JP2015517806A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015517806A5 JP2015517806A5 JP2015503617A JP2015503617A JP2015517806A5 JP 2015517806 A5 JP2015517806 A5 JP 2015517806A5 JP 2015503617 A JP2015503617 A JP 2015503617A JP 2015503617 A JP2015503617 A JP 2015503617A JP 2015517806 A5 JP2015517806 A5 JP 2015517806A5
- Authority
- JP
- Japan
- Prior art keywords
- aptamer
- unsubstituted
- linker
- substituted
- deoxyuridine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019006667A JP6914284B2 (ja) | 2012-03-28 | 2019-01-18 | Ｐｄｇｆおよびｖｅｇｆ結合アプタマー、および、ｐｄｇｆおよびｖｅｇｆが介在する病気の治療へのそれらの使用 |
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261616881P | 2012-03-28 | 2012-03-28 | |
| US61/616,881 | 2012-03-28 | ||
| US201261648394P | 2012-05-17 | 2012-05-17 | |
| US61/648,394 | 2012-05-17 | ||
| US201261719354P | 2012-10-26 | 2012-10-26 | |
| US61/719,354 | 2012-10-26 | ||
| US201261722099P | 2012-11-02 | 2012-11-02 | |
| US61/722,099 | 2012-11-02 | ||
| PCT/US2013/034493 WO2013149086A1 (en) | 2012-03-28 | 2013-03-28 | Aptamers to pdgf and vegf and their use in treating pdgf and vegf mediated conditions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019006667A Division JP6914284B2 (ja) | 2012-03-28 | 2019-01-18 | Ｐｄｇｆおよびｖｅｇｆ結合アプタマー、および、ｐｄｇｆおよびｖｅｇｆが介在する病気の治療へのそれらの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015517806A JP2015517806A (ja) | 2015-06-25 |
| JP2015517806A5 true JP2015517806A5 (enExample) | 2016-02-25 |
| JP6587934B2 JP6587934B2 (ja) | 2019-10-09 |
Family
ID=49261267
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015503617A Expired - Fee Related JP6587934B2 (ja) | 2012-03-28 | 2013-03-28 | Ｐｄｇｆおよびｖｅｇｆ結合アプタマー、および、ｐｄｇｆおよびｖｅｇｆが介在する病気の治療へのそれらの使用 |
| JP2019006667A Expired - Fee Related JP6914284B2 (ja) | 2012-03-28 | 2019-01-18 | Ｐｄｇｆおよびｖｅｇｆ結合アプタマー、および、ｐｄｇｆおよびｖｅｇｆが介在する病気の治療へのそれらの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019006667A Expired - Fee Related JP6914284B2 (ja) | 2012-03-28 | 2019-01-18 | Ｐｄｇｆおよびｖｅｇｆ結合アプタマー、および、ｐｄｇｆおよびｖｅｇｆが介在する病気の治療へのそれらの使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US9410156B2 (enExample) |
| EP (1) | EP2831278B1 (enExample) |
| JP (2) | JP6587934B2 (enExample) |
| CN (1) | CN104379764B (enExample) |
| CA (1) | CA2868096C (enExample) |
| ES (1) | ES2742284T3 (enExample) |
| WO (1) | WO2013149086A1 (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7803931B2 (en) | 2004-02-12 | 2010-09-28 | Archemix Corp. | Aptamer therapeutics useful in the treatment of complement-related disorders |
| EP2558586B1 (en) * | 2010-04-12 | 2016-10-12 | Somalogic, Inc. | APTAMERS TO ß-NGF AND THEIR USE IN TREATING ß-NGF MEDIATED DISEASES AND DISORDERS |
| WO2013149086A1 (en) | 2012-03-28 | 2013-10-03 | Somalogic, Inc. | Aptamers to pdgf and vegf and their use in treating pdgf and vegf mediated conditions |
| FR2992185B1 (fr) * | 2012-06-21 | 2015-03-27 | Oreal | Composition a effet matifiant comprenant des particules d'aerogels hydrophobes et des particules de silice |
| MX2016000364A (es) | 2013-07-12 | 2016-05-09 | Ophthotech Corp | Metodos para tratar o prevenir afecciones oftalmologicas. |
