JP2004501618A5 - - Google Patents
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- Publication number
- JP2004501618A5 JP2004501618A5 JP2002504289A JP2002504289A JP2004501618A5 JP 2004501618 A5 JP2004501618 A5 JP 2004501618A5 JP 2002504289 A JP2002504289 A JP 2002504289A JP 2002504289 A JP2002504289 A JP 2002504289A JP 2004501618 A5 JP2004501618 A5 JP 2004501618A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- acid sequence
- polypeptide
- seq
- isolated polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 description 29
- 102000004196 processed proteins & peptides Human genes 0.000 description 29
- 108090000765 processed proteins & peptides Proteins 0.000 description 29
- 125000003275 alpha amino acid group Chemical group 0.000 description 21
- 241000193998 Streptococcus pneumoniae Species 0.000 description 5
- 239000012634 fragment Substances 0.000 description 5
- 230000028993 immune response Effects 0.000 description 5
- 102000040430 polynucleotide Human genes 0.000 description 5
- 108091033319 polynucleotide Proteins 0.000 description 5
- 239000002157 polynucleotide Substances 0.000 description 5
- 229940031000 streptococcus pneumoniae Drugs 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 4
- 229960005486 vaccine Drugs 0.000 description 4
- 241000194017 Streptococcus Species 0.000 description 3
- 239000013604 expression vector Substances 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 230000000069 prophylactic effect Effects 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21268300P | 2000-06-20 | 2000-06-20 | |
| US60/212,683 | 2000-06-20 | ||
| PCT/CA2001/000908 WO2001098334A2 (en) | 2000-06-20 | 2001-06-19 | Streptococcus antigens |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012117846A Division JP5889103B2 (ja) | 2000-06-20 | 2012-05-23 | ストレプトコッカス抗原 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004501618A JP2004501618A (ja) | 2004-01-22 |
| JP2004501618A5 true JP2004501618A5 (enExample) | 2008-08-07 |
| JP5051959B2 JP5051959B2 (ja) | 2012-10-17 |
Family
ID=22792041
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002504289A Expired - Fee Related JP5051959B2 (ja) | 2000-06-20 | 2001-06-19 | ストレプトコッカス抗原 |
| JP2012117846A Expired - Fee Related JP5889103B2 (ja) | 2000-06-20 | 2012-05-23 | ストレプトコッカス抗原 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012117846A Expired - Fee Related JP5889103B2 (ja) | 2000-06-20 | 2012-05-23 | ストレプトコッカス抗原 |
Country Status (18)
| Country | Link |
|---|---|
| EP (2) | EP1303612A2 (enExample) |
| JP (2) | JP5051959B2 (enExample) |
| KR (1) | KR100927767B1 (enExample) |
| CN (2) | CN101260149B (enExample) |
| AR (1) | AR033980A1 (enExample) |
| AU (2) | AU7038101A (enExample) |
| CA (1) | CA2413450C (enExample) |
| CZ (1) | CZ2003154A3 (enExample) |
| EA (1) | EA006232B1 (enExample) |
| HU (1) | HU228706B1 (enExample) |
| IL (2) | IL153558A0 (enExample) |
| MX (1) | MXPA03000103A (enExample) |
| NO (1) | NO331103B1 (enExample) |
| NZ (1) | NZ553554A (enExample) |
| PL (1) | PL214229B1 (enExample) |
| TR (1) | TR200704553T2 (enExample) |
| UY (1) | UY26783A1 (enExample) |
| WO (1) | WO2001098334A2 (enExample) |
