MA43347B1 - Compositions et méthodes permettant d'inhiber l'expression du gène de lpa - Google Patents

Compositions et méthodes permettant d'inhiber l'expression du gène de lpa

Info

Publication number
MA43347B1
MA43347B1 MA43347A MA43347A MA43347B1 MA 43347 B1 MA43347 B1 MA 43347B1 MA 43347 A MA43347 A MA 43347A MA 43347 A MA43347 A MA 43347A MA 43347 B1 MA43347 B1 MA 43347B1
Authority
MA
Morocco
Prior art keywords
agents
gene expression
compositions
methods
lpa
Prior art date
Application number
MA43347A
Other languages
English (en)
Other versions
MA43347A (fr
Inventor
Steven Kanner
David Rozema
David Lewis
Lauren Almeida
Darren Wakefield
Vladimir Trubetskoy
Tao Pei
Zhen Li
Aaron Almeida
Original Assignee
Arrowhead Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arrowhead Pharmaceuticals Inc filed Critical Arrowhead Pharmaceuticals Inc
Publication of MA43347A publication Critical patent/MA43347A/fr
Publication of MA43347B1 publication Critical patent/MA43347B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3517—Marker; Tag

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Des agents d'interférence d'arn (arni) et des conjugués d'agents d'arni pour inhiber l'expression du gène de la lpa (apo (a)) sont décrits. Des compositions pharmaceutiques comprenant un ou plusieurs agents arni lpa, éventuellement avec un ou plusieurs agents thérapeutiques supplémentaires, sont également décrites. La délivrance des agents arni lpa décrits aux cellules hépatiques in vivo permet d'inhiber l'expression du gène lpa et le traitement des maladies cardiovasculaires et cardiovasculaires.
MA43347A 2015-10-01 2017-04-06 Compositions et méthodes permettant d'inhiber l'expression du gène de lpa MA43347B1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562235816P 2015-10-01 2015-10-01
US201662346304P 2016-06-06 2016-06-06
US201662383221P 2016-09-02 2016-09-02
PCT/US2016/054729 WO2017059223A2 (fr) 2015-10-01 2016-09-30 Compositions et méthodes permettant d'inhiber l'expression du gène de lpa

Publications (2)

Publication Number Publication Date
MA43347A MA43347A (fr) 2018-08-08
MA43347B1 true MA43347B1 (fr) 2021-11-30

Family

ID=58424351

Family Applications (1)

Application Number Title Priority Date Filing Date
MA43347A MA43347B1 (fr) 2015-10-01 2017-04-06 Compositions et méthodes permettant d'inhiber l'expression du gène de lpa

Country Status (37)

