JP2005512518A5 - - Google Patents

Info

Publication number

JP2005512518A5

JP2005512518A5 JP2003532534A JP2003532534A JP2005512518A5 JP 2005512518 A5 JP2005512518 A5 JP 2005512518A5 JP 2003532534 A JP2003532534 A JP 2003532534A JP 2003532534 A JP2003532534 A JP 2003532534A JP 2005512518 A5 JP2005512518 A5 JP 2005512518A5

Authority

JP

Japan

Prior art keywords

heat shock

shock protein

protein fragment

fragment

adjuvant

Prior art date

2002-10-03

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

• Espacenet
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• 108010004889 Heat-Shock Proteins Proteins 0.000 claims 29
• 102000002812 Heat-Shock Proteins Human genes 0.000 claims 29
• 239000012634 fragment Substances 0.000 claims 29
• 102000004196 processed proteins & peptides Human genes 0.000 claims 7
• 108090000765 processed proteins & peptides Proteins 0.000 claims 7
• 239000002671 adjuvant Substances 0.000 claims 6
• 125000000539 amino acid group Chemical group 0.000 claims 6
• 102000004127 Cytokines Human genes 0.000 claims 5
• 108090000695 Cytokines Proteins 0.000 claims 5
• 239000003814 drug Substances 0.000 claims 5
• 108700009457 Mycobacterium tuberculosis HSP70 Proteins 0.000 claims 4
• 229940079593 drug Drugs 0.000 claims 4
• 238000004519 manufacturing process Methods 0.000 claims 4
• 229920001184 polypeptide Polymers 0.000 claims 4
• 102000001902 CC Chemokines Human genes 0.000 claims 3
• 108010040471 CC Chemokines Proteins 0.000 claims 3
• 101710163595 Chaperone protein DnaK Proteins 0.000 claims 3
• 101710178376 Heat shock 70 kDa protein Proteins 0.000 claims 3
• 101710152018 Heat shock cognate 70 kDa protein Proteins 0.000 claims 3
• 210000004027 cell Anatomy 0.000 claims 3
• 201000010099 disease Diseases 0.000 claims 3
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
• 108020004707 nucleic acids Proteins 0.000 claims 3
• 102000039446 nucleic acids Human genes 0.000 claims 3
• 150000007523 nucleic acids Chemical class 0.000 claims 3
• 229960005486 vaccine Drugs 0.000 claims 3
• MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 2
• 108020004414 DNA Proteins 0.000 claims 2
• 102000053602 DNA Human genes 0.000 claims 2
• 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 2
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 2
• 208000036142 Viral infection Diseases 0.000 claims 2
• 210000004899 c-terminal region Anatomy 0.000 claims 2
• 239000003795 chemical substances by application Substances 0.000 claims 2
• 201000007294 immune system cancer Diseases 0.000 claims 2
• 208000026278 immune system disease Diseases 0.000 claims 2
• 208000015181 infectious disease Diseases 0.000 claims 2
• 230000000813 microbial effect Effects 0.000 claims 2
• 230000035939 shock Effects 0.000 claims 2
• 230000009385 viral infection Effects 0.000 claims 2
• 101150013553 CD40 gene Proteins 0.000 claims 1
• 102000001327 Chemokine CCL5 Human genes 0.000 claims 1
• 108010055166 Chemokine CCL5 Proteins 0.000 claims 1
• 102000019034 Chemokines Human genes 0.000 claims 1
• 108010012236 Chemokines Proteins 0.000 claims 1
• 229940033330 HIV vaccine Drugs 0.000 claims 1
• 102000015696 Interleukins Human genes 0.000 claims 1
• 108010063738 Interleukins Proteins 0.000 claims 1
• 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims 1
• 230000036436 anti-hiv Effects 0.000 claims 1
• 239000000427 antigen Substances 0.000 claims 1
• 102000036639 antigens Human genes 0.000 claims 1
• 108091007433 antigens Proteins 0.000 claims 1
• -1 carrier Substances 0.000 claims 1
• 230000006806 disease prevention Effects 0.000 claims 1
• 230000028993 immune response Effects 0.000 claims 1
• 230000002163 immunogen Effects 0.000 claims 1
• 238000000338 in vitro Methods 0.000 claims 1
• 229940047122 interleukins Drugs 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 102000004169 proteins and genes Human genes 0.000 claims 1
• 108090000623 proteins and genes Proteins 0.000 claims 1
• 230000004044 response Effects 0.000 claims 1