JP2012223202A5 - - Google Patents
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- Publication number
- JP2012223202A5 JP2012223202A5 JP2012179638A JP2012179638A JP2012223202A5 JP 2012223202 A5 JP2012223202 A5 JP 2012223202A5 JP 2012179638 A JP2012179638 A JP 2012179638A JP 2012179638 A JP2012179638 A JP 2012179638A JP 2012223202 A5 JP2012223202 A5 JP 2012223202A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- stranded rna
- rna effector
- sequence
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 28
- 102000040650 (ribonucleotides)n+m Human genes 0.000 claims 27
- 239000012636 effector Substances 0.000 claims 27
- 239000013604 expression vector Substances 0.000 claims 8
- 210000004962 mammalian cell Anatomy 0.000 claims 7
- 102000040430 polynucleotide Human genes 0.000 claims 6
- 108091033319 polynucleotide Proteins 0.000 claims 6
- 239000002157 polynucleotide Substances 0.000 claims 6
- 241000700721 Hepatitis B virus Species 0.000 claims 3
- 230000000295 complement effect Effects 0.000 claims 3
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 230000002438 mitochondrial effect Effects 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63829404P | 2004-12-22 | 2004-12-22 | |
| US60/638,294 | 2004-12-22 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007548393A Division JP2008525029A (ja) | 2004-12-22 | 2005-12-20 | 遺伝子サイレンシングに有用なｈｂｖおよびｈｃｖ保存配列 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014179056A Division JP5934310B2 (ja) | 2004-12-22 | 2014-09-03 | 遺伝子サイレンシングに有用なｈｂｖおよびｈｃｖ保存配列 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012223202A JP2012223202A (ja) | 2012-11-15 |
| JP2012223202A5 true JP2012223202A5 (enExample) | 2015-10-29 |
Family
ID=36602266
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007548393A Pending JP2008525029A (ja) | 2004-12-22 | 2005-12-20 | 遺伝子サイレンシングに有用なｈｂｖおよびｈｃｖ保存配列 |
| JP2012179638A Pending JP2012223202A (ja) | 2004-12-22 | 2012-08-13 | 遺伝子サイレンシングに有用なｈｂｖおよびｈｃｖ保存配列 |
| JP2014179056A Expired - Lifetime JP5934310B2 (ja) | 2004-12-22 | 2014-09-03 | 遺伝子サイレンシングに有用なｈｂｖおよびｈｃｖ保存配列 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007548393A Pending JP2008525029A (ja) | 2004-12-22 | 2005-12-20 | 遺伝子サイレンシングに有用なｈｂｖおよびｈｃｖ保存配列 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014179056A Expired - Lifetime JP5934310B2 (ja) | 2004-12-22 | 2014-09-03 | 遺伝子サイレンシングに有用なｈｂｖおよびｈｃｖ保存配列 |
Country Status (7)
| Country | Link |
|---|---|
| EP (2) | EP2316942B1 (enExample) |
| JP (3) | JP2008525029A (enExample) |
| AT (1) | ATE507293T1 (enExample) |
| AU (1) | AU2005319306B9 (enExample) |
| CA (1) | CA2592099A1 (enExample) |
| DE (1) | DE602005027747D1 (enExample) |
| WO (1) | WO2006069064A2 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8575327B2 (en) * | 2003-06-12 | 2013-11-05 | Alnylam Pharmaceuticals, Inc. | Conserved HBV and HCV sequences useful for gene silencing |
| EP1797185B1 (en) * | 2004-09-24 | 2011-04-13 | Alnylam Pharmaceuticals, Inc. | Targeting opposite strand replication intermediates of single-stranded viruses by rnai |
| HUE044815T2 (hu) * | 2010-08-17 | 2019-11-28 | Sirna Therapeutics Inc | Hepatitisz B vírus (HBV) génexpressziójának RNS-interferencia közvetített gátlása, rövid interferáló nukleinsav (SINS) alkalmazásával |
| SI3505528T1 (sl) | 2011-04-21 | 2021-04-30 | Glaxo Group Limited | Modulacija izražanja virusa hepatitisa B (HBV) |
| WO2013119793A1 (en) * | 2012-02-07 | 2013-08-15 | University Of Kansas | Chemiluminescent nanoparticles and uses thereof |
| WO2013159109A1 (en) * | 2012-04-20 | 2013-10-24 | Isis Pharmaceuticals, Inc. | Modulation of hepatitis b virus (hbv) expression |
| AU2013355214B2 (en) * | 2012-12-06 | 2017-06-15 | Sigma-Aldrich Co. Llc | Crispr-based genome modification and regulation |
