JP2018518163A5 - - Google Patents
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- JP2018518163A5 JP2018518163A5 JP2017559861A JP2017559861A JP2018518163A5 JP 2018518163 A5 JP2018518163 A5 JP 2018518163A5 JP 2017559861 A JP2017559861 A JP 2017559861A JP 2017559861 A JP2017559861 A JP 2017559861A JP 2018518163 A5 JP2018518163 A5 JP 2018518163A5
- Authority
- JP
- Japan
- Prior art keywords
- lytic bacteriophage
- repeat
- spacer
- lytic
- type
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 241001515965 unidentified phage Species 0.000 claims 22
- 230000002101 lytic effect Effects 0.000 claims 21
- 125000006850 spacer group Chemical group 0.000 claims 10
- 230000001580 bacterial effect Effects 0.000 claims 7
- 241000894007 species Species 0.000 claims 7
- 108091033409 CRISPR Proteins 0.000 claims 4
- 238000010354 CRISPR gene editing Methods 0.000 claims 4
- 108020004414 DNA Proteins 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 241000588724 Escherichia coli Species 0.000 claims 1
- 241000588747 Klebsiella pneumoniae Species 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022054902A JP7290368B2 (ja) | 2015-06-15 | 2022-03-30 | 核酸およびｒｎａに基づく抗菌剤の効率的な送達のための方法および組成物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562175749P | 2015-06-15 | 2015-06-15 | |
| US62/175,749 | 2015-06-15 | ||
| PCT/US2016/037493 WO2016205276A1 (en) | 2015-06-15 | 2016-06-15 | Methods and compositions for efficient delivery of nucleic acids and rna-based antimicrobials |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022054902A Division JP7290368B2 (ja) | 2015-06-15 | 2022-03-30 | 核酸およびｒｎａに基づく抗菌剤の効率的な送達のための方法および組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018518163A JP2018518163A (ja) | 2018-07-12 |
| JP2018518163A5 true JP2018518163A5 (enExample) | 2019-07-18 |
| JP7051438B2 JP7051438B2 (ja) | 2022-04-11 |
Family
ID=57546192
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017559861A Active JP7051438B2 (ja) | 2015-06-15 | 2016-06-15 | 核酸およびｒｎａに基づく抗菌剤の効率的な送達のための方法および組成物 |
| JP2022054902A Active JP7290368B2 (ja) | 2015-06-15 | 2022-03-30 | 核酸およびｒｎａに基づく抗菌剤の効率的な送達のための方法および組成物 |
| JP2023084331A Pending JP2023109907A (ja) | 2015-06-15 | 2023-05-23 | 核酸およびｒｎａに基づく抗菌剤の効率的な送達のための方法および組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022054902A Active JP7290368B2 (ja) | 2015-06-15 | 2022-03-30 | 核酸およびｒｎａに基づく抗菌剤の効率的な送達のための方法および組成物 |
| JP2023084331A Pending JP2023109907A (ja) | 2015-06-15 | 2023-05-23 | 核酸およびｒｎａに基づく抗菌剤の効率的な送達のための方法および組成物 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US11155823B2 (enExample) |
| EP (2) | EP4299754A3 (enExample) |
| JP (3) | JP7051438B2 (enExample) |
| KR (2) | KR102468240B1 (enExample) |
| CN (2) | CN115537421A (enExample) |
| AU (2) | AU2016280002B2 (enExample) |
| CA (1) | CA2983874C (enExample) |
| DK (1) | DK3307872T3 (enExample) |
| ES (1) | ES2960226T3 (enExample) |
| FI (1) | FI3307872T3 (enExample) |
| WO (1) | WO2016205276A1 (enExample) |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2734621B1 (en) | 2011-07-22 | 2019-09-04 | President and Fellows of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US9340800B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | Extended DNA-sensing GRNAS |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US10584358B2 (en) | 2013-10-30 | 2020-03-10 | North Carolina State University | Compositions and methods related to a type-II CRISPR-Cas system in Lactobacillus buchneri |
