MX346835B - Mutantes de la polimerasa de virus de hepatitis b (hbv). - Google Patents

Mutantes de la polimerasa de virus de hepatitis b (hbv).

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Publication number
MX346835B
MX346835B MX2014000488A MX2014000488A MX346835B MX 346835 B MX346835 B MX 346835B MX 2014000488 A MX2014000488 A MX 2014000488A MX 2014000488 A MX2014000488 A MX 2014000488A MX 346835 B MX346835 B MX 346835B
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MX
Mexico
Prior art keywords
polymerase
hbv
relates
present
hbv polymerase
Prior art date
Application number
MX2014000488A
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English (en)
Other versions
MX2014000488A (es
Inventor
Nathalie Silvestre
Perrine Martin
Jean-Baptiste Marchand
Original Assignee
Transgene Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Transgene Sa filed Critical Transgene Sa
Publication of MX2014000488A publication Critical patent/MX2014000488A/es
Publication of MX346835B publication Critical patent/MX346835B/es

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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C12N9/1252—DNA-directed DNA polymerase (2.7.7.7), i.e. DNA replicase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/29—Hepatitis virus
    • A61K39/292—Serum hepatitis virus, hepatitis B virus, e.g. Australia antigen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C12N9/1276—RNA-directed DNA polymerase (2.7.7.49), i.e. reverse transcriptase or telomerase
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • C—CHEMISTRY; METALLURGY
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    • C12P21/00—Preparation of peptides or proteins
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    • C—CHEMISTRY; METALLURGY
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    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/07—Nucleotidyltransferases (2.7.7)
    • C12Y207/07007—DNA-directed DNA polymerase (2.7.7.7), i.e. DNA replicase
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    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/26—Endoribonucleases producing 5'-phosphomonoesters (3.1.26)
    • C12Y301/26004—Ribonuclease H (3.1.26.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
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    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
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    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus
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    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/023—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a poxvirus

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  • Health & Medical Sciences (AREA)
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  • Wood Science & Technology (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invención se refiere a un polipéptido mutante, caracterizado porque comprende un dominio de polimerasa mutado con una deleción interna que interrumpe funcionalmente la actividad de polimerasa, en donde dicha deleción interna es de por lo menos 4 residuos de aminoácidos y como máximo 30 residuos de aminoácidos y comprende por lo menos el motivo YMDD presente de manera natural en el dominio de polimerasa de una polimerasa de HBV nativa, donde dicho dominio de polimerasa mutado comprende la secuencia de aminoácidos mostrada en la SEQ ID NO: 1 pero carece de por lo menos el residuo Tyr en la posición 203, el residuo Met en la posición 204, el residuo Asp en la posición 205, el residuo Asp en la posición 206, el residuo Val en la posición 207, el residuo Val en la posición 208 y el residuo Leu en la posición 209.
MX2014000488A 2011-07-12 2012-07-12 Mutantes de la polimerasa de virus de hepatitis b (hbv). MX346835B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11305909 2011-07-12
EP12305450 2012-04-18
PCT/EP2012/063640 WO2013007772A1 (en) 2011-07-12 2012-07-12 Hbv polymerase mutants

Publications (2)

Publication Number Publication Date
MX2014000488A MX2014000488A (es) 2014-06-05
MX346835B true MX346835B (es) 2017-03-31

Family

ID=46506427

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MX2014000488A MX346835B (es) 2011-07-12 2012-07-12 Mutantes de la polimerasa de virus de hepatitis b (hbv).

Country Status (17)

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US (3) US9512412B2 (es)
EP (1) EP2732034B1 (es)
JP (1) JP6189293B2 (es)
KR (1) KR102061357B1 (es)
CN (1) CN103998604B (es)
AU (1) AU2012282506C1 (es)
BR (1) BR112014000627B1 (es)
CA (1) CA2841890C (es)
DK (1) DK2732034T3 (es)
ES (1) ES2632497T3 (es)
HU (1) HUE033789T2 (es)
IL (1) IL230402B (es)
MX (1) MX346835B (es)
PE (2) PE20190660A1 (es)
RU (1) RU2625021C2 (es)
TW (2) TWI575070B (es)
WO (1) WO2013007772A1 (es)

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CN116333170B (zh) * 2023-03-28 2026-02-17 陇东学院 一种用于免疫治疗胃癌的重组病毒样纳米颗粒及其应用
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