JP2002507396A5 - - Google Patents
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- Publication number
- JP2002507396A5 JP2002507396A5 JP2000532528A JP2000532528A JP2002507396A5 JP 2002507396 A5 JP2002507396 A5 JP 2002507396A5 JP 2000532528 A JP2000532528 A JP 2000532528A JP 2000532528 A JP2000532528 A JP 2000532528A JP 2002507396 A5 JP2002507396 A5 JP 2002507396A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- polynucleotide
- seq
- group
- isolated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002157 polynucleotide Substances 0.000 description 57
- 102000040430 polynucleotide Human genes 0.000 description 54
- 108091033319 polynucleotide Proteins 0.000 description 54
- 229920001184 polypeptide Polymers 0.000 description 53
- 102000004196 processed proteins & peptides Human genes 0.000 description 53
- 108090000765 processed proteins & peptides Proteins 0.000 description 53
- 230000028993 immune response Effects 0.000 description 15
- 239000012634 fragment Substances 0.000 description 14
- 241000699670 Mus sp. Species 0.000 description 12
- 208000035895 Guillain-Barré syndrome Diseases 0.000 description 11
- 241001465754 Metazoa Species 0.000 description 8
- 210000004027 cell Anatomy 0.000 description 8
- 102000004169 proteins and genes Human genes 0.000 description 7
- 108090000623 proteins and genes Proteins 0.000 description 7
- 229960005486 vaccine Drugs 0.000 description 7
- 239000002671 adjuvant Substances 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 230000003053 immunization Effects 0.000 description 5
- 238000002649 immunization Methods 0.000 description 5
- 238000002965 ELISA Methods 0.000 description 4
- 208000015181 infectious disease Diseases 0.000 description 4
- 241000283973 Oryctolagus cuniculus Species 0.000 description 3
- 230000001580 bacterial effect Effects 0.000 description 3
- 239000003085 diluting agent Substances 0.000 description 3
- 239000003937 drug carrier Substances 0.000 description 3
- 108020001507 fusion proteins Proteins 0.000 description 3
- 102000037865 fusion proteins Human genes 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 238000011321 prophylaxis Methods 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 241000588724 Escherichia coli Species 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical class O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 125000003275 alpha amino acid group Chemical group 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 238000012258 culturing Methods 0.000 description 2
- 230000000521 hyperimmunizing effect Effects 0.000 description 2
- 210000003000 inclusion body Anatomy 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 229910017119 AlPO Inorganic materials 0.000 description 1
- 239000005995 Aluminium silicate Chemical class 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 102000009016 Cholera Toxin Human genes 0.000 description 1
- 108010049048 Cholera Toxin Proteins 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241001644525 Nastus productus Species 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000007792 addition Methods 0.000 description 1
- 230000000735 allogeneic effect Effects 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000012217 deletion Methods 0.000 description 1
- 230000037430 deletion Effects 0.000 description 1
- YMCDYRGMTRCAPZ-UHFFFAOYSA-N ethyl 2-acetyl-3-oxobutanoate Chemical compound CCOC(=O)C(C(C)=O)C(C)=O YMCDYRGMTRCAPZ-UHFFFAOYSA-N 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000028996 humoral immune response Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000002163 immunogen Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000007928 intraperitoneal injection Substances 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical class O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 231100000518 lethal Toxicity 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 239000001397 quillaja saponaria molina bark Chemical class 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229930182490 saponin Chemical class 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 230000037384 skin absorption Effects 0.000 description 1
