JOP20160211B1 - تراكيب وأساليب لتثبيط تعبير جيني للـ lpa - Google Patents
تراكيب وأساليب لتثبيط تعبير جيني للـ lpaInfo
- Publication number
- JOP20160211B1 JOP20160211B1 JOP/2016/0211A JOP20160211A JOP20160211B1 JO P20160211 B1 JOP20160211 B1 JO P20160211B1 JO P20160211 A JOP20160211 A JO P20160211A JO P20160211 B1 JOP20160211 B1 JO P20160211B1
- Authority
- JO
- Jordan
- Prior art keywords
- lpa
- gene expression
- compositions
- methods
- rnai
- Prior art date
Links
- 230000014509 gene expression Effects 0.000 title abstract 3
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- 238000012228 RNA interference-mediated gene silencing Methods 0.000 abstract 5
- 230000009368 gene silencing by RNA Effects 0.000 abstract 5
- 102100040214 Apolipoprotein(a) Human genes 0.000 abstract 4
- 239000003795 chemical substances by application Substances 0.000 abstract 4
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 2
- 101710115418 Apolipoprotein(a) Proteins 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 210000005229 liver cell Anatomy 0.000 abstract 1
- 101150091521 lpa gene Proteins 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3517—Marker; Tag
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
Abstract
يتعلق الاختراع الحالي بوصف عوامل تداخل RNA (RNAi) ومترافقات RNAiandnbsp; لتثبيط التعبير عن جين LPA (apo (a)). كذلك يتم وصف تركيبات صيدلانية مشتملة واحد او اكثر من عواملLPA RNAi اختياريا مع واحد او اكثر من العوامل العلاجية. يتيح توصيل عوامل LPA RNAi التي تم وصفها الى خلايا الكبد في جسم الكائن الحي تثبيط التعبير ع ن جين LPA وعلاج الامراض القلبية الوعائية والامراض ذات الصلة بها.andnbsp;
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562235816P | 2015-10-01 | 2015-10-01 | |
US201662346304P | 2016-06-06 | 2016-06-06 | |
US201662383221P | 2016-09-02 | 2016-09-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
JOP20160211B1 true JOP20160211B1 (ar) | 2021-08-17 |
Family
ID=58424351
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JOP/2021/0043A JOP20210043A1 (ar) | 2015-10-01 | 2015-10-01 | تراكيب وأساليب لتثبيط تعبير جيني للـ lpa |
JOP/2016/0211A JOP20160211B1 (ar) | 2015-10-01 | 2016-09-28 | تراكيب وأساليب لتثبيط تعبير جيني للـ lpa |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JOP/2021/0043A JOP20210043A1 (ar) | 2015-10-01 | 2015-10-01 | تراكيب وأساليب لتثبيط تعبير جيني للـ lpa |
Country Status (37)
Country | Link |
---|---|
US (3) | US9932586B2 (ar) |
EP (2) | EP4029941A1 (ar) |
JP (4) | JP6991966B2 (ar) |
KR (1) | KR20180052703A (ar) |
CN (1) | CN108368506A (ar) |
AU (2) | AU2016331084B2 (ar) |
BR (1) | BR112018006489A2 (ar) |
CA (1) | CA3000397A1 (ar) |
CL (1) | CL2018000803A1 (ar) |
CO (1) | CO2018003678A2 (ar) |
CR (1) | CR20180231A (ar) |
CY (1) | CY1125263T1 (ar) |
DK (1) | DK3356529T3 (ar) |
EA (1) | EA038478B1 (ar) |
ES (1) | ES2896298T3 (ar) |
HK (1) | HK1259063A1 (ar) |
HR (1) | HRP20211410T1 (ar) |
HU (1) | HUE055942T2 (ar) |
IL (3) | IL300438A (ar) |
JO (2) | JOP20210043A1 (ar) |
LT (1) | LT3356529T (ar) |
MA (1) | MA43347B1 (ar) |
MX (2) | MX2018003833A (ar) |
MY (1) | MY195796A (ar) |
PE (1) | PE20181139A1 (ar) |
PH (1) | PH12018500713A1 (ar) |
