JPH01125328A - 髄膜炎菌ワクチン - Google Patents
髄膜炎菌ワクチンInfo
- Publication number
- JPH01125328A JPH01125328A JP63190500A JP19050088A JPH01125328A JP H01125328 A JPH01125328 A JP H01125328A JP 63190500 A JP63190500 A JP 63190500A JP 19050088 A JP19050088 A JP 19050088A JP H01125328 A JPH01125328 A JP H01125328A
- Authority
- JP
- Japan
- Prior art keywords
- protein
- treatment
- chromatography
- meningococcus
- molecular weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229960005486 vaccine Drugs 0.000 title claims abstract description 9
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 12
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 12
- 150000004676 glycans Chemical class 0.000 claims abstract description 7
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 7
- 239000005017 polysaccharide Substances 0.000 claims abstract description 7
- 238000004587 chromatography analysis Methods 0.000 claims abstract description 6
- 239000002671 adjuvant Substances 0.000 claims abstract description 5
- 241000894006 Bacteria Species 0.000 claims abstract description 4
- 239000004094 surface-active agent Substances 0.000 claims abstract description 4
- 102000004190 Enzymes Human genes 0.000 claims abstract description 3
- 108090000790 Enzymes Proteins 0.000 claims abstract description 3
- 238000001042 affinity chromatography Methods 0.000 claims abstract description 3
- 238000010494 dissociation reaction Methods 0.000 claims abstract description 3
- 230000005593 dissociations Effects 0.000 claims abstract description 3
- 102000039446 nucleic acids Human genes 0.000 claims abstract description 3
- 108020004707 nucleic acids Proteins 0.000 claims abstract description 3
- 150000007523 nucleic acids Chemical class 0.000 claims abstract description 3
- 102000036639 antigens Human genes 0.000 claims abstract 5
- 108091007433 antigens Proteins 0.000 claims abstract 5
- 239000000427 antigen Substances 0.000 claims abstract 2
- 230000000694 effects Effects 0.000 claims abstract 2
- 238000004128 high performance liquid chromatography Methods 0.000 claims abstract 2
- 238000000746 purification Methods 0.000 claims abstract 2
- 230000001717 pathogenic effect Effects 0.000 claims description 12
- 230000000890 antigenic effect Effects 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 7
- 230000000844 anti-bacterial effect Effects 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 241000588650 Neisseria meningitidis Species 0.000 claims description 3
- 230000004044 response Effects 0.000 claims description 3
- 230000001948 anti-meningococcal effect Effects 0.000 claims description 2
- 230000007969 cellular immunity Effects 0.000 claims description 2
- 238000004440 column chromatography Methods 0.000 claims description 2
- 239000002158 endotoxin Substances 0.000 claims description 2
- 108010074605 gamma-Globulins Proteins 0.000 claims description 2
- 230000002209 hydrophobic effect Effects 0.000 claims description 2
- 230000000521 hyperimmunizing effect Effects 0.000 claims description 2
- 230000005847 immunogenicity Effects 0.000 claims description 2
- 230000002779 inactivation Effects 0.000 claims description 2
