CY1125263T1 - Συνθεσεις και μεθοδοι για την αναστολη γονιδιακης εκφρασης της lpa - Google Patents
Συνθεσεις και μεθοδοι για την αναστολη γονιδιακης εκφρασης της lpaInfo
- Publication number
- CY1125263T1 CY1125263T1 CY20211100962T CY211100962T CY1125263T1 CY 1125263 T1 CY1125263 T1 CY 1125263T1 CY 20211100962 T CY20211100962 T CY 20211100962T CY 211100962 T CY211100962 T CY 211100962T CY 1125263 T1 CY1125263 T1 CY 1125263T1
- Authority
- CY
- Cyprus
- Prior art keywords
- lpa
- gene expression
- rnai
- compositions
- methods
- Prior art date
Links
- 230000014509 gene expression Effects 0.000 title abstract 3
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- 238000012228 RNA interference-mediated gene silencing Methods 0.000 abstract 5
- 230000009368 gene silencing by RNA Effects 0.000 abstract 5
- 102100040214 Apolipoprotein(a) Human genes 0.000 abstract 4
- 239000003795 chemical substances by application Substances 0.000 abstract 4
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 2
- 101710115418 Apolipoprotein(a) Proteins 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 210000005229 liver cell Anatomy 0.000 abstract 1
- 101150091521 lpa gene Proteins 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3517—Marker; Tag
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Περιγράφονται παράγοντες παρεμβολής RNA (RNAi) και συζεύγματα παράγοντα RNAi για αναστολή της έκφρασης του γονιδίου (apo(a)) LPA. Περιγράφονται επίσης φαρμακευτικές συνθέσεις που αποτελούνται από έναν ή περισσότερους παράγοντες RNAi LPA προαιρετικά με μια ή περισσότερες πρόσθετες θεραπευτικές. Η αποδέσμευση των περιγραφέντων παραγόντων RNAi LPA σε ηπατικά κύτταρα in vivo παρέχει αναστολή της γονιδιακής έκφρασης LPA και θεραπευτική αγωγή καρδιαγγειακών και σχετιζόμενων με καρδιαγγειακά ασθενειών.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562235816P | 2015-10-01 | 2015-10-01 | |
US201662346304P | 2016-06-06 | 2016-06-06 | |
US201662383221P | 2016-09-02 | 2016-09-02 | |
PCT/US2016/054729 WO2017059223A2 (en) | 2015-10-01 | 2016-09-30 | Compositions and methods for inhibiting gene expression of lpa |
Publications (1)
Publication Number | Publication Date |
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CY1125263T1 true CY1125263T1 (el) | 2023-03-24 |
Family
ID=58424351
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20211100962T CY1125263T1 (el) | 2015-10-01 | 2021-11-08 | Συνθεσεις και μεθοδοι για την αναστολη γονιδιακης εκφρασης της lpa |
Country Status (37)
Country | Link |
---|---|
US (3) | US9932586B2 (el) |
EP (2) | EP4029941A1 (el) |
JP (4) | JP6991966B2 (el) |
KR (1) | KR20180052703A (el) |
CN (1) | CN108368506A (el) |
AU (2) | AU2016331084B2 (el) |
BR (1) | BR112018006489A2 (el) |
CA (1) | CA3000397A1 (el) |
CL (1) | CL2018000803A1 (el) |
CO (1) | CO2018003678A2 (el) |
CR (1) | CR20180231A (el) |
CY (1) | CY1125263T1 (el) |
DK (1) | DK3356529T3 (el) |
EA (1) | EA038478B1 (el) |
ES (1) | ES2896298T3 (el) |
HK (1) | HK1259063A1 (el) |
