JP2018529732A5 - - Google Patents
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- JP2018529732A5 JP2018529732A5 JP2018516738A JP2018516738A JP2018529732A5 JP 2018529732 A5 JP2018529732 A5 JP 2018529732A5 JP 2018516738 A JP2018516738 A JP 2018516738A JP 2018516738 A JP2018516738 A JP 2018516738A JP 2018529732 A5 JP2018529732 A5 JP 2018529732A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- sequence
- strand comprises
- rnai agent
- sense strand
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562235816P | 2015-10-01 | 2015-10-01 | |
| US62/235,816 | 2015-10-01 | ||
| US201662346304P | 2016-06-06 | 2016-06-06 | |
| US62/346,304 | 2016-06-06 | ||
| US201662383221P | 2016-09-02 | 2016-09-02 | |
| US62/383,221 | 2016-09-02 | ||
| PCT/US2016/054729 WO2017059223A2 (en) | 2015-10-01 | 2016-09-30 | Compositions and methods for inhibiting gene expression of lpa |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021039949A Division JP7116212B2 (ja) | 2015-10-01 | 2021-03-12 | Lpaの遺伝子発現の阻害のための組成物及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018529732A JP2018529732A (ja) | 2018-10-11 |
| JP2018529732A5 true JP2018529732A5 (enExample) | 2019-11-07 |
| JP6991966B2 JP6991966B2 (ja) | 2022-02-03 |
Family
ID=58424351
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018516738A Active JP6991966B2 (ja) | 2015-10-01 | 2016-09-30 | Lpaの遺伝子発現の阻害のための組成物及び方法 |
| JP2021039949A Active JP7116212B2 (ja) | 2015-10-01 | 2021-03-12 | Lpaの遺伝子発現の阻害のための組成物及び方法 |
| JP2022096415A Active JP7442574B2 (ja) | 2015-10-01 | 2022-06-15 | Lpaの遺伝子発現の阻害のための組成物及び方法 |
| JP2023199857A Withdrawn JP2024009262A (ja) | 2015-10-01 | 2023-11-27 | Lpaの遺伝子発現の阻害のための組成物及び方法 |
| JP2025179509A Pending JP2026040461A (ja) | 2015-10-01 | 2025-10-24 | Lpaの遺伝子発現の阻害のための組成物及び方法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021039949A Active JP7116212B2 (ja) | 2015-10-01 | 2021-03-12 | Lpaの遺伝子発現の阻害のための組成物及び方法 |
| JP2022096415A Active JP7442574B2 (ja) | 2015-10-01 | 2022-06-15 | Lpaの遺伝子発現の阻害のための組成物及び方法 |
| JP2023199857A Withdrawn JP2024009262A (ja) | 2015-10-01 | 2023-11-27 | Lpaの遺伝子発現の阻害のための組成物及び方法 |
| JP2025179509A Pending JP2026040461A (ja) | 2015-10-01 | 2025-10-24 | Lpaの遺伝子発現の阻害のための組成物及び方法 |
Country Status (36)
Families Citing this family (49)
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| US7718133B2 (en) | 2003-10-09 | 2010-05-18 | 3M Innovative Properties Company | Multilayer processing devices and methods |
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| CN116832169A (zh) * | 2016-09-02 | 2023-10-03 | 箭头药业股份有限公司 | 靶向配体 |
| RS63836B1 (sr) | 2017-04-05 | 2023-01-31 | Silence Therapeutics Gmbh | Proizvodi i sastavi |
| KR20200024793A (ko) * | 2017-07-06 | 2020-03-09 | 애로우헤드 파마슈티컬스 인코포레이티드 | 알파-ENaC의 발현을 억제하기 위한 RNAi 작용제 및 사용 방법 |
| JOP20200054A1 (ar) * | 2017-09-11 | 2020-03-10 | Arrowhead Pharmaceuticals Inc | عوامل RNAi وتركيبات لتثبيط تعبير صَميمُ البروتينِ الشَّحْمِيّ C-III (APOC3) |
| AU2018331383B2 (en) * | 2017-09-14 | 2024-12-05 | Arrowhead Pharmaceuticals, Inc. | RNAi agents and compositions for inhibiting expression of angiopoietin-like 3 (ANGPTL3), and methods of use |