Families Citing this family (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7128918B1 (en) | 1998-12-23 | 2006-10-31 | Id Biomedical Corporation | Streptococcus antigens |
| US7074415B2 (en) | 2000-06-20 | 2006-07-11 | Id Biomedical Corporation | Streptococcus antigens |
| WO2003054007A2 (en) * | 2001-12-20 | 2003-07-03 | Shire Biochem Inc. | Streptococcus antigens |
| TWI457133B (zh) | 2005-12-13 | 2014-10-21 | Glaxosmithkline Biolog Sa | 新穎組合物 |
| AR058592A1 (es) | 2005-12-22 | 2008-02-13 | Glaxosmithkline Biolog Sa | Vacuna |
| GB0607088D0 (en) | 2006-04-07 | 2006-05-17 | Glaxosmithkline Biolog Sa | Vaccine |
| KR20090057423A (ko) | 2006-09-07 | 2009-06-05 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 백신 |
| TW200914042A (en) | 2007-05-02 | 2009-04-01 | Glaxosmithkline Biolog Sa | Vaccine |
| WO2009000824A2 (en) | 2007-06-26 | 2008-12-31 | Glaxosmithkline Biologicals S.A. | Vaccine comprising streptococcus pneumoniae capsular polysaccharide conjugates |
| US8337846B2 (en) * | 2007-07-23 | 2012-12-25 | Sanofi Pasteur Limited | Immunogenic polypeptides and monoclonal antibodies |
| PL2271360T3 (pl) | 2008-04-16 | 2016-03-31 | Glaxosmithkline Biologicals Sa | Szczepionka |
| CA2738245A1 (en) | 2008-09-26 | 2010-04-01 | Nanobio Corporation | Nanoemulsion therapeutic compositions and methods of using the same |
| ES2552153T3 (es) | 2009-04-30 | 2015-11-26 | Coley Pharmaceutical Group, Inc. | Vacuna neumocócica y usos de la misma |
| US8668911B2 (en) | 2009-05-14 | 2014-03-11 | The Regents Of The University Of Michigan | Streptococcus vaccine compositions and methods of using the same |
| US20120135037A1 (en) | 2009-06-01 | 2012-05-31 | Mizel Steven B | Flagellin fusion proteins and conjugates comprising pneumococcus antigens and methods of using the same |
| AU2010290931B2 (en) | 2009-09-03 | 2014-02-06 | Pfizer Vaccines Llc | PCSK9 vaccine |
| GB201003924D0 (en) | 2010-03-09 | 2010-04-21 | Glaxosmithkline Biolog Sa | Immunogenic composition |
| GB201003920D0 (en) | 2010-03-09 | 2010-04-21 | Glaxosmithkline Biolog Sa | Method of treatment |
| KR101272351B1 (ko) | 2010-04-23 | 2013-06-07 | 이화여자대학교 산학협력단 | 새로운 카나마이신 화합물, 카나마이신 생산 스트렙토마이세스 속 미생물 및 카나마이신의 생산 방법 |
| EP2680883B1 (en) | 2011-03-02 | 2018-09-05 | Pfizer Inc | Pcsk9 vaccine |
| UY34073A (es) | 2011-05-17 | 2013-01-03 | Glaxosmithkline Biolog Sa | Vacuna mejorada de streptococcus pneumoniae y métodos de preparación. |
| US11708411B2 (en) | 2013-12-20 | 2023-07-25 | Wake Forest University Health Sciences | Methods and compositions for increasing protective antibody levels induced by pneumococcal polysaccharide vaccines |
| ES2965616T3 (es) | 2014-01-21 | 2024-04-16 | Pfizer | Polisacáridos capsulares de Streptococcus pneumoniae y conjugados de los mismos |
| US11160855B2 (en) | 2014-01-21 | 2021-11-02 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| JP6612260B2 (ja) | 2014-01-21 | 2019-11-27 | ファイザー・インク | 肺炎連鎖球菌（Ｓｔｒｅｐｔｏｃｏｃｃｕｓ ｐｎｅｕｍｏｎｉａｅ）莢膜多糖およびそのコンジュゲート |
| CA3170344C (en) | 2014-01-21 | 2023-08-29 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| EP3104886B1 (en) | 2014-02-14 | 2018-10-17 | Pfizer Inc | Immunogenic glycoprotein conjugates |