| PT3074517T (pt) * | 2013-11-28 | 2021-11-03 | Bavarian Nordic As | Composições e métodos para indução de uma resposta imunitária intensificada usando vetores de poxvírus |
| JOP20200092A1 (ar) | 2014-11-10 | 2017-06-16 | Alnylam Pharmaceuticals Inc | تركيبات iRNA لفيروس الكبد B (HBV) وطرق لاستخدامها |
| EP3292202A4 (en) * | 2015-05-06 | 2019-04-10 | Benitec Biopharma Limited | REAGENTS FOR THE TREATMENT OF HEPATITIS B VIRUS INFECTION AND USE THEREOF |
| CN109415733A (zh) | 2016-05-05 | 2019-03-01 | 贝尼泰克生物制药有限公司 | 用于治疗乙型肝炎病毒(hbv)感染的药剂及其使用 |
| KR20190076050A (ko) * | 2016-11-11 | 2019-07-01 | 얀센 바이오파마, 인크. | Hbv cccdna용 올리고뉴클레오티드 표적화 방법 |
| CA3043768A1 (en) | 2016-11-29 | 2018-06-07 | PureTech Health LLC | Exosomes for delivery of therapeutic agents |
| US11324820B2 (en) | 2017-04-18 | 2022-05-10 | Alnylam Pharmaceuticals, Inc. | Methods for the treatment of subjects having a hepatitis b virus (HBV) infection |
| US11492623B2 (en) | 2018-08-13 | 2022-11-08 | Alnylam Pharmaceuticals, Inc. | Hepatitis B virus (HBV) dsRNA agent compositions and methods of use thereof |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5643771A (en) | 1980-05-19 | 1997-07-01 | The Board Of Trustees Of The Leland Stanford Junior University | Non-reverting live bacterial vaccines |
| US4897355A (en) | 1985-01-07 | 1990-01-30 | Syntex (U.S.A.) Inc. | N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| DE68927996T2 (de) | 1988-02-05 | 1997-12-04 | Hughes Howard Med Inst | Modifizierte hepatozyten und deren anwendung |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5279833A (en) | 1990-04-04 | 1994-01-18 | Yale University | Liposomal transfection of nucleic acids into animal cells |
| US5264618A (en) | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
| US5283185A (en) | 1991-08-28 | 1994-02-01 | University Of Tennessee Research Corporation | Method for delivering nucleic acids into cells |
| US5593972A (en) | 1993-01-26 | 1997-01-14 | The Wistar Institute | Genetic immunization |
| US5739118A (en) | 1994-04-01 | 1998-04-14 | Apollon, Inc. | Compositions and methods for delivery of genetic material |
| WO1995027788A1 (en) * | 1994-04-11 | 1995-10-19 | Dainabot Co., Ltd. | Polypeptide derived from variant hepatitis b virus, gene encoding the same, and related dna |
| US5837533A (en) | 1994-09-28 | 1998-11-17 | American Home Products Corporation | Complexes comprising a nucleic acid bound to a cationic polyamine having an endosome disruption agent |
| US5877159A (en) | 1995-05-03 | 1999-03-02 | University Of Maryland At Baltimore | Method for introducing and expressing genes in animal cells and live invasive bacterial vectors for use in the same |
| US5932241A (en) | 1995-06-07 | 1999-08-03 | Valentis, Incorporated | Cationic lipid DNA complexes for gene targeting |
| US5874565A (en) | 1995-08-29 | 1999-02-23 | Washington University | Nucleic acids comprising a highly conserved novel 3 terminal sequence element of the hepatitis C virus |
| US5824538A (en) | 1995-09-06 | 1998-10-20 | The United States Of America As Represented By The Secretary Of The Army | Shigella vector for delivering DNA to a mammalian cell |
| US5843770A (en) * | 1996-03-11 | 1998-12-01 | The Immune Response Corporation | Antisense constructs directed against viral post-transcriptional regulatory sequences |
| US6217900B1 (en) | 1997-04-30 | 2001-04-17 | American Home Products Corporation | Vesicular complexes and methods of making and using the same |
| EP1027074A1 (en) | 1997-10-28 | 2000-08-16 | American Home Products Corporation | Compositions and methods for delivery of genetic material |
| US6506559B1 (en) | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
| AU3000499A (en) | 1998-03-16 | 1999-10-11 | Procter & Gamble Company, The | Method of reducing cellulite in mammalian skin |
| IL145778A0 (en) | 1999-04-21 | 2002-07-25 | American Home Prod | Methods and compositions for inhibiting the function of polynucleotide sequences |
