JP2018530530A5 - - Google Patents
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- JP2018530530A5 JP2018530530A5 JP2018512125A JP2018512125A JP2018530530A5 JP 2018530530 A5 JP2018530530 A5 JP 2018530530A5 JP 2018512125 A JP2018512125 A JP 2018512125A JP 2018512125 A JP2018512125 A JP 2018512125A JP 2018530530 A5 JP2018530530 A5 JP 2018530530A5
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- JP
- Japan
- Prior art keywords
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- group
- deoxyribonucleic acid
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108091026890 Coding region Proteins 0.000 claims 8
- 239000002773 nucleotide Substances 0.000 claims 5
- 125000003729 nucleotide group Chemical group 0.000 claims 5
- 210000001744 T-lymphocyte Anatomy 0.000 claims 4
- 108020004414 DNA Proteins 0.000 claims 3
- 102000053602 DNA Human genes 0.000 claims 2
- 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 claims 2
- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical group O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 claims 2
- 102100036856 Tumor necrosis factor receptor superfamily member 9 Human genes 0.000 claims 2
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 210000000987 immune system Anatomy 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- YKBGVTZYEHREMT-KVQBGUIXSA-N 2'-deoxyguanosine Chemical compound C1=NC=2C(=O)NC(N)=NC=2N1[C@H]1C[C@H](O)[C@@H](CO)O1 YKBGVTZYEHREMT-KVQBGUIXSA-N 0.000 claims 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- CKTSBUTUHBMZGZ-ULQXZJNLSA-N 4-amino-1-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-tritiopyrimidin-2-one Chemical compound O=C1N=C(N)C([3H])=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 CKTSBUTUHBMZGZ-ULQXZJNLSA-N 0.000 claims 1
- 102100026882 Alpha-synuclein Human genes 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 102000008096 B7-H1 Antigen Human genes 0.000 claims 1
- 108010074708 B7-H1 Antigen Proteins 0.000 claims 1
- 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 claims 1
- 101710083479 Hepatitis A virus cellular receptor 2 homolog Proteins 0.000 claims 1
- 101000834898 Homo sapiens Alpha-synuclein Proteins 0.000 claims 1
- 101001137987 Homo sapiens Lymphocyte activation gene 3 protein Proteins 0.000 claims 1
- 101000611936 Homo sapiens Programmed cell death protein 1 Proteins 0.000 claims 1
- 101000652359 Homo sapiens Spermatogenesis-associated protein 2 Proteins 0.000 claims 1
- 229940076838 Immune checkpoint inhibitor Drugs 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 102000017578 LAG3 Human genes 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 108020004682 Single-Stranded DNA Proteins 0.000 claims 1
- 229940126547 T-cell immunoglobulin mucin-3 Drugs 0.000 claims 1
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims 1
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 230000037396 body weight Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000000139 costimulatory effect Effects 0.000 claims 1
- 239000012274 immune-checkpoint protein inhibitor Substances 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 238000002255 vaccination Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LU92821 | 2015-09-09 | ||
| LU92821A LU92821B1 (en) | 2015-09-09 | 2015-09-09 | Combination comprising immunostimulatory oligonucleotides |
