HK1248760A1 - 通過對選擇性剪接進行適體介導的調節來實現的基因表達調控 - Google Patents

通過對選擇性剪接進行適體介導的調節來實現的基因表達調控

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Publication number
HK1248760A1
HK1248760A1 HK18108359.8A HK18108359A HK1248760A1 HK 1248760 A1 HK1248760 A1 HK 1248760A1 HK 18108359 A HK18108359 A HK 18108359A HK 1248760 A1 HK1248760 A1 HK 1248760A1
Authority
HK
Hong Kong
Prior art keywords
aptamer
regulation
gene expression
alternative splicing
mediated modulation
Prior art date
Application number
HK18108359.8A
Other languages
English (en)
Inventor
A‧R‧博伊奈
F‧O‧達諾斯
J‧M‧沃勒斯
郭雪翠
Original Assignee
梅里特斯英國第二有限公司
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Publication date
Application filed by 梅里特斯英國第二有限公司 filed Critical 梅里特斯英國第二有限公司
Publication of HK1248760A1 publication Critical patent/HK1248760A1/zh

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
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    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
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    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
    • A61K48/0033—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being non-polymeric
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    • A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
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    • C12N9/0026—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5)
    • C12N9/0028—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5) with NAD or NADP as acceptor (1.5.1)
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HK18108359.8A 2015-02-02 2018-06-28 通過對選擇性剪接進行適體介導的調節來實現的基因表達調控 HK1248760A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562110919P 2015-02-02 2015-02-02
PCT/US2016/016234 WO2016126747A1 (en) 2015-02-02 2016-02-02 Regulation of gene expression by aptamer-mediated modulation of alternative splicing

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HK1248760A1 true HK1248760A1 (zh) 2018-10-19

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US (3) US10494646B2 (zh)
EP (2) EP3265563B1 (zh)
JP (3) JP6871174B2 (zh)
KR (1) KR102699584B1 (zh)
CN (2) CN107849563B (zh)
AU (2) AU2016215454B2 (zh)
BR (1) BR112017016639A2 (zh)
CA (1) CA2975735A1 (zh)
CY (1) CY1124189T1 (zh)
DK (1) DK3265563T3 (zh)
EA (2) EA202092665A3 (zh)
ES (1) ES2873400T3 (zh)
HK (1) HK1248760A1 (zh)
HR (1) HRP20210854T1 (zh)
HU (1) HUE054624T2 (zh)
IL (2) IL253786B (zh)
LT (1) LT3265563T (zh)
MX (2) MX2017009953A (zh)
MY (1) MY186203A (zh)
NZ (1) NZ735054A (zh)
PH (1) PH12017501389A1 (zh)
PL (1) PL3265563T3 (zh)
PT (1) PT3265563T (zh)
RS (1) RS61924B1 (zh)
SG (1) SG11201706297RA (zh)
SI (1) SI3265563T1 (zh)
WO (1) WO2016126747A1 (zh)

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