HR (1) | HRP20211410T1 (el) |
HU (1) | HUE055942T2 (el) |
IL (3) | IL300438A (el) |
JO (2) | JOP20210043A1 (el) |
LT (1) | LT3356529T (el) |
MA (1) | MA43347B1 (el) |
MX (2) | MX2018003833A (el) |
MY (1) | MY195796A (el) |
PE (1) | PE20181139A1 (el) |
PH (1) | PH12018500713A1 (el) |
PL (1) | PL3356529T3 (el) |
PT (1) | PT3356529T (el) |
RS (1) | RS62523B1 (el) |
SG (1) | SG10202008530TA (el) |
SI (1) | SI3356529T1 (el) |
TN (1) | TN2018000094A1 (el) |
TW (2) | TWI784934B (el) |
UA (1) | UA121998C2 (el) |
UY (1) | UY36926A (el) |
WO (1) | WO2017059223A2 (el) |
ZA (1) | ZA202106265B (el) |
Families Citing this family (29)
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US7718133B2 (en) | 2003-10-09 | 2010-05-18 | 3M Innovative Properties Company | Multilayer processing devices and methods |
CN113797348A (zh) * | 2016-03-07 | 2021-12-17 | 箭头药业股份有限公司 | 用于治疗性化合物的靶向配体 |
JP6989521B2 (ja) | 2016-09-02 | 2022-01-05 | アローヘッド ファーマシューティカルズ インコーポレイテッド | 標的化リガンド |
WO2018185241A1 (en) | 2017-04-05 | 2018-10-11 | Silence Therapeutics Gmbh | Products and compositions |
WO2019010274A1 (en) * | 2017-07-06 | 2019-01-10 | Arrowhead Pharmaceuticals, Inc. | RNAI AGENTS OF INHIBITION OF ALPHA-ENAC GENE EXPRESSION AND METHODS OF USE |
TN2020000039A1 (en) * | 2017-09-11 | 2021-10-04 | Arrowhead Pharmaceuticals Inc | Rnai agents and compositions for inhibiting expression of apolipoprotein c-iii (apoc3) |
SG11201912188RA (en) * | 2017-09-14 | 2020-01-30 | Arrowhead Pharmaceuticals Inc | Rnai agents and compositions for inhibiting expression of angiopoietin-like 3 (angptl3), and methods of use |
AU2018352379A1 (en) * | 2017-10-17 | 2020-06-04 | Arrowhead Pharmaceuticals, Inc. | RNAi agents and compositions for inhibiting expression of Asialoglycoprotein receptor 1 |
EP3483270A1 (en) * | 2017-11-13 | 2019-05-15 | Silence Therapeutics GmbH | Products and compositions |
EP3710586B1 (en) * | 2017-11-13 | 2022-11-23 | Silence Therapeutics GmbH | Nucleic acids for inhibiting expression of lpa in a cell |
AU2019342117A1 (en) * | 2018-09-19 | 2021-03-04 | Arrowhead Pharmaceuticals, Inc. | RNAi agents for inhibiting expression of 17beta-HSD type 13- (HSD17B13), compositions thereof, and methods of use |
BR112021009213A2 (pt) * | 2018-11-13 | 2021-08-10 | Silence Therapeutics Gmbh | ácidos nucleicos para inibição da expressão de lpa em uma célula |
WO2021119034A1 (en) | 2019-12-09 | 2021-06-17 | Amgen Inc. | RNAi CONSTRUCTS AND METHODS FOR INHIBITING LPA EXPRESSION |
AU2021320550A1 (en) * | 2020-08-05 | 2023-02-16 | Dicerna Pharmaceuticals, Inc. | Compositions and methods for inhibiting |
WO2022079221A1 (en) * | 2020-10-16 | 2022-04-21 | Sanofi | Rna compositions and methods for inhibiting lipoprotein(a) |
TW202233837A (zh) | 2020-11-05 | 2022-09-01 | 美商安進公司 | 用靶向LPA的RNAi構建體治療動脈粥樣硬化性心血管疾病之方法 |
WO2022121959A1 (zh) * | 2020-12-09 | 2022-06-16 | 纳肽得有限公司 | siRNA分子及其在治疗冠状动脉疾病中的应用 |
JP2024500035A (ja) | 2020-12-23 | 2024-01-04 | アルゴノート アールエヌエー リミテッド | 心血管疾患の治療 |
