (zh) * | 2015-03-25 | 2020-01-24 | 复旦大学 | 一种人乙型肝炎病毒重组载体及其应用 |
| JP6566368B2 (ja) * | 2015-04-16 | 2019-08-28 | 国立研究開発法人産業技術総合研究所 | Ｂ型肝炎ウイルス分泌阻害剤 |
| EP4177348A1 (en) * | 2015-11-04 | 2023-05-10 | Hookipa Biotech GmbH | Vaccines against hepatitis b virus |
| ES2922981T3 (es) | 2015-11-12 | 2022-09-22 | Hookipa Biotech Gmbh | Partículas de arenavirus como vacunas contra el cáncer |
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| CA3002508A1 (en) * | 2016-01-12 | 2017-07-20 | Ulrike Protzer | Means and methods for treating hbv |
| WO2017180770A1 (en) | 2016-04-13 | 2017-10-19 | Synthetic Genomics, Inc. | Recombinant arterivirus replicon systems and uses thereof |
| US11052148B2 (en) | 2016-05-30 | 2021-07-06 | Geo Vax, Inc. | Compositions and methods for generating an immune response to hepatitis B virus |
| KR20190020745A (ko) * | 2016-06-15 | 2019-03-04 | 옥스포드 유니버시티 이노베이션 리미티드 | Abc4a를 발현시키기 위한 이중 중첩 아데노-관련 바이러스 벡터 시스템 |
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| JP7382230B2 (ja) | 2016-10-17 | 2023-11-16 | ヤンセン ファーマシューティカルズ，インコーポレーテッド | 組み換えウイルスレプリコン系及びその使用 |
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| CN110769850A (zh) | 2017-05-15 | 2020-02-07 | 扬森疫苗与预防公司 | 稳定的含病毒组合物 |
| EP3624851A1 (en) | 2017-05-15 | 2020-03-25 | Janssen Vaccines & Prevention B.V. | Stable virus-containing composition |
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| EA202091516A1 (ru) | 2017-12-19 | 2020-11-03 | Янссен Сайенсиз Айрлэнд Анлимитед Компани | Способы и композиции для индукции иммунного ответа против вируса гепатита b (hbv) |
| EA202091517A1 (ru) | 2017-12-19 | 2020-11-03 | Янссен Сайенсиз Айрлэнд Анлимитед Компани | Способы и устройство для доставки вакцин против вируса гепатита b (hbv) |
| EA202091513A1 (ru) | 2017-12-19 | 2020-09-09 | Янссен Сайенсиз Айрлэнд Анлимитед Компани | Вакцины против вируса гепатита b (hbv) и их применение |
| CA3085492A1 (en) * | 2017-12-19 | 2019-06-27 | Janssen Sciences Ireland Unlimited Company | Methods and apparatus for the delivery of hepatitis b virus (hbv) vaccines |
| SG11202005710YA (en) * | 2017-12-19 | 2020-07-29 | Janssen Sciences Ireland Unlimited Co | Methods and compositions for inducing an immune response against hepatitis b virus (hbv) |
| KR20200111729A (ko) | 2018-01-19 | 2020-09-29 | 얀센 파마슈티칼즈, 인코포레이티드 | 재조합 레플리콘 시스템을 이용한 면역 반응 유도 및 증진 |
| IL277128B2 (en) | 2018-03-06 | 2025-11-01 | Precigen Inc | Hepatitis b vaccines and uses of the same |
| KR102234027B1 (ko) * | 2018-05-09 | 2021-03-31 | 서울대학교산학협력단 | B형 간염 바이러스 유래 폴리펩티드 및 이의 항바이러스 용도 |
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| CN114340663A (zh) * | 2019-06-18 | 2022-04-12 | 爱尔兰詹森科学公司 | 乙型肝炎病毒(HBV)疫苗和靶向HBV的RNAi的组合 |
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| JP7635208B2 (ja) | 2019-08-29 | 2025-02-25 | ブイアイアール バイオテクノロジー インコーポレイテッド | Ｂ型肝炎ウイルスワクチン |
| FI4037708T3 (fi) | 2019-09-30 | 2024-10-31 | Gilead Sciences Inc | Hbv-rokotteita ja menetelmiä, hbv:n hoitamiseksi |
| JP2023505304A (ja) | 2019-12-07 | 2023-02-08 | アイエスエー ファーマシューティカルズ ビー．ヴイ． | Ｂ型肝炎ウイルスに関連する疾患の治療 |
| CN115461358A (zh) * | 2020-07-17 | 2022-12-09 | 养生堂有限公司 | 一种细胞穿膜肽及其应用 |
| CN114107377A (zh) * | 2020-08-31 | 2022-03-01 | 复旦大学附属华山医院 | 一种乙肝病毒载体及其应用 |
| WO2024223299A2 (en) | 2023-04-26 | 2024-10-31 | Isa Pharmaceuticals B.V. | Methods of treating cancer by administering immunogenic compositions and a pd-1 inhibitor |
