JP2016527891A5 - - Google Patents

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Publication number
JP2016527891A5
JP2016527891A5 JP2016532782A JP2016532782A JP2016527891A5 JP 2016527891 A5 JP2016527891 A5 JP 2016527891A5 JP 2016532782 A JP2016532782 A JP 2016532782A JP 2016532782 A JP2016532782 A JP 2016532782A JP 2016527891 A5 JP2016527891 A5 JP 2016527891A5
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JP
Japan
Prior art keywords
protein
peptide
mutant
seq
acid sequence
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JP2016532782A
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English (en)
Japanese (ja)
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JP6554099B2 (ja
JP2016527891A (ja
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Priority claimed from PCT/IB2014/063777 external-priority patent/WO2015019318A1/en
Publication of JP2016527891A publication Critical patent/JP2016527891A/ja
Publication of JP2016527891A5 publication Critical patent/JP2016527891A5/ja
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Publication of JP6554099B2 publication Critical patent/JP6554099B2/ja
Expired - Fee Related legal-status Critical Current
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JP2016532782A 2013-08-07 2014-08-07 ｐ５３変異体を再活性化することの可能なペプチド Expired - Fee Related JP6554099B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361862977P 2013-08-07 2013-08-07
US61/862,977 2013-08-07
PCT/IB2014/063777 WO2015019318A1 (en) 2013-08-07 2014-08-07 Peptides capable of reactivating p53 mutants

Related Child Applications (1)

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JP2019125644A Division JP2019214573A (ja) 2013-08-07 2019-07-04 ｐ５３変異体を再活性化することの可能なペプチド

Publications (3)

Publication Number Publication Date
JP2016527891A JP2016527891A (ja) 2016-09-15
JP2016527891A5 true JP2016527891A5 (enExample) 2017-09-14
JP6554099B2 JP6554099B2 (ja) 2019-07-31

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JP2016532782A Expired - Fee Related JP6554099B2 (ja) 2013-08-07 2014-08-07 ｐ５３変異体を再活性化することの可能なペプチド
JP2019125644A Pending JP2019214573A (ja) 2013-08-07 2019-07-04 ｐ５３変異体を再活性化することの可能なペプチド

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JP2019125644A Pending JP2019214573A (ja) 2013-08-07 2019-07-04 ｐ５３変異体を再活性化することの可能なペプチド

Country Status (12)

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US (4) US9856289B2 (enExample)
EP (1) EP3030571B1 (enExample)
JP (2) JP6554099B2 (enExample)
CN (1) CN105579464B (enExample)
AU (2) AU2016200713B2 (enExample)
BR (1) BR112016002721A2 (enExample)
CA (1) CA2920147C (enExample)
ES (1) ES2795982T3 (enExample)
HU (1) HUE049292T2 (enExample)
IL (2) IL243944B (enExample)
RU (2) RU2721423C2 (enExample)
WO (1) WO2015019318A1 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112016002721A2 (pt) 2013-08-07 2018-07-10 Yeda Research And Development Company Ltd. peptídeos capazes de reativar p53 mutantes
CN105112377B (zh) * 2015-09-25 2018-10-30 福州迈新生物技术开发有限公司 一株分泌抗p53单克隆抗体的杂交瘤细胞株及其应用
US20220251159A1 (en) * 2016-02-04 2022-08-11 Yeda Research And Development Co., Ltd Peptides and use of same in the treatment of diseases, disroders or conditions associated with a mutant p53
CA3012302A1 (en) * 2016-02-04 2017-08-10 Yeda Research And Development Co. Ltd. Peptides and use of same in the treatment of diseases, disorders or conditions associated with a mutant p53
US11939365B2 (en) * 2017-09-29 2024-03-26 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services T cell receptors recognizing mutated P53
JOP20200134A1 (ar) 2017-12-07 2022-10-30 Reven Llc تركيبات وطرق لمعالجة حالات أيضية
EP3723785A1 (en) * 2017-12-17 2020-10-21 Yeda Research and Development Co. Ltd Cop9 signalosome (csn) complex modulators and uses thereof
WO2019134070A1 (en) * 2018-01-02 2019-07-11 Rui Jin Hospital, Shanghai Jiao Tong University School Of Medicine Panda as novel therapeutic
WO2019134650A1 (en) * 2018-01-02 2019-07-11 Rui Jin Hospital, Shanghai Jiao Tong University School Of Medicine Mp53 rescue compounds and methods of treating a p53 disorder
BR112021025105A2 (pt) * 2019-06-12 2022-03-15 Reven Ip Holdco Llc Métodos e composições para melhorar os resultados de pacientes com câncer
JP7402026B2 (ja) 2019-11-27 2023-12-20 株式会社小松製作所 作業機械の制御システム、作業機械、作業機械の制御方法
EP4121441A1 (en) 2020-03-16 2023-01-25 Yeda Research and Development Co. Ltd Peptide analogs and use of same in treating diseases, disorders or conditions associated with a mutant p53 protein
CN111574591B (zh) * 2020-04-29 2021-09-21 西安交通大学医学院第一附属医院 一种多肽及其合成方法
CN113750246B (zh) * 2020-06-04 2023-12-05 华南理工大学 ZIF-8纳米材料在降解广谱突变p53蛋白中的应用
CN111686127B (zh) * 2020-06-04 2022-02-15 华南理工大学 锌铁纳米材料在降解突变p53蛋白中的应用
US20230049952A1 (en) * 2020-06-24 2023-02-16 Pmv Pharmaceuticals, Inc. Methods and compounds for restoring mutant p53 function
CN112921032A (zh) * 2020-12-29 2021-06-08 苏州中科先进技术研究院有限公司 一种引物对、探针、试剂盒及其使用方法
CN115466786A (zh) * 2021-06-11 2022-12-13 上海交通大学医学院附属瑞金医院 一种筛选适合用p53复活药物治疗p53异常相关疾病病人的方法

