HRP20170395T1 - Podporodice adenovirusa b majmuna sadv-28, 27,-29,-32,-33, i -35 i njihove primjene - Google Patents
Podporodice adenovirusa b majmuna sadv-28, 27,-29,-32,-33, i -35 i njihove primjene Download PDFInfo
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- HRP20170395T1 HRP20170395T1 HRP20170395TT HRP20170395T HRP20170395T1 HR P20170395 T1 HRP20170395 T1 HR P20170395T1 HR P20170395T T HRP20170395T T HR P20170395TT HR P20170395 T HRP20170395 T HR P20170395T HR P20170395 T1 HRP20170395 T1 HR P20170395T1
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- Croatia
- Prior art keywords
- adenovirus
- sadv
- adenoviral
- replication
- seq
- Prior art date
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- 241000701161 unidentified adenovirus Species 0.000 title claims 9
- 150000001413 amino acids Chemical class 0.000 claims 3
- 230000010076 replication Effects 0.000 claims 3
- 241000700605 Viruses Species 0.000 claims 2
- 238000005538 encapsulation Methods 0.000 claims 2
- 101150029662 E1 gene Proteins 0.000 claims 1
- 101710145505 Fiber protein Proteins 0.000 claims 1
- 101710094396 Hexon protein Proteins 0.000 claims 1
- 101710173835 Penton protein Proteins 0.000 claims 1
- 230000002950 deficient Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000035897 transcription Effects 0.000 claims 1
- 238000013518 transcription Methods 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
- A61K35/761—Adenovirus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/162—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10321—Viruses as such, e.g. new isolates, mutants or their genomic sequences
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- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10332—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10351—Methods of production or purification of viral material
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
- C12N2810/60—Vectors comprising as targeting moiety peptide derived from defined protein from viruses
- C12N2810/6009—Vectors comprising as targeting moiety peptide derived from defined protein from viruses dsDNA viruses
- C12N2810/6018—Adenoviridae
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Mycology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (6)
1. Adenovirus koji ima ovojnicu sadrži: hekson protein SAdV-28, amino kiseline 1 do 944 sa SEQ ID NO (identifikacijski broj sekvence): 11; penton protein SAdV-28, amino kiseline 1 do 582 SEQ ID NO: 6; i vlaknasti protein SAdV-28, amino kiseline 1 do 323 SEQ ID NO: 21; spomenuta ovojnica koji enkapsulira heterolognu molekulu koja nosi gen operativno povezan za sekvence koje kontroliraju ekspresiju što regulira transkripciju, translaciju, i/ili ekspresiju istih u stanicu domaćina i dalje sadrži 5’ i 3’ adenovirusne cis-elemente neophodne za replikaciju i enkapsulaciju.
2. Adenovirus prema patentnom zahtjevu 1, gdje spomenutom rekombinantnom adenovirusu nedostaju svi ili jedan dio E1 gena.
3. Adenovirus prema patentnom zahtjevu 1 ili patentnom zahtjevu 2, gdje je replikacija kod spomenutog virusa neispravna.
4. Adenovirus prema bilo kom od patentnih zahtjeva 1 do 3, gdje spomenuti adenovirus je pseudo-proizveden adenovirus koji sadrži 5’ i 3’ adenovirusne cis-elemente neophodne za replikaciju i enkapsulaciju, pri čemu spomenuti cis-elementi sadrže adenovirusni 5’ invertirani terminalni ponovak i adenovirusni 3’ invertirani terminalni ponovak.
