JP2009268467A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009268467A5 JP2009268467A5 JP2009147075A JP2009147075A JP2009268467A5 JP 2009268467 A5 JP2009268467 A5 JP 2009268467A5 JP 2009147075 A JP2009147075 A JP 2009147075A JP 2009147075 A JP2009147075 A JP 2009147075A JP 2009268467 A5 JP2009268467 A5 JP 2009268467A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- acid sequence
- amino acid
- helper cells
- following
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 18
- 229920001184 polypeptide Polymers 0.000 claims 16
- 102000004196 processed proteins & peptides Human genes 0.000 claims 16
- 125000003275 alpha amino acid group Chemical group 0.000 claims 8
- 210000002443 helper t lymphocyte Anatomy 0.000 claims 8
- 238000007792 addition Methods 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 4
- 230000037430 deletion Effects 0.000 claims 4
- 238000012217 deletion Methods 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 230000035755 proliferation Effects 0.000 claims 4
- 230000001737 promoting effect Effects 0.000 claims 4
- 238000006467 substitution reaction Methods 0.000 claims 4
- 239000002131 composite material Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39309099A | 1999-09-09 | 1999-09-09 | |
| US09/393,090 | 1999-09-09 | ||
| US16461699P | 1999-11-10 | 1999-11-10 | |
| US60/164,616 | 1999-11-10 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006231402A Division JP2007045830A (ja) | 1999-09-09 | 2006-08-28 | 哺乳動物インターロイキン−１２ｐ４０およびインターロイキンｂ３０、その組成物、抗体、薬学的組成物における使用 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010098317A Division JP2010233571A (ja) | 1999-09-09 | 2010-04-21 | 哺乳動物インターロイキン−１２ｐ４０およびインターロイキンｂ３０、その組成物、抗体、薬学的組成物における使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009268467A JP2009268467A (ja) | 2009-11-19 |
| JP2009268467A5 true JP2009268467A5 (enExample) | 2010-07-01 |
| JP4969610B2 JP4969610B2 (ja) | 2012-07-04 |
Family
ID=26860707
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001522273A Expired - Lifetime JP4505166B2 (ja) | 1999-09-09 | 2000-09-08 | 哺乳動物インターロイキン−１２ｐ４０およびインターロイキンｂ３０、その組成物、抗体、薬学的組成物における使用 |
| JP2006231402A Withdrawn JP2007045830A (ja) | 1999-09-09 | 2006-08-28 | 哺乳動物インターロイキン−１２ｐ４０およびインターロイキンｂ３０、その組成物、抗体、薬学的組成物における使用 |
| JP2009147075A Expired - Lifetime JP4969610B2 (ja) | 1999-09-09 | 2009-06-19 | 哺乳動物インターロイキン−１２ｐ４０およびインターロイキンｂ３０、その組成物、抗体、薬学的組成物における使用 |
| JP2010098317A Withdrawn JP2010233571A (ja) | 1999-09-09 | 2010-04-21 | 哺乳動物インターロイキン−１２ｐ４０およびインターロイキンｂ３０、その組成物、抗体、薬学的組成物における使用 |
| JP2013040389A Pending JP2013128489A (ja) | 1999-09-09 | 2013-03-01 | 哺乳動物インターロイキン−１２ｐ４０およびインターロイキンｂ３０、その組成物、抗体、薬学的組成物における使用 |
| JP2014206652A Expired - Fee Related JP6140122B2 (ja) | 1999-09-09 | 2014-10-07 | 哺乳動物インターロイキン−１２ｐ４０およびインターロイキンｂ３０、その組成物、抗体、薬学的組成物における使用 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001522273A Expired - Lifetime JP4505166B2 (ja) | 1999-09-09 | 2000-09-08 | 哺乳動物インターロイキン−１２ｐ４０およびインターロイキンｂ３０、その組成物、抗体、薬学的組成物における使用 |