| CA3221709A1 (en) | 2013-09-09 | 2015-03-12 | Somalogic Operating Co., Inc. | Pdgf and vegf aptamers having improved stability and their use in treating pdgf and vegf mediated diseases and disorders |
| ES3013534T3 (en) | 2016-07-01 | 2025-04-14 | Somalogic Operating Co Inc | Oligonucleotides comprising modified nucleosides |
| KR101833231B1 (ko) * | 2016-07-14 | 2018-03-02 | 충북대학교 산학협력단 | 혈소판 유래 생장 인자 수용체 베타 단백질에 특이적으로 결합하는 dna 앱타머 및 이의 용도 |
| CN107663220B (zh) * | 2016-07-27 | 2020-10-02 | 上海伯豪医学检验所有限公司 | 修饰碱基、包含修饰碱基的核酸、适配体及其应用 |
| EP3548652B1 (en) | 2016-12-01 | 2024-04-03 | Nautilus Subsidiary, Inc. | Methods of assaying proteins |
| CN106596971A (zh) * | 2016-12-16 | 2017-04-26 | 江南大学 | 一种基于贵金属等离子效应增强上转换荧光结构的超灵敏检测血管内皮生长因子的方法 |
| CA3086915A1 (en) | 2017-12-29 | 2019-07-04 | Sujal M. Patel | Decoding approaches for protein identification |
| WO2019210097A1 (en) * | 2018-04-25 | 2019-10-31 | Vitrisa Therapeutics, Inc. | Aptamers with stability, potency or half-life for enhanced safety and efficacy |
| WO2020180842A2 (en) * | 2019-03-04 | 2020-09-10 | Aptitude Medical Systems, Inc | Aptamers and use thereof |
| CN111171077A (zh) * | 2020-01-19 | 2020-05-19 | 上海交通大学医学院附属仁济医院 | 喜树碱衍生物及其制备方法和应用 |
| CN119552875A (zh) * | 2020-03-03 | 2025-03-04 | 爱普济德生物技术有限公司 | 适体和其用途 |
| CA3182266A1 (en) | 2020-06-11 | 2021-12-16 | Vadim Lobanov | Methods and systems for computational decoding of biological, chemical, and physical entities |
| US12092642B2 (en) | 2021-01-20 | 2024-09-17 | Nautilus Subsidiary, Inc. | Systems and methods for biomolecule quantitation |
| AU2022209365A1 (en) | 2021-01-21 | 2023-07-20 | Nautilus Subsidiary, Inc. | Systems and methods for biomolecule preparation |
| IL305336B2 (en) | 2021-03-11 | 2025-09-01 | Nautilus Subsidiary Inc | Systems and methods for preserving biomolecules |
| CA3227872A1 (en) | 2021-09-09 | 2023-03-16 | James Henry JOLY | Characterization and localization of protein modifications |
| EP4405683A1 (en) | 2021-09-22 | 2024-07-31 | Nautilus Subsidiary, Inc. | Methods and systems for determining polypeptide interactions |
| WO2023081728A1 (en) | 2021-11-03 | 2023-05-11 | Nautilus Biotechnology, Inc. | Systems and methods for surface structuring |
| KR20230136399A (ko) * | 2022-03-18 | 2023-09-26 | 주식회사 압타머사이언스 | EGFRvIII 특이적 압타머 및 이의 용도 |
| AU2023241893A1 (en) | 2022-03-29 | 2024-09-26 | Nautilus Subsidiary, Inc. | Integrated arrays for single-analyte processes |
| WO2023212490A1 (en) | 2022-04-25 | 2023-11-02 | Nautilus Subsidiary, Inc. | Systems and methods for assessing and improving the quality of multiplex molecular assays |
| US20250376716A1 (en) | 2022-06-21 | 2025-12-11 | Nautilus Subsidiary, Inc. | Method for detecting analytes at sites of optically non-resolvable distances |
| WO2024059655A1 (en) | 2022-09-15 | 2024-03-21 | Nautilus Subsidiary, Inc. | Characterizing accessibility of macromolecule structures |
| WO2024073599A1 (en) | 2022-09-29 | 2024-04-04 | Nautilus Subsidiary, Inc. | Preparation of array surfaces for single-analyte processes |
| US20240183858A1 (en) | 2022-11-15 | 2024-06-06 | Nautilus Subsidiary, Inc. | Standard polypeptides |
| WO2024124073A1 (en) | 2022-12-09 | 2024-06-13 | Nautilus Subsidiary, Inc. | A method comprising performing on a single-analyte array at least 50 cycles of a process |
