JP2014527404A5 - - Google Patents

Info

Publication number

JP2014527404A5

JP2014527404A5 JP2014519553A JP2014519553A JP2014527404A5 JP 2014527404 A5 JP2014527404 A5 JP 2014527404A5 JP 2014519553 A JP2014519553 A JP 2014519553A JP 2014519553 A JP2014519553 A JP 2014519553A JP 2014527404 A5 JP2014527404 A5 JP 2014527404A5

Authority

JP

Japan

Prior art keywords

seq

vector

residue

amino acid

acid sequence

Prior art date

2012-07-12

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 108090000765 processed proteins & peptides Proteins 0.000 claims 53
• 102000004196 processed proteins & peptides Human genes 0.000 claims 51
• 229920001184 polypeptide Polymers 0.000 claims 48
• 239000013598 vector Substances 0.000 claims 45
• 125000003275 alpha amino acid group Chemical group 0.000 claims 30
• 102000037865 fusion proteins Human genes 0.000 claims 26
• 108020001507 fusion proteins Proteins 0.000 claims 26
• 102000039446 nucleic acids Human genes 0.000 claims 22
• 108020004707 nucleic acids Proteins 0.000 claims 22
• 150000007523 nucleic acids Chemical class 0.000 claims 22
• 239000008194 pharmaceutical composition Substances 0.000 claims 18
• 210000004027 cell Anatomy 0.000 claims 15
• 239000000203 mixture Substances 0.000 claims 11
• 230000037430 deletion Effects 0.000 claims 9
• 238000012217 deletion Methods 0.000 claims 9
• 102100034343 Integrase Human genes 0.000 claims 8
• 101710203526 Integrase Proteins 0.000 claims 8
• 150000001413 amino acids Chemical class 0.000 claims 8
• 238000000034 method Methods 0.000 claims 7
• 208000015181 infectious disease Diseases 0.000 claims 6
• 238000007920 subcutaneous administration Methods 0.000 claims 6
• 238000006467 substitution reaction Methods 0.000 claims 6
• 239000002773 nucleotide Substances 0.000 claims 5
• 125000003729 nucleotide group Chemical group 0.000 claims 5
• 241000700605 Viruses Species 0.000 claims 4
• 125000000539 amino acid group Chemical group 0.000 claims 4
• 230000002950 deficient Effects 0.000 claims 4
• 230000028993 immune response Effects 0.000 claims 4
• 230000002163 immunogen Effects 0.000 claims 4
• 238000007918 intramuscular administration Methods 0.000 claims 4
• 239000002245 particle Substances 0.000 claims 4
• 108700024845 Hepatitis B virus P Proteins 0.000 claims 3
• 101100321817 Human parvovirus B19 (strain HV) 7.5K gene Proteins 0.000 claims 3
• 206010046865 Vaccinia virus infection Diseases 0.000 claims 3
• 230000002458 infectious effect Effects 0.000 claims 3
• 238000004519 manufacturing process Methods 0.000 claims 3
• 241000701161 unidentified adenovirus Species 0.000 claims 3
• 208000007089 vaccinia Diseases 0.000 claims 3
• 239000013603 viral vector Substances 0.000 claims 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• 241000700618 Vaccinia virus Species 0.000 claims 2
• 238000012258 culturing Methods 0.000 claims 2
• 230000000694 effects Effects 0.000 claims 2
• 230000001404 mediated effect Effects 0.000 claims 2
• 230000035772 mutation Effects 0.000 claims 2
• 239000013612 plasmid Substances 0.000 claims 2
• 230000037452 priming Effects 0.000 claims 2
• 230000010076 replication Effects 0.000 claims 2
• 241000710929 Alphavirus Species 0.000 claims 1
• 241000178270 Canarypox virus Species 0.000 claims 1
• 241001217856 Chimpanzee adenovirus Species 0.000 claims 1
• 241000702421 Dependoparvovirus Species 0.000 claims 1
• 241000725618 Duck hepatitis B virus Species 0.000 claims 1
• 241000700662 Fowlpox virus Species 0.000 claims 1
• 241000598171 Human adenovirus sp. Species 0.000 claims 1
• 241000714192 Human spumaretrovirus Species 0.000 claims 1
• 241000712079 Measles morbillivirus Species 0.000 claims 1
• 108010076504 Protein Sorting Signals Proteins 0.000 claims 1
• 230000005867 T cell response Effects 0.000 claims 1
• 241000711975 Vesicular stomatitis virus Species 0.000 claims 1
• 101710086987 X protein Proteins 0.000 claims 1
• 239000013543 active substance Substances 0.000 claims 1
• 238000004113 cell culture Methods 0.000 claims 1
• 230000001413 cellular effect Effects 0.000 claims 1
• 230000001684 chronic effect Effects 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 210000003527 eukaryotic cell Anatomy 0.000 claims 1
• 230000001747 exhibiting effect Effects 0.000 claims 1
• 239000012634 fragment Substances 0.000 claims 1
• 239000013600 plasmid vector Substances 0.000 claims 1
• 230000002265 prevention Effects 0.000 claims 1
• 238000011272 standard treatment Methods 0.000 claims 1
• 230000004936 stimulating effect Effects 0.000 claims 1
• 241001529453 unidentified herpesvirus Species 0.000 claims 1
• 241001430294 unidentified retrovirus Species 0.000 claims 1
• 230000003612 virological effect Effects 0.000 claims 1