| PCT/EP2016/071314 WO2017042336A1 (en) | 2015-09-09 | 2016-09-09 | Combination comprising immunostimulatory oligonucleotides |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020210230A Division JP2021059566A (ja) | 2015-09-09 | 2020-12-18 | 免疫刺激オリゴヌクレオチドを含む組合せ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018530530A JP2018530530A (ja) | 2018-10-18 |
| JP2018530530A5 true JP2018530530A5 (enExample) | 2019-09-26 |
Family
ID=54251700
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018512125A Pending JP2018530530A (ja) | 2015-09-09 | 2016-09-09 | 免疫刺激オリゴヌクレオチドを含む組合せ |
| JP2020210230A Pending JP2021059566A (ja) | 2015-09-09 | 2020-12-18 | 免疫刺激オリゴヌクレオチドを含む組合せ |
| JP2022023832A Active JP7436535B2 (ja) | 2015-09-09 | 2022-02-18 | 免疫刺激オリゴヌクレオチドを含む組合せ |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020210230A Pending JP2021059566A (ja) | 2015-09-09 | 2020-12-18 | 免疫刺激オリゴヌクレオチドを含む組合せ |
| JP2022023832A Active JP7436535B2 (ja) | 2015-09-09 | 2022-02-18 | 免疫刺激オリゴヌクレオチドを含む組合せ |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US10487333B2 (enExample) |
| EP (1) | EP3347468B1 (enExample) |
| JP (3) | JP2018530530A (enExample) |
| KR (1) | KR102411799B1 (enExample) |
| CN (1) | CN108138179B (enExample) |
| AU (1) | AU2016319214B2 (enExample) |
| CA (1) | CA2997319C (enExample) |
| ES (1) | ES2905891T3 (enExample) |
| IL (1) | IL257921B (enExample) |
| LU (1) | LU92821B1 (enExample) |
| MX (1) | MX2018002665A (enExample) |
| PL (1) | PL3347468T3 (enExample) |
| PT (1) | PT3347468T (enExample) |
| RU (1) | RU2766693C2 (enExample) |
| SI (1) | SI3347468T1 (enExample) |
| WO (1) | WO2017042336A1 (enExample) |
| ZA (1) | ZA201801001B (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20160042917A (ko) | 2013-07-25 | 2016-04-20 | 엑시큐어, 인크. | 예방 및 치료 용도를 위한 면역자극제로서의 구형 핵산-기재 구축물 |
| AU2015349680A1 (en) | 2014-11-21 | 2017-06-08 | Northwestern University | The sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates |
| LU92821B1 (en) | 2015-09-09 | 2017-03-20 | Mologen Ag | Combination comprising immunostimulatory oligonucleotides |
| GB2542425A (en) | 2015-09-21 | 2017-03-22 | Mologen Ag | Means for the treatment of HIV |
| BR112018006237A2 (pt) | 2015-09-29 | 2018-10-09 | Celgene Corp | proteínas de ligação a pd-1 e métodos de uso das mesmas |
| CN109689694B (zh) | 2016-05-19 | 2022-11-22 | 通用医疗公司 | 与其受体IL-2Rβ结合的IL2作为用来增强自然杀伤细胞和调节性T细胞活性的平台 |
| WO2018039629A2 (en) | 2016-08-25 | 2018-03-01 | Northwestern University | Micellar spherical nucleic acids from thermoresponsive, traceless templates |
| JP2019534859A (ja) | 2016-09-19 | 2019-12-05 | セルジーン コーポレイション | Ｐｄ−１結合タンパク質を使用して白斑を治療する方法 |
| US10751414B2 (en) | 2016-09-19 | 2020-08-25 | Celgene Corporation | Methods of treating psoriasis using PD-1 binding antibodies |
| EP3392345A1 (en) | 2017-04-22 | 2018-10-24 | Mologen AG | Biomarker for small cell lung cancer therapy |
| US11433131B2 (en) | 2017-05-11 | 2022-09-06 | Northwestern University | Adoptive cell therapy using spherical nucleic acids (SNAs) |
| WO2019043194A1 (en) * | 2017-08-31 | 2019-03-07 | Mologen Ag | TLR-9 AGONISTS FOR TUMOR MICROENVIRONMENT MODULATION |
| WO2019200238A1 (en) | 2018-04-14 | 2019-10-17 | Dynavax Technologies Corporation | Combinations including a cpg-c type oligonucleotide and a histone deacetylase inhibitor for treating cancer |
