JP2012223202A5 - - Google Patents

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Publication number
JP2012223202A5
JP2012223202A5 JP2012179638A JP2012179638A JP2012223202A5 JP 2012223202 A5 JP2012223202 A5 JP 2012223202A5 JP 2012179638 A JP2012179638 A JP 2012179638A JP 2012179638 A JP2012179638 A JP 2012179638A JP 2012223202 A5 JP2012223202 A5 JP 2012223202A5
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JP
Japan
Prior art keywords
seq
stranded rna
rna effector
sequence
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2012179638A
Other languages
English (en)
Japanese (ja)
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JP2012223202A (ja
Filing date
Publication date
Application filed filed Critical
Publication of JP2012223202A publication Critical patent/JP2012223202A/ja
Publication of JP2012223202A5 publication Critical patent/JP2012223202A5/ja
Pending legal-status Critical Current

Links

JP2012179638A 2004-12-22 2012-08-13 遺伝子サイレンシングに有用なhbvおよびhcv保存配列 Pending JP2012223202A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63829404P 2004-12-22 2004-12-22
US60/638,294 2004-12-22

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2007548393A Division JP2008525029A (ja) 2004-12-22 2005-12-20 遺伝子サイレンシングに有用なhbvおよびhcv保存配列

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014179056A Division JP5934310B2 (ja) 2004-12-22 2014-09-03 遺伝子サイレンシングに有用なhbvおよびhcv保存配列

Publications (2)

Publication Number Publication Date
JP2012223202A JP2012223202A (ja) 2012-11-15
JP2012223202A5 true JP2012223202A5 (enExample) 2015-10-29

Family

ID=36602266

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2007548393A Pending JP2008525029A (ja) 2004-12-22 2005-12-20 遺伝子サイレンシングに有用なhbvおよびhcv保存配列
JP2012179638A Pending JP2012223202A (ja) 2004-12-22 2012-08-13 遺伝子サイレンシングに有用なhbvおよびhcv保存配列
JP2014179056A Expired - Lifetime JP5934310B2 (ja) 2004-12-22 2014-09-03 遺伝子サイレンシングに有用なhbvおよびhcv保存配列

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2007548393A Pending JP2008525029A (ja) 2004-12-22 2005-12-20 遺伝子サイレンシングに有用なhbvおよびhcv保存配列

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2014179056A Expired - Lifetime JP5934310B2 (ja) 2004-12-22 2014-09-03 遺伝子サイレンシングに有用なhbvおよびhcv保存配列

Country Status (7)