- 231100000274 skin absorption Toxicity 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- ZZIZZTHXZRDOFM-XFULWGLBSA-N tamsulosin hydrochloride Chemical compound [H+].[Cl-].CCOC1=CC=CC=C1OCCN[C@H](C)CC1=CC=C(OC)C(S(N)(=O)=O)=C1 ZZIZZTHXZRDOFM-XFULWGLBSA-N 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7542598P | 1998-02-20 | 1998-02-20 | |
| US60/075,425 | 1998-02-20 | ||
| PCT/CA1999/000114 WO1999042588A2 (en) | 1998-02-20 | 1999-02-17 | Group b streptococcus antigens |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009132976A Division JP2009242403A (ja) | 1998-02-20 | 2009-06-02 | グループｂ連鎖球菌抗原 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002507396A JP2002507396A (ja) | 2002-03-12 |
| JP2002507396A5 true JP2002507396A5 (enExample) | 2006-04-20 |
| JP4637350B2 JP4637350B2 (ja) | 2011-02-23 |
Family
ID=22125658
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000532528A Expired - Lifetime JP4637350B2 (ja) | 1998-02-20 | 1999-02-17 | グループｂ連鎖球菌抗原 |
| JP2009132976A Pending JP2009242403A (ja) | 1998-02-20 | 2009-06-02 | グループｂ連鎖球菌抗原 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009132976A Pending JP2009242403A (ja) | 1998-02-20 | 2009-06-02 | グループｂ連鎖球菌抗原 |
Country Status (22)
| Country | Link |
|---|---|
| US (4) | US20030031682A1 (enExample) |
| EP (3) | EP2280072B1 (enExample) |
| JP (2) | JP4637350B2 (enExample) |
| KR (1) | KR100771148B1 (enExample) |
| CN (2) | CN1944652A (enExample) |
| AP (1) | AP2000001886A0 (enExample) |
| AT (1) | ATE347600T1 (enExample) |
| AU (1) | AU2505999A (enExample) |
| CA (1) | CA2321106C (enExample) |
| CZ (1) | CZ301056B6 (enExample) |
| DE (1) | DE69934299T2 (enExample) |
| EA (1) | EA200000860A1 (enExample) |
| ES (2) | ES2278436T3 (enExample) |
| HU (1) | HU228497B1 (enExample) |
| ID (1) | ID27482A (enExample) |
| IL (3) | IL137921A0 (enExample) |
| NO (2) | NO330491B1 (enExample) |
| NZ (1) | NZ529854A (enExample) |
| OA (1) | OA11686A (enExample) |
| TR (1) | TR200002437T2 (enExample) |
| WO (1) | WO1999042588A2 (enExample) |
| ZA (1) | ZA991325B (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999042588A2 (en) * | 1998-02-20 | 1999-08-26 | Biochem Pharma Inc. | Group b streptococcus antigens |
| US7098182B2 (en) | 1998-07-27 | 2006-08-29 | Microbial Technics Limited | Nucleic acids and proteins from group B streptococcus |
| CA2337102A1 (en) * | 1998-07-27 | 2000-02-10 | Richard William Falla Le Page | Nucleic acids and proteins from group b streptococcus |
| GB0105922D0 (en) * | 2001-03-09 | 2001-04-25 | Microscience Ltd | Genes and proteins, and their use |
| US6812021B1 (en) | 1998-12-22 | 2004-11-02 | Microscience Limited | Genes and proteins and their use |
| US6890539B2 (en) | 1998-12-22 | 2005-05-10 | Microscience, Ltd. | Genes and proteins, and their use |
| US7128918B1 (en) | 1998-12-23 | 2006-10-31 | Id Biomedical Corporation | Streptococcus antigens |
| US6833356B1 (en) | 1999-08-25 | 2004-12-21 | Medimmune, Inc. | Pneumococcal protein homologs and fragments for vaccines |
| JP4749641B2 (ja) * | 1999-08-25 | 2011-08-17 | メディミューン，エルエルシー | ワクチン用の肺炎球菌タンパク質の相同体および断片 |
| US6833134B2 (en) | 2000-06-12 | 2004-12-21 | University Of Saskacthewan | Immunization of dairy cattle with GapC protein against Streptococcus infection |
| PT1294771E (pt) | 2000-06-12 | 2009-01-06 | Univ Saskatchewan | Proteína gapc quimérica de streptococcus e sua utilização em vacinação e diagnóstico |
| EP1734050A3 (en) * | 2000-06-12 | 2012-12-05 | University Of Saskatchewan | Immunization of dairy cattle with GapC protein against streptococcus infection |