| US20240201182A1 (en) | 2022-12-15 | 2024-06-20 | Nautilus Subsidiary, Inc. | Inhibition of photon phenomena on single molecule arrays |
| US20240241110A1 (en) | 2023-01-12 | 2024-07-18 | Nautilus Subsidiary, Inc. | Characterization of glycans and glycoconjugates |
| WO2024206122A1 (en) | 2023-03-24 | 2024-10-03 | Nautilus Subsidiary, Inc. | Improved transfer of nanoparticles to array surfaces |
| US20240353416A1 (en) | 2023-04-13 | 2024-10-24 | Nautilus Subsidiary, Inc. | Artificial proteins for displaying epitopes |
| WO2024243237A1 (en) | 2023-05-24 | 2024-11-28 | Nautilus Subsidiary, Inc. | Systems and methods for machine vision |
| US20250189519A1 (en) | 2023-12-11 | 2025-06-12 | Nautilus Subsidiary, Inc. | Methods and compositions of particle-based arrays |
| WO2025137166A1 (en) | 2023-12-20 | 2025-06-26 | Nautilus Subsidiary, Inc. | Fluidic devices for single-analyte assays |
| WO2025199236A1 (en) | 2024-03-22 | 2025-09-25 | Nautilus Subsidiary, Inc. | Plasmonic particle systems for single-analyte assays |
| WO2025212338A1 (en) | 2024-04-01 | 2025-10-09 | Nautilus Subsidiary, Inc. | Nanostructures for modulation of analyte conformation |
Family Cites Families (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4711955A (en) | 1981-04-17 | 1987-12-08 | Yale University | Modified nucleotides and methods of preparing and using same |
| US5599720A (en) | 1982-08-27 | 1997-02-04 | Multilyte Limited | Measurement of analyte concentration |
| US4737453A (en) | 1984-12-12 | 1988-04-12 | Immunomedics, Inc. | Sandwich immunoassay utilizing a separation specific binding substance |
| US4752566A (en) | 1985-12-17 | 1988-06-21 | Genetics Institute, Inc. | Displacement polynucleotide method and reagent complex employing labeled probe polynucleotide |
| EP0527818A4 (en) | 1990-04-30 | 1993-09-15 | Isis Pharmaceuticals, Inc. | Oligonucleotide modulation of arachidonic acid metabolism |
| US5874218A (en) | 1990-06-11 | 1999-02-23 | Nexstar Pharmaceuticals, Inc. | Method for detecting a target compound in a substance using a nucleic acid ligand |
| US5270163A (en) | 1990-06-11 | 1993-12-14 | University Research Corporation | Methods for identifying nucleic acid ligands |
| US5731144A (en) | 1990-06-11 | 1998-03-24 | Nexstar Pharmaceuticals, Inc. | High affinity TGFβ nucleic acid ligands |
| US5731424A (en) | 1990-06-11 | 1998-03-24 | Nexstar Pharmaceuticals, Inc. | High affinity TGFβ nucleic acid ligands and inhibitors |
| US5674685A (en) | 1990-06-11 | 1997-10-07 | Nexstar Pharmaceuticals, Inc. | High affinity PDGF nucleic acid ligands |
| US5660985A (en) | 1990-06-11 | 1997-08-26 | Nexstar Pharmaceuticals, Inc. | High affinity nucleic acid ligands containing modified nucleotides |
| US5580737A (en) | 1990-06-11 | 1996-12-03 | Nexstar Pharmaceuticals, Inc. | High-affinity nucleic acid ligands that discriminate between theophylline and caffeine |
| US6124449A (en) | 1990-06-11 | 2000-09-26 | Nexstar Pharmaceuticals, Inc. | High affinity TGFβ nucleic acid ligands and inhibitors |
| US5849479A (en) | 1990-06-11 | 1998-12-15 | Nexstar Pharmaceuticals, Inc. | High-affinity oligonucleotide ligands to vascular endothelial growth factor (VEGF) |