PL (1) | PL3356529T3 (ar) |
PT (1) | PT3356529T (ar) |
RS (1) | RS62523B1 (ar) |
SG (1) | SG10202008530TA (ar) |
SI (1) | SI3356529T1 (ar) |
TN (1) | TN2018000094A1 (ar) |
TW (2) | TWI836693B (ar) |
UA (1) | UA121998C2 (ar) |
UY (1) | UY36926A (ar) |
WO (1) | WO2017059223A2 (ar) |
ZA (1) | ZA202106265B (ar) |
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TWI783434B (zh) * | 2016-03-07 | 2022-11-11 | 美商愛羅海德製藥公司 | 治療性化合物之標靶性配體 |
JOP20170056B1 (ar) | 2016-09-02 | 2021-08-17 | Arrowhead Pharmaceuticals Inc | مركبات ترابطية مستهدفة |
LT3607069T (lt) | 2017-04-05 | 2023-01-10 | Silence Therapeutics Gmbh | Produktai ir kompozicijos |
US10590416B2 (en) * | 2017-07-06 | 2020-03-17 | Arrowhead Pharmaceuticals, Inc. | RNAi agents for inhibiting expression of alpha-ENaC and methods of use |
KR20200044013A (ko) * | 2017-09-11 | 2020-04-28 | 애로우헤드 파마슈티컬스 인코포레이티드 | 아포지단백질 C-III (APOC3)의 발현을 억제하기 위한 RNAi 작용제 및 조성물 |
TN2020000038A1 (en) * | 2017-09-14 | 2021-10-04 | Arrowhead Pharmaceuticals Inc | Rnai agents and compositions for inhibiting expression of angiopoietin-like 3 (angptl3), and methods of use |
CA3079413A1 (en) * | 2017-10-17 | 2019-04-25 | Arrowhead Pharmaceuticals, Inc. | Rnai agents and compositions for inhibiting expression of asialoglycoprotein receptor 1 |
EP3483270A1 (en) * | 2017-11-13 | 2019-05-15 | Silence Therapeutics GmbH | Products and compositions |
EP3710586B1 (en) * | 2017-11-13 | 2022-11-23 | Silence Therapeutics GmbH | Nucleic acids for inhibiting expression of lpa in a cell |
SG11202101698WA (en) * | 2018-09-19 | 2021-04-29 | Arrowhead Pharmaceuticals Inc | Rnai agents for inhibiting expression of 17beta-hsd type 13- (hsd17b13), compositions thereof, and methods of use |
FI3880818T3 (fi) * | 2018-11-13 | 2022-12-15 | Nukleiinihappoja LPA:n ekspression inhiboimiseksi solussa | |
EP4073252A1 (en) | 2019-12-09 | 2022-10-19 | Amgen Inc. | Rnai constructs and methods for inhibiting lpa expression |
BR112023001957A2 (pt) | 2020-08-05 | 2023-04-25 | Dicerna Pharmaceuticals Inc | Composições e métodos para inibir expressão de lpa |
CN116490195A (zh) * | 2020-10-16 | 2023-07-25 | 赛诺菲 | 用于抑制脂蛋白(a)的RNA组合物和方法 |
MX2023005198A (es) | 2020-11-05 | 2023-05-16 | Amgen Inc | Metodos para tratar la enfermedad cardiovascular aterosclerotica con constructos de iarn dirigidos a lpa. |
WO2022121959A1 (zh) * | 2020-12-09 | 2022-06-16 | 纳肽得有限公司 | siRNA分子及其在治疗冠状动脉疾病中的应用 |
EP4237561A1 (en) | 2020-12-23 | 2023-09-06 | Argonaute Rna Limited | Treatment of cardiovascular disease |
EP4355756A1 (en) | 2021-06-18 | 2024-04-24 | Hongene Biotech Corporation | Functionalized n-acetylgalactosamine nucleosides |
WO2023034719A1 (en) | 2021-08-30 | 2023-03-09 | Hongene Biotech Corporation | Functionalized n-acetylgalactosamine analogs |
WO2023041508A2 (en) | 2021-09-14 | 2023-03-23 | Argonaute RNA Limited | Treatment of cardiovascular disease |
KR20240056619A (ko) * | 2021-09-18 | 2024-04-30 | 제노바 테라퓨틱스 컴퍼니 리미티드 | Lpa 억제제 및 이의 용도 |
US11993626B2 (en) | 2021-12-15 | 2024-05-28 | Hongene Biotech Corporation | Functionalized N-acetylgalactosamine analogs |
CN114703184B (zh) * | 2022-03-11 | 2024-06-18 | 厦门甘宝利生物医药有限公司 | Lpa抑制剂及其用途 |
