JP2002512800A5 - - Google Patents
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- Publication number
- JP2002512800A5 JP2002512800A5 JP2000546017A JP2000546017A JP2002512800A5 JP 2002512800 A5 JP2002512800 A5 JP 2002512800A5 JP 2000546017 A JP2000546017 A JP 2000546017A JP 2000546017 A JP2000546017 A JP 2000546017A JP 2002512800 A5 JP2002512800 A5 JP 2002512800A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- polypeptide
- polynucleotide
- nucleotide sequence
- isolated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 description 23
- 102000004196 processed proteins & peptides Human genes 0.000 description 23
- 108090000765 processed proteins & peptides Proteins 0.000 description 23
- 108091033319 polynucleotide Proteins 0.000 description 19
- 239000002157 polynucleotide Substances 0.000 description 19
- 102000040430 polynucleotide Human genes 0.000 description 19
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 13
- 239000002773 nucleotide Substances 0.000 description 10
- 125000003729 nucleotide group Chemical group 0.000 description 10
- 125000003275 alpha amino acid group Chemical group 0.000 description 9
- 210000004027 cell Anatomy 0.000 description 5
- 239000012634 fragment Substances 0.000 description 5
- 230000002163 immunogen Effects 0.000 description 4
- 230000000295 complement effect Effects 0.000 description 3
- 239000013604 expression vector Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 229960005486 vaccine Drugs 0.000 description 3
- 208000034762 Meningococcal Infections Diseases 0.000 description 2
- 241000588650 Neisseria meningitidis Species 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 230000028993 immune response Effects 0.000 description 2
- 108091026890 Coding region Proteins 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 108020001507 fusion proteins Proteins 0.000 description 1
- 102000037865 fusion proteins Human genes 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 238000009396 hybridization Methods 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 210000001768 subcellular fraction Anatomy 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9808866.9A GB9808866D0 (en) | 1998-04-24 | 1998-04-24 | Novel compounds |
| GB9808866.9 | 1998-04-24 | ||
| PCT/EP1999/002766 WO1999055873A2 (en) | 1998-04-24 | 1999-04-20 | Basb006 polynucleotide(s) and polypeptides from neisseria meningitis |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010044312A Division JP2010166920A (ja) | 1998-04-24 | 2010-03-01 | 髄膜炎菌由来のｂａｓｂ００６ポリヌクレオチドおよびポリペプチド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002512800A JP2002512800A (ja) | 2002-05-08 |
| JP2002512800A5 true JP2002512800A5 (enExample) | 2006-04-27 |
| JP4718009B2 JP4718009B2 (ja) | 2011-07-06 |
Family
ID=10830985
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000546017A Expired - Fee Related JP4718009B2 (ja) | 1998-04-24 | 1999-04-20 | 髄膜炎菌由来のｂａｓｂ００６ポリヌクレオチドおよびポリペプチド |
| JP2010044312A Pending JP2010166920A (ja) | 1998-04-24 | 2010-03-01 | 髄膜炎菌由来のｂａｓｂ００６ポリヌクレオチドおよびポリペプチド |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010044312A Pending JP2010166920A (ja) | 1998-04-24 | 2010-03-01 | 髄膜炎菌由来のｂａｓｂ００６ポリヌクレオチドおよびポリペプチド |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US6696062B1 (enExample) |
| EP (2) | EP2360260A1 (enExample) |
| JP (2) | JP4718009B2 (enExample) |
| CN (1) | CN1203180C (enExample) |
| AU (1) | AU3928499A (enExample) |
| CA (1) | CA2326375A1 (enExample) |