| IL252915B2 (en) | 2015-01-15 | 2024-04-01 | Pfizer | Immunogenic compositions for use in pneumococcal vaccines |
| TWI720448B (zh) | 2015-07-21 | 2021-03-01 | 美商輝瑞股份有限公司 | 包含經共軛之莢膜糖抗原的致免疫性組成物、包含該致免疫性組成物之套組及彼等之用途 |
| GB201518684D0 (en) | 2015-10-21 | 2015-12-02 | Glaxosmithkline Biolog Sa | Vaccine |
| CA3005524C (en) | 2015-11-20 | 2023-10-10 | Pfizer Inc. | Immunogenic compositions for use in pneumococcal vaccines |
| KR102459629B1 (ko) | 2017-01-20 | 2022-10-28 | 화이자 인코포레이티드 | 폐렴구균 백신에 사용하기 위한 면역원성 조성물 |
| EP3576784B1 (en) | 2017-01-31 | 2025-09-24 | Merck Sharp & Dohme LLC | Methods for making polysaccharide-protein conjugates |
| US20200222550A1 (en) | 2017-01-31 | 2020-07-16 | Merck Sharp & Dohme Corp. | Methods for production of capsular polysaccharide protein conjugates from streptococcus pneumoniae serotype 19f |
| FI3585803T3 (fi) | 2017-02-24 | 2025-12-19 | Merck Sharp & Dohme Llc | Pneumokokkikonjugaattirokotteen formulaatioita |
| EP4520325A1 (en) | 2017-09-07 | 2025-03-12 | Merck Sharp & Dohme LLC | Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates |
| GEAP202215382A (en) | 2017-12-06 | 2022-06-10 | Merck Sharp & Dohme Llc | Compositions comprising streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof |
| US11260119B2 (en) | 2018-08-24 | 2022-03-01 | Pfizer Inc. | Escherichia coli compositions and methods thereof |
| JP7585203B2 (ja) | 2018-12-12 | 2024-11-18 | ファイザー・インク | 免疫原性多重ヘテロ抗原多糖－タンパク質コンジュゲートおよびその使用 |
| US20220296695A1 (en) | 2018-12-19 | 2022-09-22 | Merck Sharp & Dohme Corp. | Compositions comprising streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof |
| JP7239509B6 (ja) | 2019-02-22 | 2023-03-28 | ファイザー・インク | 細菌多糖類を精製するための方法 |
| CA3136278A1 (en) | 2019-04-10 | 2020-10-15 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens, kits comprising the same and uses thereof |
| MX2022001241A (es) | 2019-07-31 | 2022-04-20 | Sanofi Pasteur Inc | Composiciones de conjugados neumococicos multivalentes polisacarido - proteina y metodos para usar los mismos. |
| KR20220092572A (ko) | 2019-11-01 | 2022-07-01 | 화이자 인코포레이티드 | 에스케리키아 콜라이 조성물 및 그 방법 |
| KR20220144393A (ko) | 2020-02-21 | 2022-10-26 | 화이자 인코포레이티드 | 당류의 정제 |
| JP2023514697A (ja) | 2020-02-23 | 2023-04-07 | ファイザー・インク | 大腸菌組成物およびその方法 |
| JP2023546446A (ja) | 2020-10-22 | 2023-11-02 | ファイザー・インク | 細菌多糖を精製する方法 |
| US12138302B2 (en) | 2020-10-27 | 2024-11-12 | Pfizer Inc. | Escherichia coli compositions and methods thereof |
| TW202227467A (zh) | 2020-10-27 | 2022-07-16 | 美商輝瑞大藥廠 | 大腸桿菌組合物及其方法 |
| CN116744965A (zh) | 2020-11-04 | 2023-09-12 | 辉瑞大药厂 | 用于肺炎球菌疫苗的免疫原性组合物 |
| US12357681B2 (en) | 2020-12-23 | 2025-07-15 | Pfizer Inc. | E. coli FimH mutants and uses thereof |
| TW202245835A (zh) | 2021-02-04 | 2022-12-01 | 美商默沙東有限責任公司 | 用於肺炎球菌結合物疫苗之奈米乳化液佐劑組合物 |
| EP4333879A1 (en) | 2021-05-03 | 2024-03-13 | Pfizer Inc. | Vaccination against bacterial and betacoronavirus infections |
| WO2022234416A1 (en) | 2021-05-03 | 2022-11-10 | Pfizer Inc. | Vaccination against pneumoccocal and covid-19 infections |
