MX2017011732A - Proteínas de fusión que comprenden glicoproteínas de la superficie del virus alfa modificado y antígeno asociado al tumor y métodos de los mismos. - Google Patents
Proteínas de fusión que comprenden glicoproteínas de la superficie del virus alfa modificado y antígeno asociado al tumor y métodos de los mismos.Info
- Publication number
- MX2017011732A MX2017011732A MX2017011732A MX2017011732A MX2017011732A MX 2017011732 A MX2017011732 A MX 2017011732A MX 2017011732 A MX2017011732 A MX 2017011732A MX 2017011732 A MX2017011732 A MX 2017011732A MX 2017011732 A MX2017011732 A MX 2017011732A
- Authority
- MX
- Mexico
- Prior art keywords
- fusion proteins
- surface glycoproteins
- virus surface
- modified alpha
- alpha virus
- Prior art date
Links
- 102000037865 fusion proteins Human genes 0.000 title abstract 5
- 108020001507 fusion proteins Proteins 0.000 title abstract 5
- 241000710929 Alphavirus Species 0.000 title abstract 4
- 102000012750 Membrane Glycoproteins Human genes 0.000 title abstract 4
- 108010090054 Membrane Glycoproteins Proteins 0.000 title abstract 4
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 239000000427 antigen Substances 0.000 title abstract 3
- 102000036639 antigens Human genes 0.000 title abstract 3
- 108091007433 antigens Proteins 0.000 title abstract 3
- 241000700605 Viruses Species 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 210000000987 immune system Anatomy 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001184—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
- A61K39/001188—NY-ESO
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6075—Viral proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/36011—Togaviridae
- C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
- C12N2770/36134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
Abstract
La presente invención se refiere a proteínas de fusión que comprenden una o más glicoproteínas de la superficie del virus alfa modificado y uno o más antígenos específicos del tumor. También se describen proteínas de fusión que comprenden una o más glicoproteínas de la superficie del virus alfa modificado y uno o más antígenos virales específicos. También se describen proteínas de fusión que comprenden una o más glicoproteínas de la superficie del virus alfa modificado. También se refiere a métodos para activar el sistema inmune en pacientes con cáncer para infiltrar y eliminar células tumorales o células infectadas con un virus latente. La presente descripción proporciona una tecnología de plataforma que estimula una respuesta inmune más rápida, más amplia y más fuerte usando las proteínas de fusión.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562134933P | 2015-03-18 | 2015-03-18 | |
PCT/US2016/023203 WO2016149643A2 (en) | 2015-03-18 | 2016-03-18 | Fusion proteins comprising modified alpha virus surface glycoproteins and tumor associated antigen and methods thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2017011732A true MX2017011732A (es) | 2018-08-15 |
Family
ID=56919485
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2017011732A MX2017011732A (es) | 2015-03-18 | 2016-03-18 | Proteínas de fusión que comprenden glicoproteínas de la superficie del virus alfa modificado y antígeno asociado al tumor y métodos de los mismos. |
Country Status (12)
Country | Link |
---|---|
US (3) | US10660948B2 (es) |
EP (1) | EP3270958A4 (es) |
JP (1) | JP6921053B2 (es) |
KR (1) | KR20170121301A (es) |
CN (2) | CN114262380A (es) |
AU (2) | AU2016232771B2 (es) |
BR (1) | BR112017019776B1 (es) |
CA (1) | CA2979697A1 (es) |
HK (1) | HK1248610A1 (es) |
MX (1) | MX2017011732A (es) |
RU (1) | RU2017132190A (es) |
WO (1) | WO2016149643A2 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3270958A4 (en) * | 2015-03-18 | 2018-11-14 | Omnicyte | Fusion proteins comprising modified alpha virus surface glycoproteins and tumor associated antigen and methods thereof |