| GB (1) | GB9808866D0 (enExample) |
| WO (1) | WO1999055873A2 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6914131B1 (en) | 1998-10-09 | 2005-07-05 | Chiron S.R.L. | Neisserial antigens |
| DE69841807D1 (de) * | 1997-11-06 | 2010-09-16 | Novartis Vaccines & Diagnostic | Neisseriale antigene |
| GB9808866D0 (en) * | 1998-04-24 | 1998-06-24 | Smithkline Beecham Biolog | Novel compounds |
| EP2270174A1 (en) | 1999-05-19 | 2011-01-05 | Novartis Vaccines and Diagnostics S.r.l. | Combination neisserial compositions |
| GB9911683D0 (en) * | 1999-05-19 | 1999-07-21 | Chiron Spa | Antigenic peptides |
| PT2275554E (pt) | 1999-10-29 | 2015-06-26 | Novartis Vaccines & Diagnostic | Péptidos antigénicos de neisseria |
| GB9928196D0 (en) | 1999-11-29 | 2000-01-26 | Chiron Spa | Combinations of B, C and other antigens |
| EP2275129A3 (en) | 2000-01-17 | 2013-11-06 | Novartis Vaccines and Diagnostics S.r.l. | Outer membrane vesicle (OMV) vaccine comprising N. meningitidis serogroup B outer membrane proteins |
| PT1790660E (pt) | 2000-02-28 | 2012-09-17 | Novartis Vaccines & Diagnostic | Expressão heteróloga de proteínas de neisseria |
| GB0103171D0 (en) | 2001-02-08 | 2001-03-28 | Smithkline Beecham Biolog | Vaccine composition |
| EP1412381B1 (en) | 2001-07-27 | 2010-06-02 | Novartis Vaccines and Diagnostics S.r.l. | Antibodies against meningococcal adhesin app |
| RU2317106C2 (ru) * | 2002-08-02 | 2008-02-20 | ГлаксоСмитКлайн Байолоджикалз с.а. | Нейссериальные вакцинные композиции, содержащие комбинацию антигенов |
| WO2004014417A2 (en) * | 2002-08-02 | 2004-02-19 | Glaxosmithkline Biologicals Sa | Vaccine compositions comprising l2 and/or l3 immunotype lipooligosaccharides from lgtb- neisseria minigitidis |
| SI2353608T1 (sl) | 2002-10-11 | 2020-12-31 | Glaxosmithkline Biologicals Sa | Polipeptidna cepiva za široko zaščito proti hipervirulentnim meningokoknim linijam |
| ES2346314T3 (es) | 2003-10-02 | 2010-10-14 | Glaxosmithkline Biolog Sa | Antigenos de b. pertussis y uso de los mismos en vacunacion. |
| US20080280987A1 (en) * | 2006-08-31 | 2008-11-13 | Desai Neil P | Methods of inhibiting angiogenesis and treating angiogenesis-associated diseases |
| EP2296699A4 (en) | 2008-05-30 | 2013-11-13 | U S A As Represented By The Secretary Of The Army On Behalf Of Walter Reed Army | POLYVALENT MENINGOCOCCULAR FUEL WITH NATIVE OUTER MEMBRANE VESICLES, METHOD OF MANUFACTURE AND USE |
| WO2011110634A1 (en) | 2010-03-10 | 2011-09-15 | Glaxosmithkline Biologicals S.A. | Vaccine composition |
| BR112012022800A2 (pt) | 2010-03-11 | 2018-05-15 | Glaxosmithkline Biologicals Sa | composição imunogênica ou vacina, cepa bacteriana gram-negativa geneticamente engenheirada, métodos para o tratamento ou prevenção de infecção ou doença, para produzir uma composição imunogênica ou uma vacina, e para preparar uma imunoglobulina, preparação da imunoglobulina, e, preparação farmacêutica |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5057540A (en) | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
| JPH01125328A (ja) * | 1987-07-30 | 1989-05-17 | Centro Natl De Biopreparados | 髄膜炎菌ワクチン |
| US4912094B1 (en) | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
| GB9022190D0 (en) | 1990-10-12 | 1990-11-28 | Perham Richard N | Immunogenic material |
| FR2682041B1 (fr) | 1991-10-03 | 1994-01-14 | Pasteur Merieux Serums Vaccins | Vaccin contre les infections a neisseria meningitidis. |
