CY1118866T1 - Αδενοϊοι της υπο-οικογενειας β των πιθηκων sadv-28,27,-29,-32,-33, και -35 και χρησεις αυτων - Google Patents

Αδενοϊοι της υπο-οικογενειας β των πιθηκων sadv-28,27,-29,-32,-33, και -35 και χρησεις αυτων

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Publication number
CY1118866T1
CY1118866T1 CY20171100382T CY171100382T CY1118866T1 CY 1118866 T1 CY1118866 T1 CY 1118866T1 CY 20171100382 T CY20171100382 T CY 20171100382T CY 171100382 T CY171100382 T CY 171100382T CY 1118866 T1 CY1118866 T1 CY 1118866T1
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Cyprus
Prior art keywords
adenovirus
monkey adenovirus
sadv
monuments
subscriptions
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CY20171100382T
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English (en)
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Soumitra Roy
James M Wilson
Luc H Vandenberghe
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The Trustees Of The University Of Pennsylvania
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Publication of CY1118866T1 publication Critical patent/CY1118866T1/el

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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/761—Adenovirus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N2710/10011—Adenoviridae
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Abstract

Παρουσιάζεται ένας ανασυνδυαστικός φορέας που περιέχει αλληλουχίες με τον αδενοϊό του πιθήκου 28, τον αδενοϊό του πιθήκου 27, τον αδενοϊό του πιθήκου 32, τον αδενοϊό του πιθήκου 33, ή/και τον αδενοϊό του πιθήκου 35 και ένα ετερόλογο γονίδιο υπό τον έλεγχο των ρυθμιστικών αλληλουχιών. Μια κυτταρική γραμμή που εκφράζει ένα ή περισσότερα γονίδια αδενοϊών -28, -27, -32, -33, ή -35 επίσης περιλαμβάνονται. Παρέχονται μέθοδοι χρήσης των φορέων και των κυτταρικών γραμμών.
CY20171100382T 2007-11-28 2017-03-28 Αδενοϊοι της υπο-οικογενειας β των πιθηκων sadv-28,27,-29,-32,-33, και -35 και χρησεις αυτων CY1118866T1 (el)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US456707P 2007-11-28 2007-11-28
US453107P 2007-11-28 2007-11-28
US453407P 2007-11-28 2007-11-28
US453307P 2007-11-28 2007-11-28
US446607P 2007-11-28 2007-11-28
US454207P 2007-11-28 2007-11-28
PCT/US2008/013065 WO2009073103A2 (en) 2007-11-28 2008-11-24 Simian subfamily b adenoviruses sadv-28,27,-29,-32,-33, and -35 and uses thereof

Publications (1)

Publication Number Publication Date
CY1118866T1 true CY1118866T1 (el) 2018-01-10

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CY20171100382T CY1118866T1 (el) 2007-11-28 2017-03-28 Αδενοϊοι της υπο-οικογενειας β των πιθηκων sadv-28,27,-29,-32,-33, και -35 και χρησεις αυτων