WO2018161092A1 (en) * | 2017-03-03 | 2018-09-07 | New York University | Induction and enhancement of antitumor immunity involving virus vectors expressing multiple epitopes of tumor associated antigens and immune checkpoint inhibitors or proteins |
CN110856724B (zh) * | 2018-08-24 | 2022-05-27 | 杭州康万达医药科技有限公司 | 包含核酸及car修饰的免疫细胞的治疗剂及其应用 |
JP7457037B2 (ja) * | 2019-05-31 | 2024-03-27 | 広州威溶特医薬科技有限公司 | M1ウイルス変異体及びその使用 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5726288A (en) * | 1989-11-13 | 1998-03-10 | Massachusetts Institute Of Technology | Localization and characterization of the Wilms' tumor gene |
AU8762991A (en) * | 1990-09-26 | 1992-04-15 | Bristol-Myers Squibb Company | Human papilloma viral protein expression for use in vaccine compositions |
AUPN015794A0 (en) | 1994-12-20 | 1995-01-19 | Csl Limited | Variants of human papilloma virus antigens |
CA2298840A1 (en) * | 1997-08-05 | 1999-02-18 | Stressgen Biotechnologies Corporation | Immune responses against hpv antigens elicited by compositions comprising an hpv antigen and a stress protein or an expression vector capable of expression of these proteins |
US6168932B1 (en) * | 1998-07-13 | 2001-01-02 | Parker Hughes Institute | Recombinant DTctGMCSF fusion toxin in a baculovirus expression vector system |
US6992174B2 (en) * | 2001-03-30 | 2006-01-31 | Emd Lexigen Research Center Corp. | Reducing the immunogenicity of fusion proteins |
US20050130259A1 (en) * | 2002-06-25 | 2005-06-16 | Akira Ideno | Expression vector, host, fused protein, process for producing fused protein and process for producing protein |
MXPA05002455A (es) | 2002-09-06 | 2005-06-03 | Mannkind Corp | Secuencias de epitopes. |
US20080026077A1 (en) * | 2002-11-12 | 2008-01-31 | John Hilfinger | Methods and compositions of gene delivery agents for systemic and local therapy |
CN100528230C (zh) * | 2003-02-19 | 2009-08-19 | 台桂香 | 重组人muc1-mbp融合蛋白抗肿瘤疫苗及生产工艺 |
CA2558811A1 (en) * | 2004-03-08 | 2005-09-22 | Zymogenetics, Inc. | Dimeric fusion proteins and materials and methods for producing them |
CN100342017C (zh) * | 2004-05-10 | 2007-10-10 | 中国医学科学院肿瘤医院肿瘤研究所 | 基因重组趋化抗原疫苗 |
WO2007046839A2 (en) * | 2005-02-15 | 2007-04-26 | University Of North Carolina At Chapel Hill | New live virus vaccines |
ES2373055T3 (es) | 2005-08-09 | 2012-01-31 | Oncotherapy Science, Inc. | Péptido antígeno de rechazo de cáncer derivado de glipican-3 (gpc3) para uso en pacientes positivos a la hla-a2 y producto farmacéutico que comprende el antígeno. |
JP5137168B2 (ja) | 2006-02-27 | 2013-02-06 | 独立行政法人科学技術振興機構 | 安定同位体標識脂肪族アミノ酸、その標的蛋白質への組み込み方法並びに蛋白質のnmr構造解析方法 |
DK2456786T4 (en) * | 2009-07-24 | 2017-08-07 | Immune Design Corp | LENTIVIRUS VECTORS DETERMINED PSEUDOTYPE WITH A COAT PEGYCLOPROTEIN FROM SINDBIS VIRUS |
KR20120052352A (ko) | 2009-08-07 | 2012-05-23 | 트랜스진 에스.에이. | Hbv 감염을 치료하는 조성물 |
EP2675473A1 (en) * | 2011-02-15 | 2013-12-25 | Immune Design Corp. | Methods for enhancing immunogen specific immune responses by vectored vaccines |
EP3632463A1 (en) * | 2011-04-08 | 2020-04-08 | Immune Design Corp. | Immunogenic compositions and methods of using the compositions for inducing humoral and cellular immune responses |
US9637532B2 (en) * | 2013-07-12 | 2017-05-02 | Vlp Therapeutics, Llc | Virus like particle comprising PD-1 antigen or PD-1 ligand antigen |
EP3270958A4 (en) * | 2015-03-18 | 2018-11-14 | Omnicyte | Fusion proteins comprising modified alpha virus surface glycoproteins and tumor associated antigen and methods thereof |
-
2016
- 2016-03-18 EP EP16765844.2A patent/EP3270958A4/en active Pending
- 2016-03-18 CA CA2979697A patent/CA2979697A1/en active Pending
- 2016-03-18 JP JP2018500274A patent/JP6921053B2/ja active Active
- 2016-03-18 CN CN202111226887.2A patent/CN114262380A/zh active Pending
- 2016-03-18 RU RU2017132190A patent/RU2017132190A/ru not_active Application Discontinuation
- 2016-03-18 MX MX2017011732A patent/MX2017011732A/es unknown
- 2016-03-18 AU AU2016232771A patent/AU2016232771B2/en active Active
- 2016-03-18 CN CN201680022074.2A patent/CN107530410B/zh active Active
