JP5051959B2 - ストレプトコッカス抗原 - Google Patents
ストレプトコッカス抗原 Download PDFInfo
- Publication number
- JP5051959B2 JP5051959B2 JP2002504289A JP2002504289A JP5051959B2 JP 5051959 B2 JP5051959 B2 JP 5051959B2 JP 2002504289 A JP2002504289 A JP 2002504289A JP 2002504289 A JP2002504289 A JP 2002504289A JP 5051959 B2 JP5051959 B2 JP 5051959B2
- Authority
- JP
- Japan
- Prior art keywords
- glu
- lys
- leu
- ala
- ser
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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| JP2010535015A (ja) * | 2007-07-23 | 2010-11-18 | サノフィ パストゥール リミテッド | 免疫原性のポリペプチドおよびモノクローナル抗体 |
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| CA2757620C (en) | 2009-04-30 | 2016-04-26 | Coley Pharmaceutical Group, Inc. | Pneumococcal vaccine and uses thereof |
| WO2010132833A1 (en) | 2009-05-14 | 2010-11-18 | The Regents Of The University Of Michigan | Streptococcus vaccine compositions and methods of using the same |
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| KR101272351B1 (ko) | 2010-04-23 | 2013-06-07 | 이화여자대학교 산학협력단 | 새로운 카나마이신 화합물, 카나마이신 생산 스트렙토마이세스 속 미생물 및 카나마이신의 생산 방법 |
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| WO2015095868A1 (en) | 2013-12-20 | 2015-06-25 | Wake Forest University Health Sciences | Methods and compositions for increasing protective antibody levels induced by pneumococcal polysaccharide vaccines |
| US11160855B2 (en) | 2014-01-21 | 2021-11-02 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| HUE064837T2 (hu) | 2014-01-21 | 2024-05-28 | Pfizer | Streptococcus pneumoniae kapszuláris poliszacharidok és azok konjugátumai |
| DK3096785T3 (da) | 2014-01-21 | 2020-09-21 | Pfizer | Immunogene sammensætninger omfattende konjugerede kapsel-saccharid-antigener og anvendelser deraf |
| RU2710393C2 (ru) | 2014-01-21 | 2019-12-26 | Пфайзер Инк. | Способ получения иммуногенного конъюгата капсульный полисахарид Streptococcus pneumoniae-белок-носитель |
| ES2701169T3 (es) | 2014-02-14 | 2019-02-21 | Pfizer | Conjugados glucoproteicos inmunogénicos |
| AU2016207820B2 (en) | 2015-01-15 | 2020-12-17 | Pfizer Inc. | Immunogenic compositions for use in pneumococcal vaccines |
| JP6994453B2 (ja) | 2015-07-21 | 2022-01-14 | ファイザー・インク | コンジュゲート化莢膜糖類抗原を含む免疫原性組成物、それを含むキットおよびこれらの使用 |
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| BR112019014833A2 (pt) | 2017-01-20 | 2020-04-14 | Pfizer | composições imunogênicas para uso em vacinas pneumococais |
| CN110225764A (zh) | 2017-01-31 | 2019-09-10 | 默沙东公司 | 制备多糖-蛋白缀合物的方法 |
| US20200222550A1 (en) | 2017-01-31 | 2020-07-16 | Merck Sharp & Dohme Corp. | Methods for production of capsular polysaccharide protein conjugates from streptococcus pneumoniae serotype 19f |
| US20200054740A1 (en) | 2017-02-24 | 2020-02-20 | Merck Sharp & Dohme Corp. | Pneumococcal conjugate vaccine formulations |
| RS65893B1 (sr) | 2017-09-07 | 2024-09-30 | Merck Sharp & Dohme Llc | Pneumokokni polisaharidi i njihova primena u imunogenim konjugatima polisaharid-proteinski nosač |
| EA202091382A1 (ru) | 2017-12-06 | 2021-01-15 | Мерк Шарп И Доум Корп. | Композиции, содержащие конъюгаты полисахарид streptococcus pneumoniae с белком, и способы их применения |