| ES2273861T3 (es) * | 2000-06-12 | 2007-05-16 | University Of Saskatchewan | Inmunizacion de ganado vacuno lechero con proteina gapc frente a infecciones por streptococcus. |
| US6866855B2 (en) | 2000-06-12 | 2005-03-15 | University Of Saskatchewan | Immunization of dairy cattle with GapC protein against Streptococcus infection |
| AU2002210301A1 (en) | 2000-10-13 | 2002-04-22 | Shire Biochem Inc. | Bvh-a2 and bvh-a3 antigens of group b streptococcus |
| US7939087B2 (en) | 2000-10-27 | 2011-05-10 | Novartis Vaccines And Diagnostics, Inc. | Nucleic acids and proteins from Streptococcus groups A & B |
| DE60134494D1 (de) * | 2000-12-21 | 2008-07-31 | Id Biomedical Corp | Antigene aus streptococcus pyogenes und zugehörige dna-fragmente |
| FR2824074A1 (fr) * | 2001-04-26 | 2002-10-31 | Pasteur Institut | Sequence du genome streptococcus agalactiae, application au developpement de vaccins, d'outils de diagnostic, et a l'identification de cibles therapeutiques |
| ES2381967T3 (es) * | 2002-02-11 | 2012-06-04 | Id Biomedical Corporation | Antígeno de streptococcus del grupo B |
| GB0210128D0 (en) * | 2002-05-02 | 2002-06-12 | Chiron Spa | Nucleic acids and proteins from streptococcus groups A & B |
| PT1648500E (pt) | 2003-07-31 | 2014-10-10 | Novartis Vaccines & Diagnostic | Composições imunogénicas para estreptococos piogenes |
| US8945589B2 (en) | 2003-09-15 | 2015-02-03 | Novartis Vaccines And Diagnostics, Srl | Immunogenic compositions for Streptococcus agalactiae |
| US20090317420A1 (en) | 2004-07-29 | 2009-12-24 | Chiron Corporation | Immunogenic compositions for gram positive bacteria such as streptococcus agalactiae |
| US7838010B2 (en) | 2004-10-08 | 2010-11-23 | Novartis Vaccines And Diagnostics S.R.L. | Immunogenic and therapeutic compositions for Streptococcus pyogenes |
| EP1845944A4 (en) * | 2005-02-08 | 2011-07-27 | Id Biomedical Corp Of Quebec C O B As Glaxosmithkline Biolog North America | PHARMACEUTICAL COMPOSITIONS |
| GB0605247D0 (en) * | 2006-03-15 | 2006-04-26 | Chiron Srl | Compositions and methods for immunisation |
| US8287885B2 (en) | 2007-09-12 | 2012-10-16 | Novartis Ag | GAS57 mutant antigens and GAS57 antibodies |
| AU2008339551B2 (en) | 2007-12-21 | 2013-10-24 | Glaxosmithkline Biologicals S.A. | Mutant forms of streptolysin O |
| CN102304185A (zh) * | 2011-09-02 | 2012-01-04 | 黑龙江八一农垦大学 | 预防奶牛乳房炎的融合蛋白sip-trap及制备方法和应用 |
| EP2949340A1 (en) * | 2014-05-30 | 2015-12-02 | IDT Biologika GmbH | Vaccine composition against Streptococcus suis infection |
| CN115057944B (zh) * | 2022-06-24 | 2025-06-24 | 南京农业大学 | 一种针对所有gbs血清型的多表位亚单位疫苗 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4431739A (en) | 1979-11-05 | 1984-02-14 | Genentech, Inc. | Transformant bacterial culture capable of expressing heterologous protein |
| US4425437A (en) | 1979-11-05 | 1984-01-10 | Genentech, Inc. | Microbial polypeptide expression vehicle |
| US5302386A (en) | 1986-04-16 | 1994-04-12 | Brigham And Women's Hospital, Inc. | Bacterial antigens, antibodies, vaccines and methods of manufacture |
| US5472696A (en) | 1988-02-26 | 1995-12-05 | Univ. Of Florida Research Foundation, Inc. | Antigen of group B streptococci |
| US5648241A (en) * | 1989-09-15 | 1997-07-15 | The General Hospital Corporation | Conjugate vaccine against group B streptococcus |
| US5679768A (en) | 1991-02-15 | 1997-10-21 | Uab Research Foundation | Epitopic regions of pneumococcal surface protein A |
| US5225331A (en) | 1991-04-25 | 1993-07-06 | National Research Council Of Canada | Immunoassay for detecting group b streptococcus |
| WO1994021685A1 (en) | 1993-03-19 | 1994-09-29 | Gunnar Lindahl | Protein rib, a cell surface protein that confers immunity to many strains of the group b streptococcus; process for purification of the protein, reagent kit and pharmaceutical composition |
