MX2019006446A - Métodos para inducir tolerancia inmunológica a factores de coagulación. - Google Patents
Métodos para inducir tolerancia inmunológica a factores de coagulación.Info
- Publication number
- MX2019006446A MX2019006446A MX2019006446A MX2019006446A MX2019006446A MX 2019006446 A MX2019006446 A MX 2019006446A MX 2019006446 A MX2019006446 A MX 2019006446A MX 2019006446 A MX2019006446 A MX 2019006446A MX 2019006446 A MX2019006446 A MX 2019006446A
- Authority
- MX
- Mexico
- Prior art keywords
- immune tolerance
- methods
- inducing immune
- clotting factors
- human
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/37—Factors VIII
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21022—Coagulation factor IXa (3.4.21.22)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La presente descripción proporciona métodos que inducen tolerancia inmunológica en un ser humano, que comprende administrar al ser humano una cantidad eficaz de una composición o una proteína quimérica que comprende un factor de coagulación y una región Fc.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662429516P | 2016-12-02 | 2016-12-02 | |
US201762466937P | 2017-03-03 | 2017-03-03 | |
US201762529866P | 2017-07-07 | 2017-07-07 | |
US201762558790P | 2017-09-14 | 2017-09-14 | |
US201762582829P | 2017-11-07 | 2017-11-07 | |
PCT/US2017/064323 WO2018102760A1 (en) | 2016-12-02 | 2017-12-01 | Methods of inducing immune tolerance to clotting factors |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019006446A true MX2019006446A (es) | 2019-12-11 |
Family
ID=61006303
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019006446A MX2019006446A (es) | 2016-12-02 | 2017-12-01 | Métodos para inducir tolerancia inmunológica a factores de coagulación. |
Country Status (13)
Country | Link |
---|---|
US (1) | US20200085915A1 (es) |
EP (1) | EP3548063A1 (es) |
JP (2) | JP2019536794A (es) |
KR (1) | KR20190091292A (es) |
CN (1) | CN110520149A (es) |
AU (1) | AU2017368328A1 (es) |
BR (1) | BR112019011198A2 (es) |
CA (1) | CA3044838A1 (es) |
IL (1) | IL266970A (es) |
MA (1) | MA46968A (es) |
MX (1) | MX2019006446A (es) |
TW (2) | TW202408564A (es) |
WO (1) | WO2018102760A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2968498A4 (en) | 2013-03-15 | 2016-09-07 | Biogen Ma Inc | PREPARATIONS CONTAINING FACTOR IX POLYPEPTIDE |
WO2019222682A1 (en) | 2018-05-18 | 2019-11-21 | Bioverativ Therapeutics Inc. | Methods of treating hemophilia a |
WO2021043127A1 (zh) * | 2019-09-02 | 2021-03-11 | 甘李药业股份有限公司 | 嵌合蛋白 |
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EA038705B1 (ru) * | 2012-01-12 | 2021-10-07 | Биовератив Терапьютикс Инк. | Способы снижения иммуногенности фактора свёртывания крови viii у пациентов, получающих лечение фактором viii |
LT2804623T (lt) | 2012-01-12 | 2019-12-10 | Bioverativ Therapeutics Inc | Chimeriniai viii faktoriaus polipeptidai ir jų panaudojimas |
RS63870B1 (sr) | 2012-02-15 | 2023-01-31 | Bioverativ Therapeutics Inc | Sastavi faktora viii i postupci za pravljenje i upotrebu istih |
LT2882450T (lt) | 2012-07-11 | 2020-03-25 | Bioverativ Therapeutics Inc. | Faktoriaus viii komplekso su xten ir von vilebrando faktoriumi baltymas ir jo panaudojimas |
UY35462A (es) | 2013-03-15 | 2014-10-31 | Biogen Idec Inc | Formulación de un polipéptido del factor viii. |
CN116731201A (zh) | 2014-01-10 | 2023-09-12 | 比奥贝拉蒂治疗公司 | 因子viii嵌合蛋白及其用途 |
-
2017
- 2017-12-01 MA MA046968A patent/MA46968A/fr unknown
- 2017-12-01 EP EP17832387.9A patent/EP3548063A1/en active Pending
- 2017-12-01 WO PCT/US2017/064323 patent/WO2018102760A1/en unknown
- 2017-12-01 CN CN201780085212.6A patent/CN110520149A/zh active Pending
- 2017-12-01 BR BR112019011198A patent/BR112019011198A2/pt unknown
- 2017-12-01 CA CA3044838A patent/CA3044838A1/en active Pending
- 2017-12-01 MX MX2019006446A patent/MX2019006446A/es unknown
- 2017-12-01 JP JP2019529527A patent/JP2019536794A/ja active Pending
- 2017-12-01 US US16/464,105 patent/US20200085915A1/en active Pending
- 2017-12-01 AU AU2017368328A patent/AU2017368328A1/en active Pending
- 2017-12-01 KR KR1020197018601A patent/KR20190091292A/ko not_active IP Right Cessation
- 2017-12-04 TW TW112115972A patent/TW202408564A/zh unknown
- 2017-12-04 TW TW106142381A patent/TW201821101A/zh unknown
-
2019
- 2019-05-29 IL IL266970A patent/IL266970A/en unknown
-
2022
- 2022-12-09 JP JP2022196725A patent/JP2023027231A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
MA46968A (fr) | 2019-10-09 |
JP2019536794A (ja) | 2019-12-19 |
US20200085915A1 (en) | 2020-03-19 |
TW202408564A (zh) | 2024-03-01 |
CA3044838A1 (en) | 2018-06-07 |
WO2018102760A1 (en) | 2018-06-07 |
BR112019011198A2 (pt) | 2019-12-17 |
JP2023027231A (ja) | 2023-03-01 |
IL266970A (en) | 2019-07-31 |
CN110520149A (zh) | 2019-11-29 |
TW201821101A (zh) | 2018-06-16 |
EP3548063A1 (en) | 2019-10-09 |
AU2017368328A1 (en) | 2019-07-18 |
KR20190091292A (ko) | 2019-08-05 |
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