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US (3) US8524219B2 (el)
EP (1) EP2220242B1 (el)
JP (3) JP5740157B2 (el)
KR (3) KR101662571B1 (el)
CN (1) CN101883857B (el)
AU (2) AU2008331905B2 (el)
BR (1) BRPI0822651A2 (el)
CA (1) CA2706257C (el)
CY (1) CY1118866T1 (el)
DK (1) DK2220242T3 (el)
ES (1) ES2621165T3 (el)
HR (1) HRP20170395T1 (el)
HU (1) HUE031636T2 (el)
LT (1) LT2220242T (el)
MX (2) MX2010005859A (el)
PL (1) PL2220242T3 (el)
PT (1) PT2220242T (el)
SG (2) SG10201603993TA (el)
SI (1) SI2220242T1 (el)
WO (1) WO2009073103A2 (el)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2220241T3 (en) 2007-11-28 2017-01-09 Univ Pennsylvania Adenovirus comprising a simian adenovirus E-SAdV-39-capsidhexonprotein and uses thereof
JP5661476B2 (ja) * 2008-03-04 2015-01-28 ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア サルアデノウイルスＳＡｄＶ−３６、−４２．１、−４２．２および−４４ならびにそれらの用途
EP2350269B1 (en) * 2008-10-31 2015-09-09 The Trustees Of The University Of Pennsylvania Simian adenoviruses with sadv-46 hexon capsid proteins and uses thereof
US8846031B2 (en) 2009-05-29 2014-09-30 The Trustees Of The University Of Pennsylvania Simian adenovirus 41 and uses thereof
EP2643465B1 (en) 2010-11-23 2016-05-11 The Trustees Of The University Of Pennsylvania Subfamily e simian adenovirus a1321 and uses thereof
TWI575070B (zh) 2011-07-12 2017-03-21 傳斯堅公司 Ｈｂｖ聚合酶突變體
TW201321016A (zh) 2011-09-29 2013-06-01 Transgene Sa 免疫療法組成物及用於治療ｃ型肝炎病毒感染之療程（二）
TW201318637A (zh) 2011-09-29 2013-05-16 Transgene Sa 免疫療法組成物及用於治療ｃ型肝炎病毒感染之療程（一）
BR112014028684A2 (pt) 2012-05-18 2017-07-25 Univ Pennsylvania subfamília e adenovírus de símio a1302, a1320, a1331 e a1337 e usos dos mesmos
WO2014153204A1 (en) 2013-03-14 2014-09-25 Salk Institute For Biological Studies Oncolytic adenovirus compositions
WO2015191508A1 (en) 2014-06-09 2015-12-17 Voyager Therapeutics, Inc. Chimeric capsids
CN107106689A (zh) 2014-11-05 2017-08-29 沃雅戈治疗公司 用于治疗帕金森病的aadc多核苷酸
MX2017006216A (es) 2014-11-14 2018-08-29 Voyager Therapeutics Inc Composiciones y métodos para tratar la esclerosis lateral amiotrófica (ela).
SG11201703419UA (en) 2014-11-14 2017-05-30 Voyager Therapeutics Inc Modulatory polynucleotides
EP3230441A4 (en) 2014-12-12 2018-10-03 Voyager Therapeutics, Inc. Compositions and methods for the production of scaav
WO2016131945A1 (en) 2015-02-20 2016-08-25 Transgene Sa Combination product with autophagy modulator
CN108025058B (zh) * 2015-06-12 2022-12-16 葛兰素史密丝克莱恩生物有限公司 腺病毒多核苷酸和多肽
EP3384035A4 (en) 2015-12-02 2019-08-07 Voyager Therapeutics, Inc. ASSAYS FOR DETECTION OF NEUTRALIZING ANTIBODIES OF VAA
JP7054527B2 (ja) 2016-02-23 2022-04-14 ソーク インスティテュート フォー バイオロジカル スタディーズ アデノウイルスの複製動態を測定するための高スループットアッセイ
KR20180112024A (ko) 2016-02-23 2018-10-11 더 솔크 인스티튜트 포 바이올로지칼 스터디즈 바이러스 동역학에 미치는 영향 최소화를 위한 치료용 아데노바이러스의 외인성 유전자 발현
US11326182B2 (en) 2016-04-29 2022-05-10 Voyager Therapeutics, Inc. Compositions for the treatment of disease
US11299751B2 (en) 2016-04-29 2022-04-12 Voyager Therapeutics, Inc. Compositions for the treatment of disease
CA3023022A1 (en) 2016-05-04 2017-11-09 Transgene Sa Combination therapy with cpg tlr9 ligand
SG11201809643UA (en) 2016-05-18 2018-12-28 Voyager Therapeutics Inc Compositions and methods of treating huntington's disease
KR102392236B1 (ko) 2016-05-18 2022-05-03 보이저 테라퓨틱스, 인크. 조절성 폴리뉴클레오티드
AU2017313917B2 (en) 2016-08-18 2023-12-21 The Regents Of The University Of California CRISPR-Cas genome engineering via a modular AAV delivery system
EP3831281A1 (en) 2016-08-30 2021-06-09 The Regents of The University of California Methods for biomedical targeting and delivery and devices and systems for practicing the same
WO2018069316A2 (en) 2016-10-10 2018-04-19 Transgene Sa Immunotherapeutic product and mdsc modulator combination therapy
CN110062630A (zh) 2016-12-12 2019-07-26 萨克生物研究学院 肿瘤靶向合成腺病毒及其用途
CA3061652A1 (en) 2017-05-05 2018-11-08 Voyager Therapeutics, Inc. Compositions and methods of treating amyotrophic lateral sclerosis (als)
EP3619308A4 (en) 2017-05-05 2021-01-27 Voyager Therapeutics, Inc. COMPOSITIONS AND METHODS OF TREATMENT FOR HUNTINGTON'S MORBUS
JOP20190269A1 (ar) 2017-06-15 2019-11-20 Voyager Therapeutics Inc بولي نوكليوتيدات aadc لعلاج مرض باركنسون
JP7229989B2 (ja) 2017-07-17 2023-02-28 ボイジャー セラピューティクス インコーポレイテッド 軌道アレイガイドシステム
