CY1113711T1 - Ρυθμιστικα στοιχεια νουκλεϊκου οξεος - Google Patents

Ρυθμιστικα στοιχεια νουκλεϊκου οξεος

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Publication number
CY1113711T1
CY1113711T1 CY20131100160T CY131100160T CY1113711T1 CY 1113711 T1 CY1113711 T1 CY 1113711T1 CY 20131100160 T CY20131100160 T CY 20131100160T CY 131100160 T CY131100160 T CY 131100160T CY 1113711 T1 CY1113711 T1 CY 1113711T1
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CY
Cyprus
Prior art keywords
expression
sequence
elements
genome
position effects
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CY20131100160T
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English (en)
Inventor
Barbara Enenkel
Kerstin Sautter
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Boehringer Ingelheim Pharma Gmbh & Co. Kg
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Application filed by Boehringer Ingelheim Pharma Gmbh & Co. Kg filed Critical Boehringer Ingelheim Pharma Gmbh & Co. Kg
Publication of CY1113711T1 publication Critical patent/CY1113711T1/el

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    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/106—Plasmid DNA for vertebrates
    • C12N2800/107—Plasmid DNA for vertebrates for mammalian
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/46—Vector systems having a special element relevant for transcription elements influencing chromatin structure, e.g. scaffold/matrix attachment region, methylation free island
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian

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  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Η εφεύρεση αφορά αλληλουχίες DNA, ιδιαιτέρως στοιχεία που αυξάνουν τη μεταγραφή ή την έκφραση (ΤΕ-στοιχεία), καθώς και τη χρήση τους σε έναν φορέα έκφρασης σε σύνδεση με έναν ενισχυτή, έναν υποκινητή, ένα γονίδιο προϊόντος και έναν δείκτη επιλογής. Η εφεύρεση περιγράφει την αλληλουχία Nr. 1, καθώς και τα ΤΕ-στοιχεία ΤΕ-01, -02, -03, -04, -06, -07, -08, -10, -11 ή -12. Λόγω του μικρού μεγέθους τους είναι προτιμώμενα τα ΤΕ-06, ΤΕ-07 ή ΤΕ-08. Η αλληλουχία Nr. 1 προέρχεται από μια περιοχή αλληλουχίας, η οποία βρίσκεται ανοδικά από την κωδικοποιούσα περιοχή του γονιδίου Ub/S27a από κύτταρα CHO. Τα ΤΕ-στοιχεία προκαλούν αύξηση της έκφρασης του γονιδίου προϊόντος με σταθερή ενσωμάτωση στο ευκαρυωτικό γονιδίωμα, κατά προτίμηση το γονιδίωμα CHO-DG44. Έτσι, υπερνικώνται, ή εξαλείφονται χρωμοσωμικές επιδράσεις θέσης ή υπάρχει προστασία από χρωμοσωμικές επιδράσεις θέσης. Έτσι, τόσο το ποσοστό σε κύτταρα υψηλής παραγωγικότητας ενός μείγματος επιμόλυνσης όσο και το απόλυτο επίπεδο έκφρασης αυξάνονται έως δεκαπέντε φορές.
CY20131100160T 2006-07-26 2013-02-21 Ρυθμιστικα στοιχεια νουκλεϊκου οξεος CY1113711T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06117862 2006-07-26
EP07730192A EP2049671B1 (de) 2006-07-26 2007-06-15 Regulatorische nukleinsäureelemente

Publications (1)

Publication Number Publication Date
CY1113711T1 true CY1113711T1 (el) 2016-06-22

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US (3) US20080124760A1 (el)
EP (1) EP2049671B1 (el)
JP (1) JP5270544B2 (el)
KR (1) KR101485853B1 (el)
CN (1) CN101517085B (el)
AR (1) AR061472A1 (el)
AU (1) AU2007278368B2 (el)
BR (1) BRPI0714594A2 (el)
CA (1) CA2658595C (el)
CY (1) CY1113711T1 (el)
DK (1) DK2049671T3 (el)
EA (1) EA016880B1 (el)
ES (1) ES2401654T3 (el)
HK (1) HK1134107A1 (el)
IL (1) IL196676A0 (el)
MX (1) MX2009000781A (el)
NO (1) NO20090057L (el)
NZ (1) NZ575115A (el)
PL (1) PL2049671T3 (el)
PT (1) PT2049671E (el)
SI (1) SI2049671T1 (el)
TW (1) TW200815591A (el)
WO (1) WO2008012142A1 (el)

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Also Published As

Publication number Publication date
EP2049671A1 (de) 2009-04-22
WO2008012142A1 (de) 2008-01-31
CN101517085A (zh) 2009-08-26
US9708626B2 (en) 2017-07-18
KR20090046887A (ko) 2009-05-11
ES2401654T3 (es) 2013-04-23
JP5270544B2 (ja) 2013-08-21
HK1134107A1 (en) 2010-04-16
EA200900212A1 (ru) 2009-10-30
AU2007278368B2 (en) 2013-12-19
EP2049671B1 (de) 2012-12-19
MX2009000781A (es) 2009-01-29
US20150337333A1 (en) 2015-11-26
BRPI0714594A2 (pt) 2013-02-19
CA2658595A1 (en) 2008-01-31
SI2049671T1 (sl) 2013-04-30
CN101517085B (zh) 2013-08-07
US20080124760A1 (en) 2008-05-29
CA2658595C (en) 2016-05-31
NO20090057L (no) 2009-02-16
PL2049671T3 (pl) 2013-05-31
DK2049671T3 (da) 2013-04-08
TW200815591A (en) 2008-04-01
US9045776B2 (en) 2015-06-02
JP2009544293A (ja) 2009-12-17
KR101485853B1 (ko) 2015-01-23
IL196676A0 (en) 2011-08-01
EA016880B1 (ru) 2012-08-30
US20100311121A1 (en) 2010-12-09
PT2049671E (pt) 2013-01-24
AR061472A1 (es) 2008-08-27
AU2007278368A1 (en) 2008-01-31
NZ575115A (en) 2011-10-28

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