MA43347A - Compositions et méthodes permettant d'inhiber l'expression du gène de lpa - Google Patents
Compositions et méthodes permettant d'inhiber l'expression du gène de lpaInfo
- Publication number
- MA43347A MA43347A MA43347A MA43347A MA43347A MA 43347 A MA43347 A MA 43347A MA 43347 A MA43347 A MA 43347A MA 43347 A MA43347 A MA 43347A MA 43347 A MA43347 A MA 43347A
- Authority
- MA
- Morocco
- Prior art keywords
- agents
- arni
- lpa
- compositions
- methods
- Prior art date
Links
- 230000014509 gene expression Effects 0.000 title abstract 3
- 101150091521 lpa gene Proteins 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- 241000320892 Clerodendrum phlomidis Species 0.000 abstract 4
- 239000003795 chemical substances by application Substances 0.000 abstract 4
- 102100040214 Apolipoprotein(a) Human genes 0.000 abstract 1
- 101710115418 Apolipoprotein(a) Proteins 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 238000012228 RNA interference-mediated gene silencing Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- 230000009368 gene silencing by RNA Effects 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 210000005229 liver cell Anatomy 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3517—Marker; Tag
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Des agents d'interférence d'arn (arni) et des conjugués d'agents d'arni pour inhiber l'expression du gène de la lpa (apo (a)) sont décrits. Des compositions pharmaceutiques comprenant un ou plusieurs agents arni lpa, éventuellement avec un ou plusieurs agents thérapeutiques supplémentaires, sont également décrites. La délivrance des agents arni lpa décrits aux cellules hépatiques in vivo permet d'inhiber l'expression du gène lpa et le traitement des maladies cardiovasculaires et cardiovasculaires.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562235816P | 2015-10-01 | 2015-10-01 | |
US201662346304P | 2016-06-06 | 2016-06-06 | |
US201662383221P | 2016-09-02 | 2016-09-02 | |
PCT/US2016/054729 WO2017059223A2 (fr) | 2015-10-01 | 2016-09-30 | Compositions et méthodes permettant d'inhiber l'expression du gène de lpa |
Publications (2)
Publication Number | Publication Date |
---|---|
MA43347A true MA43347A (fr) | 2018-08-08 |
MA43347B1 MA43347B1 (fr) | 2021-11-30 |
Family
ID=58424351
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA43347A MA43347B1 (fr) | 2015-10-01 | 2017-04-06 | Compositions et méthodes permettant d'inhiber l'expression du gène de lpa |
Country Status (37)
Country | Link |
---|---|
US (3) | US9932586B2 (fr) |
EP (2) | EP3356529B1 (fr) |
JP (4) | JP6991966B2 (fr) |
KR (1) | KR20180052703A (fr) |
CN (1) | CN108368506A (fr) |
AU (2) | AU2016331084B2 (fr) |
BR (1) | BR112018006489A2 (fr) |
CA (1) | CA3000397A1 (fr) |
CL (1) | CL2018000803A1 (fr) |
CO (1) | CO2018003678A2 (fr) |
CR (1) | CR20180231A (fr) |
CY (1) | CY1125263T1 (fr) |
DK (1) | DK3356529T3 (fr) |
EA (1) | EA038478B1 (fr) |
ES (1) | ES2896298T3 (fr) |
HK (1) | HK1259063A1 (fr) |
HR (1) | HRP20211410T1 (fr) |
HU (1) | HUE055942T2 (fr) |
IL (3) | IL300438A (fr) |
JO (2) | JOP20210043A1 (fr) |
LT (1) | LT3356529T (fr) |
MA (1) | MA43347B1 (fr) |
MX (2) | MX2018003833A (fr) |
MY (1) | MY195796A (fr) |
PE (1) | PE20181139A1 (fr) |
PH (1) | PH12018500713A1 (fr) |
PL (1) | PL3356529T3 (fr) |
PT (1) | PT3356529T (fr) |
RS (1) | RS62523B1 (fr) |
SG (1) | SG10202008530TA (fr) |
SI (1) | SI3356529T1 (fr) |
TN (1) | TN2018000094A1 (fr) |
TW (2) | TWI836693B (fr) |