| US5811533A (en) | 1990-06-11 | 1998-09-22 | Nexstar Pharmaceuticals, Inc. | High-affinity oligonucleotide ligands to vascular endothelial growth factor (VEGF) |
| ES2101083T3 (es) | 1990-12-21 | 1997-07-01 | Hoffmann La Roche | Tipado del dna hla dqbeta. |
| US5840867A (en) | 1991-02-21 | 1998-11-24 | Gilead Sciences, Inc. | Aptamer analogs specific for biomolecules |
| US6762290B1 (en) | 1999-07-29 | 2004-07-13 | Gilead Sciences, Inc. | High affinity vascular endothelial growth factor (VEGF) receptor nucleic acid ligands and inhibitors |
| US5582981A (en) | 1991-08-14 | 1996-12-10 | Gilead Sciences, Inc. | Method for identifying an oligonucleotide aptamer specific for a target |
| US5412087A (en) | 1992-04-24 | 1995-05-02 | Affymax Technologies N.V. | Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces |
| US5719273A (en) | 1993-06-14 | 1998-02-17 | Nexstar Pharmaceuticals, Inc. | Palladium catalyzed nucleoside modifications methods using nucleophiles and carbon monoxide |
| US5580972A (en) | 1993-06-14 | 1996-12-03 | Nexstar Pharmaceuticals, Inc. | Purine nucleoside modifications by palladium catalyzed methods |
| DE4403869C2 (de) | 1994-02-08 | 1998-01-15 | Veitsch Radex Ag | Feuerfester keramischer Versatz und dessen Verwendung |
| WO1996027604A1 (en) | 1995-03-06 | 1996-09-12 | Nexstar Pharmaceuticals, Inc. | High-affinity oligonucleotide ligands to secretory phospholipase a2(spla2) |
| US5859228A (en) | 1995-05-04 | 1999-01-12 | Nexstar Pharmaceuticals, Inc. | Vascular endothelial growth factor (VEGF) nucleic acid ligand complexes |
| WO1996038579A1 (en) | 1995-06-02 | 1996-12-05 | Nexstar Pharmaceuticals, Inc. | High-affinity oligonucleotide ligands to growth factors |
| US5723594A (en) | 1995-06-07 | 1998-03-03 | Nexstar Pharmaceuticals, Inc. | High affinity PDGF nucleic acid ligands |
| US6229002B1 (en) | 1995-06-07 | 2001-05-08 | Nexstar Pharmaceuticlas, Inc. | Platelet derived growth factor (PDGF) nucleic acid ligand complexes |
| US5945527A (en) | 1996-05-30 | 1999-08-31 | Nexstar Pharmaceuticals, Inc. | Palladium catalyzed nucleoside modification methods using nucleophiles and carbon monoxide |
| US6051698A (en) | 1997-06-06 | 2000-04-18 | Janjic; Nebojsa | Vascular endothelial growth factor (VEGF) nucleic acid ligand complexes |
| US6168788B1 (en) | 1997-09-26 | 2001-01-02 | Leon Wortham | Fibrin glue without fibrinogen and biosealant compositions and methods |
| US20070166741A1 (en) | 1998-12-14 | 2007-07-19 | Somalogic, Incorporated | Multiplexed analyses of test samples |
| US20030054360A1 (en) | 1999-01-19 | 2003-03-20 | Larry Gold | Method and apparatus for the automated generation of nucleic acid ligands |
| US6312949B1 (en) | 1999-03-26 | 2001-11-06 | The Salk Institute For Biological Studies | Regulation of tyrosine hydroxylase expression |
| JP2001245671A (ja) | 2000-03-07 | 2001-09-11 | Chiba Prefecture | ヒト神経芽細胞腫においてクローニングされた新規遺伝子及び新規遺伝子の断片 |
| US6579276B2 (en) * | 2001-01-22 | 2003-06-17 | Iomed, Inc. | Ocular iontophoretic device and method for inhibiting vascular endothelial growth factor (VEGF) using the same |
