JP2018529732A5 - - Google Patents
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- JP2018529732A5 JP2018529732A5 JP2018516738A JP2018516738A JP2018529732A5 JP 2018529732 A5 JP2018529732 A5 JP 2018529732A5 JP 2018516738 A JP2018516738 A JP 2018516738A JP 2018516738 A JP2018516738 A JP 2018516738A JP 2018529732 A5 JP2018529732 A5 JP 2018529732A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- sequence
- strand comprises
- rnai agent
- sense strand
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562235816P | 2015-10-01 | 2015-10-01 | |
| US62/235,816 | 2015-10-01 | ||
| US201662346304P | 2016-06-06 | 2016-06-06 | |
| US62/346,304 | 2016-06-06 | ||
| US201662383221P | 2016-09-02 | 2016-09-02 | |
| US62/383,221 | 2016-09-02 | ||
| PCT/US2016/054729 WO2017059223A2 (en) | 2015-10-01 | 2016-09-30 | Compositions and methods for inhibiting gene expression of lpa |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021039949A Division JP7116212B2 (ja) | 2015-10-01 | 2021-03-12 | Lpaの遺伝子発現の阻害のための組成物及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018529732A JP2018529732A (ja) | 2018-10-11 |
| JP2018529732A5 true JP2018529732A5 (enExample) | 2019-11-07 |
| JP6991966B2 JP6991966B2 (ja) | 2022-02-03 |
Family
ID=58424351
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018516738A Active JP6991966B2 (ja) | 2015-10-01 | 2016-09-30 | Lpaの遺伝子発現の阻害のための組成物及び方法 |
| JP2021039949A Active JP7116212B2 (ja) | 2015-10-01 | 2021-03-12 | Lpaの遺伝子発現の阻害のための組成物及び方法 |
| JP2022096415A Active JP7442574B2 (ja) | 2015-10-01 | 2022-06-15 | Lpaの遺伝子発現の阻害のための組成物及び方法 |
| JP2023199857A Withdrawn JP2024009262A (ja) | 2015-10-01 | 2023-11-27 | Lpaの遺伝子発現の阻害のための組成物及び方法 |
| JP2025179509A Pending JP2026040461A (ja) | 2015-10-01 | 2025-10-24 | Lpaの遺伝子発現の阻害のための組成物及び方法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021039949A Active JP7116212B2 (ja) | 2015-10-01 | 2021-03-12 | Lpaの遺伝子発現の阻害のための組成物及び方法 |
| JP2022096415A Active JP7442574B2 (ja) | 2015-10-01 | 2022-06-15 | Lpaの遺伝子発現の阻害のための組成物及び方法 |
| JP2023199857A Withdrawn JP2024009262A (ja) | 2015-10-01 | 2023-11-27 | Lpaの遺伝子発現の阻害のための組成物及び方法 |
| JP2025179509A Pending JP2026040461A (ja) | 2015-10-01 | 2025-10-24 | Lpaの遺伝子発現の阻害のための組成物及び方法 |
Country Status (35)
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7718133B2 (en) | 2003-10-09 | 2010-05-18 | 3M Innovative Properties Company | Multilayer processing devices and methods |
| JOP20170057B1 (ar) * | 2016-03-07 | 2022-03-14 | Arrowhead Pharmaceuticals Inc | مركبات ترابطية مستهدفة كمركبات علاجية |
| JOP20170056B1 (ar) | 2016-09-02 | 2021-08-17 | Arrowhead Pharmaceuticals Inc | مركبات ترابطية مستهدفة |
| US11015198B2 (en) * | 2017-04-05 | 2021-05-25 | Silence Therapeutics Gmbh | Products and compositions |