| US20150165054A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting caspase-9 point mutations |
| WO2015155686A2 (en) | 2014-04-08 | 2015-10-15 | North Carolina State University | Methods and compositions for rna-directed repression of transcription using crispr-associated genes |
| CA2956224A1 (en) | 2014-07-30 | 2016-02-11 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| US10450584B2 (en) | 2014-08-28 | 2019-10-22 | North Carolina State University | Cas9 proteins and guiding features for DNA targeting and genome editing |
| PL3291679T3 (pl) | 2015-05-06 | 2022-04-25 | Snipr Technologies Limited | Zmiana populacji drobnoustrojowych i modyfikowanie mikrobioty |
| AU2016270649B2 (en) | 2015-05-29 | 2022-04-21 | North Carolina State University | Methods for screening bacteria, archaea, algae, and yeast using crispr nucleic acids |
| WO2017058751A1 (en) | 2015-09-28 | 2017-04-06 | North Carolina State University | Methods and compositions for sequence specific antimicrobials |
| EP4434589A3 (en) | 2015-10-23 | 2025-05-14 | President and Fellows of Harvard College | Evolved cas9 proteins for gene editing |
| WO2017074788A1 (en) * | 2015-10-27 | 2017-05-04 | The Broad Institute Inc. | Compositions and methods for targeting cancer-specific sequence variations |
| US11311582B2 (en) | 2015-11-19 | 2022-04-26 | Locus Biosciences, Inc. | Bacteriophage compositions and methods of use thereof |
| WO2017112620A1 (en) | 2015-12-22 | 2017-06-29 | North Carolina State University | Methods and compositions for delivery of crispr based antimicrobials |
| GB201609811D0 (en) | 2016-06-05 | 2016-07-20 | Snipr Technologies Ltd | Methods, cells, systems, arrays, RNA and kits |
| JP7231935B2 (ja) | 2016-08-03 | 2023-03-08 | プレジデント アンド フェローズ オブ ハーバード カレッジ | アデノシン核酸塩基編集因子およびそれらの使用 |
| US11661590B2 (en) | 2016-08-09 | 2023-05-30 | President And Fellows Of Harvard College | Programmable CAS9-recombinase fusion proteins and uses thereof |
| WO2018039438A1 (en) | 2016-08-24 | 2018-03-01 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| AU2017342543B2 (en) | 2016-10-14 | 2024-06-27 | President And Fellows Of Harvard College | AAV delivery of nucleobase editors |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| AU2018217936A1 (en) * | 2017-02-10 | 2019-08-29 | Eth Zurich | Rebooting of synthetic bacteriophage genome in L-form bacteria |
| CN110662556A (zh) | 2017-03-09 | 2020-01-07 | 哈佛大学的校长及成员们 | 癌症疫苗 |
| US11898179B2 (en) | 2017-03-09 | 2024-02-13 | President And Fellows Of Harvard College | Suppression of pain by gene editing |
| JP2020510439A (ja) | 2017-03-10 | 2020-04-09 | プレジデント アンド フェローズ オブ ハーバード カレッジ | シトシンからグアニンへの塩基編集因子 |
| WO2018176009A1 (en) | 2017-03-23 | 2018-09-27 | President And Fellows Of Harvard College | Nucleobase editors comprising nucleic acid programmable dna binding proteins |
| US11560566B2 (en) | 2017-05-12 | 2023-01-24 | President And Fellows Of Harvard College | Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation |
| EP4623922A3 (en) * | 2017-06-25 | 2026-02-25 | SNIPR Technologies Limited | Altering microbial populations & modifying microbiota |
