JP2012223202A5 - - Google Patents

Download PDF

Info

Publication number
JP2012223202A5
JP2012223202A5 JP2012179638A JP2012179638A JP2012223202A5 JP 2012223202 A5 JP2012223202 A5 JP 2012223202A5 JP 2012179638 A JP2012179638 A JP 2012179638A JP 2012179638 A JP2012179638 A JP 2012179638A JP 2012223202 A5 JP2012223202 A5 JP 2012223202A5
Authority
JP
Japan
Prior art keywords
seq
stranded rna
rna effector
sequence
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2012179638A
Other languages
English (en)
Japanese (ja)
Other versions
JP2012223202A (ja
Filing date
Publication date
Application filed filed Critical
Publication of JP2012223202A publication Critical patent/JP2012223202A/ja
Publication of JP2012223202A5 publication Critical patent/JP2012223202A5/ja
Pending legal-status Critical Current

Links

JP2012179638A 2004-12-22 2012-08-13 遺伝子サイレンシングに有用なhbvおよびhcv保存配列 Pending JP2012223202A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63829404P 2004-12-22 2004-12-22
US60/638,294 2004-12-22

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2007548393A Division JP2008525029A (ja) 2004-12-22 2005-12-20 遺伝子サイレンシングに有用なhbvおよびhcv保存配列

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014179056A Division JP5934310B2 (ja) 2004-12-22 2014-09-03 遺伝子サイレンシングに有用なhbvおよびhcv保存配列

Publications (2)

Publication Number Publication Date
JP2012223202A JP2012223202A (ja) 2012-11-15
JP2012223202A5 true JP2012223202A5 (enExample) 2015-10-29

Family

ID=36602266

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2007548393A Pending JP2008525029A (ja) 2004-12-22 2005-12-20 遺伝子サイレンシングに有用なhbvおよびhcv保存配列
JP2012179638A Pending JP2012223202A (ja) 2004-12-22 2012-08-13 遺伝子サイレンシングに有用なhbvおよびhcv保存配列
JP2014179056A Expired - Fee Related JP5934310B2 (ja) 2004-12-22 2014-09-03 遺伝子サイレンシングに有用なhbvおよびhcv保存配列

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2007548393A Pending JP2008525029A (ja) 2004-12-22 2005-12-20 遺伝子サイレンシングに有用なhbvおよびhcv保存配列

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2014179056A Expired - Fee Related JP5934310B2 (ja) 2004-12-22 2014-09-03 遺伝子サイレンシングに有用なhbvおよびhcv保存配列

Country Status (7)

