JP2019506175A5 - - Google Patents

Info

Publication number

JP2019506175A5

JP2019506175A5 JP2018544819A JP2018544819A JP2019506175A5 JP 2019506175 A5 JP2019506175 A5 JP 2019506175A5 JP 2018544819 A JP2018544819 A JP 2018544819A JP 2018544819 A JP2018544819 A JP 2018544819A JP 2019506175 A5 JP2019506175 A5 JP 2019506175A5

Authority

JP

Japan

Prior art keywords

seq

signal peptide

nucleic acid

ige signal

fragment

Prior art date

2017-02-24

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 108010076504 Protein Sorting Signals Proteins 0.000 claims description 72
• 150000007523 nucleic acids Chemical class 0.000 claims description 66
• 108020004707 nucleic acids Proteins 0.000 claims description 64
• 102000039446 nucleic acids Human genes 0.000 claims description 64
• 239000012634 fragment Substances 0.000 claims description 51
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 44
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 24
• 239000000427 antigen Substances 0.000 claims description 17
• 102000036639 antigens Human genes 0.000 claims description 17
• 108091007433 antigens Proteins 0.000 claims description 17
• 241000282994 Cervidae Species 0.000 claims description 16
• 150000001413 amino acids Chemical class 0.000 claims description 12
• 230000028993 immune response Effects 0.000 claims description 6
• 239000013612 plasmid Substances 0.000 claims description 6
• 241000907316 Zika virus Species 0.000 claims description 5
• 230000001939 inductive effect Effects 0.000 claims description 3
• 108091028043 Nucleic acid sequence Proteins 0.000 claims description 2
• 238000001962 electrophoresis Methods 0.000 claims description 2
• 102000004169 proteins and genes Human genes 0.000 claims description 2
• 108090000623 proteins and genes Proteins 0.000 claims description 2
• 208000036142 Viral infection Diseases 0.000 claims 1
• 241000700605 Viruses Species 0.000 claims 1
• 230000009385 viral infection Effects 0.000 claims 1
• 238000000034 method Methods 0.000 description 5
• 108020004414 DNA Proteins 0.000 description 4
• 241000124008 Mammalia Species 0.000 description 4
• VZQHRKZCAZCACO-PYJNHQTQSA-N (2s)-2-[[(2s)-2-[2-[[(2s)-2-[[(2s)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]prop-2-enoylamino]-3-methylbutanoyl]amino]propanoic acid Chemical compound OC(=O)[C@H](C)NC(=O)[C@H](C(C)C)NC(=O)C(=C)NC(=O)[C@H](C)NC(=O)[C@@H](N)CCCNC(N)=N VZQHRKZCAZCACO-PYJNHQTQSA-N 0.000 description 3
• 229960005486 vaccine Drugs 0.000 description 2
• 241001465754 Metazoa Species 0.000 description 1
• 208000001455 Zika Virus Infection Diseases 0.000 description 1
• 208000035332 Zika virus disease Diseases 0.000 description 1
• 208000020329 Zika virus infectious disease Diseases 0.000 description 1