| CA2138997C (en) | 1992-06-25 | 2003-06-03 | Jean-Paul Prieels | Vaccine composition containing adjuvants |
| AU685443B2 (en) | 1993-03-23 | 1998-01-22 | Smithkline Beecham Biologicals (Sa) | Vaccine compositions containing 3-O deacylated monophosphoryl lipid A |
| US5747292A (en) | 1993-04-06 | 1998-05-05 | Fred Hutchinson Cancer Research Center | Chimeric cytokine receptors in lymphocytes |
| EP0705341A1 (en) | 1993-06-07 | 1996-04-10 | Amgen Inc. | Hybrid receptor molecules |
| GB9326253D0 (en) | 1993-12-23 | 1994-02-23 | Smithkline Beecham Biolog | Vaccines |
| DK0772619T4 (da) | 1994-07-15 | 2011-02-21 | Univ Iowa Res Found | Immunmodulatoriske oligonukleotider |
| US6245337B1 (en) * | 1994-08-25 | 2001-06-12 | Washington University | Haemophilus adherence and penetration proteins |
| US6121037A (en) * | 1994-10-18 | 2000-09-19 | Stojiljkovic; Igor | Bacterial hemoglobin receptor genes |
| US6265567B1 (en) * | 1995-04-07 | 2001-07-24 | University Of North Carolina At Chapel Hill | Isolated FrpB nucleic acid molecule |
| AU5552396A (en) * | 1995-04-21 | 1996-11-07 | Human Genome Sciences, Inc. | Nucleotide sequence of the haemophilus influenzae rd genome, fragments thereof, and uses thereof |
| UA56132C2 (uk) | 1995-04-25 | 2003-05-15 | Смітклайн Бічем Байолоджікалс С.А. | Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини |
| CU22559A1 (es) | 1996-01-17 | 1999-05-03 | Ct Ingenieria Genetica Biotech | Sistema de expresión de antígenos heterologos en e. coli como proteínas de fusión |
| PT939647E (pt) * | 1996-08-27 | 2002-04-29 | Chiron Corp | Glicpconjugados do serogrupo b de neisseria meningitidis e metodos de utilizacao dos mesmos |
| DE69841807D1 (de) * | 1997-11-06 | 2010-09-16 | Novartis Vaccines & Diagnostic | Neisseriale antigene |
| US6914131B1 (en) * | 1998-10-09 | 2005-07-05 | Chiron S.R.L. | Neisserial antigens |
| GB9808734D0 (en) * | 1998-04-23 | 1998-06-24 | Smithkline Beecham Biolog | Novel compounds |
| GB9808866D0 (en) * | 1998-04-24 | 1998-06-24 | Smithkline Beecham Biolog | Novel compounds |
| ES2337650T3 (es) * | 1999-03-12 | 2010-04-28 | Glaxosmithkline Biologicals S.A. | Polipeptidos antigenicos de neisseria meningitidis polinucleotidos y anticuerpos protectores correspondientes. |
| GB0025171D0 (en) * | 2000-10-13 | 2000-11-29 | Smithkline Beecham Biolog | Novel compounds |
| EP1412381B1 (en) * | 2001-07-27 | 2010-06-02 | Novartis Vaccines and Diagnostics S.r.l. | Antibodies against meningococcal adhesin app |
-
1998
- 1998-04-24 GB GBGB9808866.9A patent/GB9808866D0/en not_active Ceased
-
1999
- 1999-04-20 CA CA002326375A patent/CA2326375A1/en not_active Abandoned
- 1999-04-20 WO PCT/EP1999/002766 patent/WO1999055873A2/en not_active Ceased
- 1999-04-20 EP EP10011715A patent/EP2360260A1/en not_active Withdrawn
- 1999-04-20 EP EP99922122A patent/EP1071783A2/en not_active Withdrawn
- 1999-04-20 AU AU39284/99A patent/AU3928499A/en not_active Abandoned
- 1999-04-20 JP JP2000546017A patent/JP4718009B2/ja not_active Expired - Fee Related
- 1999-04-20 CN CNB998077712A patent/CN1203180C/zh not_active Expired - Fee Related
- 1999-04-20 US US09/673,896 patent/US6696062B1/en not_active Expired - Fee Related
-
2003
- 2003-12-19 US US10/742,345 patent/US7419824B2/en not_active Expired - Fee Related
-
2008
- 2008-07-25 US US12/180,055 patent/US20100196409A1/en not_active Abandoned
-
2010
- 2010-03-01 JP JP2010044312A patent/JP2010166920A/ja active Pending
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