JP6587934B2 - Pdgfおよびvegf結合アプタマー、および、pdgfおよびvegfが介在する病気の治療へのそれらの使用 - Google Patents
Pdgfおよびvegf結合アプタマー、および、pdgfおよびvegfが介在する病気の治療へのそれらの使用 Download PDFInfo
- Publication number
- JP6587934B2 JP6587934B2 JP2015503617A JP2015503617A JP6587934B2 JP 6587934 B2 JP6587934 B2 JP 6587934B2 JP 2015503617 A JP2015503617 A JP 2015503617A JP 2015503617 A JP2015503617 A JP 2015503617A JP 6587934 B2 JP6587934 B2 JP 6587934B2
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- Prior art keywords
- aptamer
- pdgf
- vegf
- binding
- aptamers
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- C—CHEMISTRY; METALLURGY
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P27/04—Artificial tears; Irrigation solutions
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P27/06—Antiglaucoma agents or miotics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P27/12—Ophthalmic agents for cataracts
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/16—Aptamers
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
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- C—CHEMISTRY; METALLURGY
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/322—2'-R Modification
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/335—Modified T or U
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
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- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
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- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Ophthalmology & Optometry (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
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- Biophysics (AREA)
- Biochemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019006667A JP6914284B2 (ja) | 2012-03-28 | 2019-01-18 | Pdgfおよびvegf結合アプタマー、および、pdgfおよびvegfが介在する病気の治療へのそれらの使用 |
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261616881P | 2012-03-28 | 2012-03-28 | |
| US61/616,881 | 2012-03-28 | ||
| US201261648394P | 2012-05-17 | 2012-05-17 | |
| US61/648,394 | 2012-05-17 | ||
| US201261719354P | 2012-10-26 | 2012-10-26 | |
| US61/719,354 | 2012-10-26 | ||
| US201261722099P | 2012-11-02 | 2012-11-02 | |
| US61/722,099 | 2012-11-02 | ||
| PCT/US2013/034493 WO2013149086A1 (en) | 2012-03-28 | 2013-03-28 | Aptamers to pdgf and vegf and their use in treating pdgf and vegf mediated conditions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019006667A Division JP6914284B2 (ja) | 2012-03-28 | 2019-01-18 | Pdgfおよびvegf結合アプタマー、および、pdgfおよびvegfが介在する病気の治療へのそれらの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015517806A JP2015517806A (ja) | 2015-06-25 |
| JP2015517806A5 JP2015517806A5 (enExample) | 2016-02-25 |
| JP6587934B2 true JP6587934B2 (ja) | 2019-10-09 |
Family
ID=49261267
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015503617A Expired - Fee Related JP6587934B2 (ja) | 2012-03-28 | 2013-03-28 | Pdgfおよびvegf結合アプタマー、および、pdgfおよびvegfが介在する病気の治療へのそれらの使用 |
| JP2019006667A Expired - Fee Related JP6914284B2 (ja) | 2012-03-28 | 2019-01-18 | Pdgfおよびvegf結合アプタマー、および、pdgfおよびvegfが介在する病気の治療へのそれらの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019006667A Expired - Fee Related JP6914284B2 (ja) | 2012-03-28 | 2019-01-18 | Pdgfおよびvegf結合アプタマー、および、pdgfおよびvegfが介在する病気の治療へのそれらの使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US9410156B2 (enExample) |
| EP (1) | EP2831278B1 (enExample) |
| JP (2) | JP6587934B2 (enExample) |
| CN (1) | CN104379764B (enExample) |
| CA (1) | CA2868096C (enExample) |
| ES (1) | ES2742284T3 (enExample) |
| WO (1) | WO2013149086A1 (enExample) |