- 238000004255 ion exchange chromatography Methods 0.000 claims description 2
- 239000012528 membrane Substances 0.000 claims description 2
- 230000003472 neutralizing effect Effects 0.000 claims description 2
- 238000000527 sonication Methods 0.000 claims description 2
- 230000001954 sterilising effect Effects 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims description 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 230000005875 antibody response Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 201000009906 Meningitis Diseases 0.000 abstract description 3
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 210000002966 serum Anatomy 0.000 abstract 2
- 238000009210 therapy by ultrasound Methods 0.000 abstract 2
- 230000009849 deactivation Effects 0.000 abstract 1
- 230000007123 defense Effects 0.000 abstract 1
- GUTLYIVDDKVIGB-OUBTZVSYSA-N Cobalt-60 Chemical compound [60Co] GUTLYIVDDKVIGB-OUBTZVSYSA-N 0.000 description 1
- 206010058858 Meningococcal bacteraemia Diseases 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 208000022089 meningococcemia Diseases 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1217—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Neisseriaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Abstract
め要約のデータは記録されません。
Description
の任意の既知病原性血清型の生菌に出発することを特徴
とするB型髄膜炎菌の各種病原性血清型に対するワクチ
ンを製造する方法に関する。
菌に、不活化することなく、界面活性剤処理、酵素処理
および超音波処理の組合せを適用して外膜のベジクルお
よび分子量65〜95KDの蛋白質抗原性複合体を抽出
し、得られた生成物に核酸除去操作を施したのち、界面
活性剤、超音波浴およびカラムクロマトグラフィーによ
る解離処理を行い、得られた多重抗原物質を、1−IP
LCクロマトグラフィー(TSK 300 SWG
カラム)、モノクローナル抗体によるアフイニテイ
クロマトグラフイー、疎水性クロマトグラフィーもしく
はイオン交換クロマトグラフィー、またはそれらの組合
せによって精製して分子量65〜95KDの蛋白質抗原
性複合体を得、この蛋白質抗原性複合体を、ベジクルを
含有する分画に15%の割合で3回添加して超音波処理
してベジクル上に撃留させ、さらに莢膜多糖を蛋白質に
対して1.1〜1.4の割合で、またアジュバントを2
0〜100μグ/μg蛋白質の割合で加え、混合物中の
各種成分は混合物の調整前に温度1〜4℃においでコバ
ルト60による円部5〜25KGYのイオン化照射を行
って滅菌するか、または同じ操作で混合物の調整後に滅
菌することにより、B型髄膜炎菌の各種病原性血清型に
対するワクチンを製造する。
、広領域かつ持続性の防御効果を示すワクチンに関する
。このワクチンは、各種の既知病原性血清型の存在と共
通する抗原性を付与し、殺菌性抗体の生成を誘導する、
分子量65〜95KDの上記蛋白質抗原性複合体の免疫
学的有効量;抗原性血清型決定基およびエンドトキシン
に対する特異的抗体の強力な応答を誘導するのに必要な
割合のベジクル;全体の溶解性および免疫原性を増大さ
せ、また、2歳未満の乳幼児においてさえも、多糖成分
に対する応答を増大させてその多価性を付与するのに必
要な割合の莢膜多糖:ならびにその効果を至適化するの
に必要な最のアジュバントを含有する。
の菌に対して殺菌および中和活性を有し、それによって
惹起される髄膜炎および髄膜炎菌血症の予防および治療
に広領域に有効な抗髄膜炎菌超免疫ガンマグロブリンに
関する。
疫を運搬するために使用される特異的1〜ランスフアー
因子(白血球抽出物から透析できる)に関する。
Claims (4)
- (1)B型髄膜炎菌の任意の既知病原性血清型の生菌に
、不活化することなく、界面活性剤処理、酵素処理およ
び超音波処理の組合せを適用して外膜のベジクルおよび
分子量65〜95KDの蛋白質抗原性複合体を抽出し、
得られた生成物に核酸除去操作を施したのち、界面活性
剤、超音波浴およびカラムクロマトグラフィーによる解
離処理を行い、得られた多重抗原物質を、HPLCクロ
マトグラフィー、モノクローナル抗体によるアフイニテ
ィークロマトグラフィー、疎水性クロマトグラフィーも
しくはイオン交換クロマトグラフィーまたはそれらの組
合せによつて精製して分子量65〜95KDの蛋白質抗
原性複合体を得、この蛋白質抗原性複合体を、ベジクル
を含有する分画に15%の割合で3回添加し、超音波処
理してベジクル上に繋留させ、さらに莢膜多糖を蛋白質
に対して1.1〜1.4の割合で、またアジユバントを
20〜100μg/μg蛋白質の割合で加え、混合物中
の各種成分を混合物の調整前に滅菌しておくかまたは混
合物の調整後に滅菌を行うことを特徴とするB型髄膜炎
菌の各種病原性血清型に対するワクチンの製造方法 - (2)B型髄膜炎菌の任意の既知病原性血清型の存在と
共通の抗原性を付与し、殺菌性抗体の生成を誘導する、
分子量65〜95KDの蛋白質抗原性複合体の免疫学的
有効量:抗原性血清型決定基およびエンドトキシンに対
する特異的抗体の応答を誘導するのに必要な割合のベジ
クル;全体の溶解性および免疫原性を増大させ、また多
糖成分に対する応答を増大させて多価性を付与するのに
必要な割合の莢膜多糖;ならびに効果を至適化するのに
必要な量のアジユバントを含有することを特徴とするB
型髄膜炎菌の各種病原性血清型に対するワクチン - (3)B型髄膜炎菌の各種病原性血清型に対して殺菌お
よび中和活性を有する抗髄膜炎菌超免疫ガンマグロブリ
ン - (4)B型髄膜炎菌に対するT細胞免疫を運搬する特異