Country Link
EP (2) EP1833967B1 (enExample)
JP (3) JP2008525029A (enExample)
AT (1) ATE507293T1 (enExample)
AU (1) AU2005319306B9 (enExample)
CA (1) CA2592099A1 (enExample)
DE (1) DE602005027747D1 (enExample)
WO (1) WO2006069064A2 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8575327B2 (en) * 2003-06-12 2013-11-05 Alnylam Pharmaceuticals, Inc. Conserved HBV and HCV sequences useful for gene silencing
CA2824308A1 (en) * 2004-09-24 2006-04-06 Alnylam Pharmaceuticals, Inc. Targeting opposite strand replication intermediates of single-stranded viruses by rnai
RU2745848C2 (ru) 2010-08-17 2021-04-01 Сирна Терапьютикс, Инк. ОПОСРЕДУЕМОЕ РНК-ИНТЕРФЕРЕНЦИЕЙ ИНГИБИРОВАНИЕ ЭКСПРЕССИИ ГЕНОВ ВИРУСА ГЕПАТИТА B (HBV) С ПРИМЕНЕНИЕМ МАЛОЙ ИНТЕРФЕРИРУЮЩЕЙ НУКЛЕИНОВОЙ КИСЛОТЫ (миНК)
SI3505528T1 (sl) 2011-04-21 2021-04-30 Glaxo Group Limited Modulacija izražanja virusa hepatitisa B (HBV)
US20150031571A1 (en) * 2012-02-07 2015-01-29 University Of Kansas Chemiluminescent nanoparticles and uses thereof
WO2013159109A1 (en) * 2012-04-20 2013-10-24 Isis Pharmaceuticals, Inc. Modulation of hepatitis b virus (hbv) expression
DK3363902T3 (da) * 2012-12-06 2020-01-02 Sigma Aldrich Co Llc Crispr-baseret genommodifikation og -regulering
ES2895977T3 (es) * 2013-11-28 2022-02-23 Bavarian Nordic As Composiciones y métodos de inducción de una respuesta inmunitaria mejorada usando vectores de poxvirus
TWI769565B (zh) 2014-11-10 2022-07-01 美商阿尼拉製藥公司 B型肝炎病毒(HBV)iRNA組成物及其用途方法
CN107683336A (zh) * 2015-05-06 2018-02-09 贝尼泰克生物制药有限公司 用于治疗乙型肝炎病毒(hbv)感染的试剂及其用途
AU2017260580B2 (en) 2016-05-05 2022-07-28 Benitec IP Holdings Inc. Reagents for treatment of hepatitis B virus (HBV) infection and use thereof
KR20190076050A (ko) * 2016-11-11 2019-07-01 얀센 바이오파마, 인크. Hbv cccdna용 올리고뉴클레오티드 표적화 방법
US20180193270A1 (en) 2016-11-29 2018-07-12 PureTech Health LLC Exosomes for delivery of therapeutic agents
US11324820B2 (en) 2017-04-18 2022-05-10 Alnylam Pharmaceuticals, Inc. Methods for the treatment of subjects having a hepatitis b virus (HBV) infection
WO2020036862A1 (en) 2018-08-13 2020-02-20 Alnylam Pharmaceuticals, Inc. HEPATITIS B VIRUS (HBV) dsRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5643771A (en) 1980-05-19 1997-07-01 The Board Of Trustees Of The Leland Stanford Junior University Non-reverting live bacterial vaccines
US4897355A (en) 1985-01-07 1990-01-30 Syntex (U.S.A.) Inc. N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
DE68927996T2 (de) 1988-02-05 1997-12-04 Hughes Howard Med Inst Modifizierte hepatozyten und deren anwendung
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US5279833A (en) 1990-04-04 1994-01-18 Yale University Liposomal transfection of nucleic acids into animal cells
US5264618A (en) 1990-04-19 1993-11-23 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
US5283185A (en) 1991-08-28 1994-02-01 University Of Tennessee Research Corporation Method for delivering nucleic acids into cells
US5593972A (en) 1993-01-26 1997-01-14 The Wistar Institute Genetic immunization
US5739118A (en) 1994-04-01 1998-04-14 Apollon, Inc. Compositions and methods for delivery of genetic material
WO1995027788A1 (en) * 1994-04-11 1995-10-19 Dainabot Co., Ltd. Polypeptide derived from variant hepatitis b virus, gene encoding the same, and related dna
US5837533A (en) 1994-09-28 1998-11-17 American Home Products Corporation Complexes comprising a nucleic acid bound to a cationic polyamine having an endosome disruption agent
US5877159A (en) 1995-05-03 1999-03-02 University Of Maryland At Baltimore Method for introducing and expressing genes in animal cells and live invasive bacterial vectors for use in the same
US5932241A (en) 1995-06-07 1999-08-03 Valentis, Incorporated Cationic lipid DNA complexes for gene targeting
US5874565A (en) 1995-08-29 1999-02-23 Washington University Nucleic acids comprising a highly conserved novel 3 terminal sequence element of the hepatitis C virus
US5824538A (en) 1995-09-06 1998-10-20 The United States Of America As Represented By The Secretary Of The Army Shigella vector for delivering DNA to a mammalian cell
US5843770A (en) * 1996-03-11 1998-12-01 The Immune Response Corporation Antisense constructs directed against viral post-transcriptional regulatory sequences
US6217900B1 (en) 1997-04-30 2001-04-17 American Home Products Corporation Vesicular complexes and methods of making and using the same
US6482804B1 (en) 1997-10-28 2002-11-19 Wyeth Compositions and methods for delivery of genetic material
US6506559B1 (en) 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
JP2002506801A (ja) 1998-03-16 2002-03-05 ザ、プロクター、エンド、ギャンブル、カンパニー 哺乳類の皮膚のセルライトを軽減する方法
IL145778A0 (en) 1999-04-21 2002-07-25 American Home Prod Methods and compositions for inhibiting the function of polynucleotide sequences
WO2001038498A2 (en) * 1999-11-24 2001-05-31 Pharmasset, Ltd. A new genotype of hepatitis b virus
EP1234040A2 (en) * 1999-12-03 2002-08-28 Innogenetics N.V. Hbv sequences
US20020132257A1 (en) 2001-01-31 2002-09-19 Tony Giordano Use of post-transcriptional gene silencing for identifying nucleic acid sequences that modulate the function of a cell
WO2002072763A2 (en) * 2001-03-09 2002-09-19 Human Genome Sciences, Inc. Nucleic acids, proteins, and antibodies
DE10163098B4 (de) * 2001-10-12 2005-06-02 Alnylam Europe Ag Verfahren zur Hemmung der Replikation von Viren
EP1432724A4 (en) * 2002-02-20 2006-02-01 Sirna Therapeutics Inc RNA inhibition mediated inhibition of MAP KINASE GENES
JP4744874B2 (ja) 2002-05-03 2011-08-10 ハーマン インターナショナル インダストリーズ インコーポレイテッド サウンドの検出および特定システム
US20050239728A1 (en) 2002-07-31 2005-10-27 Pachuk Catherine J Double stranded rna structures and constructs, and methods for generating and using the same
US7303906B2 (en) 2002-09-06 2007-12-04 Wisconsin Alumni Research Foundation Competent bacteria
CA2502649A1 (en) 2002-10-18 2004-04-29 Nucleonics Inc. Double-stranded rna structures and constructs, and methods for generating and using the same
EP2305813A3 (en) * 2002-11-14 2012-03-28 Dharmacon, Inc. Fuctional and hyperfunctional sirna
JP3839453B2 (ja) * 2002-11-22 2006-11-01 株式会社バイオシンクタンク Rna干渉の標的塩基配列検索方法、rna干渉を生じさせるポリヌクレオチドの塩基配列設計方法、2本鎖ポリヌクレオチドの作製方法、遺伝子の発現抑制方法、塩基配列処理装置、塩基配列処理方法をコンピュータに実行させるプログラム、記録媒体、および、塩基配列処理システム
US6673661B1 (en) 2002-12-20 2004-01-06 Taiwan Semiconductor Manufacturing Co., Ltd. Self-aligned method for forming dual gate thin film transistor (TFT) device
WO2004063375A1 (en) * 2003-01-15 2004-07-29 Hans Prydz OPTIMIZING siRNA BY RNAi ANTISENSE
JP4545091B2 (ja) * 2003-01-24 2010-09-15 財団法人 東京都医学研究機構 C型肝炎ウイルスの働きを阻害するオリゴリボヌクレオチドまたはペプチド核酸
ATE554185T1 (de) 2003-02-27 2012-05-15 Alnylam Pharmaceuticals Inc Verfahren und konstrukte zur bewertung von rnai- zielen und effektormolekülen
CN1257284C (zh) * 2003-03-05 2006-05-24 北京博奥生物芯片有限责任公司 一种体外阻断乙肝病毒表达的方法
DK2270162T3 (en) * 2003-06-12 2019-01-21 Alnylam Pharmaceuticals Inc PRESERVED HBV AND HCV SEQUENCES USED FOR GEN-SILENCING
WO2005007875A2 (en) 2003-07-18 2005-01-27 University Of Massachusetts Enhanced promoters for synthesis of small hairpin rna
US20050130919A1 (en) 2003-07-18 2005-06-16 University Of Massachusetts Regulatable promoters for synthesis of small hairpin RNA
EP2169072A1 (en) * 2004-08-23 2010-03-31 Alnylam Pharmaceuticals, Inc Multiple RNA polymerase III promoter expression constructs
JP5671371B2 (ja) * 2011-03-01 2015-02-18 株式会社山本鉄工所 連続プレス装置
JP2015086965A (ja) 2013-10-31 2015-05-07 株式会社エクセディ フライホイール組立体

