DK3301177T3 - Rnai-midler, sammensætninger og fremgangsmåder til anvendelse deraf til behandling af transthyretin (ttr)-forbundne sygdomme - Google Patents

Rnai-midler, sammensætninger og fremgangsmåder til anvendelse deraf til behandling af transthyretin (ttr)-forbundne sygdomme Download PDF

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Publication number
DK3301177T3
DK3301177T3 DK17184486.3T DK17184486T DK3301177T3 DK 3301177 T3 DK3301177 T3 DK 3301177T3 DK 17184486 T DK17184486 T DK 17184486T DK 3301177 T3 DK3301177 T3 DK 3301177T3
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Prior art keywords
transthyretine
ttr
compositions
treatment
methods
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DK17184486.3T
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English (en)
Inventor
Rajeev G Kallanthottathil
Tracy Zimmermann
Muthiah Manoharan
Martin Maier
Satyanarayana Kuchimanchi
Klaus Charisse
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Alnylam Pharmaceuticals Inc
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Publication of DK3301177T3 publication Critical patent/DK3301177T3/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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DK17184486.3T 2011-11-18 2012-11-16 Rnai-midler, sammensætninger og fremgangsmåder til anvendelse deraf til behandling af transthyretin (ttr)-forbundne sygdomme DK3301177T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161561710P 2011-11-18 2011-11-18
US201261615618P 2012-03-26 2012-03-26
US201261680098P 2012-08-06 2012-08-06
EP12850255.6A EP2780353B1 (en) 2011-11-18 2012-11-16 Rnai agents, compositions and methods of use thereof for treating transthyretin (ttr) associated diseases

Publications (1)

Publication Number Publication Date
DK3301177T3 true DK3301177T3 (da) 2020-06-15

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DK17184486.3T DK3301177T3 (da) 2011-11-18 2012-11-16 Rnai-midler, sammensætninger og fremgangsmåder til anvendelse deraf til behandling af transthyretin (ttr)-forbundne sygdomme

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US (5) US9399775B2 (da)
EP (4) EP3913056A1 (da)
JP (4) JP6165158B2 (da)
KR (4) KR102095699B1 (da)
CN (2) CN104080794B (da)
AR (1) AR088911A1 (da)
AU (4) AU2012340159B2 (da)
BR (1) BR112014011896B1 (da)
CA (1) CA2856243A1 (da)
CL (3) CL2014001291A1 (da)
CO (1) CO7020872A2 (da)
CR (1) CR20140232A (da)
CY (1) CY1123693T1 (da)
DK (1) DK3301177T3 (da)
DO (1) DOP2014000107A (da)
EC (1) ECSP14005606A (da)
ES (1) ES2800065T3 (da)
GT (1) GT201400097A (da)
HK (2) HK1200171A1 (da)
HR (1) HRP20200672T1 (da)
HU (1) HUE048622T2 (da)
IL (6) IL308752A (da)
IN (1) IN2014CN03463A (da)
LT (1) LT3301177T (da)
MX (2) MX348575B (da)
MY (1) MY167390A (da)
NI (1) NI201400046A (da)
PE (1) PE20142362A1 (da)
PH (1) PH12014501106A1 (da)
PL (1) PL3301177T3 (da)
PT (1) PT3301177T (da)
RS (1) RS60414B1 (da)
RU (1) RU2678807C2 (da)
SG (2) SG11201402392QA (da)
SI (1) SI3301177T1 (da)
UA (1) UA118649C2 (da)
WO (1) WO2013075035A1 (da)

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