的トランスファー因子
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CU125/87 | 1987-07-30 | ||
CU1987125 | 1987-07-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
JPH01125328A true JPH01125328A (ja) | 1989-05-17 |
Family
ID=5459411
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP63190500A Pending JPH01125328A (ja) | 1987-07-30 | 1988-07-29 | 髄膜炎菌ワクチン |
Country Status (11)
Country | Link |
---|---|
US (2) | US5597572A (ja) |
EP (1) | EP0301992B1 (ja) |
JP (1) | JPH01125328A (ja) |
AT (1) | ATE122893T1 (ja) |
AU (3) | AU615461B2 (ja) |
CA (1) | CA1341199C (ja) |
DE (1) | DE3853854T2 (ja) |
ES (1) | ES2074445T3 (ja) |
GR (1) | GR3017218T3 (ja) |
IN (1) | IN167607B (ja) |
RU (1) | RU2023448C1 (ja) |
Families Citing this family (69)
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ES2070312T5 (es) * | 1988-12-19 | 2003-05-16 | American Cyanamid Co | Vacuna de proteina de membrana exterior meningococica de clase 1. |
US7118757B1 (en) | 1988-12-19 | 2006-10-10 | Wyeth Holdings Corporation | Meningococcal class 1 outer-membrane protein vaccine |
CU22302A1 (es) * | 1990-09-07 | 1995-01-31 | Cigb | Secuencia nucleotidica codificante para una proteina de la membrana externa de neisseria meningitidis y uso de dicha proteina en preparados vacunales |
DE69423383T2 (de) * | 1993-05-13 | 2000-08-24 | American Cyanamid Co | Herstellung und Verwendungen von LOS-verminderten Aussenmembran-Proteinen von Gram-negativen Kokken |
US6287574B1 (en) | 1995-03-17 | 2001-09-11 | Biochem Pharma Inc. | Proteinase K resistant surface protein of neisseria meningitidis |
DK0854729T3 (da) * | 1995-09-18 | 2004-07-12 | Id Biomedical Corp Quebec | Forbedrede fremgangsmåder til fremstillingen af ikke-kovalent kompleksdannede og multivalente proteosom-subunit-vacciner |
FR2751000B1 (fr) | 1996-07-12 | 1998-10-30 | Inst Nat Sante Rech Med | Adn specifiques des bacteries de l'espece neisseria meningitidis, leurs procedes d'obtention et leurs applications biologiques |
US6558677B2 (en) * | 1996-10-15 | 2003-05-06 | Wendell D. Zollinger | Vaccine against gram negative bacteria |
GB9726398D0 (en) | 1997-12-12 | 1998-02-11 | Isis Innovation | Polypeptide and coding sequences |
GB9808734D0 (en) * | 1998-04-23 | 1998-06-24 | Smithkline Beecham Biolog | Novel compounds |
GB9808866D0 (en) * | 1998-04-24 | 1998-06-24 | Smithkline Beecham Biolog | Novel compounds |
GB9810276D0 (en) * | 1998-05-13 | 1998-07-15 | Smithkline Beecham Biolog | Novel compounds |
GB9811260D0 (en) * | 1998-05-26 | 1998-07-22 | Smithkline Beecham Biolog | Novel compounds |
US10967045B2 (en) | 1998-11-02 | 2021-04-06 | Secretary of State for Health and Social Care | Multicomponent meningococcal vaccine |
GB9823978D0 (en) | 1998-11-02 | 1998-12-30 | Microbiological Res Authority | Multicomponent meningococcal vaccine |
WO2000043517A1 (en) * | 1999-01-22 | 2000-07-27 | Smithkline Beecham Biologicals S.A. | Basb055 polynucleotide and polypeptide from neisseria meningitidis. uses thereof |
CA2929348A1 (en) | 1999-05-19 | 2000-11-30 | Novartis Vaccines And Diagnostics S.R.L. | Combination neisserial compositions |
GB9918319D0 (en) | 1999-08-03 | 1999-10-06 | Smithkline Beecham Biolog | Vaccine composition |