UA (1) | UA121998C2 (fr) |
UY (1) | UY36926A (fr) |
WO (1) | WO2017059223A2 (fr) |
ZA (1) | ZA202106265B (fr) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7718133B2 (en) | 2003-10-09 | 2010-05-18 | 3M Innovative Properties Company | Multilayer processing devices and methods |
UY37146A (es) * | 2016-03-07 | 2017-09-29 | Arrowhead Pharmaceuticals Inc | Ligandos de direccionamiento para compuestos terapéuticos |
SG11201901841TA (en) | 2016-09-02 | 2019-03-28 | Arrowhead Pharmaceuticals Inc | Targeting ligands |
FI3607069T3 (fi) | 2017-04-05 | 2023-01-13 | Tuotteita ja koostumuksia | |
TN2019000308A1 (en) * | 2017-07-06 | 2021-05-07 | Arrowhead Pharmaceuticals Inc | RNAi AGENTS FOR INHIBITING EXPRESSION OF ALPHA-ENaC AND METHODS OF USE |
JOP20200054A1 (ar) * | 2017-09-11 | 2020-03-10 | Arrowhead Pharmaceuticals Inc | عوامل RNAi وتركيبات لتثبيط تعبير صَميمُ البروتينِ الشَّحْمِيّ C-III (APOC3) |
EP3681513A4 (fr) * | 2017-09-14 | 2021-09-22 | Arrowhead Pharmaceuticals, Inc. | Agents d'arni et compositions destinées à inhiber l'expression d'analogue de l'angiopoïétine 3 (angptl3) et procédés d'utilisation |
US11492624B2 (en) * | 2017-10-17 | 2022-11-08 | Arrowheads Pharmaceuticals, Inc. | RNAi agents and compositions for inhibiting expression of Asialoglycoprotein receptor 1 |
EP3483270A1 (fr) * | 2017-11-13 | 2019-05-15 | Silence Therapeutics GmbH | Produits et compositions |
EP3710586B1 (fr) * | 2017-11-13 | 2022-11-23 | Silence Therapeutics GmbH | Produits et compositions |
CN113164509A (zh) * | 2018-09-19 | 2021-07-23 | 箭头药业股份有限公司 | 用于抑制17β-HSD 13型(HSD17B13)表达的RNAi试剂、其组合物和使用方法 |
HUE060703T2 (hu) | 2018-11-13 | 2023-04-28 | Silence Therapeutics Gmbh | Nukleinsavak LPA expressziójának gátlására egy sejtben |
AU2020399636A1 (en) | 2019-12-09 | 2022-06-02 | Amgen Inc. | RNAi constructs and methods for inhibiting LPA expression |
JP7476422B2 (ja) | 2020-08-05 | 2024-04-30 | ディセルナ ファーマシューティカルズ インコーポレイテッド | Lpa発現を阻害するための組成物及び方法 |
CN116490195A (zh) * | 2020-10-16 | 2023-07-25 | 赛诺菲 | 用于抑制脂蛋白(a)的RNA组合物和方法 |
JP2023549115A (ja) | 2020-11-05 | 2023-11-22 | アムジェン インコーポレイテッド | アテローム硬化性心血管疾患をLPA標的RNAi構築体により処置する方法 |
WO2022121959A1 (fr) * | 2020-12-09 | 2022-06-16 | 纳肽得有限公司 | Molécule d'arnsi et son application dans le traitement de maladies des artères coronaires |
JP2024500035A (ja) | 2020-12-23 | 2024-01-04 | アルゴノート アールエヌエー リミテッド | 心血管疾患の治療 |
WO2022266316A1 (fr) | 2021-06-18 | 2022-12-22 | Hongene Biotech Corporation | N-acétylgalactosamine nucléosides fonctionnalisés |
EP4396193A1 (fr) | 2021-08-30 | 2024-07-10 | Hongene Biotech Corporation | Analogues de n-acétylgalactosamine fonctionnalisés |
CA3229020A1 (fr) | 2021-09-14 | 2023-03-23 | Stella Khan | Traitement d'une maladie cardiovasculaire |
AU2022348141A1 (en) * | 2021-09-18 | 2024-04-04 | Genoval Therapeutics Co., Ltd. | Lpa inhibitor and use thereof |
WO2023114746A1 (fr) | 2021-12-15 | 2023-06-22 | Hongene Biotech Corporation | Analogues de n-acétylgalactosamine fonctionnalisés |
CN114703184B (zh) * | 2022-03-11 | 2024-06-18 | 厦门甘宝利生物医药有限公司 | Lpa抑制剂及其用途 |
WO2024032681A1 (fr) * | 2022-08-11 | 2024-02-15 | 益杰立科(上海)生物科技有限公司 | Procédé pour cible d'édition d'épitope et utilisation |
CN115851723B (zh) * | 2022-10-24 | 2023-10-03 | 厦门甘宝利生物医药有限公司 | 一种抑制lpa基因表达的rna抑制剂及其应用 |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL9201440A (nl) | 1992-08-11 | 1994-03-01 | Univ Leiden | Triantennaire clusterglycosiden, hun bereiding en toepassing. |
