CN115461358A - 一种细胞穿膜肽及其应用 - Google Patents

一种细胞穿膜肽及其应用 Download PDF

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Publication number
CN115461358A
CN115461358A CN202180031071.6A CN202180031071A CN115461358A CN 115461358 A CN115461358 A CN 115461358A CN 202180031071 A CN202180031071 A CN 202180031071A CN 115461358 A CN115461358 A CN 115461358A
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amino acid
acid residues
group
cell
protein
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袁权
王邵娟
粘晟
魏敏
张雅丽
王楷
陈毅歆
张天英
葛胜祥
夏宁邵
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Yang Sheng Tang Co Ltd
Xiamen University
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Yang Sheng Tang Co Ltd
Xiamen University
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
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    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases RNAses, DNAses
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C—CHEMISTRY; METALLURGY
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
    • C07K2319/81—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor containing a Zn-finger domain for DNA binding
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    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/101—Plasmid DNA for bacteria

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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Gastroenterology & Hepatology (AREA)
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  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

提供了一种细胞穿膜肽，其能够将多种生物大分子例如蛋白质、抗体、核酸等跨膜递送入细胞中。此外，还提供了含有所述细胞穿膜肽的融合蛋白、缀合物和复合物，以及所述细胞穿膜肽的用途。

Description

PCT国内申请，说明书已公开。

Claims (22)

  1. PCT国内申请，权利要求书已公开。
CN202180031071.6A 2020-07-17 2021-07-13 一种细胞穿膜肽及其应用 Pending CN115461358A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN202010692443 2020-07-17
CN2020106924437 2020-07-17
PCT/CN2021/106043 WO2022012539A1 (zh) 2020-07-17 2021-07-13 一种细胞穿膜肽及其应用

Publications (1)

Publication Number Publication Date
CN115461358A true CN115461358A (zh) 2022-12-09

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ID=79556027

Family Applications (1)

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CN202180031071.6A Pending CN115461358A (zh) 2020-07-17 2021-07-13 一种细胞穿膜肽及其应用

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US (1) US20230287086A1 (zh)
EP (1) EP4190802A4 (zh)
JP (1) JP2023534054A (zh)
CN (1) CN115461358A (zh)
WO (1) WO2022012539A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116555197A (zh) * 2023-06-25 2023-08-08 中国科学院深圳先进技术研究院 一种沙门氏菌工程穿膜噬菌体及其构建方法与应用

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113138276B (zh) * 2020-01-19 2022-09-16 厦门万泰凯瑞生物技术有限公司 用于检测HBcAg的方法及抗体

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101052414B (zh) * 2000-08-16 2012-10-10 塞尔德克斯医疗有限公司 具有增强的稳定性的免疫原性HBc嵌合体颗粒
US7320795B2 (en) * 2003-07-30 2008-01-22 Vaccine Research Institute Of San Diego Rodent hepatitis B virus core proteins as vaccine platforms and methods of use thereof
US9096868B2 (en) * 2007-09-14 2015-08-04 Institut Pasteur Polynucleotides allowing the expression and secretion of recombinant pseudo-virus containing foreign epitopes, their production, and use
WO2010042743A2 (en) * 2008-10-08 2010-04-15 Chimeros Inc. Chimeric multiplexes, compositions, and methods for using same

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116555197A (zh) * 2023-06-25 2023-08-08 中国科学院深圳先进技术研究院 一种沙门氏菌工程穿膜噬菌体及其构建方法与应用
CN116555197B (zh) * 2023-06-25 2023-09-01 中国科学院深圳先进技术研究院 一种沙门氏菌工程穿膜噬菌体及其构建方法与应用

Also Published As

Publication number Publication date
US20230287086A1 (en) 2023-09-14
EP4190802A1 (en) 2023-06-07
JP2023534054A (ja) 2023-08-07
EP4190802A4 (en) 2024-04-03
WO2022012539A1 (zh) 2022-01-20

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