Country Link
US (3) US9932586B2 (fr)
EP (2) EP3356529B1 (fr)
JP (4) JP6991966B2 (fr)
KR (1) KR20180052703A (fr)
CN (1) CN108368506A (fr)
AU (2) AU2016331084B2 (fr)
BR (1) BR112018006489A2 (fr)
CA (1) CA3000397A1 (fr)
CL (1) CL2018000803A1 (fr)
CO (1) CO2018003678A2 (fr)
CR (1) CR20180231A (fr)
CY (1) CY1125263T1 (fr)
DK (1) DK3356529T3 (fr)
EA (1) EA038478B1 (fr)
ES (1) ES2896298T3 (fr)
HK (1) HK1259063A1 (fr)
HR (1) HRP20211410T1 (fr)
HU (1) HUE055942T2 (fr)
IL (3) IL300438A (fr)
JO (2) JOP20210043A1 (fr)
LT (1) LT3356529T (fr)
MA (1) MA43347B1 (fr)
MX (2) MX2018003833A (fr)
MY (1) MY195796A (fr)
PE (1) PE20181139A1 (fr)
PH (1) PH12018500713A1 (fr)
PL (1) PL3356529T3 (fr)
PT (1) PT3356529T (fr)
RS (1) RS62523B1 (fr)
SG (1) SG10202008530TA (fr)
SI (1) SI3356529T1 (fr)
TN (1) TN2018000094A1 (fr)
TW (2) TWI836693B (fr)
UA (1) UA121998C2 (fr)
UY (1) UY36926A (fr)
WO (1) WO2017059223A2 (fr)
ZA (1) ZA202106265B (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7718133B2 (en) 2003-10-09 2010-05-18 3M Innovative Properties Company Multilayer processing devices and methods
UY37146A (es) * 2016-03-07 2017-09-29 Arrowhead Pharmaceuticals Inc Ligandos de direccionamiento para compuestos terapéuticos
SG11201901841TA (en) 2016-09-02 2019-03-28 Arrowhead Pharmaceuticals Inc Targeting ligands
FI3607069T3 (fi) 2017-04-05 2023-01-13 Tuotteita ja koostumuksia
TN2019000308A1 (en) * 2017-07-06 2021-05-07 Arrowhead Pharmaceuticals Inc RNAi AGENTS FOR INHIBITING EXPRESSION OF ALPHA-ENaC AND METHODS OF USE
JOP20200054A1 (ar) * 2017-09-11 2020-03-10 Arrowhead Pharmaceuticals Inc عوامل RNAi وتركيبات لتثبيط تعبير صَميمُ البروتينِ الشَّحْمِيّ C-III (APOC3)
EP3681513A4 (fr) * 2017-09-14 2021-09-22 Arrowhead Pharmaceuticals, Inc. Agents d'arni et compositions destinées à inhiber l'expression d'analogue de l'angiopoïétine 3 (angptl3) et procédés d'utilisation
US11492624B2 (en) * 2017-10-17 2022-11-08 Arrowheads Pharmaceuticals, Inc. RNAi agents and compositions for inhibiting expression of Asialoglycoprotein receptor 1
EP3483270A1 (fr) * 2017-11-13 2019-05-15 Silence Therapeutics GmbH Produits et compositions
EP3710586B1 (fr) * 2017-11-13 2022-11-23 Silence Therapeutics GmbH Produits et compositions
CN113164509A (zh) * 2018-09-19 2021-07-23 箭头药业股份有限公司 用于抑制17β-HSD 13型(HSD17B13)表达的RNAi试剂、其组合物和使用方法
HUE060703T2 (hu) 2018-11-13 2023-04-28 Silence Therapeutics Gmbh Nukleinsavak LPA expressziójának gátlására egy sejtben
AU2020399636A1 (en) 2019-12-09 2022-06-02 Amgen Inc. RNAi constructs and methods for inhibiting LPA expression
JP7476422B2 (ja) 2020-08-05 2024-04-30 ディセルナ ファーマシューティカルズ インコーポレイテッド Ｌｐａ発現を阻害するための組成物及び方法
CN116490195A (zh) * 2020-10-16 2023-07-25 赛诺菲 用于抑制脂蛋白(a)的RNA组合物和方法
JP2023549115A (ja) 2020-11-05 2023-11-22 アムジェン インコーポレイテッド アテローム硬化性心血管疾患をＬＰＡ標的ＲＮＡｉ構築体により処置する方法
WO2022121959A1 (fr) * 2020-12-09 2022-06-16 纳肽得有限公司 Molécule d'arnsi et son application dans le traitement de maladies des artères coronaires
JP2024500035A (ja) 2020-12-23 2024-01-04 アルゴノート アールエヌエー リミテッド 心血管疾患の治療
WO2022266316A1 (fr) 2021-06-18 2022-12-22 Hongene Biotech Corporation N-acétylgalactosamine nucléosides fonctionnalisés
EP4396193A1 (fr) 2021-08-30 2024-07-10 Hongene Biotech Corporation Analogues de n-acétylgalactosamine fonctionnalisés
CA3229020A1 (fr) 2021-09-14 2023-03-23 Stella Khan Traitement d'une maladie cardiovasculaire
AU2022348141A1 (en) * 2021-09-18 2024-04-04 Genoval Therapeutics Co., Ltd. Lpa inhibitor and use thereof
WO2023114746A1 (fr) 2021-12-15 2023-06-22 Hongene Biotech Corporation Analogues de n-acétylgalactosamine fonctionnalisés
CN114703184B (zh) * 2022-03-11 2024-06-18 厦门甘宝利生物医药有限公司 Lpa抑制剂及其用途
WO2024032681A1 (fr) * 2022-08-11 2024-02-15 益杰立科(上海)生物科技有限公司 Procédé pour cible d'édition d'épitope et utilisation
CN115851723B (zh) * 2022-10-24 2023-10-03 厦门甘宝利生物医药有限公司 一种抑制lpa基因表达的rna抑制剂及其应用