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| AU2011240677B2 (en) * | 2010-04-12 | 2015-05-14 | Somalogic Operating Co., Inc. | 5-position modified pyrimidines and their use |
| US9410156B2 (en) | 2012-03-28 | 2016-08-09 | Somalogic, Inc. | Aptamers to PDGF and VEGF and their use in treating PDGF and VEGF mediated conditions |
| FR2992185B1 (fr) * | 2012-06-21 | 2015-03-27 | Oreal | Composition a effet matifiant comprenant des particules d'aerogels hydrophobes et des particules de silice |
| SG10201912985RA (en) | 2013-07-12 | 2020-02-27 | Ophthotech Corp | Methods for treating or preventing ophthalmological conditions |
| EP3044334B1 (en) * | 2013-09-09 | 2020-08-12 | Somalogic, Inc. | Pdgf and vegf aptamers having improved stability and their use in treating pdgf and vegf mediated diseases and disorders |
| JP7203613B2 (ja) | 2016-07-01 | 2023-01-13 | ソマロジック オペレーティング カンパニー インコーポレイテッド | 修飾ヌクレオシドを含むオリゴヌクレオチド |
| KR101833231B1 (ko) * | 2016-07-14 | 2018-03-02 | 충북대학교 산학협력단 | 혈소판 유래 생장 인자 수용체 베타 단백질에 특이적으로 결합하는 dna 앱타머 및 이의 용도 |
| CN107663220B (zh) * | 2016-07-27 | 2020-10-02 | 上海伯豪医学检验所有限公司 | 修饰碱基、包含修饰碱基的核酸、适配体及其应用 |
| JP2020514746A (ja) | 2016-12-01 | 2020-05-21 | ノーティラス バイオテクノロジー インコーポレイテッド | タンパク質をアッセイする方法 |
| CN106596971A (zh) * | 2016-12-16 | 2017-04-26 | 江南大学 | 一种基于贵金属等离子效应增强上转换荧光结构的超灵敏检测血管内皮生长因子的方法 |
| EP3735259A4 (en) | 2017-12-29 | 2021-09-08 | Nautilus Biotechnology, Inc. | DECODING PROTEIN IDENTIFICATION METHOD |
| WO2019210097A1 (en) * | 2018-04-25 | 2019-10-31 | Vitrisa Therapeutics, Inc. | Aptamers with stability, potency or half-life for enhanced safety and efficacy |
| CN113785062B (zh) * | 2019-03-04 | 2025-05-16 | 爱普济德生物技术有限公司 | 适体及其用途 |
| CN111171077A (zh) * | 2020-01-19 | 2020-05-19 | 上海交通大学医学院附属仁济医院 | 喜树碱衍生物及其制备方法和应用 |
| CN115151263A (zh) * | 2020-03-03 | 2022-10-04 | 爱普济德生物技术有限公司 | 适体和其用途 |
| AU2021288692A1 (en) | 2020-06-11 | 2023-02-02 | Nautilus Subsidiary, Inc. | Methods and systems for computational decoding of biological, chemical, and physical entities |
| WO2022159520A2 (en) | 2021-01-20 | 2022-07-28 | Nautilus Biotechnology, Inc. | Systems and methods for biomolecule quantitation |
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| CA3227872A1 (en) | 2021-09-09 | 2023-03-16 | James Henry JOLY | Characterization and localization of protein modifications |
| WO2023049073A1 (en) | 2021-09-22 | 2023-03-30 | Nautilus Biotechnology, Inc. | Methods and systems for determining polypeptide interactions |
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| KR20230136399A (ko) * | 2022-03-18 | 2023-09-26 | 주식회사 압타머사이언스 | EGFRvIII 특이적 압타머 및 이의 용도 |
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- 2013-03-28 CA CA2868096A patent/CA2868096C/en active Active
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| US11208663B2 (en) | 2021-12-28 |
| HK1204014A1 (en) | 2015-11-06 |
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| EP2831278A4 (en) | 2015-10-28 |
| CN104379764B (zh) | 2018-04-06 |
| JP2015517806A (ja) | 2015-06-25 |
| US20200056181A1 (en) | 2020-02-20 |
| US20150105452A1 (en) | 2015-04-16 |
| CA2868096C (en) | 2019-12-31 |
| CA2868096A1 (en) | 2013-10-03 |
| US9410156B2 (en) | 2016-08-09 |
| US10221421B2 (en) | 2019-03-05 |
| CN104379764A (zh) | 2015-02-25 |
| US9701967B2 (en) | 2017-07-11 |
| JP6914284B2 (ja) | 2021-08-04 |
| JP2019068851A (ja) | 2019-05-09 |
| WO2013149086A1 (en) | 2013-10-03 |
| US20160298118A1 (en) | 2016-10-13 |
| US20170260531A1 (en) | 2017-09-14 |
| ES2742284T3 (es) | 2020-02-13 |
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