| CN111655268B (zh) | 2017-10-04 | 2024-03-26 | 艾维迪提生物科学公司 | 核酸-多肽组合物及其用途 |
| WO2019079294A1 (en) * | 2017-10-17 | 2019-04-25 | Arrowhead Pharmaceuticals, Inc. | RNAI-BASED AGENTS AND COMPOSITIONS FOR INHIBITING ASIALOGLYCOPROTEIN RECEPTOR 1 RECEPTOR 1 |
| IL274503B2 (en) * | 2017-11-13 | 2024-10-01 | Silence Therapeutics Gmbh | Nucleic acids for inhibiting expression of lpa in a cell |
| EP3483270A1 (en) * | 2017-11-13 | 2019-05-15 | Silence Therapeutics GmbH | Products and compositions |
| CA3109553A1 (en) * | 2018-09-19 | 2020-03-26 | Arrowhead Pharmaceuticals, Inc. | Rnai agents for inhibiting expression of 17beta-hsd type 13 (hsd17b13), compositions thereof, and methods of use |
| JP7245328B2 (ja) * | 2018-11-13 | 2023-03-23 | サイレンス・セラピューティクス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 細胞におけるlpaの発現を抑制するための核酸 |
| US11578090B2 (en) * | 2019-06-06 | 2023-02-14 | Avidity Biosciences, Inc. | Nucleic acid-polypeptide compositions and uses thereof |
| EP3983077A4 (en) * | 2019-06-17 | 2023-12-20 | Alnylam Pharmaceuticals, Inc. | DELIVERY OF OLIGONUCLEOTIDES TO THE STRIATUM |
| CN112442499B (zh) * | 2019-08-30 | 2026-03-10 | 恩康药业科技(广州)有限公司 | 一种抑制MCM7的siRNA、组合物及其应用 |
| US20230078200A1 (en) * | 2019-12-09 | 2023-03-16 | Amgen Inc. | RNAi CONSTRUCTS AND METHODS FOR INHIBITING LPA EXPRESSION |
| AU2021244329A1 (en) * | 2020-03-23 | 2022-09-29 | Amgen Inc. | Monoclonal antibodies to chemically-modified nucleic acids and uses thereof |
| JP7476422B2 (ja) | 2020-08-05 | 2024-04-30 | ディセルナ ファーマシューティカルズ インコーポレイテッド | Lpa発現を阻害するための組成物及び方法 |
| US20240035029A1 (en) * | 2020-10-16 | 2024-02-01 | Sanofi | Rna compositions and methods for inhibiting lipoprotein(a) |
| MX2023005198A (es) * | 2020-11-05 | 2023-05-16 | Amgen Inc | Metodos para tratar la enfermedad cardiovascular aterosclerotica con constructos de iarn dirigidos a lpa. |
| WO2022121959A1 (zh) * | 2020-12-09 | 2022-06-16 | 纳肽得有限公司 | siRNA分子及其在治疗冠状动脉疾病中的应用 |
| EP4237561A1 (en) | 2020-12-23 | 2023-09-06 | Argonaute Rna Limited | Treatment of cardiovascular disease |
| JP2024523237A (ja) | 2021-06-18 | 2024-06-28 | ホンジーン バイオテック コーポレイション | 官能化されたn-アセチルガラクトサミンヌクレオシド |
| EP4396193A4 (en) | 2021-08-30 | 2025-07-02 | Hongene Biotech Corp | FUNCTIONALIZED N-ACETYLGALACTOSAMINE ANALOGUES |
| JP2024531728A (ja) | 2021-09-14 | 2024-08-29 | アルゴノート アールエヌエー リミテッド | 心血管疾患の処置 |
| AU2022348141A1 (en) * | 2021-09-18 | 2024-04-04 | Chengdu Xinzhenghe Pharmaceutical Technology Co. Ltd | Lpa inhibitor and use thereof |
| MX2024005862A (es) | 2021-11-16 | 2024-07-10 | Shanghai Argo Biopharmaceutical Co Ltd | Composiciones y metodos para inhibir la expresion de la proteina angiotensinogeno (agt). |
| EP4448540A1 (en) | 2021-12-15 | 2024-10-23 | Hongene Biotech Corporation | Functionalized n-acetylgalactosamine analogs |
| EP4450624A4 (en) * | 2021-12-16 | 2025-03-26 | Tuojie Biotech (Shanghai) Co., Ltd. | LPA-TARGETTING SIRNA AND CONJUGATE |
| CN114703184B (zh) * | 2022-03-11 | 2024-06-18 | 厦门甘宝利生物医药有限公司 | Lpa抑制剂及其用途 |
| CN119698469A (zh) * | 2022-08-11 | 2025-03-25 | 益杰立科(上海)生物科技有限公司 | 一种表观编辑靶点的方法及用途 |
