CA3000397A1 - Compositions and methods for inhibiting gene expression of lpa - Google Patents
Compositions and methods for inhibiting gene expression of lpa Download PDFInfo
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- CA3000397A1 CA3000397A1 CA3000397A CA3000397A CA3000397A1 CA 3000397 A1 CA3000397 A1 CA 3000397A1 CA 3000397 A CA3000397 A CA 3000397A CA 3000397 A CA3000397 A CA 3000397A CA 3000397 A1 CA3000397 A1 CA 3000397A1
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- rnai agent
- lpa
- nucleotide sequence
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| CN120485189A (zh) * | 2025-07-16 | 2025-08-15 | 北京悦康科创医药科技股份有限公司 | 靶向调控LPA基因表达的siRNA及其用途 |
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| CA3011668A1 (en) | 2016-09-02 | 2018-03-08 | Arrowhead Pharmaceuticals, Inc. | Targeting ligands |
| ES2932831T3 (es) * | 2017-04-05 | 2023-01-26 | Silence Therapeutics Gmbh | Productos y composiciones |
| JP2020526192A (ja) * | 2017-07-06 | 2020-08-31 | アローヘッド ファーマシューティカルズ インコーポレイテッド | アルファ−ＥＮａＣの発現を阻害するためのＲＮＡｉ剤、および使用方法 |
| WO2019051402A1 (en) * | 2017-09-11 | 2019-03-14 | Arrowhead Pharmaceuticals, Inc. | RNA INTERFERENCE AGENTS AND COMPOSITIONS FOR INHIBITING THE EXPRESSION OF APOLIPOPROTEIN C-III (APOC3) |
| EP3681513A4 (en) * | 2017-09-14 | 2021-09-22 | Arrowhead Pharmaceuticals, Inc. | RNAI AGENTS AND COMPOSITIONS FOR INHIBITING THE EXPRESSION OF ANGIOPOIETIN-LIKE 3 (ANGPTL3) AND METHOD OF USE |
| KR102822647B1 (ko) | 2017-10-04 | 2025-06-19 | 어비디티 바이오사이언시스 인크. | 핵산-폴리펩티드 조성물 및 그의 용도 |
| JP7473472B2 (ja) * | 2017-10-17 | 2024-04-23 | アローヘッド ファーマシューティカルズ インコーポレイテッド | アシアロ糖タンパク質受容体１の発現を阻害するためのＲＮＡｉ剤および組成物 |
| EP3483270A1 (en) * | 2017-11-13 | 2019-05-15 | Silence Therapeutics GmbH | Products and compositions |
| US11319537B2 (en) * | 2017-11-13 | 2022-05-03 | Silence Therapeutics Gmbh | Nucleic acids for inhibiting expression of LPA in a cell |
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| PH12021550801B1 (en) * | 2018-11-13 | 2024-04-26 | Silence Therapeutics Gmbh | Nucleic acids for inhibiting expression of lpa in a cell |
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| JP2024545222A (ja) * | 2021-12-16 | 2024-12-05 | 上海拓界生物医薬科技有限公司 | ＬＰＡを標的とするｓｉＲＮＡ及び複合体 |
| CN114703184B (zh) * | 2022-03-11 | 2024-06-18 | 厦门甘宝利生物医药有限公司 | Lpa抑制剂及其用途 |
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| CN115851723B (zh) * | 2022-10-24 | 2023-10-03 | 厦门甘宝利生物医药有限公司 | 一种抑制lpa基因表达的rna抑制剂及其应用 |
| US12116382B2 (en) | 2022-11-28 | 2024-10-15 | Hongene Biotech Corporation | Functionalized N-acetylgalactosamine analogs |
| KR20250130686A (ko) * | 2023-01-13 | 2025-09-02 | 일라이 릴리 앤드 캄파니 | 치료 올리고뉴클레오티드-함유 제약 조성물 및 그를 사용한 투여 요법 |
| CN119384503A (zh) * | 2023-04-03 | 2025-01-28 | 翰森（上海）健康科技有限公司 | 靶向LPA基因的RNAi剂及其用途 |
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| CN119343449A (zh) * | 2023-05-24 | 2025-01-21 | 云合智药（苏州）生物科技有限公司 | 用于抑制angptl3表达的rnai剂及其应用 |
| WO2024245410A1 (zh) * | 2023-05-31 | 2024-12-05 | 上海拓界生物医药科技有限公司 | 一种靶向LPA的dsRNA及其应用 |
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| TW202530406A (zh) | 2023-09-21 | 2025-08-01 | 美商Ionis製藥公司 | 用於抑制ｌｐａ的化合物及方法 |
| WO2025082058A1 (zh) * | 2023-10-16 | 2025-04-24 | 润佳(上海)医药技术有限公司 | 一种抑制LPA基因表达的dsRNA及其用途 |
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| JP7021076B2 (ja) | 2015-05-29 | 2022-02-16 | アローヘッド ファーマシューティカルズ インコーポレイテッド | Ｈｉｆ２αの遺伝子発現を阻害する組成物及び方法 |
| HUE051998T2 (hu) * | 2015-07-31 | 2021-04-28 | Alnylam Pharmaceuticals Inc | Transztiretin (TTR) iRNS készítmények és eljárások azok alkalmazása TTR-asszociált betegségek kezelésére vagy megelõzésére |
| US10246709B2 (en) | 2016-03-07 | 2019-04-02 | Arrowhead Pharmaceuticals, Inc. | Targeting ligands for therapeutic compounds |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN120485189A (zh) * | 2025-07-16 | 2025-08-15 | 北京悦康科创医药科技股份有限公司 | 靶向调控LPA基因表达的siRNA及其用途 |
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