| TN2019000308A1 (en) * | 2017-07-06 | 2021-05-07 | Arrowhead Pharmaceuticals Inc | RNAi AGENTS FOR INHIBITING EXPRESSION OF ALPHA-ENaC AND METHODS OF USE |
| SG11201912178VA (en) * | 2017-09-11 | 2020-01-30 | Arrowhead Pharmaceuticals Inc | Rnai agents and compositions for inhibiting expression of apolipoprotein c-iii (apoc3) |
| MX2020001912A (es) * | 2017-09-14 | 2020-03-24 | Arrowhead Pharmaceuticals Inc | Agentes de iarn y composiciones para inhibir la expresion de la angiopoyetina tipo 3 (angptl3) y metodos de uso. |
| SG11202003126VA (en) | 2017-10-04 | 2020-05-28 | Avidity Biosciences Inc | Nucleic acid-polypeptide compositions and uses thereof |
| CN111212909A (zh) * | 2017-10-17 | 2020-05-29 | 箭头药业股份有限公司 | 用于抑制去唾液酸糖蛋白受体1的表达的RNAi试剂和组合物 |
| CN119120476A (zh) * | 2017-11-13 | 2024-12-13 | 赛伦斯治疗有限责任公司 | 用于抑制细胞中lpa的表达的核酸 |
| EP3483270A1 (en) * | 2017-11-13 | 2019-05-15 | Silence Therapeutics GmbH | Products and compositions |
| US12534728B2 (en) * | 2018-09-19 | 2026-01-27 | Arrowhead Pharmaceuticals, Inc. | RNAi agents for inhibiting expression of 17beta-HSD type 13 (HSD17B13), compositions thereof, and methods of use |
| AU2019380628B2 (en) * | 2018-11-13 | 2024-10-31 | Silence Therapeutics Gmbh | Nucleic acids for inhibiting expression of LPA in a cell |
| WO2020247782A1 (en) | 2019-06-06 | 2020-12-10 | Avidity Biosciences, Inc. | Nucleic acid-polypeptide compositions and uses thereof |
| EP3983077A4 (en) * | 2019-06-17 | 2023-12-20 | Alnylam Pharmaceuticals, Inc. | DELIVERY OF OLIGONUCLEOTIDES TO THE STRIATUM |
| CN112442499B (zh) * | 2019-08-30 | 2026-03-10 | 恩康药业科技(广州)有限公司 | 一种抑制MCM7的siRNA、组合物及其应用 |
| JP7827623B2 (ja) * | 2019-12-09 | 2026-03-10 | アムジエン・インコーポレーテツド | LPA発現を阻害するためのRNAiコンストラクト及び方法 |
| EP4126967A1 (en) * | 2020-03-23 | 2023-02-08 | Amgen Inc. | Monoclonal antibodies to chemically-modified nucleic acids and uses thereof |
| KR20220158011A (ko) * | 2020-03-26 | 2022-11-29 | 애로우헤드 파마슈티컬스 인코포레이티드 | PNPLA3의 발현을 억제하기 위한 RNAi 작용제, 이의 약제학적 조성물, 및 사용 방법 |
| KR20250077604A (ko) * | 2020-08-05 | 2025-05-30 | 다이서나 파마수이티컬, 인크. | Lpa 발현을 저해하기 위한 조성물 및 방법 |
| EP4229201A1 (en) * | 2020-10-16 | 2023-08-23 | Sanofi | Rna compositions and methods for inhibiting lipoprotein(a) |
| KR20230104200A (ko) * | 2020-11-05 | 2023-07-07 | 암젠 인크 | LPA-표적화된 RNAi 작제물을 이용하여 죽상경화성 심혈관질환을 치료하는 방법 |
| WO2022121959A1 (zh) * | 2020-12-09 | 2022-06-16 | 纳肽得有限公司 | siRNA分子及其在治疗冠状动脉疾病中的应用 |
| US20250304966A1 (en) | 2020-12-23 | 2025-10-02 | Argonaute RNA Limited | Treatment of cardiovascular disease |
| US20250034561A1 (en) * | 2021-02-18 | 2025-01-30 | Oneglobe Holdings Limited | Novel Compositions for Conjugating Oligonucleotides and Carbohydrates |
| CN117836307A (zh) | 2021-06-18 | 2024-04-05 | 弘景生物科技有限公司 | 功能化的n-乙酰基半乳糖胺核苷 |
| EP4396193A4 (en) | 2021-08-30 | 2025-07-02 | Hongene Biotech Corp | FUNCTIONALIZED N-ACETYLGALACTOSAMINE ANALOGUES |