| US11732274B2 (en) | 2017-07-28 | 2023-08-22 | President And Fellows Of Harvard College | Methods and compositions for evolving base editors using phage-assisted continuous evolution (PACE) |
| GB201712733D0 (en) * | 2017-08-08 | 2017-09-20 | Snipr Tech Ltd | Methods & cells |
| CN107447044A (zh) * | 2017-08-09 | 2017-12-08 | 华子昂 | 一种检测大肠杆菌λ噬菌体全基因组碱基修饰单倍型的方法 |
| CN107365804B (zh) * | 2017-08-13 | 2019-12-20 | 中国人民解放军疾病预防控制所 | 一种使用温和噬菌体载体包装CRISPR-Cas9系统的方法 |
| WO2019139645A2 (en) | 2017-08-30 | 2019-07-18 | President And Fellows Of Harvard College | High efficiency base editors comprising gam |
| KR20200121782A (ko) | 2017-10-16 | 2020-10-26 | 더 브로드 인스티튜트, 인코퍼레이티드 | 아데노신 염기 편집제의 용도 |
| US12406749B2 (en) | 2017-12-15 | 2025-09-02 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| CN108300732A (zh) * | 2018-02-23 | 2018-07-20 | 上海交通大学 | 一种高转化率运动发酵单胞菌及其构建方法和应用 |
| WO2019185551A1 (en) * | 2018-03-25 | 2019-10-03 | Snipr Biome Aps. | Treating & preventing microbial infections |
| US10760075B2 (en) | 2018-04-30 | 2020-09-01 | Snipr Biome Aps | Treating and preventing microbial infections |
| TW202014519A (zh) * | 2018-05-04 | 2020-04-16 | 美商羅卡斯生物科學公司 | 殺目標細菌之組合物及方法 |
| JP6923862B2 (ja) * | 2018-05-22 | 2021-08-25 | 学校法人自治医科大学 | 抗菌ファージ、治療用組成物、殺菌剤、食品、細菌判別キット、治療用組成物製造方法、細菌除去方法、細菌判別方法、及び動物治療方法 |
| US12157760B2 (en) | 2018-05-23 | 2024-12-03 | The Broad Institute, Inc. | Base editors and uses thereof |
| US10227576B1 (en) | 2018-06-13 | 2019-03-12 | Caribou Biosciences, Inc. | Engineered cascade components and cascade complexes |
| US12227776B2 (en) | 2018-06-13 | 2025-02-18 | Caribou Biosciences, Inc. | Engineered cascade components and cascade complexes |
| US12522807B2 (en) | 2018-07-09 | 2026-01-13 | The Broad Institute, Inc. | RNA programmable epigenetic RNA modifiers and uses thereof |
| US12264313B2 (en) | 2018-10-01 | 2025-04-01 | North Carolina State University | Recombinant type I CRISPR-Cas system and uses thereof for genome modification and alteration of expression |
| WO2020072253A1 (en) | 2018-10-01 | 2020-04-09 | North Carolina State University | Recombinant type i crispr-cas system and uses thereof for screening for variant cells |
| WO2020072248A1 (en) | 2018-10-01 | 2020-04-09 | North Carolina State University | Recombinant type i crispr-cas system |
| US12264330B2 (en) | 2018-10-01 | 2025-04-01 | North Carolina State University | Recombinant type I CRISPR-Cas system and uses thereof for killing target cells |
| US11851663B2 (en) | 2018-10-14 | 2023-12-26 | Snipr Biome Aps | Single-vector type I vectors |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| WO2020154500A1 (en) | 2019-01-23 | 2020-07-30 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| WO2020163655A1 (en) * | 2019-02-06 | 2020-08-13 | Fred Hutchinson Cancer Research Center | Minicircle producing bacteria engineered to differentially methylate nucleic acid molecules therein |
| MX2021011426A (es) | 2019-03-19 | 2022-03-11 | Broad Inst Inc | Metodos y composiciones para editar secuencias de nucleótidos. |
| WO2020214842A1 (en) | 2019-04-17 | 2020-10-22 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| US20220389392A1 (en) * | 2019-11-06 | 2022-12-08 | Locus Biosciences, Inc. | Crispr cas systems and lysogeny modules |
