JP2017212998A5 - - Google Patents
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- JP2017212998A5 JP2017212998A5 JP2017136828A JP2017136828A JP2017212998A5 JP 2017212998 A5 JP2017212998 A5 JP 2017212998A5 JP 2017136828 A JP2017136828 A JP 2017136828A JP 2017136828 A JP2017136828 A JP 2017136828A JP 2017212998 A5 JP2017212998 A5 JP 2017212998A5
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- JP
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- Prior art keywords
- seq
- group
- nos
- sequence selected
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000007523 nucleic acids Chemical class 0.000 claims 42
- 102000039446 nucleic acids Human genes 0.000 claims 42
- 108020004707 nucleic acids Proteins 0.000 claims 42
- 239000013612 plasmid Substances 0.000 claims 2
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161508366P | 2011-07-15 | 2011-07-15 | |
| US61/508,366 | 2011-07-15 | ||
| US201261601409P | 2012-02-21 | 2012-02-21 | |
| US61/601,409 | 2012-02-21 | ||
| US201261610212P | 2012-03-13 | 2012-03-13 | |
| US61/610,212 | 2012-03-13 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014520317A Division JP6214530B2 (ja) | 2011-07-15 | 2012-07-12 | 転写活性化因子様エフェクターの組立て方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019043522A Division JP2019122392A (ja) | 2011-07-15 | 2019-03-11 | 転写活性化因子様エフェクターの組立て方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017212998A JP2017212998A (ja) | 2017-12-07 |
| JP2017212998A5 true JP2017212998A5 (enExample) | 2018-03-15 |
Family
ID=47558397
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014520317A Active JP6214530B2 (ja) | 2011-07-15 | 2012-07-12 | 転写活性化因子様エフェクターの組立て方法 |
| JP2017136828A Withdrawn JP2017212998A (ja) | 2011-07-15 | 2017-07-13 | 転写活性化因子様エフェクターの組立て方法 |
| JP2019043522A Pending JP2019122392A (ja) | 2011-07-15 | 2019-03-11 | 転写活性化因子様エフェクターの組立て方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014520317A Active JP6214530B2 (ja) | 2011-07-15 | 2012-07-12 | 転写活性化因子様エフェクターの組立て方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019043522A Pending JP2019122392A (ja) | 2011-07-15 | 2019-03-11 | 転写活性化因子様エフェクターの組立て方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US20140274812A1 (enExample) |
| EP (2) | EP2732038B1 (enExample) |
| JP (3) | JP6214530B2 (enExample) |
| AU (3) | AU2012284365B2 (enExample) |
| CA (1) | CA2841710C (enExample) |
| WO (1) | WO2013012674A1 (enExample) |
Families Citing this family (63)
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| US20140274812A1 (en) | 2011-07-15 | 2014-09-18 | The General Hospital Corporation | Methods of Transcription Activator Like Effector Assembly |
| WO2013066438A2 (en) | 2011-07-22 | 2013-05-10 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| WO2013017950A1 (en) * | 2011-07-29 | 2013-02-07 | Cellectis | High throughput method for assembly and cloning polynucleotides comprising highly similar polynucleotidic modules |
| US9890364B2 (en) | 2012-05-29 | 2018-02-13 | The General Hospital Corporation | TAL-Tet1 fusion proteins and methods of use thereof |
| EP2906602B1 (en) | 2012-10-12 | 2019-01-16 | The General Hospital Corporation | Transcription activator-like effector (tale) - lysine-specific demethylase 1 (lsd1) fusion proteins |
| CA2900338C (en) | 2013-02-07 | 2024-11-05 | The General Hospital Corporation | TRANSCRIPTIONAL ACTIVATORS TALE |
| WO2014204578A1 (en) | 2013-06-21 | 2014-12-24 | The General Hospital Corporation | Using rna-guided foki nucleases (rfns) to increase specificity for rna-guided genome editing |
| US10378027B2 (en) * | 2013-03-15 | 2019-08-13 | The General Hospital Corporation | RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci |
| US10760064B2 (en) | 2013-03-15 | 2020-09-01 | The General Hospital Corporation | RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci |
| US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9388430B2 (en) | 2013-09-06 | 2016-07-12 | President And Fellows Of Harvard College | Cas9-recombinase fusion proteins and uses thereof |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| CN106459995B (zh) | 2013-11-07 | 2020-02-21 | 爱迪塔斯医药有限公司 | 使用统治型gRNA的CRISPR相关方法和组合物 |
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| US11141493B2 (en) | 2014-03-10 | 2021-10-12 | Editas Medicine, Inc. | Compositions and methods for treating CEP290-associated disease |
