MX365560B - Proteinas quimericas basadas en cyaa que comprenden un polipeptido heterologo y sus usos en la induccion de respuestas inmunes. - Google Patents
Proteinas quimericas basadas en cyaa que comprenden un polipeptido heterologo y sus usos en la induccion de respuestas inmunes.Info
- Publication number
- MX365560B MX365560B MX2015001018A MX2015001018A MX365560B MX 365560 B MX365560 B MX 365560B MX 2015001018 A MX2015001018 A MX 2015001018A MX 2015001018 A MX2015001018 A MX 2015001018A MX 365560 B MX365560 B MX 365560B
- Authority
- MX
- Mexico
- Prior art keywords
- cyaa
- heterologous polypeptide
- induction
- immune responses
- chimeric proteins
- Prior art date
Links
- 102000037865 fusion proteins Human genes 0.000 title abstract 4
- 108020001507 fusion proteins Proteins 0.000 title abstract 4
- 229920001184 polypeptide Polymers 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 230000028993 immune response Effects 0.000 title 1
- 230000006698 induction Effects 0.000 title 1
- 108010083528 Adenylate Cyclase Toxin Proteins 0.000 abstract 3
- 210000004899 c-terminal region Anatomy 0.000 abstract 2
- 102000040430 polynucleotide Human genes 0.000 abstract 2
- 108091033319 polynucleotide Proteins 0.000 abstract 2
- 239000002157 polynucleotide Substances 0.000 abstract 2
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/235—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y406/00—Phosphorus-oxygen lyases (4.6)
- C12Y406/01—Phosphorus-oxygen lyases (4.6.1)
- C12Y406/01001—Aodenylate cyclase (4.6.1.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
- A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Communicable Diseases (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La invención se refiere a una proteína quimérica que comprende o consiste de, de N-terminal hacia C-terminal, (a) una parte N-terminal de una proteína CyaA de Bordetella (b) un polipéptido heterólogo, y (c) una parte C-terminal de una proteína CyaA de Bordetella. La invención también se refiere a un polinucleótido que codifica para una versión de una CyaA de Bordetella que tiene una deleción, así como a un polinucleótido que codifica para esta proteína quimérica. También son parte de la invención una composición que comprende por lo menos una proteína o proteínas quiméricas de la invención y los usos profilácticos y/o terapéuticos de dicha composición.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12305897.6A EP2690172A1 (en) | 2012-07-23 | 2012-07-23 | CYAA-based chimeric proteins comprising a heterologous polypeptide and their uses in the induction of immune responses |
| PCT/EP2013/065546 WO2014016310A1 (en) | 2012-07-23 | 2013-07-23 | Cyaa-based chimeric proteins comprising a heterologous polypeptide and their uses in the induction of immune responses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2015001018A MX2015001018A (es) | 2015-07-14 |
| MX365560B true MX365560B (es) | 2019-06-07 |
Family
ID=48832934
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015001018A MX365560B (es) | 2012-07-23 | 2013-07-23 | Proteinas quimericas basadas en cyaa que comprenden un polipeptido heterologo y sus usos en la induccion de respuestas inmunes. |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US9499809B2 (es) |
| EP (2) | EP2690172A1 (es) |
| JP (3) | JP2015524270A (es) |
| KR (1) | KR102148413B1 (es) |
| CN (1) | CN104662152B (es) |
| AU (1) | AU2013295045B2 (es) |
| BR (1) | BR112015001350A2 (es) |
| CA (1) | CA2879990C (es) |
| ES (1) | ES2780525T3 (es) |
| HK (1) | HK1208048A1 (es) |
| MX (1) | MX365560B (es) |
| RU (1) | RU2015100211A (es) |
| WO (1) | WO2014016310A1 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105481953B (zh) * | 2016-02-02 | 2018-02-13 | 成都天邦生物制品有限公司 | 作为猪繁殖与呼吸综合征病毒疫苗抗原的靶细胞特异性融合蛋白和疫苗组合物 |
| EP3323424A1 (en) * | 2016-11-17 | 2018-05-23 | Cyanimal IP | Cyaa polypeptides as immune enhancer |
| WO2018091613A1 (en) | 2016-11-17 | 2018-05-24 | Ecole Nationale Vétérinaire de Toulouse | Immunogenic and vaccine compositions for use against bordetella bronchiseptica infection |
| EP3323426A1 (en) | 2016-11-17 | 2018-05-23 | Ecole Nationale Vétérinaire de Toulouse | Immunogenic and vaccine compositions for use against bordetella bronchiseptica infection |