- 2016-03-18 BR BR112017019776-6A patent/BR112017019776B1/pt active IP Right Grant
- 2016-03-18 US US15/558,918 patent/US10660948B2/en active Active
- 2016-03-18 KR KR1020177029941A patent/KR20170121301A/ko unknown
- 2016-03-18 WO PCT/US2016/023203 patent/WO2016149643A2/en active Application Filing
-
2018
- 2018-07-04 HK HK18108646.1A patent/HK1248610A1/zh unknown
-
2020
- 2020-04-09 US US16/844,271 patent/US11471518B2/en active Active
-
2021
- 2021-11-16 AU AU2021269306A patent/AU2021269306A1/en active Pending
-
2022
- 2022-10-13 US US18/046,267 patent/US20230181706A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CA2979697A1 (en) | 2016-09-22 |
US20180243389A1 (en) | 2018-08-30 |
EP3270958A2 (en) | 2018-01-24 |
US20230181706A1 (en) | 2023-06-15 |
JP2018509937A (ja) | 2018-04-12 |
BR112017019776B1 (pt) | 2020-07-28 |
AU2016232771B2 (en) | 2021-08-19 |
WO2016149643A2 (en) | 2016-09-22 |
KR20170121301A (ko) | 2017-11-01 |
US11471518B2 (en) | 2022-10-18 |
JP6921053B2 (ja) | 2021-08-18 |
CN114262380A (zh) | 2022-04-01 |
RU2017132190A (ru) | 2019-04-18 |
BR112017019776A2 (pt) | 2018-05-22 |
HK1248610A1 (zh) | 2018-10-19 |
AU2016232771A1 (en) | 2017-10-05 |
EP3270958A4 (en) | 2018-11-14 |
CN107530410A (zh) | 2018-01-02 |
CN107530410B (zh) | 2021-11-09 |
US10660948B2 (en) | 2020-05-26 |
RU2017132190A3 (es) | 2019-08-30 |
AU2021269306A1 (en) | 2021-12-09 |
US20210077600A1 (en) | 2021-03-18 |
WO2016149643A3 (en) | 2016-12-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2022000012A (es) | Prediccion de epitopos de celulas t utiles para vacunacion. | |
MX2022006006A (es) | Proteinas de fusion inmunomoduladoras y usos de las mismas. | |
WO2018098365A3 (en) | Compositions and methods for tcr reprogramming using fusion proteins | |
MX2021014448A (es) | Modulacion de celulas mieloides estimulantes y no estimulantes. | |
MX2021006931A (es) | Antigenos del virus de la inmunodeficiencia humana, vectores, composiciones y metodos de uso de estos. | |
MX2017000838A (es) | Cepa de listeria recombinante que expresa proteinas de fusion con antigenos heterologos y metodos para el uso de estas. | |
EP3258967A4 (en) | Bivalent antibody directed against nkg2d and tumor associated antigens | |
EP4321171A3 (en) | Sirp alpha-antibody fusion proteins | |
MX2018004503A (es) | Receptores de antigeno quimerico anti-cd30. | |
SG10201903349YA (en) | Recombinant listeria vaccine strains and methods of using the same in cancer immunotherapy | |
MX2017011732A (es) | Proteínas de fusión que comprenden glicoproteínas de la superficie del virus alfa modificado y antígeno asociado al tumor y métodos de los mismos. | |
EA201891124A3 (ru) | Новые мукозные адъюванты и системы доставки | |
MX2017014397A (es) | Anticuerpos anti-receptor neonatal de fragmento cristalizable(fcrn). | |
AU2015255979B2 (en) | Using B-cell-targeting antigen IgG fusion as tolerogenic protein therapy for treating adverse immune responses | |
MX2019000215A (es) | Composiciones inmunogenicas a base de listeria que comprenden antigenos de proteinas del tumor de wilms y metodos para su uso. | |
ZA202206809B (en) | Hiv vaccines comprising one or more population episensus antigens | |
MX2017011991A (es) | Terapia virica con una combinacion de anticuerpos. | |
MX2021001883A (es) | Virus recombinantes del mixoma y usos de los mismos. | |
WO2016116905A9 (en) | Cmv antigens and uses thereof | |
WO2016077789A8 (en) | Neutralizing antibodies to ebola virus glycoprotein and their use | |
MX2017012867A (es) | Composiciones terapeuticas y metodos de uso para tratar el cancer. | |
WO2016191641A3 (en) | Methods for enhancing antigen-specific immune responses using combination therapy comprising papillomavirus capsid antigens | |
MX2016014868A (es) | Metodos para secar por congelacion y rehidratar productos biologicos. | |
SG11202008589TA (en) | Oncolytic vaccinia virus expressing immune checkpoint blockade for cancer immunotherapy | |
MX2018013685A (es) | Terapia de combinacion de cebadadura:refuerzo. |