| WO2015148863A2 (en) | 2014-03-26 | 2015-10-01 | Editas Medicine, Inc. | Crispr/cas-related methods and compositions for treating sickle cell disease |
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| EP3286571B1 (en) | 2015-04-24 | 2021-08-18 | Editas Medicine, Inc. | Evaluation of cas9 molecule/guide rna molecule complexes |
| US9512446B1 (en) | 2015-08-28 | 2016-12-06 | The General Hospital Corporation | Engineered CRISPR-Cas9 nucleases |
| US9926546B2 (en) | 2015-08-28 | 2018-03-27 | The General Hospital Corporation | Engineered CRISPR-Cas9 nucleases |
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| US11661590B2 (en) | 2016-08-09 | 2023-05-30 | President And Fellows Of Harvard College | Programmable CAS9-recombinase fusion proteins and uses thereof |
| WO2018039438A1 (en) | 2016-08-24 | 2018-03-01 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| SG11201903089RA (en) | 2016-10-14 | 2019-05-30 | Harvard College | Aav delivery of nucleobase editors |
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| EP3592381A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Cancer vaccine |
| US11898179B2 (en) | 2017-03-09 | 2024-02-13 | President And Fellows Of Harvard College | Suppression of pain by gene editing |
| WO2018165629A1 (en) | 2017-03-10 | 2018-09-13 | President And Fellows Of Harvard College | Cytosine to guanine base editor |
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| US20200405884A1 (en) * | 2018-03-09 | 2020-12-31 | Board Of Regents, The University Of Texas System | Crispr-nanoparticles and methods of use in brain disorders |
| KR102907245B1 (ko) | 2018-03-14 | 2026-01-05 | 에디타스 메디신, 인코포레이티드 | 혈색소병증 치료를 위한 시스템 및 방법 |
| US12312383B2 (en) | 2018-04-18 | 2025-05-27 | Altius Institute For Biomedical Sciences | Animal pathogen-derived polypeptides and uses thereof for genetic engineering |
| US12157760B2 (en) | 2018-05-23 | 2024-12-03 | The Broad Institute, Inc. | Base editors and uses thereof |
| WO2020006126A1 (en) | 2018-06-27 | 2020-01-02 | Altius Institute For Biomedical Sciences | Nucleic acid binding domains and methods of use thereof |
| EP3820495A4 (en) | 2018-07-09 | 2022-07-20 | The Broad Institute Inc. | RNA-PROGRAMMABLE EPIGENETIC RNA MODIFIERS AND THEIR USES |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| US12590324B2 (en) | 2019-01-14 | 2026-03-31 | Camena Bioscience Limited | Compositions and methods for template-free geometric enzymatic nucleic acid synthesis |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| EP3942043A2 (en) | 2019-03-19 | 2022-01-26 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| WO2020214842A1 (en) | 2019-04-17 | 2020-10-22 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| BR112022022603A2 (pt) | 2020-05-08 | 2023-01-17 | Broad Inst Inc | Métodos e composições para edição simultânea de ambas as fitas de sequência alvo de nucleotídeos de fita dupla |
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| EP2906602B1 (en) | 2012-10-12 | 2019-01-16 | The General Hospital Corporation | Transcription activator-like effector (tale) - lysine-specific demethylase 1 (lsd1) fusion proteins |
| CA2900338C (en) | 2013-02-07 | 2024-11-05 | The General Hospital Corporation | TRANSCRIPTIONAL ACTIVATORS TALE |
| US10378027B2 (en) | 2013-03-15 | 2019-08-13 | The General Hospital Corporation | RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci |
-
2012
- 2012-07-12 US US14/232,067 patent/US20140274812A1/en not_active Abandoned
- 2012-07-12 EP EP12814750.1A patent/EP2732038B1/en not_active Not-in-force
- 2012-07-12 JP JP2014520317A patent/JP6214530B2/ja active Active
- 2012-07-12 EP EP18191841.8A patent/EP3461896B1/en active Active
- 2012-07-12 CA CA2841710A patent/CA2841710C/en active Active
- 2012-07-12 AU AU2012284365A patent/AU2012284365B2/en not_active Ceased
- 2012-07-12 WO PCT/US2012/046451 patent/WO2013012674A1/en not_active Ceased
-
2016
- 2016-05-17 US US15/156,574 patent/US10273271B2/en active Active
-
2017
- 2017-07-13 AU AU2017204819A patent/AU2017204819A1/en not_active Abandoned
- 2017-07-13 JP JP2017136828A patent/JP2017212998A/ja not_active Withdrawn
-
2019
- 2019-02-22 US US16/283,380 patent/US11472849B2/en active Active
- 2019-03-11 JP JP2019043522A patent/JP2019122392A/ja active Pending
- 2019-09-06 AU AU2019226213A patent/AU2019226213A1/en not_active Abandoned
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