GB9929923D0 (en) * | 1999-12-17 | 2000-02-09 | Baldwin Thomas J | Antigen preparations |
AU2001280883A1 (en) * | 2000-07-27 | 2002-02-13 | The Children's Hospital & Research Center At Oakland | Vaccines for broad spectrum protection against diseases caused by neisseria meningitidis |
GB0103170D0 (en) | 2001-02-08 | 2001-03-28 | Smithkline Beecham Biolog | Vaccine composition |
GB0103171D0 (en) | 2001-02-08 | 2001-03-28 | Smithkline Beecham Biolog | Vaccine composition |
MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
IL145926A0 (en) | 2001-10-15 | 2002-07-25 | Mor Research Applic Ltd | Peptide epitopes of mimotopes useful in immunomodulation |
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NZ574530A (en) | 2002-08-02 | 2010-12-24 | Glaxosmithkline Biolog Sa | Vaccine compositions comprising L2 and/or L3 immunotype lipooligosaccharides from lgtB-neisseria minigitidis |
GB0220194D0 (en) | 2002-08-30 | 2002-10-09 | Chiron Spa | Improved vesicles |
EP2279746B1 (en) | 2002-11-15 | 2013-10-02 | Novartis Vaccines and Diagnostics S.r.l. | Surface proteins in neisseria meningitidis |
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GB0411387D0 (en) | 2004-05-21 | 2004-06-23 | Chiron Srl | Analysis of saccharide length |
GB0413868D0 (en) | 2004-06-21 | 2004-07-21 | Chiron Srl | Dimensional anlaysis of saccharide conjugates |
GB0416120D0 (en) | 2004-07-19 | 2004-08-18 | Health Prot Agency | Stable compositions containing OMV's |
GB0424092D0 (en) | 2004-10-29 | 2004-12-01 | Chiron Srl | Immunogenic bacterial vesicles with outer membrane proteins |
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EP2689775A1 (en) | 2012-07-25 | 2014-01-29 | Instituto Finlay, Centro de Investigacion-Produccion de vacunas y sueros | Cochleate with only one mamp |
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KR102199096B1 (ko) | 2013-09-08 | 2021-01-06 | 화이자 인코포레이티드 | 나이세리아 메닌지티디스 조성물 및 그의 방법 |
AU2015222121B2 (en) | 2014-02-28 | 2018-01-18 | Glaxosmithkline Biologicals Sa | Modified meningococcal fHbp polypeptides |
RU2723045C2 (ru) | 2015-02-19 | 2020-06-08 | Пфайзер Инк. | Композиции neisseria meningitidis и способы их получения |
US10183070B2 (en) | 2017-01-31 | 2019-01-22 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
RU2659948C1 (ru) * | 2017-03-14 | 2018-07-04 | Федеральное государственное бюджетное научноеучреждение "Омский аграрный научный центр" (ФГБНУ "Омский АНЦ") | Способ получения R-бруцеллёзной сыворотки на кроликах |
CN110157767A (zh) * | 2019-04-18 | 2019-08-23 | 金花企业(集团)股份有限公司 | 一种转移因子口服溶液生物活性测定方法 |
Family Cites Families (11)
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US4271147A (en) * | 1980-01-10 | 1981-06-02 | Behringwerke Aktiengesellschaft | Process for the isolation of membrane proteins from Neisseria meningitidis and vaccines containing same |
US4386066A (en) * | 1981-08-20 | 1983-05-31 | Merck & Co., Inc. | Immunogenic complex from N. gonorrhoeae |
US4451446A (en) * | 1982-03-04 | 1984-05-29 | Smithkline-Rit | Process for the preparation of polysaccharide-protein complexes from bacterial capsules, obtained products and immunogenic compositions containing them |