| WO2025226656A1 (en) * | 2024-04-23 | 2025-10-30 | Modernatx, Inc. | Hepatitis b virus mrna vaccines |
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| DE10339927A1 (de) * | 2003-08-29 | 2005-03-24 | Rhein Biotech Gesellschaft für neue Biotechnologische Prozesse und Produkte mbH | Zusammensetzung zur Prophylaxe/Therapie von HBV-Infektionen und HBV-vermittelten Erkrankungen |
| AU2004285983B2 (en) * | 2003-10-21 | 2012-06-28 | Alfred Health | HBV variants detection and application |
| GB0328753D0 (en) | 2003-12-11 | 2004-01-14 | Royal Veterinary College The | Hepatitis B vaccines |
| US8470591B2 (en) | 2004-11-08 | 2013-06-25 | Transgene S.A. | Kit of parts designed for implementing an antitumoral or antiviral treatment in a mammal |
| EP1764369A1 (de) * | 2005-09-16 | 2007-03-21 | Rhein Biotech Gesellschaft für neue biotechnologische Prozesse und Produkte mbH | Vakzine enthaltend trunkiertes HBV core protein plus Saponin-basierendes Adjuvants |
| GB0522578D0 (en) | 2005-11-04 | 2005-12-14 | King S College London | Ribozymal nucleic acid |
| JP5188400B2 (ja) * | 2006-03-09 | 2013-04-24 | トランスジーン エス．エー． | Ｃ型肝炎ウイルスの非構造融合タンパク質 |
| US20100129403A1 (en) | 2006-06-20 | 2010-05-27 | Transgene S.A. | Recombinant viral vaccine |
| WO2008020656A1 (en) * | 2006-08-14 | 2008-02-21 | Postech Foundation | A dna vaccine for curing chronic hepatitis b and a method of preparing same |
| US8337859B2 (en) * | 2007-05-15 | 2012-12-25 | Transgene S.A. | Vectors for multiple gene expression |
| CN102015753A (zh) * | 2008-01-25 | 2011-04-13 | 海德堡吕布莱希特-卡尔斯大学 | 乙肝病毒(HBV)的疏水性修饰的preS-衍生肽及其作为载体将化合物特异性递送到肝脏的用途 |
| CA2770075C (en) * | 2009-08-07 | 2021-08-24 | Perrine Martin | Composition for treating hbv infection |
| US10076570B2 (en) * | 2009-08-07 | 2018-09-18 | Transgene S.A. | Composition for treating HBV infection |
-
2010
- 2010-08-06 CA CA2770075A patent/CA2770075C/en active Active
- 2010-08-06 WO PCT/EP2010/061492 patent/WO2011015656A2/en not_active Ceased
- 2010-08-06 JP JP2012523352A patent/JP5897464B2/ja not_active Expired - Fee Related
- 2010-08-06 TW TW099126293A patent/TWI555531B/zh active
- 2010-08-06 US US13/388,826 patent/US9393299B2/en not_active Expired - Fee Related
- 2010-08-06 MX MX2012001592A patent/MX2012001592A/es active IP Right Grant
- 2010-08-06 CN CN201510884240.7A patent/CN105535960B/zh active Active
- 2010-08-06 CN CN201080042650.2A patent/CN102573903B/zh active Active
- 2010-08-06 KR KR1020127005033A patent/KR20120052352A/ko not_active Ceased
- 2010-08-06 EP EP10737945A patent/EP2461826A2/en not_active Ceased
- 2010-08-06 BR BR112012002628-3A patent/BR112012002628B1/pt not_active IP Right Cessation
- 2010-08-06 RU RU2012107671/15A patent/RU2555346C2/ru active
- 2010-08-06 SG SG2012007845A patent/SG178254A1/en unknown
- 2010-08-06 NZ NZ598000A patent/NZ598000A/xx not_active IP Right Cessation
-
2012
- 2012-02-02 IL IL217926A patent/IL217926A/en active IP Right Grant
- 2012-02-07 ZA ZA2012/00899A patent/ZA201200899B/en unknown
-
2015
- 2015-11-27 JP JP2015232256A patent/JP6246778B2/ja not_active Expired - Fee Related
-
2016
- 2016-07-06 US US15/203,046 patent/US20170072047A1/en not_active Abandoned
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