| US20250283076A1 (en) | 2021-09-14 | 2025-09-11 | Argonaute RNA Limited | Treatment of cardiovascular disease |
| KR20240103025A9 (ko) | 2021-11-16 | 2025-12-10 | 상하이 아르고 바이오파마슈티칼 씨오., 엘티디. | 안지오텐시노겐(agt) 단백질의 발현을 저해하는 조성물 및 방법 |
| CN118401539A (zh) | 2021-12-15 | 2024-07-26 | 兆维生物科技公司 | 官能化的n-乙酰半乳糖胺类似物 |
| EP4450624A4 (en) * | 2021-12-16 | 2025-03-26 | Tuojie Biotech (Shanghai) Co., Ltd. | LPA-TARGETTING SIRNA AND CONJUGATE |
| CN115851723B (zh) * | 2022-10-24 | 2023-10-03 | 厦门甘宝利生物医药有限公司 | 一种抑制lpa基因表达的rna抑制剂及其应用 |
| US12116382B2 (en) | 2022-11-28 | 2024-10-15 | Hongene Biotech Corporation | Functionalized N-acetylgalactosamine analogs |
| KR20250131826A (ko) * | 2023-01-13 | 2025-09-03 | 일라이 릴리 앤드 캄파니 | 치료 올리고뉴클레오티드-함유 제약 조성물 및 그를 사용한 투여 요법 |
| AU2024279456A1 (en) * | 2023-05-31 | 2025-12-04 | Arrowhead Pharmaceuticals, Inc. | HEPATIC DELIVERY PLATFORMS FOR MULTIMERIC RNAi AGENT CONJUGATES AND METHODS OF USE THEREOF |
| KR20260020955A (ko) | 2023-05-31 | 2026-02-12 | 투오지에 바이오텍 (상하이) 컴퍼니 리미티드 | LPA를 표적화하는 dsRNA 및 이의 응용 |
| DE102023115075A1 (de) * | 2023-06-07 | 2024-12-12 | B.Braun Avitum Ag | Schlauchrollenpumpe |
| UY40897A (es) | 2023-09-21 | 2025-03-31 | Ionis Pharmaceuticals Inc | Compuestos y métodos para inhibir lpa |
| TW202540420A (zh) | 2023-11-15 | 2025-10-16 | 大陸商北京加科瑞康醫藥科技有限公司 | 用於抑制LPA的基因表現的siRNA,含其的組合物及其用途 |
| WO2026092650A1 (zh) * | 2024-11-01 | 2026-05-07 | 迈威(上海)生物科技股份有限公司 | 一种抑制LPA基因表达的RNAi制剂及其应用 |
| WO2026133253A1 (en) | 2024-12-20 | 2026-06-25 | Novartis Ag | Combinations of antisense agents, pharmaceutical compositions and methods of use |
| CN120485189B (zh) * | 2025-07-16 | 2025-10-17 | 北京悦康科创医药科技股份有限公司 | 靶向调控LPA基因表达的siRNA及其用途 |
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| NL9201440A (nl) | 1992-08-11 | 1994-03-01 | Univ Leiden | Triantennaire clusterglycosiden, hun bereiding en toepassing. |
| US5599706A (en) | 1994-09-23 | 1997-02-04 | Stinchcomb; Dan T. | Ribozymes targeted to apo(a) mRNA |
| WO2000053722A2 (en) | 1999-03-10 | 2000-09-14 | Phogen Limited | Delivery of nucleic acids and proteins to cells |
| CN100523215C (zh) * | 2000-12-01 | 2009-08-05 | 马普科技促进协会 | 介导rna干涉的小rna分子 |
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| DE602004027798D1 (de) | 2003-03-12 | 2010-08-05 | Univ Arizona State | Verfahren zur regulierung von angiogenese mit apelin-zusammensetzungen |
| CA2559955C (en) | 2004-03-15 | 2016-02-16 | City Of Hope | Methods and compositions for the specific inhibition of gene expression by double-stranded rna |
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| CN101500548A (zh) * | 2006-08-18 | 2009-08-05 | 弗·哈夫曼-拉罗切有限公司 | 用于体内递送多核苷酸的多缀合物 |
| KR20110110776A (ko) | 2008-12-18 | 2011-10-07 | 다이서나 파마수이티컬, 인크. | 유전자 발현의 특이적 억제를 위한 연장된 다이서 기질 제제 및 방법 |