US4885005A (en) * | 1982-11-12 | 1989-12-05 | Baxter International Inc. | Surfactant treatment of implantable biological tissue to inhibit calcification |
EP0109688A3 (en) * | 1982-11-23 | 1986-12-03 | The Wellcome Foundation Limited | Improved complexes, processes for obtaining them and formulations containing such complexes |
US4505853A (en) * | 1983-11-18 | 1985-03-19 | Ortho Pharmaceutical Corporation | Enzyme-resistant immunomodulatory peptides |
US4547489A (en) * | 1984-06-11 | 1985-10-15 | Ortho Pharmaceutical Corporation | Conformationally restricted thymopentin-like compounds |
US4629723A (en) * | 1984-06-27 | 1986-12-16 | Ortho Pharmaceutical Corporation | Potent thymopentin analogs |
US4601903A (en) * | 1985-05-01 | 1986-07-22 | The United States Of America As Represented By The Department Of Health And Human Services | Vaccine against Neisseria meningitidis Group B serotype 2 invasive disease |
US4786592A (en) * | 1986-06-18 | 1988-11-22 | Scripps Clinic And Research Foundation | Neisseria gonorrhoeae lectin useful as a vaccine and diagnostic marker and means for producing this lectin |
US4838888A (en) * | 1987-04-17 | 1989-06-13 | Baxter Travenol Laboratories, Inc. | Calcification mitigation of implantable bioprostheses |
-
1988
- 1988-07-29 JP JP63190500A patent/JPH01125328A/ja active Pending
- 1988-07-29 RU SU884356456A patent/RU2023448C1/ru not_active IP Right Cessation
- 1988-07-30 AT AT88500077T patent/ATE122893T1/de not_active IP Right Cessation
- 1988-07-30 EP EP88500077A patent/EP0301992B1/en not_active Expired - Lifetime
- 1988-07-30 ES ES88500077T patent/ES2074445T3/es not_active Expired - Lifetime
- 1988-07-30 DE DE3853854T patent/DE3853854T2/de not_active Expired - Lifetime
- 1988-08-01 AU AU20312/88A patent/AU615461B2/en not_active Ceased
- 1988-08-01 CA CA000573538A patent/CA1341199C/en not_active Expired - Fee Related
- 1988-09-06 IN IN626/MAS/88A patent/IN167607B/en unknown
-
1991
- 1991-07-25 AU AU81349/91A patent/AU8134991A/en not_active Abandoned
-
1993
- 1993-11-12 US US08/152,938 patent/US5597572A/en not_active Expired - Lifetime
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1994
- 1994-01-14 AU AU53197/94A patent/AU5319794A/en not_active Abandoned
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1995
- 1995-08-24 GR GR950402324T patent/GR3017218T3/el unknown
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1996
- 1996-08-02 US US08/692,055 patent/US5747653A/en not_active Expired - Lifetime
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EP0301992A2 (en) | 1989-02-01 |
AU8134991A (en) | 1991-10-31 |
CA1341199C (en) | 2001-03-06 |
IN167607B (ja) | 1990-11-24 |
EP0301992A3 (en) | 1990-02-14 |
DE3853854D1 (de) | 1995-06-29 |
RU2023448C1 (ru) | 1994-11-30 |
AU5319794A (en) | 1994-03-24 |
US5597572A (en) | 1997-01-28 |
GR3017218T3 (en) | 1995-11-30 |
ATE122893T1 (de) | 1995-06-15 |
EP0301992B1 (en) | 1995-05-24 |
AU2031288A (en) | 1989-05-25 |
ES2074445T3 (es) | 1995-09-16 |
AU615461B2 (en) | 1991-10-03 |
DE3853854T2 (de) | 1996-02-08 |
US5747653A (en) | 1998-05-05 |
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