| EP3342421A1 (en) * | 2016-12-27 | 2018-07-04 | Genticel | Immunogenic composition comprising cyaa-derived polypeptide promoting a th1/th17-oriented immune response |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01209817A (ja) | 1988-02-17 | 1989-08-23 | Yamaha Corp | 浮動少数点形ディジタル・アナログ変換器 |
| ATE438409T1 (de) * | 2000-09-15 | 2009-08-15 | Pasteur Institut | Proteinhaltigen vektoren zur einführung von moleküle in cd11b exprimirende zellen |
| EP1489092A1 (en) | 2003-06-18 | 2004-12-22 | Institut Pasteur | Modified Bordetella adenylate cyclase comprising or lacking CD11b/CD18 interaction domain and uses thereof |
| PL1684801T3 (pl) | 2003-11-21 | 2010-07-30 | Pasteur Institut | Rekombinowana toksyna cyklazy adenylanowej indukuje odpowiedzi komórek T przeciwko antygenom nowotworowym |
| ES2293178T3 (es) * | 2004-03-18 | 2008-03-16 | Institut Pasteur | Proteina recombinante que contiene epitopos del papilomavirus humano insertados en un proteina adenilato ciclasa o un fragmento de la misma y usos terapeuticos de la misma. |
| EP1894941A1 (en) | 2006-09-01 | 2008-03-05 | Institut Pasteur | Treatment of cervical carcinoma with a recombinant adenylate cyclase carrying HPV antigens |
| RU2448729C2 (ru) | 2006-09-01 | 2012-04-27 | Жантисель | Композиции, вызывающие специфический ответ цитотоксических т-лимфоцитов, включающие лимфо-аблативное соединение и молекулу, содержащую антигенные последовательности и нацеленную на специализированные антиген-презентирующие клетки |
| EP2326953B1 (en) | 2008-07-22 | 2018-03-21 | Promega Corporation | Adp detection based luminescent phosphotransferase or atp hydrolase assay |
| WO2010136231A1 (en) * | 2009-03-23 | 2010-12-02 | Institut Pasteur | MUTANT CyaA POLYPEPTIDES AND POLYPEPTIDE DERIVATIVES SUITABLE FOR THE DELIVERY OF IMMUNOGENIC MOLECULES INTO A CELL |
| EP2478915A1 (en) * | 2011-01-24 | 2012-07-25 | Genticel | CyaA-carried polypeptide(s) and use to induce both therapeutic and prophylactic immune responses |
| EP2689786A1 (en) * | 2012-07-23 | 2014-01-29 | Genticel | HPV/CYAA-based chimeric proteins and their uses in the induction of immune responses against HPV infection and HPV-induced disorders |
-
2012
- 2012-07-23 EP EP12305897.6A patent/EP2690172A1/en not_active Withdrawn
-
2013
- 2013-07-23 AU AU2013295045A patent/AU2013295045B2/en active Active
- 2013-07-23 CN CN201380049494.6A patent/CN104662152B/zh not_active Expired - Fee Related
- 2013-07-23 MX MX2015001018A patent/MX365560B/es active IP Right Grant
- 2013-07-23 BR BR112015001350A patent/BR112015001350A2/pt not_active Application Discontinuation
- 2013-07-23 KR KR1020157004541A patent/KR102148413B1/ko active IP Right Grant
- 2013-07-23 US US14/416,569 patent/US9499809B2/en active Active
- 2013-07-23 EP EP13739724.6A patent/EP2875130B1/en active Active
- 2013-07-23 RU RU2015100211A patent/RU2015100211A/ru unknown
- 2013-07-23 ES ES13739724T patent/ES2780525T3/es active Active
- 2013-07-23 WO PCT/EP2013/065546 patent/WO2014016310A1/en active Application Filing
- 2013-07-23 JP JP2015523535A patent/JP2015524270A/ja active Pending
- 2013-07-23 CA CA2879990A patent/CA2879990C/en active Active
-
2015
- 2015-09-02 HK HK15108580.2A patent/HK1208048A1/xx unknown
-
2016
- 2016-10-12 US US15/291,517 patent/US9982024B2/en active Active
-
2018
- 2018-09-06 JP JP2018166486A patent/JP2019013229A/ja active Pending
-
2021
- 2021-12-23 JP JP2021208859A patent/JP2022046617A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN104662152B (zh) | 2020-06-12 |
| EP2875130A1 (en) | 2015-05-27 |
| ES2780525T3 (es) | 2020-08-26 |
| WO2014016310A1 (en) | 2014-01-30 |
| AU2013295045A1 (en) | 2015-02-05 |
| KR102148413B1 (ko) | 2020-08-26 |
| BR112015001350A2 (pt) | 2017-08-01 |
| JP2019013229A (ja) | 2019-01-31 |
| US20150184143A1 (en) | 2015-07-02 |
| CA2879990C (en) | 2021-11-16 |
| KR20150032341A (ko) | 2015-03-25 |
| JP2022046617A (ja) | 2022-03-23 |
| CA2879990A1 (en) | 2014-01-30 |
| JP2015524270A (ja) | 2015-08-24 |
| EP2690172A1 (en) | 2014-01-29 |
| RU2015100211A3 (es) | 2018-12-20 |
| US20170096458A1 (en) | 2017-04-06 |
| RU2015100211A (ru) | 2018-12-20 |
| EP2875130B1 (en) | 2020-01-01 |
| US9499809B2 (en) | 2016-11-22 |
| US9982024B2 (en) | 2018-05-29 |
| HK1208048A1 (en) | 2016-02-19 |
| MX2015001018A (es) | 2015-07-14 |
| AU2013295045B2 (en) | 2019-05-02 |
| CN104662152A (zh) | 2015-05-27 |
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| FG | Grant or registration |