US5599706A (en) | 1994-09-23 | 1997-02-04 | Stinchcomb; Dan T. | Ribozymes targeted to apo(a) mRNA |
MXPA01009073A (es) | 1999-03-10 | 2002-05-06 | Phogen Ltd | Suministro de acidos nucleicos y proteinas a las celulas. |
CZ302719B6 (cs) * | 2000-12-01 | 2011-09-21 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Izolovaná molekula dvouretezcové RNA, zpusob její výroby a její použití |
US7227014B2 (en) | 2001-08-07 | 2007-06-05 | Isis Pharmaceuticals, Inc. | Antisense modulation of apolipoprotein (a) expression |
US7259150B2 (en) | 2001-08-07 | 2007-08-21 | Isis Pharmaceuticals, Inc. | Modulation of apolipoprotein (a) expression |
EP1613348B1 (fr) | 2003-03-12 | 2010-06-23 | The Arizona Board of Regents on Behalf of the University of Arizona | Procedes de modulation de l'angiogenese avec des compositions d'apeline |
CA2559955C (fr) | 2004-03-15 | 2016-02-16 | City Of Hope | Procedes et compositions pour l'inhibition specifique de l'expression genetique par l'arn double brin |
CN101500548A (zh) * | 2006-08-18 | 2009-08-05 | 弗·哈夫曼-拉罗切有限公司 | 用于体内递送多核苷酸的多缀合物 |
CN102325534B (zh) | 2008-12-18 | 2016-02-17 | 戴瑟纳制药公司 | 延长的dicer酶底物和特异性抑制基因表达的方法 |
WO2010093788A2 (fr) | 2009-02-11 | 2010-08-19 | Dicerna Pharmaceuticals, Inc. | Molécules d'arn interférence substrats de dicer multiplexes ayant des séquences de jonction |
EP3023495B1 (fr) | 2010-02-24 | 2019-05-08 | Arrowhead Pharmaceuticals, Inc. | Compositions pour l'administration ciblée d'arnsi |
WO2011141703A1 (fr) * | 2010-05-12 | 2011-11-17 | Protiva Biotherapeutics Inc. | Compositions et procédés pour réduire au silence l'apolipoprotéine b |
US8501930B2 (en) | 2010-12-17 | 2013-08-06 | Arrowhead Madison Inc. | Peptide-based in vivo siRNA delivery system |
MX346144B (es) * | 2010-12-17 | 2017-03-09 | Arrowhead Res Corp * | Porcion activadora del modulador farmacocinetico del agregado de galactosa para arnsi. |
AU2011352204B2 (en) | 2010-12-29 | 2015-05-21 | Arrowhead Pharmaceuticals, Inc. | In vivo polynucleotide delivery conjugates having enzyme sensitive linkages |
US8932572B2 (en) | 2011-08-26 | 2015-01-13 | Arrowhead Madison Inc. | Poly(vinyl ester) polymers for in vivo nucleic acid delivery |
SI3301177T1 (sl) * | 2011-11-18 | 2020-07-31 | Alnylam Pharmaceuticals, Inc. | Sredstva RNAi, sestavki in postopki njihove uporabe za zdravljenje s transtiretinom (TTR) povezanih bolezni |
CN103764153A (zh) | 2012-04-18 | 2014-04-30 | 箭头研究公司 | 用于体内核酸递送的聚(丙烯酸酯)聚合物 |
CA3185392A1 (fr) * | 2012-05-24 | 2013-11-28 | Ionis Pharmaceuticals, Inc. | Procedes et compositions de modulation de l'expression de l'apolipoproteine(a) |
PT2992098T (pt) | 2013-05-01 | 2019-07-05 | Ionis Pharmaceuticals Inc | Composições e métodos para modular a expressão de hbv e ttr |
US20160272970A1 (en) | 2015-03-17 | 2016-09-22 | Arrowhead Madison Inc. | RNA Interference Agents |
CN108064156B (zh) | 2015-05-29 | 2022-02-01 | 箭头药业股份有限公司 | 抑制Hif2α基因表达的组合物及方法 |
CA2994285A1 (fr) * | 2015-07-31 | 2017-02-09 | Alnylam Pharmaceuticals, Inc. | Compositions d'arni de transthyretine (ttr) et procedes pour les utiliser pour le traitement ou la prevention de maladies associees a ttr |
UY37146A (es) | 2016-03-07 | 2017-09-29 | Arrowhead Pharmaceuticals Inc | Ligandos de direccionamiento para compuestos terapéuticos |
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2015
- 2015-10-01 JO JOP/2021/0043A patent/JOP20210043A1/ar unknown
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2016
- 2016-09-28 JO JOP/2016/0211A patent/JOP20160211B1/ar active
