JP2012505657A5 - - Google Patents

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Publication number
JP2012505657A5
JP2012505657A5 JP2011532222A JP2011532222A JP2012505657A5 JP 2012505657 A5 JP2012505657 A5 JP 2012505657A5 JP 2011532222 A JP2011532222 A JP 2011532222A JP 2011532222 A JP2011532222 A JP 2011532222A JP 2012505657 A5 JP2012505657 A5 JP 2012505657A5
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JP
Japan
Prior art keywords
sequence
rna
nucleotides
nucleotide
partially complementary
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2011532222A
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English (en)
Japanese (ja)
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JP2012505657A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2009/060712 external-priority patent/WO2010045384A2/en
Publication of JP2012505657A publication Critical patent/JP2012505657A/ja
Publication of JP2012505657A5 publication Critical patent/JP2012505657A5/ja
Pending legal-status Critical Current

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JP2011532222A 2008-10-15 2009-10-14 遺伝子発現の阻害のためのショートヘアピンｒｎａ Pending JP2012505657A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10560608P 2008-10-15 2008-10-15
US61/105,606 2008-10-15
PCT/US2009/060712 WO2010045384A2 (en) 2008-10-15 2009-10-14 Short hairpin rnas for inhibition of gene expression

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015122459A Division JP2015211680A (ja) 2008-10-15 2015-06-17 遺伝子発現の阻害のためのショートヘアピンｒｎａ

Publications (2)

Publication Number Publication Date
JP2012505657A JP2012505657A (ja) 2012-03-08
JP2012505657A5 true JP2012505657A5 (enExample) 2012-12-06

Family

ID=42107218

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2011532222A Pending JP2012505657A (ja) 2008-10-15 2009-10-14 遺伝子発現の阻害のためのショートヘアピンｒｎａ
JP2015122459A Pending JP2015211680A (ja) 2008-10-15 2015-06-17 遺伝子発現の阻害のためのショートヘアピンｒｎａ

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2015122459A Pending JP2015211680A (ja) 2008-10-15 2015-06-17 遺伝子発現の阻害のためのショートヘアピンｒｎａ

Country Status (5)

Country Link
US (2) US8283460B2 (enExample)
EP (1) EP2352744B1 (enExample)
JP (2) JP2012505657A (enExample)
CN (1) CN102245772A (enExample)
WO (1) WO2010045384A2 (enExample)

Families Citing this family (14)

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WO2006031901A2 (en) 2004-09-10 2006-03-23 Somagenics, Inc. SMALL INTERFERING RNAs THAT EFFICIENTLY INHIBIT VIRAL GENE EXPRESSION AND METHODS OF USE THEREOF
CN102245772A (zh) 2008-10-15 2011-11-16 索马根尼科斯公司 抑制基因表达的短发卡rna
WO2011008730A2 (en) 2009-07-13 2011-01-20 Somagenics Inc. Chemical modification of small hairpin rnas for inhibition of gene expression
US8796238B2 (en) * 2009-09-17 2014-08-05 Sigma-Aldrich Co. Llc Short RNA mimetics
LT2561078T (lt) 2010-04-23 2019-01-10 Cold Spring Harbor Laboratory Naujos struktūriškai sukonstruotos shrnr
JP2016514091A (ja) 2013-02-08 2016-05-19 ミスフォールディング ダイアグノスティクス， インコーポレイテッド トランスサイレチン抗体およびその使用
US10947543B2 (en) 2013-03-13 2021-03-16 Yale University Interferon production using short RNA duplexes
CN108367017A (zh) 2015-08-13 2018-08-03 索马根尼科斯公司 用于伤口愈合的短小发夹rna与微rna的组合物以及方法
CA3070809A1 (en) * 2017-07-26 2019-01-31 Nissan Chemical Corporation Single-stranded oligonucleotide
CA3091625A1 (en) * 2018-02-22 2019-08-29 Dow Agrosciences Llc Short/small hairpin rna molecules
CA3110102A1 (en) 2018-06-20 2019-12-26 Yale University Rig-i agonists and treatments using same
US11649457B2 (en) 2020-12-09 2023-05-16 Yale University Methods for treating SARS-CoV-2 infection
US11786545B2 (en) 2020-12-09 2023-10-17 Yale University Compositions and methods for treating SARS-CoV-2 infection
WO2023122805A1 (en) 2021-12-20 2023-06-29 Vestaron Corporation Sorbitol driven selection pressure method