WO2024032681A1 (zh) * | 2022-08-11 | 2024-02-15 | 益杰立科(上海)生物科技有限公司 | 一种表观编辑靶点的方法及用途 |
CN115851723B (zh) * | 2022-10-24 | 2023-10-03 | 厦门甘宝利生物医药有限公司 | 一种抑制lpa基因表达的rna抑制剂及其应用 |
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IN2014CN03463A (ar) * | 2011-11-18 | 2015-10-09 | Alnylam Pharmaceuticals Inc | |
MX2014001965A (es) | 2012-04-18 | 2014-03-31 | Arrowhead Res Corp | Polimeros de poli(acrilato) para suministro de acido nucleico in vivo. |
KR20190084354A (ko) | 2012-05-24 | 2019-07-16 | 아이오니스 파마수티컬즈, 인코포레이티드 | 아포지질단백질 (a) 발현을 조절하는 방법들 및 조성물들 |
NZ631552A (en) * | 2013-05-01 | 2017-02-24 | Ionis Pharmaceuticals Inc | Compositions and methods for modulating hbv expression |
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MA43335B1 (fr) * | 2015-07-31 | 2021-01-29 | Alnylam Pharmaceuticals Inc | Compositions d'arni de transthyrétine (ttr) et procédés pour les utiliser pour le traitement ou la prévention de maladies associées à ttr |
TWI783434B (zh) | 2016-03-07 | 2022-11-11 | 美商愛羅海德製藥公司 | 治療性化合物之標靶性配體 |
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2015
- 2015-10-01 JO JOP/2021/0043A patent/JOP20210043A1/ar unknown
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2016
- 2016-09-28 JO JOP/2016/0211A patent/JOP20160211B1/ar active
- 2016-09-30 KR KR1020187010095A patent/KR20180052703A/ko not_active Application Discontinuation
- 2016-09-30 ES ES16852695T patent/ES2896298T3/es active Active
- 2016-09-30 LT LTEPPCT/US2016/054729T patent/LT3356529T/lt unknown
- 2016-09-30 PT PT168526952T patent/PT3356529T/pt unknown
- 2016-09-30 UA UAA201804593A patent/UA121998C2/uk unknown
- 2016-09-30 TW TW111141660A patent/TWI836693B/zh active
- 2016-09-30 SG SG10202008530TA patent/SG10202008530TA/en unknown
- 2016-09-30 EP EP21191363.7A patent/EP4029941A1/en active Pending
- 2016-09-30 CR CR20180231A patent/CR20180231A/es unknown
- 2016-09-30 HR HRP20211410TT patent/HRP20211410T1/hr unknown
- 2016-09-30 SI SI201631374T patent/SI3356529T1/sl unknown
- 2016-09-30 RS RS20211351A patent/RS62523B1/sr unknown
- 2016-09-30 TN TNP/2018/000094A patent/TN2018000094A1/en unknown
- 2016-09-30 AU AU2016331084A patent/AU2016331084B2/en active Active
- 2016-09-30 CN CN201680057095.8A patent/CN108368506A/zh active Pending
- 2016-09-30 MY MYPI2018000440A patent/MY195796A/en unknown
- 2016-09-30 CA CA3000397A patent/CA3000397A1/en active Pending
- 2016-09-30 HU HUE16852695A patent/HUE055942T2/hu unknown
- 2016-09-30 PL PL16852695T patent/PL3356529T3/pl unknown
- 2016-09-30 TW TW105131823A patent/TWI784934B/zh active
- 2016-09-30 WO PCT/US2016/054729 patent/WO2017059223A2/en active Application Filing
- 2016-09-30 UY UY0001036926A patent/UY36926A/es unknown
- 2016-09-30 US US15/281,309 patent/US9932586B2/en active Active
- 2016-09-30 PE PE2018000487A patent/PE20181139A1/es unknown
- 2016-09-30 DK DK16852695.2T patent/DK3356529T3/da active
- 2016-09-30 BR BR112018006489-0A patent/BR112018006489A2/pt active Search and Examination
- 2016-09-30 IL IL300438A patent/IL300438A/en unknown
- 2016-09-30 MX MX2018003833A patent/MX2018003833A/es unknown
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