| US11260119B2 (en) | 2018-08-24 | 2022-03-01 | Pfizer Inc. | Escherichia coli compositions and methods thereof |
| CA3120922A1 (en) | 2018-12-12 | 2020-06-18 | Pfizer Inc. | Immunogenic multiple hetero-antigen polysaccharide-protein conjugates and uses thereof |
| SG11202106541WA (en) | 2018-12-19 | 2021-07-29 | Merck Sharp & Dohme | Compositions comprising streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof |
| JP7239509B6 (ja) | 2019-02-22 | 2023-03-28 | ファイザー・インク | 細菌多糖類を精製するための方法 |
| EP3952906A1 (en) | 2019-04-10 | 2022-02-16 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens, kits comprising the same and uses thereof |
| PH12022550110A1 (en) | 2019-07-31 | 2022-12-12 | Sk Bioscience Co Ltd | Multivalent pneumococcal polysaccharide-protein conjugate compositions and methods of using the same |
| AU2020375214B2 (en) | 2019-11-01 | 2024-02-08 | Pfizer Inc. | Escherichia coli compositions and methods thereof |
| BR112022015796A2 (pt) | 2020-02-21 | 2022-10-11 | Pfizer | Purificação de sacarídeos |
| IL295632A (en) | 2020-02-23 | 2022-10-01 | Pfizer | Escherichia coli compositions and methods thereof |
| US20230383324A1 (en) | 2020-10-22 | 2023-11-30 | Pfizer Inc. | Methods for purifying bacterial polysaccharides |
| MX2023004912A (es) | 2020-10-27 | 2023-05-16 | Pfizer | Composiciones de escherichia coli y metodos de las mismas. |
| US12138302B2 (en) | 2020-10-27 | 2024-11-12 | Pfizer Inc. | Escherichia coli compositions and methods thereof |
| JP2022075575A (ja) | 2020-11-04 | 2022-05-18 | ファイザー・インク | 肺炎球菌ワクチンにおける使用のための免疫原性組成物 |
| US12357681B2 (en) | 2020-12-23 | 2025-07-15 | Pfizer Inc. | E. coli FimH mutants and uses thereof |
| TW202245835A (zh) | 2021-02-04 | 2022-12-01 | 美商默沙東有限責任公司 | 用於肺炎球菌結合物疫苗之奈米乳化液佐劑組合物 |
| WO2022234405A1 (en) | 2021-05-03 | 2022-11-10 | Pfizer Inc. | Vaccination against bacterial and betacoronavirus infections |
| WO2022234416A1 (en) | 2021-05-03 | 2022-11-10 | Pfizer Inc. | Vaccination against pneumoccocal and covid-19 infections |
| EP4346893A2 (en) | 2021-05-28 | 2024-04-10 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| KR20230175284A (ko) | 2021-05-28 | 2023-12-29 | 화이자 인코포레이티드 | 접합된 피막 사카라이드 항원을 포함하는 면역원성 조성물 및 그의 용도 |
| US20250381259A1 (en) | 2022-01-13 | 2025-12-18 | Pfizer Inc. | Immunogenic Compositions Comprising Conjugated Capsular Saccharide Antigens and Uses Thereof |
| WO2023161817A1 (en) | 2022-02-25 | 2023-08-31 | Pfizer Inc. | Methods for incorporating azido groups in bacterial capsular polysaccharides |
| EP4522208A1 (en) | 2022-05-11 | 2025-03-19 | Pfizer Inc. | Process for producing of vaccine formulations with preservatives |
| WO2024084397A1 (en) | 2022-10-19 | 2024-04-25 | Pfizer Inc. | Vaccination against pneumoccocal and covid-19 infections |
| WO2024110827A1 (en) | 2022-11-21 | 2024-05-30 | Pfizer Inc. | Methods for preparing conjugated capsular saccharide antigens and uses thereof |
| CN120265317A (zh) | 2022-11-22 | 2025-07-04 | 辉瑞公司 | 包含经缀合的荚膜糖抗原的免疫原性组合物及其用途 |
| WO2024116096A1 (en) | 2022-12-01 | 2024-06-06 | Pfizer Inc. | Pneumococcal conjugate vaccine formulations |
| WO2024166008A1 (en) | 2023-02-10 | 2024-08-15 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| CN121038808A (zh) | 2023-03-30 | 2025-11-28 | 辉瑞公司 | 包含缀合的荚膜糖抗原的免疫原性组合物及其用途 |