CN117836307A (zh) | 2021-06-18 | 2024-04-05 | 弘景生物科技有限公司 | 功能化的n-乙酰基半乳糖胺核苷 |
EP4396193A1 (en) | 2021-08-30 | 2024-07-10 | Hongene Biotech Corporation | Functionalized n-acetylgalactosamine analogs |
WO2023041508A2 (en) | 2021-09-14 | 2023-03-23 | Argonaute RNA Limited | Treatment of cardiovascular disease |
CA3232191A1 (en) * | 2021-09-18 | 2023-03-23 | Chong Li | Lpa inhibitor and use thereof |
WO2023114746A1 (en) | 2021-12-15 | 2023-06-22 | Hongene Biotech Corporation | Functionalized n-acetylgalactosamine analogs |
CN114703184B (zh) * | 2022-03-11 | 2024-06-18 | 厦门甘宝利生物医药有限公司 | Lpa抑制剂及其用途 |
WO2024032681A1 (zh) * | 2022-08-11 | 2024-02-15 | 益杰立科(上海)生物科技有限公司 | 一种表观编辑靶点的方法及用途 |
CN115851723B (zh) * | 2022-10-24 | 2023-10-03 | 厦门甘宝利生物医药有限公司 | 一种抑制lpa基因表达的rna抑制剂及其应用 |
WO2024118503A1 (en) | 2022-11-28 | 2024-06-06 | Hongene Biotech Corporation | Functionalized n-acetylgalactosamine analogs |
WO2024151937A1 (en) * | 2023-01-13 | 2024-07-18 | Eli Lilly And Company | Therapeutic oligonucleotide-containing pharmaceutical compositions and dosing regimens using the same |
WO2024210530A1 (en) * | 2023-04-03 | 2024-10-10 | Olix Pharmaceuticals, Inc. | RNAi AGENTS TARGETING LPA GENE AND USE THEREOF |
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PE20142362A1 (es) * | 2011-11-18 | 2015-01-30 | Alnylam Pharmaceuticals Inc | Agentes de iarn, composiciones y metodos de uso de los mismos para tratar enfermedades asociadas con transtiretina (ttr) |
BR112014004528A2 (pt) | 2012-04-18 | 2019-09-24 | Arrowhead Res Corp | polímeros de poli(acrilato) para entrega de ácido nucleico in vivo |
WO2013177468A2 (en) | 2012-05-24 | 2013-11-28 | Isis Pharmaceuticals, Inc. | Methods and compositions for modulating apolipoprotein(a) expression |
RU2686080C2 (ru) | 2013-05-01 | 2019-04-24 | Ионис Фармасьютикалз, Инк. | Композиции и способы |
US20160272970A1 (en) | 2015-03-17 | 2016-09-22 | Arrowhead Madison Inc. | RNA Interference Agents |
CN114601845A (zh) | 2015-05-29 | 2022-06-10 | 箭头药业股份有限公司 | 抑制Hif2α基因表达的组合物及方法 |
US10208307B2 (en) * | 2015-07-31 | 2019-02-19 | Alnylam Pharmaceuticals, Inc. | Transthyretin (TTR) iRNA compositions and methods of use thereof for treating or preventing TTR-associated diseases |
CN113797348A (zh) | 2016-03-07 | 2021-12-17 | 箭头药业股份有限公司 | 用于治疗性化合物的靶向配体 |
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2015
- 2015-10-01 JO JOP/2021/0043A patent/JOP20210043A1/ar unknown
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2016
- 2016-09-28 JO JOP/2016/0211A patent/JOP20160211B1/ar active
- 2016-09-30 MX MX2018003833A patent/MX2018003833A/es unknown
- 2016-09-30 CA CA3000397A patent/CA3000397A1/en active Pending
- 2016-09-30 HU HUE16852695A patent/HUE055942T2/hu unknown
- 2016-09-30 UA UAA201804593A patent/UA121998C2/uk unknown
- 2016-09-30 KR KR1020187010095A patent/KR20180052703A/ko active IP Right Grant
- 2016-09-30 SG SG10202008530TA patent/SG10202008530TA/en unknown
- 2016-09-30 AU AU2016331084A patent/AU2016331084B2/en active Active
