LT3265563T - Genų raiškos reguliavimas aptamerų sąlygotu alternatyvaus splaisingo moduliavimu - Google Patents

Genų raiškos reguliavimas aptamerų sąlygotu alternatyvaus splaisingo moduliavimu

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Publication number
LT3265563T
LT3265563T LTEP16747144.0T LT16747144T LT3265563T LT 3265563 T LT3265563 T LT 3265563T LT 16747144 T LT16747144 T LT 16747144T LT 3265563 T LT3265563 T LT 3265563T
Authority
LT
Lithuania
Prior art keywords
aptamer
regulation
gene expression
alternative splicing
mediated modulation
Prior art date
Application number
LTEP16747144.0T
Other languages
English (en)
Inventor
Alex BOYNE
F. Danos
J. Volles
Xuecui GUO
Original Assignee
Meiragtx Uk Ii Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meiragtx Uk Ii Limited filed Critical Meiragtx Uk Ii Limited
Publication of LT3265563T publication Critical patent/LT3265563T/lt

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • A61K38/00—Medicinal preparations containing peptides
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • A61K48/0033—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being non-polymeric
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    • A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
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    • C12N9/0026—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5)
    • C12N9/0028—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5) with NAD or NADP as acceptor (1.5.1)
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LTEP16747144.0T 2015-02-02 2016-02-02 Genų raiškos reguliavimas aptamerų sąlygotu alternatyvaus splaisingo moduliavimu LT3265563T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562110919P 2015-02-02 2015-02-02
PCT/US2016/016234 WO2016126747A1 (en) 2015-02-02 2016-02-02 Regulation of gene expression by aptamer-mediated modulation of alternative splicing

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LT3265563T true LT3265563T (lt) 2021-06-25

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US (3) US10494646B2 (lt)
EP (2) EP3265563B1 (lt)
JP (3) JP6871174B2 (lt)
KR (2) KR20240133774A (lt)
CN (2) CN107849563B (lt)
AU (2) AU2016215454B2 (lt)
BR (1) BR112017016639A2 (lt)
CA (1) CA2975735A1 (lt)
CY (1) CY1124189T1 (lt)
DK (1) DK3265563T3 (lt)
EA (2) EA037120B1 (lt)
ES (1) ES2873400T3 (lt)
HK (1) HK1248760A1 (lt)
HR (1) HRP20210854T1 (lt)
HU (1) HUE054624T2 (lt)
IL (2) IL253786B (lt)
LT (1) LT3265563T (lt)
MX (2) MX2017009953A (lt)
MY (1) MY186203A (lt)
NZ (1) NZ735054A (lt)
PH (1) PH12017501389A1 (lt)
PL (1) PL3265563T3 (lt)
PT (1) PT3265563T (lt)
RS (1) RS61924B1 (lt)
SG (1) SG11201706297RA (lt)
SI (1) SI3265563T1 (lt)
WO (1) WO2016126747A1 (lt)
ZA (2) ZA202301731B (lt)

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