| CN121057590A (zh) | 2023-04-14 | 2025-12-02 | 辉瑞公司 | 包含缀合荚膜糖抗原的免疫原性组合物及其用途 |
| WO2024224266A1 (en) | 2023-04-24 | 2024-10-31 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| TW202500153A (zh) | 2023-05-18 | 2025-01-01 | 美商默沙東有限責任公司 | 用於肺炎鏈球菌疫苗之化合物及佐劑調配物 |
| WO2024241172A2 (en) | 2023-05-19 | 2024-11-28 | Glaxosmithkline Biologicals Sa | Methods for eliciting an immune response to respiratory syncycial virus and streptococcus pneumoniae infection |
| TW202527906A (zh) | 2023-09-14 | 2025-07-16 | 美商輝瑞股份有限公司 | 包含經結合之肺炎鏈球菌莢膜醣抗原之佐劑化致免疫性組成物及其用途 |
| WO2025106603A1 (en) | 2023-11-16 | 2025-05-22 | Merck Sharp & Dohme Llc | Peptide conjugate vaccine compositions and methods for the treatment of alzheimer's disease |
| WO2025133971A1 (en) | 2023-12-23 | 2025-06-26 | Pfizer Inc. | Improved methods for producing bacterial capsular saccharide glycoconjugates |
| WO2025186705A2 (en) | 2024-03-06 | 2025-09-12 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| WO2025191415A1 (en) | 2024-03-11 | 2025-09-18 | Pfizer Inc. | Immunogenic compositions comprising conjugated escherichia coli saccharides and uses thereof |
| WO2025219904A1 (en) | 2024-04-19 | 2025-10-23 | Pfizer Inc. | Improved methods for producing glycoconjugates by reductive amination in aprotic solvent |
| WO2025219908A2 (en) | 2024-04-19 | 2025-10-23 | Pfizer Inc. | Media and fermentation methods for polysaccharide production in bacterial cell culture |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4425437A (en) | 1979-11-05 | 1984-01-10 | Genentech, Inc. | Microbial polypeptide expression vehicle |
| US4431739A (en) | 1979-11-05 | 1984-02-14 | Genentech, Inc. | Transformant bacterial culture capable of expressing heterologous protein |
| US4338397A (en) | 1980-04-11 | 1982-07-06 | President And Fellows Of Harvard College | Mature protein synthesis |
| US5866135A (en) * | 1994-04-21 | 1999-02-02 | North American Vaccine, Inc. | Group A streptococcal polysaccharide immunogenic compositions and methods |
| KR19990007777A (ko) * | 1995-06-07 | 1999-01-25 | 듀크두플레시스 | 면역성 및 면역자극성 올리고당 조성물 및 이를 제조하고 이용하는 방법 |
| CA2271720A1 (en) * | 1996-10-31 | 1998-05-07 | Human Genome Sciences, Inc. | Streptococcus pneumoniae polynucleotides and sequences |
| KR20010024299A (ko) * | 1997-09-24 | 2001-03-26 | 리전츠 오브 더 유니버스티 오브 미네소타 | 스트렙토코쿠스 뉴모니애로부터의 사람 보체 ｃ3 분해단백질분해효소 |
| EP2053126A1 (en) * | 1998-07-27 | 2009-04-29 | Sanofi Pasteur Limited | Streptococcus pneumoniae proteins and nucleic acid molecules |
| HUP0103100A3 (en) * | 1998-08-19 | 2005-11-28 | Baxter Healthcare Sa | Immunogenic betha-propionamido-linked polysaccharide protein conjugate useful as a vaccine produced using an n-acryloylated polysaccharide |
| AU6060899A (en) * | 1998-09-24 | 2000-04-10 | American Cyanamid Company | Human complement c3-degrading polypeptide from (streptococcus pneumoniae) |
| DK1140157T3 (da) * | 1998-12-21 | 2009-06-08 | Medimmune Inc | Streptococcus pneumoniae-proteiner og immunogene fragmenter til vacciner |
| CN1191362C (zh) * | 1998-12-23 | 2005-03-02 | 夏尔生化公司 | 新颖的链球菌抗原 |
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