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EP0759979A4 (en) * 1994-05-10 1999-10-20 Gen Hospital Corp THE ANTISENSE INHIBITION OF HEPATITIS C VIRUS
DE19956568A1 (de) * 1999-01-30 2000-08-17 Roland Kreutzer Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
FR2790757B1 (fr) * 1999-03-09 2003-08-01 Bioalliance Pharma Oligonucleotides contenant une sequence antisens stabilises par une structure secondaire et compositions pharmaceutiques les contenant.
US8202979B2 (en) * 2002-02-20 2012-06-19 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid
WO2002081628A2 (en) * 2001-04-05 2002-10-17 Ribozyme Pharmaceuticals, Incorporated Modulation of gene expression associated with inflammation proliferation and neurite outgrowth, using nucleic acid based technologies
CZ302719B6 (cs) * 2000-12-01 2011-09-21 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Izolovaná molekula dvouretezcové RNA, zpusob její výroby a její použití
US20040209831A1 (en) * 2002-02-20 2004-10-21 Mcswiggen James RNA interference mediated inhibition of hepatitis C virus (HCV) gene expression using short interfering nucleic acid (siNA)
US10590418B2 (en) 2001-07-23 2020-03-17 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for RNAi mediated inhibition of gene expression in mammals
US20040138163A1 (en) * 2002-05-29 2004-07-15 Mcswiggen James RNA interference mediated inhibition of vascular edothelial growth factor and vascular edothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
US7294504B1 (en) * 2001-12-27 2007-11-13 Allele Biotechnology & Pharmaceuticals, Inc. Methods and compositions for DNA mediated gene silencing
GB2397062B (en) 2002-02-20 2005-06-15 Sirna Therapeutics Inc RNA interference mediated inhibition of hepatitis c virus (HCV) gene expression using short interfering nucleic acid (siNA)
US20040053876A1 (en) * 2002-03-26 2004-03-18 The Regents Of The University Of Michigan siRNAs and uses therof
US20040058886A1 (en) * 2002-08-08 2004-03-25 Dharmacon, Inc. Short interfering RNAs having a hairpin structure containing a non-nucleotide loop
JP4948163B2 (ja) * 2003-05-23 2012-06-06 サーナ・セラピューティクス・インコーポレイテッド 化学修飾した低分子干渉核酸（ｓｉＮＡ）を使用する遺伝子発現のＲＮＡ干渉仲介抑制
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US20050130919A1 (en) * 2003-07-18 2005-06-16 University Of Massachusetts Regulatable promoters for synthesis of small hairpin RNA
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WO2005028646A1 (ja) 2003-09-22 2005-03-31 Riken 効率的なdna逆位反復構造の調製方法
US20060134787A1 (en) * 2004-12-22 2006-06-22 University Of Massachusetts Methods and compositions for enhancing the efficacy and specificity of single and double blunt-ended siRNA
US20050164210A1 (en) * 2004-01-23 2005-07-28 Vivek Mittal Regulated polymerase III expression systems and related methods
WO2005079533A2 (en) * 2004-02-17 2005-09-01 University Of Massachusetts Methods and compositions for mediating gene silencing
US20090035784A1 (en) * 2004-07-30 2009-02-05 Mount Sinai School Of Medicine Of New York University Npc1l1 and npc1l1 inhibitors and methods of use thereof
WO2006031901A2 (en) 2004-09-10 2006-03-23 Somagenics, Inc. SMALL INTERFERING RNAs THAT EFFICIENTLY INHIBIT VIRAL GENE EXPRESSION AND METHODS OF USE THEREOF
US20060142228A1 (en) * 2004-12-23 2006-06-29 Ambion, Inc. Methods and compositions concerning siRNA's as mediators of RNA interference
EP1838875A4 (en) * 2004-12-30 2010-08-25 Todd M Hauser COMPOSITIONS AND METHODS FOR MODULATING GENE EXPRESSION USING SELF-PROTECTED OLIGONUCLEOTIDES
US20060223777A1 (en) * 2005-03-29 2006-10-05 Dharmacon, Inc. Highly functional short hairpin RNA
US20070048759A1 (en) * 2005-06-10 2007-03-01 Dan Luo Detection of target molecules with labeled nucleic acid detection molecules
RU2008114304A (ru) * 2005-09-12 2009-11-20 Сомадженикс Инк. (Us) Ингибирование вирусной экспрессии генов с использованием малой интерферирующей рнк
US20070259827A1 (en) * 2006-01-25 2007-11-08 University Of Massachusetts Compositions and methods for enhancing discriminatory RNA interference
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CA2735166C (en) * 2007-08-27 2020-12-01 Boston Biomedical, Inc. Compositions of asymmetric interfering rna and uses thereof
KR100949791B1 (ko) * 2007-12-18 2010-03-30 이동기 오프-타겟 효과를 최소화하고 ＲＮＡｉ 기구를 포화시키지않는 신규한 ｓｉＲＮＡ 구조 및 그 용도
CN102245772A (zh) 2008-10-15 2011-11-16 索马根尼科斯公司 抑制基因表达的短发卡rna

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