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| RU2013117288A (ru) * | 2010-12-17 | 2015-01-27 | Эрроухэд Рисерч Корпорейшн | СОДЕРЖАЩАЯ ГАЛАКТОЗНЫЙ КЛАСТЕР НАЦЕЛИВАЮЩАЯ ГРУППА ДЛЯ миРНК, МОДУЛИРУЮЩАЯ ФОРМАКОКИНЕТИЧЕСКИЕ СВОЙСТВА |
| MX347298B (es) | 2010-12-29 | 2017-04-21 | Arrowhead Res Corp | Conjugados de suministro de polinucleotidos in vivo que tienen acoplamientos sensibles a enzima. |
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| RU2624028C2 (ru) * | 2012-05-24 | 2017-06-30 | Ионис Фармасьютикалз, Инк. | Способы и композиции для модулирования экспрессии аполипопротеина (а) |
| HK1219422A1 (zh) * | 2013-02-28 | 2017-04-07 | Immunogen, Inc. | 包含细胞结合剂及细胞毒素剂的轭合物 |
| PL2992098T3 (pl) | 2013-05-01 | 2019-09-30 | Ionis Pharmaceuticals, Inc. | Kompozycje i sposoby modulowania ekspresji hbv i ttr |
| WO2015021092A1 (en) * | 2013-08-07 | 2015-02-12 | Arrowhead Research Corporation | Polyconjugates for delivery of rnai triggers to tumor cells in vivo |
| US20160272970A1 (en) | 2015-03-17 | 2016-09-22 | Arrowhead Madison Inc. | RNA Interference Agents |
| TWI761305B (zh) | 2015-05-29 | 2022-04-21 | 美商愛羅海德製藥公司 | 抑制Hif2α基因表現之組合物及方法 |
| LT3329002T (lt) * | 2015-07-31 | 2021-01-11 | Alnylam Pharmaceuticals, Inc. | Transtiretino (ttr) irnr kompozicijos ir jų naudojimo būdai, skirti naudoti su ttr susijusių ligų gydymui arba prevencijai |
| JOP20170057B1 (ar) | 2016-03-07 | 2022-03-14 | Arrowhead Pharmaceuticals Inc | مركبات ترابطية مستهدفة كمركبات علاجية |
-
2016
- 2016-09-28 JO JOP/2016/0211A patent/JOP20160211B1/ar active
- 2016-09-30 CA CA3000397A patent/CA3000397A1/en active Pending
- 2016-09-30 TW TW105131823A patent/TWI784934B/zh active
- 2016-09-30 WO PCT/US2016/054729 patent/WO2017059223A2/en not_active Ceased
- 2016-09-30 TN TNP/2018/000094A patent/TN2018000094A1/en unknown
- 2016-09-30 RS RS20211351A patent/RS62523B1/sr unknown
- 2016-09-30 LT LTEPPCT/US2016/054729T patent/LT3356529T/lt unknown
- 2016-09-30 HR HRP20211410TT patent/HRP20211410T1/hr unknown
- 2016-09-30 CA CA3310628A patent/CA3310628A1/en active Pending
- 2016-09-30 KR KR1020247036942A patent/KR102942707B1/ko active Active
- 2016-09-30 MX MX2018003833A patent/MX2018003833A/es unknown
- 2016-09-30 PT PT168526952T patent/PT3356529T/pt unknown
- 2016-09-30 SM SM20210622T patent/SMT202100622T1/it unknown
- 2016-09-30 EP EP16852695.2A patent/EP3356529B1/en active Active
- 2016-09-30 SG SG10202008530TA patent/SG10202008530TA/en unknown
- 2016-09-30 EA EA201890864A patent/EA038478B1/ru unknown
- 2016-09-30 UY UY0001036926A patent/UY36926A/es active IP Right Grant
- 2016-09-30 US US15/281,309 patent/US9932586B2/en active Active
- 2016-09-30 PE PE2018000487A patent/PE20181139A1/es unknown