| WO2021092210A1 (en) * | 2019-11-06 | 2021-05-14 | Locus Biosciences, Inc. | Phage compositions comprising crispr-cas systems and methods of use thereof |
| US11584781B2 (en) | 2019-12-30 | 2023-02-21 | Eligo Bioscience | Chimeric receptor binding proteins resistant to proteolytic degradation |
| US12098372B2 (en) | 2019-12-30 | 2024-09-24 | Eligo Bioscience | Microbiome modulation of a host by delivery of DNA payloads with minimized spread |
| US11746352B2 (en) * | 2019-12-30 | 2023-09-05 | Eligo Bioscience | Microbiome modulation of a host by delivery of DNA payloads with minimized spread |
| WO2021226558A1 (en) | 2020-05-08 | 2021-11-11 | The Broad Institute, Inc. | Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence |
| GB202007943D0 (en) | 2020-05-27 | 2020-07-08 | Snipr Biome Aps | Products & methods |
| WO2022098916A1 (en) * | 2020-11-05 | 2022-05-12 | Locus Biosciences, Inc. | Phage compositions for pseudomonas comprising crispr-cas systems and methods of use thereof |
| WO2022098899A1 (en) * | 2020-11-05 | 2022-05-12 | Locus Biosciences, Inc. | Phage compositions for escherichia comprising crispr-cas systems and methods of use thereof |
| EP4370665A4 (en) * | 2021-07-15 | 2025-08-13 | Univ North Carolina State | COMPOSITIONS, METHODS AND SYSTEMS FOR ENHANCED DNA TRANSFORMATION IN BACTERIA |
| WO2023111286A1 (en) | 2021-12-17 | 2023-06-22 | Snipr Biome Aps | Nucleic acid delivery methods and compositions |
| GB202209518D0 (en) | 2022-06-29 | 2022-08-10 | Snipr Biome Aps | Treating & preventing E coli infections |
| KR20250060133A (ko) | 2023-10-24 | 2025-05-07 | 중앙대학교 산학협력단 | CRISPR-Cas 탑재 박테리오파지 및 이의 용도 |
| WO2025208072A1 (en) * | 2024-03-29 | 2025-10-02 | The General Hospital Corporation | Methods and materials for treating disorders related to bacterial infections |
Family Cites Families (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4723202A (en) | 1987-04-02 | 1988-02-02 | The Garrett Corporation | Converter-fed AC machine without damper winding |
| AU2002365188A1 (en) * | 2001-11-07 | 2003-07-30 | Musc Foundation For Research Development | Nucleic acid delivery and expression |
| US7919277B2 (en) | 2004-04-28 | 2011-04-05 | Danisco A/S | Detection and typing of bacterial strains |
| EP2444496A1 (en) | 2005-04-15 | 2012-04-25 | Del Monte Fresh Produce Company | Plant promoters, terminators, genes, vectors and related transformed plants |
| ATE530669T1 (de) * | 2006-05-19 | 2011-11-15 | Danisco | Markierte mikroorganismen und entsprechende markierungsverfahren |
| ES2719789T3 (es) * | 2007-03-02 | 2019-07-16 | Dupont Nutrition Biosci Aps | Cultivos con resistencia mejorada a fagos |
| US10662227B2 (en) | 2008-11-07 | 2020-05-26 | Dupont Nutrition Biosciences Aps | Bifidobacteria CRISPR sequences |
| WO2010075424A2 (en) | 2008-12-22 | 2010-07-01 | The Regents Of University Of California | Compositions and methods for downregulating prokaryotic genes |
| BR112013009583A2 (pt) | 2010-10-20 | 2017-05-30 | Dupont Nutrition Biosci Aps | ácido nucleico, vetor, célula hospedeira, métodos de preparação de uma linhagem bacteriana variante de tipificação, de marcação, de geração e de controle de populações bacterianas, linhagem e célula bacteriana variante, kit, uso de um ácido nucleico, cultivo celular, produto, processo de preparação de produtos, mutantes de fago e mutante de escape de fago |