| WO2020206169A1 (en) | 2019-04-02 | 2020-10-08 | Kupper Thomas S | Methods for identifying progression of a primary melanoma |
| CN112007149A (zh) * | 2019-05-29 | 2020-12-01 | 思格(苏州)生物科技有限公司 | 一种新型复合免疫佐剂及其应用 |
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| GB684057A (en) | 1949-11-30 | 1952-12-10 | Stockholms Bryggerier Ab | Machine of the rotatory table type for the treatment of bottles and the like containers |
| US2699718A (en) | 1952-04-10 | 1955-01-18 | Francis X Wright | Filling apparatus with beverage preparation mechanism |
| FR1418965A (fr) | 1964-10-14 | 1965-11-26 | Chelle Ets | Tireuse de liquides à double utilisation |
| AU554222B2 (en) | 1981-10-13 | 1986-08-14 | Toyo Garasu K.K. | Inspecting glass containers |
| EP0464638B1 (de) | 1990-07-02 | 1997-04-02 | Hoechst Aktiengesellschaft | Oligonucleotid-analoge mit terminalen 3'-3'-bzw. 5'-5'-Internucleotidverknüpfungen |
| WO1995006731A2 (en) | 1993-09-02 | 1995-03-09 | Ribozyme Pharmaceuticals, Inc. | Non-nucleotide containing enzymatic nucleic acid |
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| GB2523187A (en) * | 2014-02-18 | 2015-08-19 | Mologen Ag | Covalently closed non-coding immunomodulatory DNA construct |
| LU92821B1 (en) | 2015-09-09 | 2017-03-20 | Mologen Ag | Combination comprising immunostimulatory oligonucleotides |
| GB2542425A (en) | 2015-09-21 | 2017-03-22 | Mologen Ag | Means for the treatment of HIV |
| EP3392345A1 (en) | 2017-04-22 | 2018-10-24 | Mologen AG | Biomarker for small cell lung cancer therapy |
| WO2019043194A1 (en) | 2017-08-31 | 2019-03-07 | Mologen Ag | TLR-9 AGONISTS FOR TUMOR MICROENVIRONMENT MODULATION |
-
2015
- 2015-09-09 LU LU92821A patent/LU92821B1/en active IP Right Grant
-
2016
- 2016-09-09 SI SI201631440T patent/SI3347468T1/sl unknown
- 2016-09-09 JP JP2018512125A patent/JP2018530530A/ja active Pending
- 2016-09-09 KR KR1020187006249A patent/KR102411799B1/ko active Active
- 2016-09-09 MX MX2018002665A patent/MX2018002665A/es unknown
- 2016-09-09 CN CN201680059686.9A patent/CN108138179B/zh active Active
- 2016-09-09 CA CA2997319A patent/CA2997319C/en active Active
- 2016-09-09 US US15/756,798 patent/US10487333B2/en active Active
- 2016-09-09 IL IL257921A patent/IL257921B/en unknown
- 2016-09-09 AU AU2016319214A patent/AU2016319214B2/en active Active
- 2016-09-09 PL PL16767192T patent/PL3347468T3/pl unknown
- 2016-09-09 PT PT167671924T patent/PT3347468T/pt unknown
- 2016-09-09 EP EP16767192.4A patent/EP3347468B1/en active Active
- 2016-09-09 ES ES16767192T patent/ES2905891T3/es active Active
- 2016-09-09 RU RU2018108353A patent/RU2766693C2/ru not_active Application Discontinuation
- 2016-09-09 WO PCT/EP2016/071314 patent/WO2017042336A1/en not_active Ceased
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2018
- 2018-02-14 ZA ZA2018/01001A patent/ZA201801001B/en unknown
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2019
- 2019-06-26 US US16/450,324 patent/US10604760B2/en active Active
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2020
- 2020-02-18 US US16/793,334 patent/US11578331B2/en active Active
- 2020-12-18 JP JP2020210230A patent/JP2021059566A/ja active Pending
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2022
- 2022-02-18 JP JP2022023832A patent/JP7436535B2/ja active Active
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