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL9201440A (nl) 1992-08-11 1994-03-01 Univ Leiden Triantennaire clusterglycosiden, hun bereiding en toepassing.
US5599706A (en) 1994-09-23 1997-02-04 Stinchcomb; Dan T. Ribozymes targeted to apo(a) mRNA
MXPA01009073A (es) 1999-03-10 2002-05-06 Phogen Ltd Suministro de acidos nucleicos y proteinas a las celulas.
CZ302719B6 (cs) * 2000-12-01 2011-09-21 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Izolovaná molekula dvouretezcové RNA, zpusob její výroby a její použití
US7227014B2 (en) 2001-08-07 2007-06-05 Isis Pharmaceuticals, Inc. Antisense modulation of apolipoprotein (a) expression
US7259150B2 (en) 2001-08-07 2007-08-21 Isis Pharmaceuticals, Inc. Modulation of apolipoprotein (a) expression
EP1613348B1 (fr) 2003-03-12 2010-06-23 The Arizona Board of Regents on Behalf of the University of Arizona Procedes de modulation de l'angiogenese avec des compositions d'apeline
CA2559955C (fr) 2004-03-15 2016-02-16 City Of Hope Procedes et compositions pour l'inhibition specifique de l'expression genetique par l'arn double brin
CN101500548A (zh) * 2006-08-18 2009-08-05 弗·哈夫曼-拉罗切有限公司 用于体内递送多核苷酸的多缀合物
CN102325534B (zh) 2008-12-18 2016-02-17 戴瑟纳制药公司 延长的dicer酶底物和特异性抑制基因表达的方法
WO2010093788A2 (fr) 2009-02-11 2010-08-19 Dicerna Pharmaceuticals, Inc. Molécules d'arn interférence substrats de dicer multiplexes ayant des séquences de jonction
EP3023495B1 (fr) 2010-02-24 2019-05-08 Arrowhead Pharmaceuticals, Inc. Compositions pour l'administration ciblée d'arnsi
WO2011141703A1 (fr) * 2010-05-12 2011-11-17 Protiva Biotherapeutics Inc. Compositions et procédés pour réduire au silence l'apolipoprotéine b
US8501930B2 (en) 2010-12-17 2013-08-06 Arrowhead Madison Inc. Peptide-based in vivo siRNA delivery system
MX346144B (es) * 2010-12-17 2017-03-09 Arrowhead Res Corp * Porcion activadora del modulador farmacocinetico del agregado de galactosa para arnsi.
AU2011352204B2 (en) 2010-12-29 2015-05-21 Arrowhead Pharmaceuticals, Inc. In vivo polynucleotide delivery conjugates having enzyme sensitive linkages
US8932572B2 (en) 2011-08-26 2015-01-13 Arrowhead Madison Inc. Poly(vinyl ester) polymers for in vivo nucleic acid delivery
SI3301177T1 (sl) * 2011-11-18 2020-07-31 Alnylam Pharmaceuticals, Inc. Sredstva RNAi, sestavki in postopki njihove uporabe za zdravljenje s transtiretinom (TTR) povezanih bolezni
CN103764153A (zh) 2012-04-18 2014-04-30 箭头研究公司 用于体内核酸递送的聚(丙烯酸酯)聚合物
CA3185392A1 (fr) * 2012-05-24 2013-11-28 Ionis Pharmaceuticals, Inc. Procedes et compositions de modulation de l'expression de l'apolipoproteine(a)
PT2992098T (pt) 2013-05-01 2019-07-05 Ionis Pharmaceuticals Inc Composições e métodos para modular a expressão de hbv e ttr
US20160272970A1 (en) 2015-03-17 2016-09-22 Arrowhead Madison Inc. RNA Interference Agents
CN108064156B (zh) 2015-05-29 2022-02-01 箭头药业股份有限公司 抑制Hif2α基因表达的组合物及方法
CA2994285A1 (fr) * 2015-07-31 2017-02-09 Alnylam Pharmaceuticals, Inc. Compositions d'arni de transthyretine (ttr) et procedes pour les utiliser pour le traitement ou la prevention de maladies associees a ttr
UY37146A (es) 2016-03-07 2017-09-29 Arrowhead Pharmaceuticals Inc Ligandos de direccionamiento para compuestos terapéuticos