| WO2012164565A1 (en) | 2011-06-01 | 2012-12-06 | Yeda Research And Development Co. Ltd. | Compositions and methods for downregulating prokaryotic genes |
| DK2726652T3 (en) * | 2011-06-29 | 2017-01-23 | Affinity Biosciences Pty Ltd | PROCEDURE FOR PROTEIN INSTRUCTIONS |
| GB201122458D0 (en) | 2011-12-30 | 2012-02-08 | Univ Wageningen | Modified cascade ribonucleoproteins and uses thereof |
| US9637739B2 (en) | 2012-03-20 | 2017-05-02 | Vilnius University | RNA-directed DNA cleavage by the Cas9-crRNA complex |
| WO2013141680A1 (en) | 2012-03-20 | 2013-09-26 | Vilnius University | RNA-DIRECTED DNA CLEAVAGE BY THE Cas9-crRNA COMPLEX |
| PL4289948T3 (pl) | 2012-05-25 | 2025-06-02 | The Regents Of The University Of California | Sposoby i kompozycje do modyfikacji kierowanego na rna docelowego dna i do nakierowanej na rna modulacji transkrypcji |
| RU2014153918A (ru) | 2012-06-12 | 2016-07-27 | Дженентек, Инк. | Способы и композиции для получения условно нокаутных аллелей |
| US9688971B2 (en) | 2012-06-15 | 2017-06-27 | The Regents Of The University Of California | Endoribonuclease and methods of use thereof |
| WO2014022702A2 (en) | 2012-08-03 | 2014-02-06 | The Regents Of The University Of California | Methods and compositions for controlling gene expression by rna processing |
| EP2912175B1 (en) | 2012-10-23 | 2018-08-22 | Toolgen Incorporated | Composition for cleaving a target dna comprising a guide rna specific for the target dna and cas protein-encoding nucleic acid or cas protein, and use thereof |
| US20150315576A1 (en) | 2012-11-01 | 2015-11-05 | Massachusetts Institute Of Technology | Genetic device for the controlled destruction of dna |
| CN105142669B (zh) | 2012-12-06 | 2018-07-03 | 西格马-奥尔德里奇有限责任公司 | 基于crispr的基因组修饰和调控 |
| WO2014093479A1 (en) | 2012-12-11 | 2014-06-19 | Montana State University | Crispr (clustered regularly interspaced short palindromic repeats) rna-guided control of gene regulation |
| WO2014093655A2 (en) | 2012-12-12 | 2014-06-19 | The Broad Institute, Inc. | Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains |
| EP4282970A3 (en) | 2012-12-17 | 2024-01-17 | President and Fellows of Harvard College | Rna-guided human genome engineering |
| AU2014205648B2 (en) | 2013-01-10 | 2017-05-04 | Dharmacon, Inc. | Templates, libraries, kits and methods for generating molecules |
| AU2014207618A1 (en) | 2013-01-16 | 2015-08-06 | Emory University | Cas9-nucleic acid complexes and uses related thereto |
| WO2014124226A1 (en) | 2013-02-07 | 2014-08-14 | The Rockefeller University | Sequence specific antimicrobials |
| KR20170108172A (ko) | 2013-03-14 | 2017-09-26 | 카리부 바이오사이언시스 인코포레이티드 | 핵산-표적화 핵산의 조성물 및 방법 |
| IL289396B2 (en) | 2013-03-15 | 2023-12-01 | The General Hospital Coporation | Using truncated guide rnas (tru-grnas) to increase specificity for rna-guided genome editing |
| US20140273230A1 (en) | 2013-03-15 | 2014-09-18 | Sigma-Aldrich Co., Llc | Crispr-based genome modification and regulation |
| EP2970997A1 (en) | 2013-03-15 | 2016-01-20 | Regents of the University of Minnesota | Engineering plant genomes using crispr/cas systems |
| WO2014186686A2 (en) | 2013-05-17 | 2014-11-20 | Two Blades Foundation | Targeted mutagenesis and genome engineering in plants using rna-guided cas nucleases |