| JP2006231402A Withdrawn JP2007045830A (ja) | 1999-09-09 | 2006-08-28 | 哺乳動物インターロイキン−１２ｐ４０およびインターロイキンｂ３０、その組成物、抗体、薬学的組成物における使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010098317A Withdrawn JP2010233571A (ja) | 1999-09-09 | 2010-04-21 | 哺乳動物インターロイキン−１２ｐ４０およびインターロイキンｂ３０、その組成物、抗体、薬学的組成物における使用 |
| JP2013040389A Pending JP2013128489A (ja) | 1999-09-09 | 2013-03-01 | 哺乳動物インターロイキン−１２ｐ４０およびインターロイキンｂ３０、その組成物、抗体、薬学的組成物における使用 |
| JP2014206652A Expired - Fee Related JP6140122B2 (ja) | 1999-09-09 | 2014-10-07 | 哺乳動物インターロイキン−１２ｐ４０およびインターロイキンｂ３０、その組成物、抗体、薬学的組成物における使用 |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1210434B2 (enExample) |
| JP (6) | JP4505166B2 (enExample) |
| KR (1) | KR100894359B1 (enExample) |
| CN (1) | CN100529076C (enExample) |
| AR (1) | AR035560A1 (enExample) |
| AT (1) | ATE389019T1 (enExample) |
| AU (2) | AU780163B2 (enExample) |
| CA (1) | CA2388562C (enExample) |
| DE (1) | DE60038304T3 (enExample) |
| ES (1) | ES2300276T5 (enExample) |
| HK (1) | HK1044170B (enExample) |
| HU (1) | HU230679B1 (enExample) |
| IL (1) | IL148300A0 (enExample) |
| MX (1) | MXPA02002684A (enExample) |
| WO (1) | WO2001018051A2 (enExample) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2007202362B2 (en) * | 1999-09-03 | 2011-06-23 | Merck Sharp & Dohme Corp. | Mammalian receptor proteins; related reagents and methods |
| US6756481B2 (en) | 2000-05-10 | 2004-06-29 | Schering Corporation | IL-23 receptor binding compositions |
| US7422743B2 (en) | 2000-05-10 | 2008-09-09 | Schering Corporation | Mammalian receptor protein DCRS5;methods of treatment |
| NZ539271A (en) | 2002-10-30 | 2008-12-24 | Genentech Inc | Inhibition of the production of proinflammatory cytokine interleukin-17 (IL-17) by T cells, using an antagonist of interleukin-23 (IL-23) |
| AU2003303384A1 (en) | 2002-12-23 | 2004-07-22 | Schering Corporation | Uses of mammalian cytokine; related reagents |
| ATE440864T1 (de) * | 2003-03-10 | 2009-09-15 | Schering Corp | Verwendung von il-23-antagonisten; verwandte reagenzien |
| EP1623011B1 (en) | 2003-05-09 | 2013-01-02 | Janssen Biotech, Inc. | Il-23p40 specific immunoglobulin derived proteins, compositions, methods and uses |
| EP1522858A1 (en) * | 2003-10-10 | 2005-04-13 | Jean-Christophe Roegel | Methods for selecting compounds using antibodies with activity as agonist, antagonist or allosteric modulators |
| WO2005108425A1 (en) * | 2004-05-10 | 2005-11-17 | Cytos Biotechnology Ag | Il-23 p19 antigen array and uses thereof |
| AR051444A1 (es) | 2004-09-24 | 2007-01-17 | Centocor Inc | Proteinas derivadas de inmunoglobulina especifica de il-23p40, composiciones, epitopos, metodos y usos |
| EP1853707A2 (en) * | 2004-12-20 | 2007-11-14 | Schering Corporation | Uses of il-23 antagonists in the treatment of diabetes mellitus |
| CA2613818C (en) | 2005-06-30 | 2013-08-27 | Centocor, Inc. | Anti-il-23 antibodies, compositions, methods and uses |