Similar Documents

Publication Publication Date Title
JP2016526529A5 (enExample)
RU2015103901A (ru) Векторные композиции с модифицированным аденоассоциированным вирусом
JP2018512041A5 (enExample)
JP2018513668A5 (enExample)
JP2013532952A5 (enExample)
JP2018512110A5 (enExample)
JP2018512876A5 (enExample)
HK1221978A1 (zh) Tmprss6 irna组合物及其使用方法
NZ715007A (en) Nucleic acid molecules that target the vacuolar atpase c subunit and confer resistance to coleopteran pests
JP2014527401A5 (enExample)
MX356792B (es) Elementos de regulacion de plantas y sus usos.
EP4328322A3 (en) Probe library construction
WO2011056005A3 (ko) 안티센스 가닥에 의한 오프-타겟 효과를 최소화한 신규한 siRNA 구조 및 그 용도
JP2017502668A5 (enExample)
JP2016525888A5 (enExample)
JP2018518163A5 (enExample)
JP2016537990A5 (enExample)
NZ612323A (en) Nucleic acid molecules that confer resistance to coleopteran pests
RU2015128098A (ru) Конструирование систем, способы и оптимизированные направляющие композиции для манипуляции с последовательностями
JP2013226147A5 (enExample)
EA201490534A1 (ru) Способы мечения днк-кодированных библиотек
JP2013530689A5 (enExample)
JP2017529849A5 (enExample)
AU2014219019A8 (en) Short interfering nucleic acid (siNA) molecules containing a 2' internucleoside linkage
JP2015533791A5 (enExample)