JP2012505657A5 - - Google Patents

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Publication number
JP2012505657A5
JP2012505657A5 JP2011532222A JP2011532222A JP2012505657A5 JP 2012505657 A5 JP2012505657 A5 JP 2012505657A5 JP 2011532222 A JP2011532222 A JP 2011532222A JP 2011532222 A JP2011532222 A JP 2011532222A JP 2012505657 A5 JP2012505657 A5 JP 2012505657A5
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JP
Japan
Prior art keywords
sequence
rna
nucleotides
nucleotide
partially complementary
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2011532222A
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English (en)
Japanese (ja)
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JP2012505657A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2009/060712 external-priority patent/WO2010045384A2/en
Publication of JP2012505657A publication Critical patent/JP2012505657A/ja
Publication of JP2012505657A5 publication Critical patent/JP2012505657A5/ja
Pending legal-status Critical Current

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JP2011532222A 2008-10-15 2009-10-14 遺伝子発現の阻害のためのショートヘアピンｒｎａ Pending JP2012505657A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10560608P 2008-10-15 2008-10-15
US61/105,606 2008-10-15
PCT/US2009/060712 WO2010045384A2 (en) 2008-10-15 2009-10-14 Short hairpin rnas for inhibition of gene expression

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015122459A Division JP2015211680A (ja) 2008-10-15 2015-06-17 遺伝子発現の阻害のためのショートヘアピンｒｎａ

Publications (2)

Publication Number Publication Date
JP2012505657A JP2012505657A (ja) 2012-03-08
JP2012505657A5 true JP2012505657A5 (enExample) 2012-12-06

Family

ID=42107218

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2011532222A Pending JP2012505657A (ja) 2008-10-15 2009-10-14 遺伝子発現の阻害のためのショートヘアピンｒｎａ
JP2015122459A Pending JP2015211680A (ja) 2008-10-15 2015-06-17 遺伝子発現の阻害のためのショートヘアピンｒｎａ

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2015122459A Pending JP2015211680A (ja) 2008-10-15 2015-06-17 遺伝子発現の阻害のためのショートヘアピンｒｎａ

Country Status (5)

Country Link
US (2) US8283460B2 (enExample)
EP (1) EP2352744B1 (enExample)
JP (2) JP2012505657A (enExample)
CN (1) CN102245772A (enExample)
WO (1) WO2010045384A2 (enExample)

Families Citing this family (14)

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WO2006031901A2 (en) * 2004-09-10 2006-03-23 Somagenics, Inc. SMALL INTERFERING RNAs THAT EFFICIENTLY INHIBIT VIRAL GENE EXPRESSION AND METHODS OF USE THEREOF
CN102245772A (zh) 2008-10-15 2011-11-16 索马根尼科斯公司 抑制基因表达的短发卡rna
EP2454371B1 (en) 2009-07-13 2021-01-20 Somagenics, Inc. Chemical modification of small hairpin rnas for inhibition of gene expression
WO2011034811A1 (en) * 2009-09-17 2011-03-24 Sigma-Aldrich Co. Short rna mimetics
ES2699630T3 (es) * 2010-04-23 2019-02-12 Cold Spring Harbor Laboratory Novedosos ARNhc diseñados estructuralmente
EP2953970A4 (en) 2013-02-08 2016-06-29 Misfolding Diagnostics Inc TRANSTYRETIN ANTIBODIES AND USES THEREOF
WO2014159990A1 (en) 2013-03-13 2014-10-02 Yale University Interferon production using short rna duplexes
US10450569B2 (en) * 2015-08-13 2019-10-22 Somagenics, Inc. Methods and compositions of short small hairpin RNAS and microRNAS for wound healing
AU2018307294B2 (en) * 2017-07-26 2025-04-17 Nissan Chemical Corporation Single-stranded oligonucleotide
RU2020130915A (ru) 2018-02-22 2022-03-22 ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи Молекулы коротких/малых шпилечных рнк
JP2021529173A (ja) 2018-06-20 2021-10-28 イエール ユニバーシティ Ｒｉｇ−ｉアゴニストおよびそれを使用した処置
US11786545B2 (en) 2020-12-09 2023-10-17 Yale University Compositions and methods for treating SARS-CoV-2 infection
US11649457B2 (en) 2020-12-09 2023-05-16 Yale University Methods for treating SARS-CoV-2 infection
WO2023122805A1 (en) 2021-12-20 2023-06-29 Vestaron Corporation Sorbitol driven selection pressure method