| JP7065564B2 (ja) | 2013-05-29 | 2022-05-12 | セレクティス | Ｃａｓ９ニッカーゼ活性を用いて正確なｄｎａ切断をもたらすための方法 |
| US9873907B2 (en) | 2013-05-29 | 2018-01-23 | Agilent Technologies, Inc. | Method for fragmenting genomic DNA using CAS9 |
| US9890393B2 (en) | 2013-05-29 | 2018-02-13 | Cellectis | Methods for engineering T cells for immunotherapy by using RNA-guided CAS nuclease system |
| US20140356956A1 (en) | 2013-06-04 | 2014-12-04 | President And Fellows Of Harvard College | RNA-Guided Transcriptional Regulation |
| US9982277B2 (en) | 2013-06-11 | 2018-05-29 | The Regents Of The University Of California | Methods and compositions for target DNA modification |
| EP3674411A1 (en) | 2013-06-17 | 2020-07-01 | The Broad Institute, Inc. | Delivery, engineering and optimization of tandem guide systems, methods and compositions for sequence manipulation |
| EP3011033B1 (en) | 2013-06-17 | 2020-02-19 | The Broad Institute, Inc. | Functional genomics using crispr-cas systems, compositions methods, screens and applications thereof |
| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
| MX363842B (es) | 2013-08-22 | 2019-04-05 | Du Pont | Métodos para producir modificaciones genéticas en un genoma vegetal sin incorporar un marcador transgénico seleccionable, y composiciones de éstas. |
| EP3041498B1 (en) | 2013-09-05 | 2022-02-16 | Massachusetts Institute of Technology | Tuning microbial populations with programmable nucleases |
| US9340800B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | Extended DNA-sensing GRNAS |
| EP3418379B1 (en) | 2013-09-18 | 2020-12-09 | Kymab Limited | Methods, cells & organisms |
| US20150098954A1 (en) | 2013-10-08 | 2015-04-09 | Elwha Llc | Compositions and Methods Related to CRISPR Targeting |
| US10584358B2 (en) | 2013-10-30 | 2020-03-10 | North Carolina State University | Compositions and methods related to a type-II CRISPR-Cas system in Lactobacillus buchneri |
| WO2015070193A1 (en) | 2013-11-11 | 2015-05-14 | Liu Oliver | Compositions and methods for targeted gene disruption in prokaryotes |
| WO2015071474A2 (en) | 2013-11-18 | 2015-05-21 | Crispr Therapeutics Ag | Crispr-cas system materials and methods |
| US10787684B2 (en) | 2013-11-19 | 2020-09-29 | President And Fellows Of Harvard College | Large gene excision and insertion |
| US20150165054A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting caspase-9 point mutations |
| US9994831B2 (en) | 2013-12-12 | 2018-06-12 | The Regents Of The University Of California | Methods and compositions for modifying a single stranded target nucleic acid |
| EP3080271B1 (en) | 2013-12-12 | 2020-02-12 | The Broad Institute, Inc. | Systems, methods and compositions for sequence manipulation with optimized functional crispr-cas systems |
| US10787654B2 (en) | 2014-01-24 | 2020-09-29 | North Carolina State University | Methods and compositions for sequence guiding Cas9 targeting |
| EP3097212A4 (en) | 2014-01-24 | 2017-10-04 | North Carolina State University | Methods and compositions for sequences guiding cas9 targeting |
| WO2015116686A1 (en) | 2014-01-29 | 2015-08-06 | Agilent Technologies, Inc. | Cas9-based isothermal method of detection of specific dna sequence |
| PL3102722T3 (pl) | 2014-02-04 | 2021-03-08 | Jumpcode Genomics, Inc. | Frakcjonowanie genomu |