Country Link
EP (2) EP1833967B1 (enExample)
JP (3) JP2008525029A (enExample)
AT (1) ATE507293T1 (enExample)
AU (1) AU2005319306B9 (enExample)
CA (1) CA2592099A1 (enExample)
DE (1) DE602005027747D1 (enExample)
WO (1) WO2006069064A2 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8575327B2 (en) * 2003-06-12 2013-11-05 Alnylam Pharmaceuticals, Inc. Conserved HBV and HCV sequences useful for gene silencing
ES2362670T3 (es) * 2004-09-24 2011-07-11 Alnylam Pharmaceuticals, Inc Orientación a intermedios de replicación de hebra no codificante de virus monocatenarios por arni.
EP3587574B1 (en) 2010-08-17 2022-03-16 Sirna Therapeutics, Inc. Rna interference mediated inhibition of hepatitis b virus (hbv) gene expression using short interfering nucleic acid (sina)
JP6042871B2 (ja) 2011-04-21 2016-12-14 アイオーニス ファーマシューティカルズ, インコーポレーテッドIonis Pharmaceuticals,Inc. B型肝炎ウイルス(hbv)発現の調節
WO2013119793A1 (en) * 2012-02-07 2013-08-15 University Of Kansas Chemiluminescent nanoparticles and uses thereof
WO2013159109A1 (en) * 2012-04-20 2013-10-24 Isis Pharmaceuticals, Inc. Modulation of hepatitis b virus (hbv) expression
PT3363902T (pt) * 2012-12-06 2019-12-19 Sigma Aldrich Co Llc Modificação e regulação de genoma baseadas em crispr
LT3074517T (lt) * 2013-11-28 2021-11-25 Bavarian Nordic A/S Kompozicijos ir būdai, skirti sukelti padidintą imuninį atsaką, naudojant raupų viruso vektorius
JOP20200092A1 (ar) 2014-11-10 2017-06-16 Alnylam Pharmaceuticals Inc تركيبات iRNA لفيروس الكبد B (HBV) وطرق لاستخدامها
KR20170141257A (ko) * 2015-05-06 2017-12-22 베니텍 바이오파마 리미티드 B형 간염 바이러스 (hbv) 감염의 치료를 위한 시약 및 이의 용도
US11535851B2 (en) 2016-05-05 2022-12-27 Benitec IP Holdings Inc. Reagents for treatment of hepatitis B virus (HBV) infection and use thereof
CN110234763A (zh) * 2016-11-11 2019-09-13 詹森生物制药有限公司 针对hbv cccdna的寡核苷酸靶向策略
AU2017368050A1 (en) 2016-11-29 2019-06-20 Puretech Lyt, Inc. Exosomes for delivery of therapeutic agents
US11324820B2 (en) 2017-04-18 2022-05-10 Alnylam Pharmaceuticals, Inc. Methods for the treatment of subjects having a hepatitis b virus (HBV) infection
UA127745C2 (uk) 2018-08-13 2023-12-20 Альнілам Фармасьютікалз, Інк. КОМПОЗИЦІЇ, ЩО МІСТЯТЬ ЗАСІБ НА ОСНОВІ dsRNA ВІРУСУ ГЕПАТИТУ В (HBV), ТА СПОСОБИ ЇХ ВИКОРИСТАННЯ

