MX2019009660A - Uso de anticuerpos antigeno 4 del linfocito t (ctla-4) con citotoxicidad celular dependiente de anticuerpos (adcc) mejorada para mejorar la respuesta inmune a una vacuna. - Google Patents
Uso de anticuerpos antigeno 4 del linfocito t (ctla-4) con citotoxicidad celular dependiente de anticuerpos (adcc) mejorada para mejorar la respuesta inmune a una vacuna.Info
- Publication number
- MX2019009660A MX2019009660A MX2019009660A MX2019009660A MX2019009660A MX 2019009660 A MX2019009660 A MX 2019009660A MX 2019009660 A MX2019009660 A MX 2019009660A MX 2019009660 A MX2019009660 A MX 2019009660A MX 2019009660 A MX2019009660 A MX 2019009660A
- Authority
- MX
- Mexico
- Prior art keywords
- ctla
- antibodies
- vaccine
- immune response
- enhanced adcc
- Prior art date
Links
- 230000028993 immune response Effects 0.000 title abstract 2
- 229960005486 vaccine Drugs 0.000 title abstract 2
- 229940045513 CTLA4 antagonist Drugs 0.000 abstract 2
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 229960005386 ipilimumab Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/21—Retroviridae, e.g. equine infectious anemia virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
La presente invención se refiere a métodos para mejorar la respuesta inmune a una vacuna usando formas variantes de anticuerpos anti-CTLA-4 que tienen actividad de ADCC mejorada. Los anticuerpos anti-CTLA-4 variantes para uso en la presente invención incluyen ipilimumab no fucosilado.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762464738P | 2017-02-28 | 2017-02-28 | |
US201762468527P | 2017-03-08 | 2017-03-08 | |
PCT/US2018/019868 WO2018160536A1 (en) | 2017-02-28 | 2018-02-27 | Use of anti-ctla-4 antibodies with enhanced adcc to enhance immune response to a vaccine |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019009660A true MX2019009660A (es) | 2019-10-02 |
Family
ID=61622729
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019009660A MX2019009660A (es) | 2017-02-28 | 2018-02-27 | Uso de anticuerpos antigeno 4 del linfocito t (ctla-4) con citotoxicidad celular dependiente de anticuerpos (adcc) mejorada para mejorar la respuesta inmune a una vacuna. |
Country Status (12)
Country | Link |
---|---|
US (2) | US20190382490A1 (es) |
EP (1) | EP3596122A1 (es) |
JP (2) | JP2020509037A (es) |
KR (1) | KR20190124256A (es) |
CN (2) | CN110366565A (es) |
AU (1) | AU2018227428A1 (es) |
BR (1) | BR112019017695A2 (es) |
CA (1) | CA3054928A1 (es) |
IL (1) | IL268881A (es) |
MX (1) | MX2019009660A (es) |
SG (1) | SG11201907867TA (es) |
WO (1) | WO2018160536A1 (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
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SG10201912560YA (en) | 2016-12-07 | 2020-02-27 | Agenus Inc | Anti-ctla-4 antibodies and methods of use thereof |
AU2017414149A1 (en) | 2017-05-19 | 2019-11-07 | Wuxi Biologics (Shanghai) Co., Ltd. | Novel monoclonal antibodies to cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) |
BR112020018539A2 (pt) | 2018-03-23 | 2020-12-29 | Bristol-Myers Squibb Company | Anticorpos contra mica e/ou micb e usos dos mesmos |
BR112021012037A2 (pt) | 2018-12-21 | 2021-11-03 | Ose Immunotherapeutics | Molécula anti-pd-1/il-7 bifuncional |
WO2020165374A1 (en) | 2019-02-14 | 2020-08-20 | Ose Immunotherapeutics | Bifunctional molecule comprising il-15ra |