| US5595740A (en) | 1994-05-16 | 1997-01-21 | University Of Florida | Cloning of non-IgA FC binding forms of the group B streptococcal beta antigens |
| EP0754703A4 (en) * | 1994-11-01 | 1999-11-24 | Kirin Brewery | PEPTIDE SEQUENCE FORMING A MUCIN CHAIN AND TECHNIQUE FOR MODIFYING THE PROTEIN TO BE LINKED TO THE MUCIN CHAIN |
| PT942983E (pt) * | 1996-10-31 | 2007-02-28 | Human Genome Sciences Inc | Antigénios e vacinas de streptococcus pneumoniae |
| WO1999042588A2 (en) * | 1998-02-20 | 1999-08-26 | Biochem Pharma Inc. | Group b streptococcus antigens |
| US6248329B1 (en) * | 1998-06-01 | 2001-06-19 | Ramaswamy Chandrashekar | Parasitic helminth cuticlin nucleic acid molecules and uses thereof |
| CA2337102A1 (en) | 1998-07-27 | 2000-02-10 | Richard William Falla Le Page | Nucleic acids and proteins from group b streptococcus |
| DK1140157T3 (da) | 1998-12-21 | 2009-06-08 | Medimmune Inc | Streptococcus pneumoniae-proteiner og immunogene fragmenter til vacciner |
| US7128918B1 (en) * | 1998-12-23 | 2006-10-31 | Id Biomedical Corporation | Streptococcus antigens |
| WO2000039299A2 (en) | 1998-12-23 | 2000-07-06 | Shire Biochem Inc. | Streptococcus antigens |
| GB9921125D0 (en) | 1999-09-07 | 1999-11-10 | Microbial Technics Limited | Proteins |
| ES2381967T3 (es) | 2002-02-11 | 2012-06-04 | Id Biomedical Corporation | Antígeno de streptococcus del grupo B |
-
1999
- 1999-02-17 WO PCT/CA1999/000114 patent/WO1999042588A2/en not_active Ceased
- 1999-02-17 CN CNA2006100913640A patent/CN1944652A/zh active Pending
- 1999-02-17 JP JP2000532528A patent/JP4637350B2/ja not_active Expired - Lifetime
- 1999-02-17 CA CA2321106A patent/CA2321106C/en not_active Expired - Lifetime
- 1999-02-17 HU HU0102304A patent/HU228497B1/hu unknown
- 1999-02-17 OA OA1200000228A patent/OA11686A/en unknown
- 1999-02-17 ES ES99904646T patent/ES2278436T3/es not_active Expired - Lifetime
- 1999-02-17 CZ CZ20003054A patent/CZ301056B6/cs not_active IP Right Cessation
- 1999-02-17 EA EA200000860A patent/EA200000860A1/ru unknown
- 1999-02-17 EP EP10180962.2A patent/EP2280072B1/en not_active Expired - Lifetime
- 1999-02-17 AT AT99904646T patent/ATE347600T1/de not_active IP Right Cessation
- 1999-02-17 TR TR2000/02437T patent/TR200002437T2/xx unknown
- 1999-02-17 CN CNB998052485A patent/CN1268745C/zh not_active Expired - Lifetime
- 1999-02-17 AP APAP/P/2000/001886A patent/AP2000001886A0/en unknown
- 1999-02-17 ID IDW20001856A patent/ID27482A/id unknown
- 1999-02-17 ES ES10180962.2T patent/ES2540281T3/es not_active Expired - Lifetime
- 1999-02-17 EP EP20060022306 patent/EP1757697A3/en not_active Withdrawn
- 1999-02-17 AU AU25059/99A patent/AU2505999A/en not_active Abandoned
- 1999-02-17 EP EP99904646A patent/EP1054971B1/en not_active Expired - Lifetime
- 1999-02-17 DE DE69934299T patent/DE69934299T2/de not_active Expired - Lifetime
- 1999-02-17 IL IL13792199A patent/IL137921A0/xx active IP Right Grant
- 1999-02-17 KR KR1020007009237A patent/KR100771148B1/ko not_active Expired - Lifetime
- 1999-02-18 ZA ZA9901325A patent/ZA991325B/xx unknown
- 1999-02-18 US US09/252,088 patent/US20030031682A1/en active Pending
-
2000
- 2000-08-17 IL IL137921A patent/IL137921A/en not_active IP Right Cessation
- 2000-08-18 NO NO20004161A patent/NO330491B1/no not_active IP Right Cessation
-
2003
- 2003-01-13 US US10/340,792 patent/US7914794B2/en not_active Expired - Lifetime
- 2003-11-28 NZ NZ529854A patent/NZ529854A/en not_active IP Right Cessation
-
2008
- 2008-03-09 IL IL190018A patent/IL190018A/en not_active IP Right Cessation
-
2009
- 2009-06-02 JP JP2009132976A patent/JP2009242403A/ja active Pending
-
2010
- 2010-11-30 NO NO20101682A patent/NO20101682L/no not_active Application Discontinuation
- 2010-12-28 US US12/980,172 patent/US8226953B2/en not_active Expired - Fee Related
-
2012
- 2012-07-16 US US13/550,363 patent/US8580262B2/en not_active Expired - Fee Related
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