| SI1937721T1 (sl) * | 2005-08-25 | 2010-11-30 | Lilly Co Eli | Anti il protitelesa |
| ME02705B (me) | 2005-08-31 | 2017-10-20 | Merck Sharp & Dohme | Inženjerisana anti-il-23 antitela |
| SI3219328T1 (sl) | 2005-12-29 | 2020-10-30 | Janssen Biotech, Inc. | Človeška protitelesa proti-IL-23, sestavki, postopki in uporabe |
| SI1966238T1 (sl) * | 2005-12-30 | 2012-08-31 | Merck Patent Gmbh | Variante interlevkina-12P40 z izboljšano stabilnostjo |
| US7910703B2 (en) | 2006-03-10 | 2011-03-22 | Zymogenetics, Inc. | Antagonists to IL-17A, IL-17F, and IL-23P19 and methods of use |
| JP2009540018A (ja) | 2006-06-13 | 2009-11-19 | ザイモジェネティクス， インコーポレイテッド | Ｉｌ−１７およびｉｌ−２３アンタゴニストならびにその使用方法 |
| TWI426918B (zh) | 2007-02-12 | 2014-02-21 | Merck Sharp & Dohme | Ｉｌ-２３拮抗劑於治療感染之用途 |
| CN103396489A (zh) | 2007-02-23 | 2013-11-20 | 默沙东公司 | 工程改造的抗IL-23p19抗体 |
| HUE042172T2 (hu) | 2007-02-23 | 2019-06-28 | Merck Sharp & Dohme | Genetikailag elõállított anti-il-23P19 antitestek |
| MX2009009167A (es) | 2007-02-28 | 2009-09-04 | Schering Corp | Terapia de combinacion para el tratamiento de trastornos inmunes. |
| CA2679381A1 (en) | 2007-02-28 | 2008-09-04 | Schering Corporation | Engineered anti-il-23r antibodies |
| CA2706425A1 (en) | 2007-11-27 | 2009-06-04 | Ablynx N.V. | Method for obtaining polypeptide constructs comprising two or more single domain antibodies |
| JPWO2009133863A1 (ja) * | 2008-04-28 | 2011-09-01 | 国立大学法人浜松医科大学 | Ｅｐ１アゴニストを含有してなる免疫増強剤 |
| JO3244B1 (ar) | 2009-10-26 | 2018-03-08 | Amgen Inc | بروتينات ربط مستضادات il – 23 البشرية |
| KR102049223B1 (ko) | 2010-11-04 | 2019-11-28 | 베링거 인겔하임 인터내셔날 게엠베하 | 항－ｉｌ－２３ 항체 |
| CN102462837B (zh) * | 2010-11-19 | 2016-08-03 | 生物林格斯Ip有限公司 | 抗炎组合物 |
| US9512194B2 (en) | 2012-01-27 | 2016-12-06 | The Board Of Trustees Of The Leland Stanford Junior University | Modified IL-13 polypeptides |
| CN109206516A (zh) | 2012-05-03 | 2019-01-15 | 勃林格殷格翰国际有限公司 | 抗IL-23p19抗体 |
| US9803010B2 (en) | 2012-06-27 | 2017-10-31 | Merck Sharp & Dohme Corp. | Crystalline anti-human IL-23p19 antibodies |
| IN2015KN00329A (enExample) | 2012-08-09 | 2015-07-10 | Univ Leland Stanford Junior | |
| UA117466C2 (uk) | 2012-12-13 | 2018-08-10 | Мерк Шарп Енд Доме Корп. | СТАБІЛЬНИЙ СКЛАД У ВИГЛЯДІ РОЗЧИНУ АНТИТІЛА ДО IL-23p19 |
| KR101625112B1 (ko) | 2013-04-16 | 2016-05-27 | 가톨릭대학교 산학협력단 | 아이케이 인자 및 아이케이 인자를 코딩하는 핵산의 약학적 용도 |
| WO2014171721A1 (ko) * | 2013-04-16 | 2014-10-23 | 가톨릭대학교 산학협력단 | 아이케이 인자 및 아이케이 인자를 코딩하는 핵산의 약학적 용도 |
| JP6936934B2 (ja) * | 2013-09-24 | 2021-09-22 | メディシナ セラピューティクス インコーポレイテッド | インターロイキン−４受容体結合融合タンパク質及びその使用 |
| EP3172339A1 (en) | 2014-07-24 | 2017-05-31 | Boehringer Ingelheim International GmbH | Biomarkers useful in the treatment of il-23a related diseases |
| CA2959629C (en) | 2014-09-03 | 2023-10-31 | Boehringer Ingelheim International Gmbh | Compound targeting il-23a and tnf-alpha and uses thereof |