- 2016-09-30 TW TW105131823A patent/TWI784934B/zh active
- 2016-09-30 US US15/281,309 patent/US9932586B2/en active Active
- 2016-09-30 HR HRP20211410TT patent/HRP20211410T1/hr unknown
- 2016-09-30 RS RS20211351A patent/RS62523B1/sr unknown
- 2016-09-30 CN CN201680057095.8A patent/CN108368506A/zh active Pending
- 2016-09-30 LT LTEPPCT/US2016/054729T patent/LT3356529T/lt unknown
- 2016-09-30 PT PT168526952T patent/PT3356529T/pt unknown
- 2016-09-30 UY UY0001036926A patent/UY36926A/es active IP Right Grant
- 2016-09-30 TN TNP/2018/000094A patent/TN2018000094A1/en unknown
- 2016-09-30 JP JP2018516738A patent/JP6991966B2/ja active Active
- 2016-09-30 IL IL300438A patent/IL300438A/en unknown
- 2016-09-30 CR CR20180231A patent/CR20180231A/es unknown
- 2016-09-30 PE PE2018000487A patent/PE20181139A1/es unknown
- 2016-09-30 SI SI201631374T patent/SI3356529T1/sl unknown
- 2016-09-30 EP EP21191363.7A patent/EP4029941A1/en active Pending
- 2016-09-30 DK DK16852695.2T patent/DK3356529T3/da active
- 2016-09-30 WO PCT/US2016/054729 patent/WO2017059223A2/en active Application Filing
- 2016-09-30 PL PL16852695T patent/PL3356529T3/pl unknown
- 2016-09-30 EP EP16852695.2A patent/EP3356529B1/en active Active
- 2016-09-30 EA EA201890864A patent/EA038478B1/ru unknown
- 2016-09-30 MY MYPI2018000440A patent/MY195796A/en unknown
- 2016-09-30 BR BR112018006489-0A patent/BR112018006489A2/pt active Search and Examination
- 2016-09-30 TW TW111141660A patent/TWI836693B/zh active
- 2016-09-30 ES ES16852695T patent/ES2896298T3/es active Active
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2017
- 2017-04-06 MA MA43347A patent/MA43347B1/fr unknown
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2018
- 2018-02-21 US US15/901,810 patent/US10662427B2/en active Active
- 2018-03-25 IL IL258333A patent/IL258333B/en unknown
- 2018-03-27 MX MX2022013010A patent/MX2022013010A/es unknown
- 2018-03-28 PH PH12018500713A patent/PH12018500713A1/en unknown
- 2018-03-28 CL CL2018000803A patent/CL2018000803A1/es unknown
- 2018-04-05 CO CONC2018/0003678A patent/CO2018003678A2/es unknown
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2019
- 2019-01-29 HK HK19101563.4A patent/HK1259063A1/zh unknown
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2020
- 2020-05-06 US US16/867,925 patent/US20200263179A1/en not_active Abandoned
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2021
- 2021-03-12 JP JP2021039949A patent/JP7116212B2/ja active Active
- 2021-08-30 ZA ZA2021/06265A patent/ZA202106265B/en unknown
- 2021-11-08 CY CY20211100962T patent/CY1125263T1/el unknown
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2022
- 2022-02-13 IL IL290566A patent/IL290566B2/en unknown
- 2022-06-15 JP JP2022096415A patent/JP7442574B2/ja active Active
- 2022-12-05 AU AU2022283623A patent/AU2022283623A1/en active Pending
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2023
- 2023-11-27 JP JP2023199857A patent/JP2024009262A/ja active Pending
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