| CN115851723B (zh) * | 2022-10-24 | 2023-10-03 | 厦门甘宝利生物医药有限公司 | 一种抑制lpa基因表达的rna抑制剂及其应用 |
| WO2024118503A1 (en) | 2022-11-28 | 2024-06-06 | Hongene Biotech Corporation | Functionalized n-acetylgalactosamine analogs |
| JP2026502533A (ja) * | 2023-01-13 | 2026-01-23 | イーライ リリー アンド カンパニー | 治療用オリゴヌクレオチド含有医薬組成物及びそれを用いる投与レジメン |
| WO2024210530A1 (en) * | 2023-04-03 | 2024-10-10 | Olix Pharmaceuticals, Inc. | RNAi AGENTS TARGETING LPA GENE AND USE THEREOF |
| CN121127587A (zh) * | 2023-04-24 | 2025-12-12 | 上海京新生物医药有限公司 | 用于抑制LPA表达的RNAi剂及其应用 |
| EP4714939A1 (en) | 2023-05-19 | 2026-03-25 | Shenzhen Salubris Pharmaceuticals Co., Ltd. | Sulfonamide compound, preparation method therefor, and pharmaceutical use thereof |
| CN119343449A (zh) * | 2023-05-24 | 2025-01-21 | 云合智药(苏州)生物科技有限公司 | 用于抑制angptl3表达的rnai剂及其应用 |
| AU2024280186A1 (en) | 2023-05-31 | 2025-12-04 | Tuojie Biotech (Shanghai) Co., Ltd. | Dsrna targeting lpa and use thereof |
| KR20260034076A (ko) * | 2023-05-31 | 2026-03-10 | 애로우헤드 파마슈티컬스 인코포레이티드 | 다량체성 RNAi 작용제 접합체를 위한 간 전달 플랫폼 및 그의 사용 방법 |
| DE102023115075A1 (de) * | 2023-06-07 | 2024-12-12 | B.Braun Avitum Ag | Schlauchrollenpumpe |
| WO2025064821A2 (en) | 2023-09-21 | 2025-03-27 | Ionis Pharmaceuticals, Inc. | Compounds and methods for inhibiting lpa |
| WO2025082058A1 (zh) * | 2023-10-16 | 2025-04-24 | 润佳(上海)医药技术有限公司 | 一种抑制LPA基因表达的dsRNA及其用途 |
| CN120344664A (zh) * | 2023-10-27 | 2025-07-18 | 北京安龙生物医药有限公司 | 靶向脂蛋白a的寡核苷酸及其用途 |
| TW202540420A (zh) * | 2023-11-15 | 2025-10-16 | 大陸商北京加科瑞康醫藥科技有限公司 | 用於抑制LPA的基因表現的siRNA,含其的組合物及其用途 |
| CN120020252A (zh) * | 2023-11-17 | 2025-05-20 | 纳肽得(青岛)生物医药有限公司 | 抑制LPA表达的siRNA及其用途 |
| CN120098993A (zh) * | 2023-12-05 | 2025-06-06 | 广东东阳光药业股份有限公司 | 一种新型的双链siRNA、其缀合物及其用途 |
| CN120485189B (zh) * | 2025-07-16 | 2025-10-17 | 北京悦康科创医药科技股份有限公司 | 靶向调控LPA基因表达的siRNA及其用途 |
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| US5599706A (en) | 1994-09-23 | 1997-02-04 | Stinchcomb; Dan T. | Ribozymes targeted to apo(a) mRNA |
| WO2000053722A2 (en) | 1999-03-10 | 2000-09-14 | Phogen Limited | Delivery of nucleic acids and proteins to cells |
| KR100909681B1 (ko) * | 2000-12-01 | 2009-07-29 | 막스-플랑크-게젤샤프트 츄어 푀르더룽 데어 비쎈샤프텐 에.파우. | Rna 간섭을 매개하는 작은 rna 분자 |
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| CN101500548A (zh) * | 2006-08-18 | 2009-08-05 | 弗·哈夫曼-拉罗切有限公司 | 用于体内递送多核苷酸的多缀合物 |
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2015
- 2015-10-01 JO JOP/2021/0043A patent/JOP20210043A1/ar unknown
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2016
- 2016-09-28 JO JOP/2016/0211A patent/JOP20160211B1/ar active
- 2016-09-30 TW TW111141660A patent/TWI836693B/zh active
- 2016-09-30 UY UY0001036926A patent/UY36926A/es active IP Right Grant
- 2016-09-30 HR HRP20211410TT patent/HRP20211410T1/hr unknown
- 2016-09-30 SG SG10202008530TA patent/SG10202008530TA/en unknown
- 2016-09-30 PE PE2018000487A patent/PE20181139A1/es unknown
- 2016-09-30 TN TNP/2018/000094A patent/TN2018000094A1/en unknown
- 2016-09-30 HU HUE16852695A patent/HUE055942T2/hu unknown
- 2016-09-30 US US15/281,309 patent/US9932586B2/en active Active