| EP1238061A2 (en) * | 1999-11-24 | 2002-09-11 | Pharmasset, Ltd. | A new genotype of hepatitis b virus |
| CA2392853A1 (en) * | 1999-12-03 | 2001-06-07 | Innogenetics N.V. | Hbv sequences |
| CA2369944A1 (en) | 2001-01-31 | 2002-07-31 | Nucleonics Inc. | Use of post-transcriptional gene silencing for identifying nucleic acid sequences that modulate the function of a cell |
| AU2002250254A1 (en) * | 2001-03-09 | 2002-09-24 | Human Genome Sciences, Inc. | Nucleic acids, proteins, and antibodies |
| DE10163098B4 (de) * | 2001-10-12 | 2005-06-02 | Alnylam Europe Ag | Verfahren zur Hemmung der Replikation von Viren |
| EP1432724A4 (en) * | 2002-02-20 | 2006-02-01 | Sirna Therapeutics Inc | INTERFERENCE MEDIATION INHIBITION OF GENE RNA FROM MAP KINASE |
| US7492908B2 (en) | 2002-05-03 | 2009-02-17 | Harman International Industries, Incorporated | Sound localization system based on analysis of the sound field |
| WO2004011624A2 (en) * | 2002-07-31 | 2004-02-05 | Nucleonics, Inc. | Double stranded rna structures and constructs, and methods for generating and using the same |
| US7303906B2 (en) | 2002-09-06 | 2007-12-04 | Wisconsin Alumni Research Foundation | Competent bacteria |
| US20060035344A1 (en) | 2002-10-18 | 2006-02-16 | Pachuk Catherine J | Double-stranded rna structures and constructs, and methods for generating and using the same |
| EP2314691A3 (en) * | 2002-11-14 | 2012-01-18 | Dharmacon, Inc. | Fuctional and hyperfunctional siRNA |
| CA2511481A1 (en) * | 2002-11-22 | 2004-06-10 | Bio-Think Tank Co., Ltd. | Method of designing polynucleotides for rna interference |
| US6673661B1 (en) | 2002-12-20 | 2004-01-06 | Taiwan Semiconductor Manufacturing Co., Ltd. | Self-aligned method for forming dual gate thin film transistor (TFT) device |
| WO2004063375A1 (en) * | 2003-01-15 | 2004-07-29 | Hans Prydz | OPTIMIZING siRNA BY RNAi ANTISENSE |
| EP1591524A4 (en) * | 2003-01-24 | 2007-12-26 | Tokyo Metropolitan Org Med Res | OLIGORIBONUCLEOTIDE OR PEPTIDIC NUCLEIC ACID, THE BZW. THE FUNCTION OF THE HEPATITIS C-VIRUS HEMMT |
| WO2004076629A2 (en) | 2003-02-27 | 2004-09-10 | Nucleonics Inc. | METHODS AND CONSTRUCTS FOR EVALUATION OF RNAi TARGETS AND EFFECTOR MOLECULES |
| CN1257284C (zh) * | 2003-03-05 | 2006-05-24 | 北京博奥生物芯片有限责任公司 | 一种体外阻断乙肝病毒表达的方法 |
| CA3040025C (en) * | 2003-06-12 | 2023-01-10 | Alnylam Pharmaceuticals, Inc. | Conserved hbv and hcv sequences useful for gene silencing |
| US20050130184A1 (en) | 2003-07-18 | 2005-06-16 | University Of Massachusetts | Enhanced promoters for synthesis of small hairpin RNA |
| US20050130919A1 (en) | 2003-07-18 | 2005-06-16 | University Of Massachusetts | Regulatable promoters for synthesis of small hairpin RNA |
| EP2169072A1 (en) * | 2004-08-23 | 2010-03-31 | Alnylam Pharmaceuticals, Inc | Multiple RNA polymerase III promoter expression constructs |
| JP5671371B2 (ja) * | 2011-03-01 | 2015-02-18 | 株式会社山本鉄工所 | 連続プレス装置 |
| JP2015086965A (ja) | 2013-10-31 | 2015-05-07 | 株式会社エクセディ | フライホイール組立体 |
-
2005
- 2005-12-20 WO PCT/US2005/046162 patent/WO2006069064A2/en not_active Ceased
- 2005-12-20 JP JP2007548393A patent/JP2008525029A/ja active Pending
- 2005-12-20 EP EP10010655.8A patent/EP2316942B1/en not_active Expired - Lifetime
- 2005-12-20 EP EP05854816A patent/EP1833967B1/en not_active Expired - Lifetime
- 2005-12-20 CA CA002592099A patent/CA2592099A1/en not_active Abandoned
- 2005-12-20 AT AT05854816T patent/ATE507293T1/de not_active IP Right Cessation
- 2005-12-20 AU AU2005319306A patent/AU2005319306B9/en not_active Ceased
- 2005-12-20 DE DE602005027747T patent/DE602005027747D1/de not_active Expired - Lifetime
-
2012
- 2012-08-13 JP JP2012179638A patent/JP2012223202A/ja active Pending
-
2014
- 2014-09-03 JP JP2014179056A patent/JP5934310B2/ja not_active Expired - Lifetime