| US20070082337A1 (en) | 2004-01-27 | 2007-04-12 | Compugen Ltd. | Methods of identifying putative gene products by interspecies sequence comparison and biomolecular sequences uncovered thereby |
| EP1481090A4 (en) | 2002-02-15 | 2006-08-09 | Somalogic Inc | METHOD AND REAGENTS FOR DETECTING BINDING OF TARGET MOLECULES BY NUCLEIC ACID ELECTRODES |
| US7831974B2 (en) | 2002-11-12 | 2010-11-09 | Intel Corporation | Method and apparatus for serialized mutual exclusion |
| DK2284266T3 (da) | 2002-11-14 | 2014-01-13 | Thermo Fisher Scient Biosciences Inc | sIRNA-MOLEKYLE MOD TP53 |
| US20040180360A1 (en) | 2002-11-21 | 2004-09-16 | Charles Wilson | Multivalent aptamer therapeutics with improved pharmacodynamic properties and methods of making and using the same |
| EP1606301A4 (en) | 2003-01-21 | 2006-06-14 | Archemix Corp | APTAMERIC THERAPEUTICS FOR MEDICINAL THERAPY FOR EYES |
| WO2004067765A2 (en) | 2003-01-29 | 2004-08-12 | Keck Graduate Institute | Organism fingerprinting using nicking agents |
| EP2623601B1 (en) * | 2003-04-21 | 2015-02-18 | Archemix LLC | Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics |
| CL2004001996A1 (es) * | 2003-08-08 | 2005-05-06 | Eyetech Pharmaceuticals Inc | Aptameros anti-vegf (factor de crecimiento endotelial vascular) con bloqueo nucleotidico 5'-5' o 3'-3' invertido, composicion que lo contiene, util para trastornos de neovascularizacion. |
| PL1660057T3 (pl) | 2003-08-27 | 2012-10-31 | Ophthotech Corp | Terapia łączona do leczenia zaburzeń związanych z neowaskularyzacją gałki ocznej |
| WO2005052121A2 (en) * | 2003-11-21 | 2005-06-09 | Archemix Corp. | Multivalent aptamers |
| WO2005062881A2 (en) | 2003-12-24 | 2005-07-14 | Transgenrx, Inc. | Gene therapy using transposon-based vectors |
| DE502005010290D1 (de) * | 2004-02-27 | 2010-11-04 | Hauni Maschinenbau Ag | Leimmengenermittlung |
| EP1791557A4 (en) * | 2004-09-07 | 2009-09-23 | Archemix Corp | MEDICAL CHEMISTRY USING APTAMERS |
| EP3034089A1 (en) * | 2004-11-02 | 2016-06-22 | Archemix LLC | Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics |
| SI1994171T1 (sl) | 2006-01-17 | 2015-07-31 | Somalogic, Inc. | Multipleksirane analize testnih vzorcev |
| BRPI0720000A2 (pt) * | 2006-12-08 | 2013-12-17 | Sachtleben Chemie Gmbh | Corpo moldado contendo titâno |
| US20110136099A1 (en) | 2007-01-16 | 2011-06-09 | Somalogic, Inc. | Multiplexed Analyses of Test Samples |
| US7947447B2 (en) | 2007-01-16 | 2011-05-24 | Somalogic, Inc. | Method for generating aptamers with improved off-rates |
| US8975026B2 (en) | 2007-01-16 | 2015-03-10 | Somalogic, Inc. | Method for generating aptamers with improved off-rates |
| US7855054B2 (en) | 2007-01-16 | 2010-12-21 | Somalogic, Inc. | Multiplexed analyses of test samples |
| SI2489743T1 (sl) | 2007-07-17 | 2015-04-30 | Somalogic, Inc. | Aptameri s 5-(N-naftilno) substituiranimi uridini |
| WO2010108126A2 (en) | 2009-03-19 | 2010-09-23 | Fate Therapeutics, Inc. | Reprogramming compositions and methods of using the same |
| US8569252B2 (en) * | 2009-04-15 | 2013-10-29 | Postech Academy-Industry Foundation | Nucleolin specific aptamer and use thereof |
| DE102009031995A1 (de) | 2009-07-06 | 2011-01-13 | Neutrik Aktiengesellschaft | Verfahren zur drahtlosen Echtzeitübertragung zumindest eines Audiosignales |