- 2016-09-30 RS RS20211351A patent/RS62523B1/sr unknown
- 2016-09-30 PT PT168526952T patent/PT3356529T/pt unknown
- 2016-09-30 EP EP16852695.2A patent/EP3356529B1/fr active Active
- 2016-09-30 PL PL16852695T patent/PL3356529T3/pl unknown
- 2016-09-30 SG SG10202008530TA patent/SG10202008530TA/en unknown
- 2016-09-30 UA UAA201804593A patent/UA121998C2/uk unknown
- 2016-09-30 JP JP2018516738A patent/JP6991966B2/ja active Active
- 2016-09-30 IL IL300438A patent/IL300438A/en unknown
- 2016-09-30 CN CN201680057095.8A patent/CN108368506A/zh active Pending
- 2016-09-30 EP EP21191363.7A patent/EP4029941A1/fr active Pending
- 2016-09-30 BR BR112018006489-0A patent/BR112018006489A2/pt active Search and Examination
- 2016-09-30 MX MX2018003833A patent/MX2018003833A/es unknown
- 2016-09-30 CA CA3000397A patent/CA3000397A1/fr active Pending
- 2016-09-30 CR CR20180231A patent/CR20180231A/es unknown
- 2016-09-30 EA EA201890864A patent/EA038478B1/ru unknown
- 2016-09-30 MY MYPI2018000440A patent/MY195796A/en unknown
- 2016-09-30 DK DK16852695.2T patent/DK3356529T3/da active
- 2016-09-30 KR KR1020187010095A patent/KR20180052703A/ko not_active Application Discontinuation
- 2016-09-30 ES ES16852695T patent/ES2896298T3/es active Active
- 2016-09-30 LT LTEPPCT/US2016/054729T patent/LT3356529T/lt unknown
- 2016-09-30 WO PCT/US2016/054729 patent/WO2017059223A2/fr active Application Filing
- 2016-09-30 HR HRP20211410TT patent/HRP20211410T1/hr unknown
- 2016-09-30 AU AU2016331084A patent/AU2016331084B2/en active Active
- 2016-09-30 HU HUE16852695A patent/HUE055942T2/hu unknown
- 2016-09-30 TW TW111141660A patent/TWI836693B/zh active
- 2016-09-30 TW TW105131823A patent/TWI784934B/zh active
- 2016-09-30 US US15/281,309 patent/US9932586B2/en active Active
- 2016-09-30 SI SI201631374T patent/SI3356529T1/sl unknown
- 2016-09-30 UY UY0001036926A patent/UY36926A/es unknown
- 2016-09-30 TN TNP/2018/000094A patent/TN2018000094A1/en unknown
- 2016-09-30 PE PE2018000487A patent/PE20181139A1/es unknown
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2017
- 2017-04-06 MA MA43347A patent/MA43347B1/fr unknown
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2018
- 2018-02-21 US US15/901,810 patent/US10662427B2/en active Active
- 2018-03-25 IL IL258333A patent/IL258333B/en unknown
- 2018-03-27 MX MX2022013010A patent/MX2022013010A/es unknown
- 2018-03-28 CL CL2018000803A patent/CL2018000803A1/es unknown
- 2018-03-28 PH PH12018500713A patent/PH12018500713A1/en unknown
- 2018-04-05 CO CONC2018/0003678A patent/CO2018003678A2/es unknown
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2019
- 2019-01-29 HK HK19101563.4A patent/HK1259063A1/zh unknown
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2020
- 2020-05-06 US US16/867,925 patent/US20200263179A1/en active Pending
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2021
- 2021-03-12 JP JP2021039949A patent/JP7116212B2/ja active Active
- 2021-08-30 ZA ZA2021/06265A patent/ZA202106265B/en unknown
- 2021-11-08 CY CY20211100962T patent/CY1125263T1/el unknown
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2022
- 2022-02-13 IL IL290566A patent/IL290566B2/en unknown
- 2022-06-15 JP JP2022096415A patent/JP7442574B2/ja active Active
- 2022-12-05 AU AU2022283623A patent/AU2022283623A1/en active Pending
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2023
- 2023-11-27 JP JP2023199857A patent/JP2024009262A/ja active Pending
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