- 2016-09-30 JP JP2018516738A patent/JP6991966B2/ja active Active
- 2016-09-30 DK DK16852695.2T patent/DK3356529T3/da active
- 2016-09-30 ES ES16852695T patent/ES2896298T3/es active Active
- 2016-09-30 SI SI201631374T patent/SI3356529T1/sl unknown
- 2016-09-30 EP EP16852695.2A patent/EP3356529B1/en active Active
- 2016-09-30 UA UAA201804593A patent/UA121998C2/uk unknown
- 2016-09-30 CA CA3000397A patent/CA3000397A1/en active Pending
- 2016-09-30 KR KR1020187010095A patent/KR102728481B1/ko active Active
- 2016-09-30 EP EP21191363.7A patent/EP4029941A1/en active Pending
- 2016-09-30 CN CN201680057095.8A patent/CN108368506A/zh active Pending
- 2016-09-30 SM SM20210622T patent/SMT202100622T1/it unknown
- 2016-09-30 EA EA201890864A patent/EA038478B1/ru unknown
- 2016-09-30 MX MX2018003833A patent/MX2018003833A/es unknown
- 2016-09-30 LT LTEPPCT/US2016/054729T patent/LT3356529T/lt unknown
- 2016-09-30 MY MYPI2018000440A patent/MY195796A/en unknown
- 2016-09-30 IL IL300438A patent/IL300438A/en unknown
- 2016-09-30 WO PCT/US2016/054729 patent/WO2017059223A2/en not_active Ceased
- 2016-09-30 PT PT168526952T patent/PT3356529T/pt unknown
- 2016-09-30 RS RS20211351A patent/RS62523B1/sr unknown
- 2016-09-30 AU AU2016331084A patent/AU2016331084B2/en active Active
- 2016-09-30 CR CR20180231A patent/CR20180231A/es unknown
- 2016-09-30 TW TW113106862A patent/TWI880645B/zh active
- 2016-09-30 TW TW105131823A patent/TWI784934B/zh active
- 2016-09-30 PL PL16852695T patent/PL3356529T3/pl unknown
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2017
- 2017-04-06 MA MA43347A patent/MA43347B1/fr unknown
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2018
- 2018-02-21 US US15/901,810 patent/US10662427B2/en active Active
- 2018-03-25 IL IL258333A patent/IL258333B/en unknown
- 2018-03-27 MX MX2022013010A patent/MX2022013010A/es unknown
- 2018-03-28 CL CL2018000803A patent/CL2018000803A1/es unknown
- 2018-03-28 PH PH12018500713A patent/PH12018500713A1/en unknown
- 2018-04-05 CO CONC2018/0003678A patent/CO2018003678A2/es unknown
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2020
- 2020-05-06 US US16/867,925 patent/US20200263179A1/en not_active Abandoned
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2021
- 2021-03-12 JP JP2021039949A patent/JP7116212B2/ja active Active
- 2021-08-30 ZA ZA2021/06265A patent/ZA202106265B/en unknown
- 2021-11-08 CY CY20211100962T patent/CY1125263T1/el unknown
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2022
- 2022-02-13 IL IL290566A patent/IL290566B2/en unknown
- 2022-06-15 JP JP2022096415A patent/JP7442574B2/ja active Active
- 2022-12-05 AU AU2022283623A patent/AU2022283623B2/en active Active
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2023
- 2023-11-27 JP JP2023199857A patent/JP2024009262A/ja not_active Withdrawn
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2024
- 2024-06-17 US US18/745,289 patent/US20250115907A1/en active Pending
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2025
- 2025-10-03 AU AU2025242219A patent/AU2025242219A1/en active Pending
- 2025-10-24 JP JP2025179509A patent/JP2026040461A/ja active Pending