KR20200044793A (ko) 2017-08-03 2020-04-29 보이저 테라퓨틱스, 인크. Aav의 전달을 위한 조성물 및 방법
JP7502991B2 (ja) 2017-10-16 2024-06-19 ボイジャー セラピューティクス インコーポレイテッド 筋萎縮性側索硬化症（ａｌｓ）の治療
WO2019079242A1 (en) 2017-10-16 2019-04-25 Voyager Therapeutics, Inc. TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS (ALS)
WO2019241486A1 (en) 2018-06-13 2019-12-19 Voyager Therapeutics, Inc. Engineered 5' untranslated regions (5' utr) for aav production
JP7413629B2 (ja) 2018-07-17 2024-01-16 ヘリックスミス カンパニー， リミテッド Ｉｇｆ－１異型体を発現させるｄｎａコンストラクトを用いた神経病症の治療
CA3107462A1 (en) 2018-07-24 2020-01-30 Voyager Therapeutics, Inc. Systems and methods for producing gene therapy formulations
EP3861113A1 (en) 2018-10-04 2021-08-11 Voyager Therapeutics, Inc. Methods for measuring the titer and potency of viral vector particles
SG11202103425YA (en) 2018-10-05 2021-05-28 Voyager Therapeutics Inc Engineered nucleic acid constructs encoding aav production proteins
EP3867389A1 (en) 2018-10-15 2021-08-25 Voyager Therapeutics, Inc. Expression vectors for large-scale production of raav in the baculovirus/sf9 system
US20230193315A1 (en) 2019-01-31 2023-06-22 Oregon Health & Science University Methods for using transcription-dependent directed evolution of aav capsids
NL2023464B1 (en) * 2019-07-09 2021-02-02 Academisch Ziekenhuis Leiden Oncolytic Non-human adenoviruses and uses thereof
CA3189238A1 (en) 2020-07-13 2022-01-20 Transgene Treatment of immune depression
AU2022214429A1 (en) 2021-02-01 2023-09-14 Regenxbio Inc. Gene therapy for neuronal ceroid lipofuscinoses
WO2022218997A1 (en) 2021-04-12 2022-10-20 Centre National De La Recherche Scientifique (Cnrs) Novel universal vaccine presenting system
WO2023173114A2 (en) * 2022-03-10 2023-09-14 Technovax, Inc. Recombinant virus-like particle capsid vaccines against adenoviruses and compositions, methods, and use thereof
WO2023213764A1 (en) 2022-05-02 2023-11-09 Transgene Fusion polypeptide comprising an anti-pd-l1 sdab and a member of the tnfsf
CN117143833B (zh) * 2023-08-21 2024-06-04 暨南大学 一种猴腺病毒毒株及其应用
CN117089577B (zh) * 2023-08-21 2024-06-25 暨南大学 重组的猴腺病毒、病毒载体及构建方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2008A (en) * 1841-03-18 Gas-lamp eok conducting gas pkom ah elevated buhner to one below it
US2009A (en) * 1841-03-18 Improvement in machines for boring war-rockets
US6083716A (en) 1996-09-06 2000-07-04 The Trustees Of The University Of Pennsylvania Chimpanzee adenovirus vectors
AU1822499A (en) 1997-12-12 1999-06-28 Saint Louis University Ctip, a novel protein that interacts with ctbp and uses therefor
US20040136963A1 (en) 2001-06-22 2004-07-15 The Trustees Of The University Of Pennsylvania Simian adenovirus vectors and methods of use
KR20040043129A (ko) * 2001-06-22 2004-05-22 더 위스타 인스티튜트 오브 아나토미 앤드 바이올로지 세포독성 면역 반응을 유도하는 방법과 그에 유용한재조합체 원숭이 아데노바이러스 조성물
US7344872B2 (en) 2001-06-22 2008-03-18 The Trustees Of The University Of Pennsylvania Method for rapid screening of bacterial transformants and novel simian adenovirus proteins
NZ532383A (en) 2001-11-21 2007-03-30 Univ Pennsylvania Pan-7 simian adenovirus nucleic acid and amino acid sequences, vectors containing same, and methods of use
US7291498B2 (en) 2003-06-20 2007-11-06 The Trustees Of The University Of Pennsylvania Methods of generating chimeric adenoviruses and uses for such chimeric adenoviruses
EP1636370B1 (en) * 2003-06-20 2014-04-16 The Trustees of The University of Pennsylvania Methods of generating chimeric adenoviruses and uses for such chimeric adenoviruses
CA2880061C (en) 2004-01-23 2018-03-13 Agostino Cirillo Chimpanzee adenovirus vaccine carriers
US20080004236A1 (en) * 2004-02-06 2008-01-03 Comper Wayne D High Dose, Short Interval Use of Sulfated Polysaccharides for Treatment of Infections
KR20070104881A (ko) * 2004-10-14 2007-10-29 크루셀 홀란드 비.브이. 말라리아 프라임/부스트 백신
TW200716750A (en) 2005-05-12 2007-05-01 Glaxo Group Ltd Vaccine composition
DE602007004470D1 (de) 2006-04-28 2010-03-11 Univ Pennsylvania Modifiziertes adenovirus-hexon-protein und anwendungen davon
DK2220241T3 (en) 2007-11-28 2017-01-09 Univ Pennsylvania Adenovirus comprising a simian adenovirus E-SAdV-39-capsidhexonprotein and uses thereof
BRPI0819774A2 (pt) 2007-11-28 2014-10-14 Univ Pennsylvania Subfamília c de adenovírus sadv-40, -31 e -34 de símio e seus usos

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