| JP6219875B2 (ja) * | 2015-04-10 | 2017-10-25 | 株式会社スクウェア・エニックス | ネットワークゲームシステム、ゲーム装置及びプログラム |
| JOP20190260A1 (ar) | 2017-05-02 | 2019-10-31 | Merck Sharp & Dohme | صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها |
| CN110913906A (zh) | 2017-05-02 | 2020-03-24 | 默沙东公司 | 抗lag3抗体的制剂和抗lag3抗体与抗pd-1抗体的共制剂 |
| CA3078434A1 (en) | 2017-10-10 | 2019-04-18 | Medicenna Therapeutics, Inc. | Il-4-fusion formulations for treatment of central nervous system (cns) tumors |
| WO2019239213A2 (en) | 2018-06-01 | 2019-12-19 | Medicenna Therapeutics Inc. | Uses and methods for oncolytic virus targeting of il-4/il-13 and fusions thereof |
| WO2019232523A1 (en) | 2018-06-01 | 2019-12-05 | The Board Of Trustees Of The Leland Stanford Junior University | Il-13/il-4 superkines: immune cell targeting constructs and methods of use thereof |
| MX2021004356A (es) | 2018-10-18 | 2021-05-31 | Merck Sharp & Dohme Llc | Formulaciones de anticuerpos anti-rsv y metodos de uso de las mismas. |
| MA54089A (fr) | 2018-10-31 | 2022-02-09 | Merck Sharp & Dohme | Anticorps anti-pd-1 humain et procédés d'utilisation associés |
| JP7503056B6 (ja) | 2018-11-07 | 2024-07-16 | メルク・シャープ・アンド・ドーム・エルエルシー | 抗ｌａｇ３抗体および抗ｐｄ－１抗体の共－製剤 |
| MA55149A (fr) | 2018-11-20 | 2021-09-29 | Janssen Biotech Inc | Procédé sûr et efficace de traitement du psoriasis avec un anticorps spécifique anti-il-23 |
| EP3972690A4 (en) | 2019-05-23 | 2023-07-05 | Janssen Biotech, Inc. | METHOD OF TREATMENT OF INFLAMMATORY BOWEL DISEASE USING COMBINATION THERAPY OF ANTIBODIES TO IL-23 AND TNF-ALPHA |
| TW202535466A (zh) | 2019-09-09 | 2025-09-16 | 德商百靈佳殷格翰國際股份有限公司 | 抗-il-23p19抗體調配物 |
| CA3183927A1 (en) | 2020-05-21 | 2021-11-25 | Janssen Biotech, Inc. | Method of treating inflammatory bowel disease with a combination therapy of antibodies to il-23 and tnf alpha |
| US12702710B2 (en) | 2020-10-12 | 2026-08-11 | Medicenna Therapeutics Inc. | Combination therapy of MDNA55 and a vascular endothelial growth factor a (VEGF-A) |
| CN114317430A (zh) * | 2021-12-28 | 2022-04-12 | 河北银丰鼎诚生物技术有限公司 | 一种适用于脐血来源免疫细胞扩增的培养液 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0433827T3 (da) * | 1989-12-22 | 1998-09-28 | Hoffmann La Roche | Cytotoksisk lumfocytmodningsfaktor |
| DE4315127A1 (de) * | 1993-05-07 | 1994-11-10 | Behringwerke Ag | Arzneimittel enthaltend die Untereinheit p40 von Interleukin-12 |
| US5851523A (en) * | 1994-03-24 | 1998-12-22 | Ludwig Institute For Cancer Research. | Isolated, peptides derived from MAGE tumor rejection antigen precursors which complex with HLA-A2 molecules and uses thereof |
| US5853721A (en) * | 1995-01-31 | 1998-12-29 | Hoffmann-La Roche Inc. | Antibody to interleukin-12 receptor |
| GB9609932D0 (en) * | 1996-05-13 | 1996-07-17 | Hoffmann La Roche | Use of IL-12 and IFN alpha for the treatment of infectious diseases |
| WO1998017689A2 (en) * | 1996-10-18 | 1998-04-30 | Valentis Inc. | Il-12 gene expression and delivery systems and uses |