- 2016-09-30 KR KR1020187010095A patent/KR102728481B1/ko active Active
- 2016-09-30 UA UAA201804593A patent/UA121998C2/uk unknown
- 2016-09-30 SI SI201631374T patent/SI3356529T1/sl unknown
- 2016-09-30 JO JOP/2021/0043A patent/JOP20210043A1/ar unknown
- 2016-09-30 HU HUE16852695A patent/HUE055942T2/hu unknown
- 2016-09-30 EP EP21191363.7A patent/EP4029941A1/en active Pending
- 2016-09-30 JP JP2018516738A patent/JP6991966B2/ja active Active
- 2016-09-30 AU AU2016331084A patent/AU2016331084B2/en active Active
- 2016-09-30 PL PL16852695T patent/PL3356529T3/pl unknown
- 2016-09-30 KR KR1020267008441A patent/KR20260046241A/ko active Pending
- 2016-09-30 CR CR20180231A patent/CR20180231A/es unknown
- 2016-09-30 MY MYPI2018000440A patent/MY195796A/en unknown
- 2016-09-30 TW TW114109608A patent/TW202600825A/zh unknown
- 2016-09-30 ES ES16852695T patent/ES2896298T3/es active Active
- 2016-09-30 TW TW113106862A patent/TWI880645B/zh active
- 2016-09-30 TW TW111141660A patent/TWI836693B/zh active
- 2016-09-30 DK DK16852695.2T patent/DK3356529T3/da active
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2017
- 2017-04-06 MA MA43347A patent/MA43347B1/fr unknown
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2018
- 2018-02-21 US US15/901,810 patent/US10662427B2/en active Active
- 2018-03-25 IL IL258333A patent/IL258333B/en unknown
- 2018-03-27 MX MX2022013010A patent/MX2022013010A/es unknown
- 2018-03-28 PH PH12018500713A patent/PH12018500713A1/en unknown
- 2018-03-28 CL CL2018000803A patent/CL2018000803A1/es unknown
- 2018-04-05 CO CONC2018/0003678A patent/CO2018003678A2/es unknown
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2020
- 2020-05-06 US US16/867,925 patent/US20200263179A1/en not_active Abandoned
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2021
- 2021-03-12 JP JP2021039949A patent/JP7116212B2/ja active Active
- 2021-08-30 ZA ZA2021/06265A patent/ZA202106265B/en unknown
- 2021-11-08 CY CY20211100962T patent/CY1125263T1/el unknown
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2022
- 2022-02-13 IL IL290566A patent/IL290566B2/en unknown
- 2022-06-15 JP JP2022096415A patent/JP7442574B2/ja active Active
- 2022-12-05 AU AU2022283623A patent/AU2022283623B2/en active Active
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2023
- 2023-02-06 IL IL300438A patent/IL300438B2/en unknown
- 2023-11-27 JP JP2023199857A patent/JP2024009262A/ja not_active Withdrawn
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2024
- 2024-06-17 US US18/745,289 patent/US20250115907A1/en active Pending
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2025
- 2025-10-03 AU AU2025242219A patent/AU2025242219A1/en active Pending
- 2025-10-24 JP JP2025179509A patent/JP2026040461A/ja active Pending
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