| US8815779B2 (en) | 2009-09-16 | 2014-08-26 | SwitchGear Genomics, Inc. | Transcription biomarkers of biological responses and methods |
| EP2558586B1 (en) | 2010-04-12 | 2016-10-12 | Somalogic, Inc. | APTAMERS TO ß-NGF AND THEIR USE IN TREATING ß-NGF MEDIATED DISEASES AND DISORDERS |
| WO2011130065A1 (en) * | 2010-04-12 | 2011-10-20 | Merck Sharp & Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF MET GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| ITRM20100536A1 (it) | 2010-10-12 | 2012-04-12 | Consiglio Nazionale Ricerche | Aptamero inibitore di egfr per uso in terapia e diagnosi |
| MY163004A (en) * | 2011-04-01 | 2017-07-31 | Ionis Pharmaceuticals Inc | Modulation of signal transducer and activator of transcription 3 (stat3) expression |
| WO2013064702A2 (en) | 2011-11-03 | 2013-05-10 | Diagenic Asa | Probes for diagnosis and monitoring of neurodegenerative disease |
| WO2013149086A1 (en) | 2012-03-28 | 2013-10-03 | Somalogic, Inc. | Aptamers to pdgf and vegf and their use in treating pdgf and vegf mediated conditions |
| CA3221709A1 (en) | 2013-09-09 | 2015-03-12 | Somalogic Operating Co., Inc. | Pdgf and vegf aptamers having improved stability and their use in treating pdgf and vegf mediated diseases and disorders |
-
2013
- 2013-03-28 WO PCT/US2013/034493 patent/WO2013149086A1/en not_active Ceased
- 2013-03-28 CA CA2868096A patent/CA2868096C/en active Active
- 2013-03-28 JP JP2015503617A patent/JP6587934B2/ja not_active Expired - Fee Related
- 2013-03-28 CN CN201380026124.0A patent/CN104379764B/zh active Active
- 2013-03-28 ES ES13767724T patent/ES2742284T3/es active Active
- 2013-03-28 US US14/381,679 patent/US9410156B2/en active Active
- 2013-03-28 EP EP13767724.1A patent/EP2831278B1/en active Active
-
2016
- 2016-06-22 US US15/189,159 patent/US9701967B2/en active Active
-
2017
- 2017-05-23 US US15/602,377 patent/US10221421B2/en active Active
-
2019
- 2019-01-18 JP JP2019006667A patent/JP6914284B2/ja not_active Expired - Fee Related
- 2019-02-22 US US16/283,022 patent/US11208663B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2015517806A5 (enExample) | ||
| Panigaj et al. | Aptamers as modular components of therapeutic nucleic acid nanotechnology | |
| JP2014509511A5 (enExample) | ||
| JP2022113690A (ja) | Ｒｎａ治療薬を含むエクソソーム | |
| Dua et al. | Nucleic acid aptamers targeting cell-surface proteins | |
| JP2014511686A5 (enExample) | ||
| JP2013535212A5 (enExample) | ||
| JP2020022483A5 (enExample) | ||
| JP2013511990A5 (enExample) | ||
| JP2012505657A5 (enExample) | ||
| JP2018529732A5 (enExample) | ||
| JP2016116520A5 (enExample) | ||
| JP2012105686A5 (enExample) | ||
| JP2020500929A5 (enExample) | ||
| JP2016513976A5 (enExample) | ||
| JP2017505623A5 (enExample) | ||
| JP2019513372A5 (enExample) | ||
| TW201202262A (en) | Oligonucleotide analogues having modified intersubunit linkages and/or terminal groups | |
| US9540412B2 (en) | Methods of preparing targeted aptamer prodrugs | |
| JP2016513669A5 (enExample) | ||
| JP2008518608A5 (enExample) | ||
| JP2015517466A5 (enExample) | ||
| EP2997148B1 (en) | Bacteriophage | |
| JP2018530530A5 (enExample) | ||
| JP2014504857A5 (enExample) |