| US10323073B2 (en) | 2014-03-20 | 2019-06-18 | UNIVERSITé LAVAL | CRISPR-based methods and products for increasing frataxin levels and uses thereof |
| EP3122870B1 (en) | 2014-03-25 | 2022-06-29 | Ginkgo Bioworks Inc. | Methods and genetic systems for cell engineering |
| WO2015153791A1 (en) | 2014-04-01 | 2015-10-08 | Editas Medicine, Inc. | Crispr/cas-related methods and compositions for treating herpes simplex virus type 2 (hsv-2) |
| US10507232B2 (en) | 2014-04-02 | 2019-12-17 | University Of Florida Research Foundation, Incorporated | Materials and methods for the treatment of latent viral infection |
| JP2017509350A (ja) | 2014-04-03 | 2017-04-06 | マサチューセッツ インスティテュート オブ テクノロジー | ガイドｒｎａの生成のための方法および組成物 |
| WO2015155686A2 (en) | 2014-04-08 | 2015-10-15 | North Carolina State University | Methods and compositions for rna-directed repression of transcription using crispr-associated genes |
| DK3132034T3 (da) | 2014-04-14 | 2020-10-19 | Nemesis Bioscience Ltd | Terapeutikum |
| JP2017513477A (ja) | 2014-04-14 | 2017-06-01 | マックスサイト インコーポレーティッド | ゲノムｄｎａを改変するための方法および組成物 |
| GB201406970D0 (en) | 2014-04-17 | 2014-06-04 | Green Biologics Ltd | Targeted mutations |
| GB201406968D0 (en) | 2014-04-17 | 2014-06-04 | Green Biologics Ltd | Deletion mutants |
| WO2015189693A1 (en) | 2014-06-12 | 2015-12-17 | King Abdullah University Of Science And Technology | Targeted viral-mediated plant genome editing using crispr/cas9 |
| WO2015200555A2 (en) | 2014-06-25 | 2015-12-30 | Caribou Biosciences, Inc. | Rna modification to engineer cas9 activity |
| US10450584B2 (en) | 2014-08-28 | 2019-10-22 | North Carolina State University | Cas9 proteins and guiding features for DNA targeting and genome editing |
| EP3224353B9 (en) | 2014-11-26 | 2023-08-09 | Technology Innovation Momentum Fund (Israel) Limited Partnership | Targeted elimination of bacterial genes |
| US12129471B2 (en) | 2015-02-23 | 2024-10-29 | Vertex Pharmaceuticals Incorporated | Materials and methods for treatment of human genetic diseases including hemoglobinopathies |
| PL3291679T3 (pl) | 2015-05-06 | 2022-04-25 | Snipr Technologies Limited | Zmiana populacji drobnoustrojowych i modyfikowanie mikrobioty |
| AU2016270649B2 (en) | 2015-05-29 | 2022-04-21 | North Carolina State University | Methods for screening bacteria, archaea, algae, and yeast using crispr nucleic acids |
| US9580727B1 (en) | 2015-08-07 | 2017-02-28 | Caribou Biosciences, Inc. | Compositions and methods of engineered CRISPR-Cas9 systems using split-nexus Cas9-associated polynucleotides |
| WO2017053713A1 (en) | 2015-09-25 | 2017-03-30 | Tarveda Therapeutics, Inc. | Compositions and methods for genome editing |
| WO2017058751A1 (en) | 2015-09-28 | 2017-04-06 | North Carolina State University | Methods and compositions for sequence specific antimicrobials |
| US11970710B2 (en) | 2015-10-13 | 2024-04-30 | Duke University | Genome engineering with Type I CRISPR systems in eukaryotic cells |
| WO2017112620A1 (en) | 2015-12-22 | 2017-06-29 | North Carolina State University | Methods and compositions for delivery of crispr based antimicrobials |
| US11504404B2 (en) | 2016-02-24 | 2022-11-22 | Crown Laboratories, Inc. | Skin probiotic formulation |
-
2016
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