JP2012505657A5 - - Google Patents

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Publication number
JP2012505657A5
JP2012505657A5 JP2011532222A JP2011532222A JP2012505657A5 JP 2012505657 A5 JP2012505657 A5 JP 2012505657A5 JP 2011532222 A JP2011532222 A JP 2011532222A JP 2011532222 A JP2011532222 A JP 2011532222A JP 2012505657 A5 JP2012505657 A5 JP 2012505657A5
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JP
Japan
Prior art keywords
sequence
rna
nucleotides
nucleotide
partially complementary
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2011532222A
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English (en)
Japanese (ja)
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JP2012505657A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2009/060712 external-priority patent/WO2010045384A2/en
Publication of JP2012505657A publication Critical patent/JP2012505657A/ja
Publication of JP2012505657A5 publication Critical patent/JP2012505657A5/ja
Pending legal-status Critical Current

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JP2011532222A 2008-10-15 2009-10-14 遺伝子発現の阻害のためのショートヘアピンｒｎａ Pending JP2012505657A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10560608P 2008-10-15 2008-10-15
US61/105,606 2008-10-15
PCT/US2009/060712 WO2010045384A2 (en) 2008-10-15 2009-10-14 Short hairpin rnas for inhibition of gene expression

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015122459A Division JP2015211680A (ja) 2008-10-15 2015-06-17 遺伝子発現の阻害のためのショートヘアピンｒｎａ

Publications (2)

Publication Number Publication Date
JP2012505657A JP2012505657A (ja) 2012-03-08
JP2012505657A5 true JP2012505657A5 (enExample) 2012-12-06

Family

ID=42107218

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2011532222A Pending JP2012505657A (ja) 2008-10-15 2009-10-14 遺伝子発現の阻害のためのショートヘアピンｒｎａ
JP2015122459A Pending JP2015211680A (ja) 2008-10-15 2015-06-17 遺伝子発現の阻害のためのショートヘアピンｒｎａ

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2015122459A Pending JP2015211680A (ja) 2008-10-15 2015-06-17 遺伝子発現の阻害のためのショートヘアピンｒｎａ

Country Status (5)

Country Link
US (2) US8283460B2 (enExample)
EP (1) EP2352744B1 (enExample)
JP (2) JP2012505657A (enExample)
CN (1) CN102245772A (enExample)
WO (1) WO2010045384A2 (enExample)

Families Citing this family (14)

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US20090170794A1 (en) * 2004-09-10 2009-07-02 Somagenics Inc. Small interfering rnas that efficiently inhibit viral expression and methods of use thereof
EP2352744B1 (en) 2008-10-15 2016-09-21 Somagenics, Inc. Short hairpin rnas for inhibition of gene expression
US8871730B2 (en) 2009-07-13 2014-10-28 Somagenics Inc. Chemical modification of short small hairpin RNAs for inhibition of gene expression
US8796238B2 (en) * 2009-09-17 2014-08-05 Sigma-Aldrich Co. Llc Short RNA mimetics
DK2561078T3 (en) 2010-04-23 2019-01-14 Cold Spring Harbor Laboratory NEW STRUCTURALLY DESIGNED SHRNAs
EP2953970A4 (en) 2013-02-08 2016-06-29 Misfolding Diagnostics Inc TRANSTYRETIN ANTIBODIES AND USES THEREOF
US10947543B2 (en) 2013-03-13 2021-03-16 Yale University Interferon production using short RNA duplexes
CN108367017A (zh) 2015-08-13 2018-08-03 索马根尼科斯公司 用于伤口愈合的短小发夹rna与微rna的组合物以及方法
TWI902655B (zh) * 2017-07-26 2025-11-01 日商日產化學股份有限公司 單股寡核苷酸
MX2020008719A (es) 2018-02-22 2021-02-15 Dow Agrosciences Llc Moléculas de arn en horquilla corto/pequeño.
WO2019246450A1 (en) 2018-06-20 2019-12-26 Yale University Rig-i agonists and treatments using same
US11786545B2 (en) 2020-12-09 2023-10-17 Yale University Compositions and methods for treating SARS-CoV-2 infection
US11649457B2 (en) 2020-12-09 2023-05-16 Yale University Methods for treating SARS-CoV-2 infection
WO2023122805A1 (en) 2021-12-20 2023-06-29 Vestaron Corporation Sorbitol driven selection pressure method

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DE19956568A1 (de) * 1999-01-30 2000-08-17 Roland Kreutzer Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
FR2790757B1 (fr) * 1999-03-09 2003-08-01 Bioalliance Pharma Oligonucleotides contenant une sequence antisens stabilises par une structure secondaire et compositions pharmaceutiques les contenant.
US8202979B2 (en) * 2002-02-20 2012-06-19 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid
US20070026394A1 (en) * 2000-02-11 2007-02-01 Lawrence Blatt Modulation of gene expression associated with inflammation proliferation and neurite outgrowth using nucleic acid based technologies
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US20040209831A1 (en) * 2002-02-20 2004-10-21 Mcswiggen James RNA interference mediated inhibition of hepatitis C virus (HCV) gene expression using short interfering nucleic acid (siNA)
US10590418B2 (en) 2001-07-23 2020-03-17 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for RNAi mediated inhibition of gene expression in mammals
US20040138163A1 (en) * 2002-05-29 2004-07-15 Mcswiggen James RNA interference mediated inhibition of vascular edothelial growth factor and vascular edothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
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WO2004015075A2 (en) * 2002-08-08 2004-02-19 Dharmacon, Inc. Short interfering rnas having a hairpin structure containing a non-nucleotide loop
ATE439438T1 (de) * 2003-05-23 2009-08-15 Sirna Therapeutics Inc Durch rna-interferenz vermittelte hemmung der genexpression unter verwendung von chemisch modifizierter sina (short interfering nucleic acid)
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US20060069050A1 (en) * 2004-02-17 2006-03-30 University Of Massachusetts Methods and compositions for mediating gene silencing
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US20090170794A1 (en) * 2004-09-10 2009-07-02 Somagenics Inc. Small interfering rnas that efficiently inhibit viral expression and methods of use thereof
US20060142228A1 (en) * 2004-12-23 2006-06-29 Ambion, Inc. Methods and compositions concerning siRNA's as mediators of RNA interference
MX2007008065A (es) * 2004-12-30 2008-03-04 Todd M Hauser Composiciones y metodos para modular la expresion genica usando oligonucleotidos autoprotegidos.
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WO2007087451A2 (en) * 2006-01-25 2007-08-02 University Of Massachusetts Compositions and methods for enhancing discriminatory rna interference
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KR100949791B1 (ko) * 2007-12-18 2010-03-30 이동기 오프-타겟 효과를 최소화하고 ＲＮＡｉ 기구를 포화시키지않는 신규한 ｓｉＲＮＡ 구조 및 그 용도
EP2352744B1 (en) 2008-10-15 2016-09-21 Somagenics, Inc. Short hairpin rnas for inhibition of gene expression

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