Also Published As

Publication number Publication date
EA038478B1 (ru) 2021-09-03
WO2017059223A9 (fr) 2017-08-17
AU2016331084A1 (en) 2018-04-19
TWI784934B (zh) 2022-12-01
WO2017059223A3 (fr) 2017-05-11
IL300438A (en) 2023-04-01
TW201726918A (zh) 2017-08-01
PL3356529T3 (pl) 2021-12-20
EP3356529A4 (fr) 2019-09-04
EA201890864A1 (ru) 2018-09-28
WO2017059223A2 (fr) 2017-04-06
NZ741086A (en) 2023-11-24
JP2018529732A (ja) 2018-10-11
IL290566B1 (en) 2023-03-01
CA3000397A1 (fr) 2017-04-06
US9932586B2 (en) 2018-04-03
JP2022113835A (ja) 2022-08-04
IL290566B2 (en) 2023-07-01
UA121998C2 (uk) 2020-08-25
LT3356529T (lt) 2021-12-27
US20180195070A1 (en) 2018-07-12
MA43347A (fr) 2018-08-08
PT3356529T (pt) 2021-11-04
HUE055942T2 (hu) 2022-01-28
RS62523B1 (sr) 2021-11-30
SI3356529T1 (sl) 2022-01-31
EP3356529B1 (fr) 2021-08-25
TN2018000094A1 (en) 2019-07-08
CY1125263T1 (el) 2023-03-24
IL258333B (en) 2022-03-01
US20200263179A1 (en) 2020-08-20
HK1259063A1 (zh) 2019-11-22
CR20180231A (es) 2018-05-31
CO2018003678A2 (es) 2018-11-30
ES2896298T3 (es) 2022-02-24
KR20180052703A (ko) 2018-05-18
MX2022013010A (es) 2022-11-09
CN108368506A (zh) 2018-08-03
IL258333A (en) 2018-05-31
US10662427B2 (en) 2020-05-26
MX2018003833A (es) 2018-06-18
DK3356529T3 (da) 2021-11-08
MY195796A (en) 2023-02-21
BR112018006489A2 (pt) 2018-10-09
TW202332769A (zh) 2023-08-16
EP4029941A1 (fr) 2022-07-20
JP7116212B2 (ja) 2022-08-09
ZA202106265B (en) 2023-08-30
AU2016331084B2 (en) 2022-09-08
SG10202008530TA (en) 2020-10-29
TWI836693B (zh) 2024-03-21
UY36926A (es) 2017-04-28
JP2024009262A (ja) 2024-01-19
JP6991966B2 (ja) 2022-02-03
JP2021087459A (ja) 2021-06-10
JOP20210043A1 (ar) 2017-06-16
EP3356529A2 (fr) 2018-08-08
PH12018500713A1 (en) 2018-10-15
AU2022283623A1 (en) 2023-02-02
US20170096665A1 (en) 2017-04-06
CL2018000803A1 (es) 2018-08-31
HRP20211410T1 (hr) 2021-12-24
JP7442574B2 (ja) 2024-03-04
PE20181139A1 (es) 2018-07-17
IL290566A (en) 2022-04-01
JOP20160211B1 (ar) 2021-08-17

Similar Documents

Publication Publication Date Title
MA43347B1 (fr) Compositions et méthodes permettant d'inhiber l'expression du gène de lpa
JOP20200054A1 (ar) عوامل RNAi وتركيبات لتثبيط تعبير صَميمُ البروتينِ الشَّحْمِيّ C-III (APOC3)
JOP20200050A1 (ar) عوامل RNAi وتركيبات لتثبيط التعبير عن شبيه آنجيوبويتين 3 (ANGPTL3)، وطرق استخدام
WO2016106403A3 (fr) Compositions thérapeutiques et méthodes destinées à traiter les tumeurs malignes à l'aide de molécules d'arni ciblant hsp47 et p21
NZ630805A (en) Pharmaceutical combinations comprising a thionucleotide analog
PH12015500940A1 (en) Bruton`s tyrosine kinase inhibitors
MX2015001122A (es) Combinaciones farmaceuticas de un inhibidor de cdk4/6 y un inhibidor de b-raf.
EA201692318A1 (ru) Композиции и способы для ингибирования экспрессии гена альфа-1-антитрипсина
MX2017005861A (es) Metodos para el control transcripcional objetivo en regiones del super mejorador.
MA40791A (fr) Ciblage lysosomal d'enzymes et utilisations associées
EA201791225A1 (ru) Композиции и способы применения солабегрона с модифицированным высвобождением при симптомах нижних мочевых путей
GB201302343D0 (en) Pharmaceutical compositions comprising 15-OHEPA and methods for using the same
PH12017502081A1 (en) Composition, containing quisqualis indica extract, for preventing or treating prostatic hyperplasia
PH12019502660A1 (en) RNAi AGENTS FOR INHIBITING EXPRESSION OF ALPHA-ENaC AND METHODS OF USE
AU2017260019A1 (en) Valerian composition and related methods
TW201613926A (en) Inhibitors of bruton's tyrosine kinase
CR20200117A (es) Agentes de iarn y composiciones para inhibir la expresión de la angiopoyetina tipo 3 (angptl3) y métodos de uso
MX2022002340A (es) Inhibidores conjugados de la respuesta al daño de adn.
EA202090234A1 (ru) СРЕДСТВА РНКи ДЛЯ ИНГИБИРОВАНИЯ ЭКСПРЕССИИ АЛЬФА-ENaC И СПОСОБЫ ПРИМЕНЕНИЯ
EA202090717A1 (ru) СРЕДСТВА И КОМПОЗИЦИИ РНКи ДЛЯ ИНГИБИРОВАНИЯ ЭКСПРЕССИИ АНГИОПОЭТИН-ПОДОБНОГО БЕЛКА 3 (ANGPTL3) И СПОСОБЫ ПРИМЕНЕНИЯ
UA110910C2 (uk) Карбоксамідні похідні піразолу як інгібітори тирозинкінази брутона, фармацевтична композиція на їх основі та спосіб лікування захворювань (варіанти)