CN110218707B (zh) * | 2019-05-29 | 2021-10-22 | 上海市公共卫生临床中心 | 一种新型溶瘤病毒及其制备方法和应用 |
TW202136287A (zh) | 2019-12-17 | 2021-10-01 | 法商Ose免疫治療公司 | 包含il-7變體之雙官能分子 |
US20230203164A1 (en) * | 2019-12-25 | 2023-06-29 | Bio-Thera Solutions, Ltd. | Anti-ctla-4 monoclonal antibody, preparation method therefor, and application thereof |
IL300835A (en) | 2020-09-02 | 2023-04-01 | Genmab As | Antibody therapy |
CN116390949A (zh) | 2020-11-06 | 2023-07-04 | 百时美施贵宝公司 | 作为单一疗法给药和施用非岩藻糖基化抗ctla-4抗体 |
WO2022112198A1 (en) | 2020-11-24 | 2022-06-02 | Worldwide Innovative Network | Method to select the optimal immune checkpoint therapies |
TW202229354A (zh) * | 2020-12-03 | 2022-08-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 多特異性抗原結合蛋白 |
CA3213917A1 (en) | 2021-04-09 | 2022-10-13 | Nicolas Poirier | New scaffold for bifunctional molecules with improved properties |
WO2022214652A1 (en) | 2021-04-09 | 2022-10-13 | Ose Immunotherapeutics | Scaffold for bifunctioanl molecules comprising pd-1 or cd28 and sirp binding domains |
WO2024003360A1 (en) | 2022-07-01 | 2024-01-04 | Institut Curie | Biomarkers and uses thereof for the treatment of neuroblastoma |
WO2024028386A1 (en) | 2022-08-02 | 2024-02-08 | Ose Immunotherapeutics | Multifunctional molecule directed against cd28 |
WO2024046389A1 (zh) * | 2022-08-31 | 2024-03-07 | 百奥泰生物制药股份有限公司 | 抗tigit抗体和抗ctla-4抗体联合用于治疗肿瘤中的应用 |
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US5811097A (en) | 1995-07-25 | 1998-09-22 | The Regents Of The University Of California | Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling |
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MA53355A (fr) * | 2015-05-29 | 2022-03-16 | Agenus Inc | Anticorps anti-ctla-4 et leurs procédés d'utilisation |
-
2018
- 2018-02-27 BR BR112019017695A patent/BR112019017695A2/pt unknown
- 2018-02-27 SG SG11201907867TA patent/SG11201907867TA/en unknown
- 2018-02-27 CN CN201880014676.2A patent/CN110366565A/zh active Pending
- 2018-02-27 MX MX2019009660A patent/MX2019009660A/es unknown
- 2018-02-27 CN CN202211603585.7A patent/CN116440257A/zh active Pending
- 2018-02-27 AU AU2018227428A patent/AU2018227428A1/en active Pending
- 2018-02-27 US US16/488,118 patent/US20190382490A1/en not_active Abandoned
- 2018-02-27 CA CA3054928A patent/CA3054928A1/en active Pending
- 2018-02-27 WO PCT/US2018/019868 patent/WO2018160536A1/en unknown
- 2018-02-27 EP EP18710641.4A patent/EP3596122A1/en not_active Withdrawn
- 2018-02-27 JP JP2019547378A patent/JP2020509037A/ja active Pending
- 2018-02-27 KR KR1020197028077A patent/KR20190124256A/ko not_active Application Discontinuation
-
2019
- 2019-08-23 IL IL26888119A patent/IL268881A/en unknown
-
2022
- 2022-01-13 US US17/575,498 patent/US20220127363A1/en active Pending
-
2023
- 2023-02-03 JP JP2023015068A patent/JP2023055885A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2023055885A (ja) | 2023-04-18 |
US20190382490A1 (en) | 2019-12-19 |
US20220127363A1 (en) | 2022-04-28 |
KR20190124256A (ko) | 2019-11-04 |
IL268881A (en) | 2019-10-31 |
JP2020509037A (ja) | 2020-03-26 |
CN116440257A (zh) | 2023-07-18 |
CN110366565A (zh) | 2019-10-22 |
BR112019017695A2 (pt) | 2020-04-07 |
AU2018227428A1 (en) | 2019-10-17 |
WO2018160536A1 (en) | 2018-09-07 |
CA3054928A1 (en) | 2018-09-07 |
SG11201907867TA (en) | 2019-09-27 |
EP3596122A1 (en) | 2020-01-22 |
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