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JPH10503364A (ja) * 1994-05-10 1998-03-31 ザ ジェネラル ホスピタル コーポレーション Ｃ型肝炎ウイルスのアンチセンス阻害
DE19956568A1 (de) * 1999-01-30 2000-08-17 Roland Kreutzer Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
FR2790757B1 (fr) * 1999-03-09 2003-08-01 Bioalliance Pharma Oligonucleotides contenant une sequence antisens stabilises par une structure secondaire et compositions pharmaceutiques les contenant.
US8202979B2 (en) * 2002-02-20 2012-06-19 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid
US20070026394A1 (en) * 2000-02-11 2007-02-01 Lawrence Blatt Modulation of gene expression associated with inflammation proliferation and neurite outgrowth using nucleic acid based technologies
KR100909681B1 (ko) * 2000-12-01 2009-07-29 막스-플랑크-게젤샤프트 츄어 푀르더룽 데어 비쎈샤프텐 에.파우. Ｒｎａ 간섭을 매개하는 작은 ｒｎａ 분자
US20040209831A1 (en) * 2002-02-20 2004-10-21 Mcswiggen James RNA interference mediated inhibition of hepatitis C virus (HCV) gene expression using short interfering nucleic acid (siNA)
US10590418B2 (en) 2001-07-23 2020-03-17 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for RNAi mediated inhibition of gene expression in mammals
US20040138163A1 (en) * 2002-05-29 2004-07-15 Mcswiggen James RNA interference mediated inhibition of vascular edothelial growth factor and vascular edothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
US7294504B1 (en) * 2001-12-27 2007-11-13 Allele Biotechnology & Pharmaceuticals, Inc. Methods and compositions for DNA mediated gene silencing
ATE519774T1 (de) 2002-02-20 2011-08-15 Sirna Therapeutics Inc Durch eine störung der rna vermittelte inhibierung der genexpression des hepatitis c virus (hcv) mit kurzer, störender nukleinsäure (short interfering nucleic acid, sina)
US20040053876A1 (en) * 2002-03-26 2004-03-18 The Regents Of The University Of Michigan siRNAs and uses therof
WO2004015075A2 (en) * 2002-08-08 2004-02-19 Dharmacon, Inc. Short interfering rnas having a hairpin structure containing a non-nucleotide loop
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US20060134787A1 (en) * 2004-12-22 2006-06-22 University Of Massachusetts Methods and compositions for enhancing the efficacy and specificity of single and double blunt-ended siRNA
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WO2005079533A2 (en) 2004-02-17 2005-09-01 University Of Massachusetts Methods and compositions for mediating gene silencing
CA2579790A1 (en) * 2004-07-30 2006-02-09 Mount Sinai School Of Medicine Of New York University Npc1l1 and npc1l1 inhibitors and methods of use thereof
WO2006031901A2 (en) 2004-09-10 2006-03-23 Somagenics, Inc. SMALL INTERFERING RNAs THAT EFFICIENTLY INHIBIT VIRAL GENE EXPRESSION AND METHODS OF USE THEREOF
US20060142228A1 (en) * 2004-12-23 2006-06-29 Ambion, Inc. Methods and compositions concerning siRNA's as mediators of RNA interference
US20090005332A1 (en) * 2004-12-30 2009-01-01 Hauser Todd M Compositions and Methods for Modulating Gene Expression Using Self-Protected Oligonucleotides
US20060223777A1 (en) * 2005-03-29 2006-10-05 Dharmacon, Inc. Highly functional short hairpin RNA
US20070048759A1 (en) * 2005-06-10 2007-03-01 Dan Luo Detection of target molecules with labeled nucleic acid detection molecules
CN101305095B (zh) 2005-09-12 2012-09-26 索马根尼科斯公司 利用小干扰rna抑制病毒基因表达
WO2007087451A2 (en) * 2006-01-25 2007-08-02 University Of Massachusetts Compositions and methods for enhancing discriminatory rna interference
EP2002004B1 (en) * 2006-03-23 2015-10-14 Roche Innovation Center Copenhagen A/S Small internally segmented interfering rna
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KR100949791B1 (ko) * 2007-12-18 2010-03-30 이동기 오프-타겟 효과를 최소화하고 ＲＮＡｉ 기구를 포화시키지않는 신규한 ｓｉＲＮＡ 구조 및 그 용도
CN102245772A (zh) 2008-10-15 2011-11-16 索马根尼科斯公司 抑制基因表达的短发卡rna

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