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US5614393A (en) * 1991-10-10 1997-03-25 Rhone-Poulenc Agrochimie Production of γ-linolenic acid by a Δ6-desaturase
US5969120A (en) * 1993-09-03 1999-10-19 Research Development Foundation Mutants of the RB and P53 genes
US6184205B1 (en) 1994-07-22 2001-02-06 University Of North Carolina At Chapel Hill GRB2 SH3 binding peptides and methods of isolating and using same
US6169073B1 (en) * 1995-02-16 2001-01-02 Bayer Corporation Peptides and peptidomimetics with structural similarity to human p53 that activate p53 function
US5877282A (en) 1996-09-20 1999-03-02 Bristol-Myers Squibb Company Peptide inhibitors of nuclear protein translocation having nuclear localization sequences and methods of use thereof
AU7238098A (en) * 1997-05-15 1998-12-08 Kyowa Hakko Kogyo Co. Ltd. Peptides having cyclic structures and exerting p53 protein activty-restoring effect on p53 protein mutants
US20030224379A1 (en) * 2000-01-21 2003-12-04 Tang Y. Tom Novel nucleic acids and polypeptides
BR0207068A (pt) 2001-01-26 2004-12-21 Inhibitex Inc Anticorpo monoclonal para a protéina clfa, anti-soro isolado, anticorpo isolado e anticorpo humanizado contendo o referido anticorpo, kit diagnóstico compreendendo o referido anticorpo, método para diagnóstico de uma infecção por s.aureus, composição farmacêutica para o tratamento ou prevenção da referida infecção, método para indução de de uma resposta imunológica, método para identificação de anticorpos monoclonais para a protéina clfa e fragmento ativo isolado a partir do domìnio a da protéina clfa do s.aureus
WO2002068601A2 (en) * 2001-02-28 2002-09-06 Skubitz Keith M Small peptides capable of modulating the function of cd66 (ceacam) family members
US20070128657A1 (en) * 2002-01-23 2007-06-07 El-Gewely Mohamed R Molecular libraries
US7361747B2 (en) * 2003-05-22 2008-04-22 The University Of Hong Kong Isolation and characterization of the precursor virus of human SARS virus: SARS-associated corona virus-like virus
RU2007138027A (ru) * 2005-03-14 2009-04-20 Борд Оф Риджентс Оф Дзе Юниверсити Оф Техас Систем (Us) Биоактивные пептиды fus-1 и комплексы полипептидов с наночастицами
WO2009094006A2 (en) * 2007-10-25 2009-07-30 Wake Forest University Health Sciences Bordetella outer-membrane protein antigens and methods of making and using the same
WO2009112075A1 (en) * 2008-03-13 2009-09-17 Universita' Degli Studi Di Trieste Peptides and aptamers thereof as specific modulators of mutant p53 function
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WO2013040142A2 (en) * 2011-09-16 2013-03-21 Iogenetics, Llc Bioinformatic processes for determination of peptide binding
SG11201401043SA (en) * 2011-09-09 2014-08-28 Agency Science Tech & Res P53 activating peptides
JP6306593B2 (ja) * 2012-09-13 2018-04-04 ユニベルシテ ドゥ ジュネーブ 細胞透過性ペプチド
BR112016002721A2 (pt) 2013-08-07 2018-07-10 Yeda Research And Development Company Ltd. peptídeos capazes de reativar p53 mutantes
CA3012302A1 (en) 2016-02-04 2017-08-10 Yeda Research And Development Co. Ltd. Peptides and use of same in the treatment of diseases, disorders or conditions associated with a mutant p53

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