5. Kompozicija koja sadrži virus prema bilo kojem od patentnih zahtjeva 1 do 4 u farmaceutski prihvatljivom nosaču.
6. Adenovirus prema bilo kom od patentnih zahtjeva 1 do 4 za primjenu u isporučivanju molekula u ciljnu stanicu.
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US454207P | 2007-11-28 | 2007-11-28 | |
| US453407P | 2007-11-28 | 2007-11-28 | |
| US453307P | 2007-11-28 | 2007-11-28 | |
| US446607P | 2007-11-28 | 2007-11-28 | |
| US456707P | 2007-11-28 | 2007-11-28 | |
| US453107P | 2007-11-28 | 2007-11-28 | |
| PCT/US2008/013065 WO2009073103A2 (en) | 2007-11-28 | 2008-11-24 | Simian subfamily b adenoviruses sadv-28,27,-29,-32,-33, and -35 and uses thereof |
| EP08857781.2A EP2220242B1 (en) | 2007-11-28 | 2008-11-24 | Simian subfamily b adenoviruses sadv-28,27,-29,-32,-33, and -35 and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20170395T1 true HRP20170395T1 (hr) | 2017-05-05 |
Family
ID=40718407
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20170395TT HRP20170395T1 (hr) | 2007-11-28 | 2017-03-10 | Podporodice adenovirusa b majmuna sadv-28, 27,-29,-32,-33, i -35 i njihove primjene |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US8524219B2 (hr) |
| EP (1) | EP2220242B1 (hr) |
| JP (3) | JP5740157B2 (hr) |
| KR (3) | KR101761683B1 (hr) |
| CN (1) | CN101883857B (hr) |
| AU (2) | AU2008331905B2 (hr) |
| BR (1) | BRPI0822651A2 (hr) |
| CA (1) | CA2706257C (hr) |
| CY (1) | CY1118866T1 (hr) |
| DK (1) | DK2220242T3 (hr) |
| ES (1) | ES2621165T3 (hr) |
| HR (1) | HRP20170395T1 (hr) |
| HU (1) | HUE031636T2 (hr) |
| LT (1) | LT2220242T (hr) |
| MX (2) | MX344106B (hr) |
| PL (1) | PL2220242T3 (hr) |
| PT (1) | PT2220242T (hr) |
| SG (2) | SG186022A1 (hr) |
| SI (1) | SI2220242T1 (hr) |
| WO (1) | WO2009073103A2 (hr) |
Families Citing this family (51)
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| CN101883858B (zh) | 2007-11-28 | 2015-07-22 | 宾夕法尼亚大学托管会 | 猿猴亚家族E腺病毒SAdV-39、-25.2、-26、-30、-37和-38及其应用 |
| EP2325298B1 (en) * | 2008-03-04 | 2016-10-05 | The Trustees Of The University Of Pennsylvania | SIMIAN ADENOVIRUSES SAdV-36, -42.1, -42.2, AND -44 AND USES THEREOF |
| DK2350269T3 (en) | 2008-10-31 | 2015-12-07 | Univ Pennsylvania | ABE ADENOVIRUS WITH SADV-46 HEXONCAPSIDE PROTEINS AND APPLICATIONS THEREOF |
| EP2435559A1 (en) | 2009-05-29 | 2012-04-04 | The Trustees Of The University Of Pennsylvania | Simian adenovirus 41 and uses thereof |
| AU2011332025B2 (en) | 2010-11-23 | 2015-06-25 | The Trustees Of The University Of Pennsylvania | Subfamily E simian adenoviruses A1321, A1325, A1295, A1309 and A1322 and uses thereof |
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| WO2023213764A1 (en) | 2022-05-02 | 2023-11-09 | Transgene | Fusion polypeptide comprising an anti-pd-l1 sdab and a member of the tnfsf |
| CN117089577B (zh) * | 2023-08-21 | 2024-06-25 | 暨南大学 | 重组的猴腺病毒、病毒载体及构建方法 |
| CN117143833B (zh) * | 2023-08-21 | 2024-06-04 | 暨南大学 | 一种猴腺病毒毒株及其应用 |
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| US2009A (en) * | 1841-03-18 | Improvement in machines for boring war-rockets | ||
| US2008A (en) * | 1841-03-18 | Gas-lamp eok conducting gas pkom ah elevated buhner to one below it | ||
| AU4255397A (en) | 1996-09-06 | 1998-03-26 | Trustees Of The University Of Pennsylvania, The | Chimpanzee adenovirus vectors |
| AU1822499A (en) | 1997-12-12 | 1999-06-28 | Saint Louis University | Ctip, a novel protein that interacts with ctbp and uses therefor |
| PT1409012E (pt) * | 2001-06-22 | 2009-05-11 | Wistar Inst | Métodos de indução de uma resposta imunitária citotóxica e composições de adenovírus recombinantes de símio úteis para esse efeito |
| AU2002322285A1 (en) | 2001-06-22 | 2003-01-08 | The Trustees Of The University Of Pennsylvania | Method for rapid screening of bacterial transformants and novel simian adenovirus proteins |
| US20040136963A1 (en) | 2001-06-22 | 2004-07-15 | The Trustees Of The University Of Pennsylvania | Simian adenovirus vectors and methods of use |
| NZ532383A (en) | 2001-11-21 | 2007-03-30 | Univ Pennsylvania | Pan-7 simian adenovirus nucleic acid and amino acid sequences, vectors containing same, and methods of use |
| US7491508B2 (en) | 2003-06-20 | 2009-02-17 | The Trustees Of The University Of Pennsylvania | Methods of generating chimeric adenoviruses and uses for such chimeric adenoviruses |
| US7291498B2 (en) | 2003-06-20 | 2007-11-06 | The Trustees Of The University Of Pennsylvania | Methods of generating chimeric adenoviruses and uses for such chimeric adenoviruses |
| PT1711518E (pt) | 2004-01-23 | 2010-02-26 | Isti Di Ric Di Bio Moleco P An | Transportadores de vacinas de adenovírus de chimpanzé |
| US20080004236A1 (en) * | 2004-02-06 | 2008-01-03 | Comper Wayne D | High Dose, Short Interval Use of Sulfated Polysaccharides for Treatment of Infections |
| JP5108521B2 (ja) * | 2004-10-14 | 2012-12-26 | クルセル ホランド ベー ヴェー | マラリア初回免疫／追加免疫ワクチン |
| AR053275A1 (es) | 2005-05-12 | 2007-04-25 | Glaxo Group Ltd | Composicion de vacuna |
| ATE455558T1 (de) | 2006-04-28 | 2010-02-15 | Univ Pennsylvania | Modifiziertes adenovirus-hexon-protein und anwendungen davon |
| CN101883858B (zh) | 2007-11-28 | 2015-07-22 | 宾夕法尼亚大学托管会 | 猿猴亚家族E腺病毒SAdV-39、-25.2、-26、-30、-37和-38及其应用 |
| EP2463362B1 (en) | 2007-11-28 | 2017-11-08 | The Trustees Of The University Of Pennsylvania | Simian subfamily c adenovirus SAdv-31 and uses thereof |
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