| ZA986596B (en) * | 1997-07-25 | 1999-02-08 | Schering Corp | Mammalian cytokine related reagents |
| AU2661199A (en) * | 1998-02-06 | 1999-08-23 | Schering Corporation | Mammalian receptor proteins; related reagents and methods |
-
2000
- 2000-09-08 DE DE60038304.0T patent/DE60038304T3/de not_active Expired - Lifetime
- 2000-09-08 AT AT00961688T patent/ATE389019T1/de not_active IP Right Cessation
- 2000-09-08 CN CNB008154007A patent/CN100529076C/zh not_active Expired - Lifetime
- 2000-09-08 JP JP2001522273A patent/JP4505166B2/ja not_active Expired - Lifetime
- 2000-09-08 HK HK02105118.4A patent/HK1044170B/en not_active IP Right Cessation
- 2000-09-08 AU AU73608/00A patent/AU780163B2/en not_active Expired
- 2000-09-08 IL IL14830000A patent/IL148300A0/xx active IP Right Grant
- 2000-09-08 MX MXPA02002684A patent/MXPA02002684A/es active IP Right Grant
- 2000-09-08 EP EP00961688.9A patent/EP1210434B2/en not_active Expired - Lifetime
- 2000-09-08 WO PCT/US2000/024686 patent/WO2001018051A2/en not_active Ceased
- 2000-09-08 CA CA2388562A patent/CA2388562C/en not_active Expired - Lifetime
- 2000-09-08 HU HU0301102A patent/HU230679B1/hu unknown
- 2000-09-08 KR KR1020027003089A patent/KR100894359B1/ko not_active Expired - Lifetime
- 2000-09-08 ES ES00961688.9T patent/ES2300276T5/es not_active Expired - Lifetime
- 2000-09-11 AR ARP000104753A patent/AR035560A1/es unknown
-
2006
- 2006-08-28 JP JP2006231402A patent/JP2007045830A/ja not_active Withdrawn
-
2008
- 2008-10-31 AU AU2008240348A patent/AU2008240348B2/en not_active Expired
-
2009
- 2009-06-19 JP JP2009147075A patent/JP4969610B2/ja not_active Expired - Lifetime
-
2010
- 2010-04-21 JP JP2010098317A patent/JP2010233571A/ja not_active Withdrawn
-
2013
- 2013-03-01 JP JP2013040389A patent/JP2013128489A/ja active Pending
-
2014
- 2014-10-07 JP JP2014206652A patent/JP6140122B2/ja not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2012532601A5 (enExample) | ||
| JP2005120106A5 (enExample) | ||
| JP2010065037A5 (enExample) | ||
| JP2018138049A5 (enExample) | ||
| JP2022503959A5 (enExample) | ||
| JP2010529860A5 (enExample) | ||
| JP2012126742A5 (enExample) | ||
| JP2010534684A5 (enExample) | ||
| JP2013048638A5 (enExample) | ||
| JP2007175057A5 (enExample) | ||
| JP2011177189A5 (enExample) | ||
| WO2006119987A3 (en) | Recombinant n-glycosylated proteins from procaryotic cells | |
| RU2016106583A (ru) | Пептиды, способные реактивировать мутанты р53 | |
| JP2010227108A5 (enExample) | ||
| JP2010512160A5 (enExample) | ||
| JP2010532656A5 (enExample) | ||
| JP2011511933A5 (enExample) | ||
| PH12012502272A1 (en) | Biological materials related to her3 | |
| JP2016527891A5 (enExample) | ||
| JP2006516189A5 (enExample) | ||
| JP2011530309A5 (enExample) | ||
| JP2011528895A5 (enExample) | ||
| JP2014529399A5 (enExample) | ||
| JP2011521661A5 (enExample) | ||
| JP2012529293A5 (enExample) |