| US20220387576A1 (en) | 2021-05-28 | 2022-12-08 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| MX2023013434A (es) | 2021-05-28 | 2023-12-12 | Pfizer | Composiciones inmunogenas que comprenden antigenos de sacarido capsular conjugados y sus usos. |
| CA3247998A1 (en) | 2022-01-13 | 2023-07-20 | Pfizer Inc. | Immunogenic compositions based on conjugated capsular saccharidic antigens and their uses |
| US20250163484A1 (en) | 2022-02-25 | 2025-05-22 | Pfizer Inc. | Methods for Incorporating Azido Groups in Bacterial Capsular Polysaccharides |
| KR20250008122A (ko) | 2022-05-11 | 2025-01-14 | 화이자 인코포레이티드 | 보존제를 갖는 백신 제형의 제조 방법 |
| WO2024084397A1 (en) | 2022-10-19 | 2024-04-25 | Pfizer Inc. | Vaccination against pneumoccocal and covid-19 infections |
| WO2024110827A1 (en) | 2022-11-21 | 2024-05-30 | Pfizer Inc. | Methods for preparing conjugated capsular saccharide antigens and uses thereof |
| IL321062A (en) | 2022-11-22 | 2025-07-01 | Pfizer | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| EP4626405A1 (en) | 2022-12-01 | 2025-10-08 | Pfizer Inc. | Pneumococcal conjugate vaccine formulations |
| WO2024166008A1 (en) | 2023-02-10 | 2024-08-15 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| WO2024201324A2 (en) | 2023-03-30 | 2024-10-03 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| AU2024255922A1 (en) | 2023-04-14 | 2025-10-30 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| WO2024224266A1 (en) | 2023-04-24 | 2024-10-31 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| AR132702A1 (es) | 2023-05-18 | 2025-07-23 | Merck Sharp & Dohme Llc | Compuestos y formulaciones adyuvantes útiles en vacunas neumocócicas |
| CN121263203A (zh) | 2023-05-19 | 2026-01-02 | 葛兰素史克生物有限公司 | 诱导对呼吸道合胞病毒和肺炎链球菌感染的免疫反应的方法 |
| TW202527906A (zh) | 2023-09-14 | 2025-07-16 | 美商輝瑞股份有限公司 | 包含經結合之肺炎鏈球菌莢膜醣抗原之佐劑化致免疫性組成物及其用途 |
| WO2025106603A1 (en) | 2023-11-16 | 2025-05-22 | Merck Sharp & Dohme Llc | Peptide conjugate vaccine compositions and methods for the treatment of alzheimer's disease |
| WO2025133971A1 (en) | 2023-12-23 | 2025-06-26 | Pfizer Inc. | Improved methods for producing bacterial capsular saccharide glycoconjugates |
| WO2025186705A2 (en) | 2024-03-06 | 2025-09-12 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| WO2025191415A1 (en) | 2024-03-11 | 2025-09-18 | Pfizer Inc. | Immunogenic compositions comprising conjugated escherichia coli saccharides and uses thereof |
| WO2025219908A2 (en) | 2024-04-19 | 2025-10-23 | Pfizer Inc. | Media and fermentation methods for polysaccharide production in bacterial cell culture |
| WO2025219904A1 (en) | 2024-04-19 | 2025-10-23 | Pfizer Inc. | Improved methods for producing glycoconjugates by reductive amination in aprotic solvent |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4425437A (en) | 1979-11-05 | 1984-01-10 | Genentech, Inc. | Microbial polypeptide expression vehicle |
| US4431739A (en) | 1979-11-05 | 1984-02-14 | Genentech, Inc. | Transformant bacterial culture capable of expressing heterologous protein |
| US4338397A (en) | 1980-04-11 | 1982-07-06 | President And Fellows Of Harvard College | Mature protein synthesis |