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5643771A (en) 1980-05-19 1997-07-01 The Board Of Trustees Of The Leland Stanford Junior University Non-reverting live bacterial vaccines
US4897355A (en) 1985-01-07 1990-01-30 Syntex (U.S.A.) Inc. N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
EP0400047B1 (en) 1988-02-05 1997-04-23 Whitehead Institute For Biomedical Research Modified hepatocytes and uses therefor
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US5279833A (en) 1990-04-04 1994-01-18 Yale University Liposomal transfection of nucleic acids into animal cells
US5264618A (en) 1990-04-19 1993-11-23 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
US5283185A (en) 1991-08-28 1994-02-01 University Of Tennessee Research Corporation Method for delivering nucleic acids into cells
US5593972A (en) 1993-01-26 1997-01-14 The Wistar Institute Genetic immunization
US5739118A (en) 1994-04-01 1998-04-14 Apollon, Inc. Compositions and methods for delivery of genetic material
WO1995027788A1 (en) * 1994-04-11 1995-10-19 Dainabot Co., Ltd. Polypeptide derived from variant hepatitis b virus, gene encoding the same, and related dna
US5837533A (en) 1994-09-28 1998-11-17 American Home Products Corporation Complexes comprising a nucleic acid bound to a cationic polyamine having an endosome disruption agent
US5877159A (en) 1995-05-03 1999-03-02 University Of Maryland At Baltimore Method for introducing and expressing genes in animal cells and live invasive bacterial vectors for use in the same
US5932241A (en) 1995-06-07 1999-08-03 Valentis, Incorporated Cationic lipid DNA complexes for gene targeting
US5874565A (en) 1995-08-29 1999-02-23 Washington University Nucleic acids comprising a highly conserved novel 3 terminal sequence element of the hepatitis C virus
US5824538A (en) 1995-09-06 1998-10-20 The United States Of America As Represented By The Secretary Of The Army Shigella vector for delivering DNA to a mammalian cell
US5843770A (en) * 1996-03-11 1998-12-01 The Immune Response Corporation Antisense constructs directed against viral post-transcriptional regulatory sequences
US6217900B1 (en) 1997-04-30 2001-04-17 American Home Products Corporation Vesicular complexes and methods of making and using the same
CA2306733A1 (en) 1997-10-28 1999-05-06 American Home Products Corporation Compositions and methods for delivery of genetic material
US6506559B1 (en) 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
JP2002506801A (ja) 1998-03-16 2002-03-05 ザ、プロクター、エンド、ギャンブル、カンパニー 哺乳類の皮膚のセルライトを軽減する方法
WO2000063364A2 (en) 1999-04-21 2000-10-26 American Home Products Corporation Methods and compositions for inhibiting the function of polynucleotide sequences
WO2001038498A2 (en) * 1999-11-24 2001-05-31 Pharmasset, Ltd. A new genotype of hepatitis b virus
HK1048492A1 (zh) * 1999-12-03 2003-04-04 Innogenetics N.V. 新的hbv序列
EP1229134A3 (en) 2001-01-31 2004-01-28 Nucleonics, Inc Use of post-transcriptional gene silencing for identifying nucleic acid sequences that modulate the function of a cell
AU2002250254A1 (en) * 2001-03-09 2002-09-24 Human Genome Sciences, Inc. Nucleic acids, proteins, and antibodies
DE10163098B4 (de) * 2001-10-12 2005-06-02 Alnylam Europe Ag Verfahren zur Hemmung der Replikation von Viren
AU2003207708A1 (en) * 2002-02-20 2003-09-09 Sirna Therapeutics, Inc. Rna interference mediated inhibition of map kinase genes
AU2003265935A1 (en) 2002-05-03 2003-11-17 Harman International Industries, Incorporated Sound detection and localization system
EP1540004A4 (en) 2002-07-31 2007-10-03 Nucleonics Inc DOUBLE-STRING RNA STRUCTURES AND CONSTRUCTS AND METHOD FOR THE PRODUCTION AND USE THEREOF
US7303906B2 (en) 2002-09-06 2007-12-04 Wisconsin Alumni Research Foundation Competent bacteria
AU2003284323A1 (en) 2002-10-18 2004-05-04 Alnylam Pharmaceuticals Inc Double-stranded rna structures and constructs, and methods for generating and using the same
DK2284266T3 (da) * 2002-11-14 2014-01-13 Thermo Fisher Scient Biosciences Inc sIRNA-MOLEKYLE MOD TP53
CN101914532A (zh) * 2002-11-22 2010-12-15 生物智囊团株式会社 Rna干扰的目标碱基序列的搜索方法
US6673661B1 (en) 2002-12-20 2004-01-06 Taiwan Semiconductor Manufacturing Co., Ltd. Self-aligned method for forming dual gate thin film transistor (TFT) device
WO2004063375A1 (en) * 2003-01-15 2004-07-29 Hans Prydz OPTIMIZING siRNA BY RNAi ANTISENSE
EP2071030A3 (en) * 2003-01-24 2009-07-22 Tokyo Metropolitan Organization for Medical Research Oligoribonucleotide or peptide nucleic acid which inhibits action of hepatitis C virus
EP1597351B1 (en) 2003-02-27 2012-04-18 Alnylam Pharmaceuticals Inc. METHODS AND CONSTRUCTS FOR EVALUATION OF RNAi TARGETS AND EFFECTOR MOLECULES
CN1257284C (zh) * 2003-03-05 2006-05-24 北京博奥生物芯片有限责任公司 一种体外阻断乙肝病毒表达的方法
BRPI0411219A (pt) * 2003-06-12 2006-07-18 Nucleonics Inc seqüências de hbv e hcv conservadas úteis para silenciamento de gene
US20050130184A1 (en) 2003-07-18 2005-06-16 University Of Massachusetts Enhanced promoters for synthesis of small hairpin RNA
US20050130919A1 (en) 2003-07-18 2005-06-16 University Of Massachusetts Regulatable promoters for synthesis of small hairpin RNA
WO2006033756A2 (en) * 2004-08-23 2006-03-30 Nucleonics, Inc. Multiple rna polymerase iii promoter expression constructs
JP5671371B2 (ja) * 2011-03-01 2015-02-18 株式会社山本鉄工所 連続プレス装置
JP2015086965A (ja) 2013-10-31 2015-05-07 株式会社エクセディ フライホイール組立体

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