| US5866135A (en) * | 1994-04-21 | 1999-02-02 | North American Vaccine, Inc. | Group A streptococcal polysaccharide immunogenic compositions and methods |
| CZ327897A3 (cs) * | 1995-06-07 | 1998-02-18 | Alberta Research Council | Imunogenní a imunostimulační oligosacharidové kompozice, způsoby jejich přípravy a použití |
| US6420135B1 (en) * | 1996-10-31 | 2002-07-16 | Human Genome Sciences, Inc. | Streptococcus pneumoniae polynucleotides and sequences |
| AU9510598A (en) * | 1997-09-24 | 1999-04-12 | American Cyanamid Company | Human complement c3-degrading proteinase from (streptococcus pneumoniae) |
| JP2002531055A (ja) * | 1998-07-27 | 2002-09-24 | マイクロビアル テクニクス リミティッド | 肺炎連鎖球菌のタンパク質及び核酸分子 |
| DE69941574D1 (de) * | 1998-08-19 | 2009-12-03 | Baxter Healthcare Sa | Immunogenes beta-propionamido-gebundenes polysaccharid-protein konjugat geeignet als impfstoff und hergestellt bei verwendung von n-acryloyliertem polysaccharid |
| WO2000017370A1 (en) * | 1998-09-24 | 2000-03-30 | Regents Of The University Of Minnesota | HUMAN COMPLEMENT C3-DEGRADING POLYPEPTIDE FROM $i(STREPTOCOCCUS PNEUMONIAE) |
| CA2355364C (en) * | 1998-12-21 | 2014-03-18 | Medimmune, Inc. | Streptococcus pneumoniae proteins and immunogenic fragments for vaccines |
| OA11736A (en) * | 1998-12-23 | 2005-06-12 | Shire Biochem Inc | Novel streptococcus antigens. |
-
2001
- 2001-06-19 WO PCT/CA2001/000908 patent/WO2001098334A2/en not_active Ceased
- 2001-06-19 EA EA200201280A patent/EA006232B1/ru not_active IP Right Cessation
- 2001-06-19 TR TR2007/04553T patent/TR200704553T2/xx unknown
- 2001-06-19 MX MXPA03000103A patent/MXPA03000103A/es active IP Right Grant
- 2001-06-19 IL IL15355801A patent/IL153558A0/xx unknown
- 2001-06-19 KR KR1020027017453A patent/KR100927767B1/ko not_active Expired - Fee Related
- 2001-06-19 NZ NZ553554A patent/NZ553554A/en not_active IP Right Cessation
- 2001-06-19 AU AU7038101A patent/AU7038101A/xx not_active Withdrawn
- 2001-06-19 EP EP01949136A patent/EP1303612A2/en not_active Withdrawn
- 2001-06-19 HU HU0301656A patent/HU228706B1/hu not_active IP Right Cessation
- 2001-06-19 CN CN200710181645.XA patent/CN101260149B/zh not_active Expired - Fee Related
- 2001-06-19 PL PL360413A patent/PL214229B1/pl unknown
- 2001-06-19 CZ CZ2003154A patent/CZ2003154A3/cs unknown
- 2001-06-19 JP JP2002504289A patent/JP5051959B2/ja not_active Expired - Fee Related
- 2001-06-19 CA CA2413450A patent/CA2413450C/en not_active Expired - Fee Related
- 2001-06-19 CN CN01814388A patent/CN1449446A/zh active Pending
- 2001-06-19 EP EP10179497A patent/EP2281891A3/en not_active Withdrawn
- 2001-06-19 AU AU2001270381A patent/AU2001270381B2/en not_active Ceased
- 2001-06-20 AR ARP010102945A patent/AR033980A1/es not_active Application Discontinuation
- 2001-06-20 UY UY26783A patent/UY26783A1/es not_active Application Discontinuation
-
2002
- 2002-12-19 IL IL153558A patent/IL153558A/en not_active IP Right Cessation
- 2002-12-19 NO NO20026121A patent/NO331103B1/no not_active IP Right Cessation
-
2012
- 2012-05-23 JP JP2012117846A patent/JP5889103B2/ja not_active Expired - Fee Related
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